389
Views
14
CrossRef citations to date
0
Altmetric
Gene of the Issue/Plenary Paper

Platelet glycoprotein VI genetic quantitative and qualitative defects

, &
Pages 708-713 | Received 27 Mar 2019, Accepted 29 Mar 2019, Published online: 08 May 2019

References

  • Qiao J, Al-Tamimi M, Baker RI. The platelet Fc receptor, FcgammaRIIa. Immunol Rev 2015;268:241–252. DOI:10.1111/imr.12370.
  • Rayes J, Watson SP, Nieswandt B. Functional significance of the platelet immune receptors GPVI and CLEC-2. J Clin Invest 2019;129:12–23. DOI:10.1172/JCI122955.
  • Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood 2003;102:449–461. DOI:10.1182/blood-2002-12-3882.
  • Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, et al. Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation. Blood 2015;126:683–691. DOI:10.1182/blood-2015-02-629717.
  • Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, Watson SP. Fibrin activates GPVI in human and mouse platelets. Blood 2015;126:1601–1608. DOI:10.1182/blood-2015-04-641654.
  • Mangin P, Onselaer M-B, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, et al. Immobilized fibrinogen activates human platelets through glycoprotein VI. Haematologica 2018;103:898–907. DOI:10.3324/haematol.2017.182972.
  • Cosemans JM, Kuijpers MJ, Lecut C, Loubele ST, Heeneman S, Jandrot-Perrus M, Heemskerk JWM. Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions. Atherosclerosis 2005;181:19–27. DOI:10.1016/j.atherosclerosis.2004.12.037.
  • Clemetson JM, Polgar J, Magnenat E, Wells TN, Clemetson KJ. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. J Biol Chem 1999;274:29019–29024.
  • Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood 2000;96:1798–1807.
  • Tsuji M, Ezumi Y, Arai M, Takayama H. A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. J Biol Chem 1997;272:23528–23531.
  • Miura Y, Ohnuma M, Jung SM, Moroi M. Cloning and expression of the platelet-specific collagen receptor glycoprotein VI. Thromb Res 2000;98:301–309.
  • Lagrue-Lak-Hal AH, Debili N, Kingbury G, Lecut C, Le Couedic JP, Villeval JL, Jandrot-Perrus M, Vainchenker W. Expression and function of the collagen receptor GPVI during megakaryocyte maturation. J Biol Chem 2001;276:15316–15325. DOI:10.1074/jbc.M009117200.
  • Horii K, Kahn ML, Herr AB. Kahn ML and Herr AB. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood 2006;108:936–942. DOI:10.1182/blood-2006-01-010215.
  • Dumont B, Minullina I, Loyau S, Monteiro RC, Lacapere JJ, Arocas V, Jandrot-Perrus M. Chimeric Fc receptors identify ligand binding regions in human glycoprotein VI. J Mol Biol 2006;361:877–887. DOI:10.1016/j.jmb.2006.06.053.
  • Smethurst PA, Joutsi-Korhonen L, O‘Connor MN, Wilson E, Jennings NS, Garner SF, Zhang Y, Knight CG, Dafforn TR, Buckle A, et al. Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. Blood 2004;103:903–911. DOI:10.1182/blood-2003-01-0308.
  • O‘Connor MN, Smethurst PA, Farndale RW, Ouwehand WH. Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen. J Thrombosis and Haemostasis: JTH 2006;4:869–873. DOI:10.1111/j.1538-7836.2005.01764.x.
  • Lecut C, Arocas V, Ulrichts H, Elbaz A, Villeval JL, Lacapere JJ, Deckmyn H, Jandrot-Perrus M. Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites. J Biol Chem 2004;279:52293–52299. DOI:10.1074/jbc.M406342200.
  • Kunicki TJ, Cheli Y, Moroi M, Furihata K. The influence of N-linked glycosylation on the function of platelet glycoprotein VI. Blood 2005;106:2744–2749. DOI:10.1182/blood-2005-04-1454.
  • O‘Connor MN, Smethurst PA, Davies LW, Joutsi-Korhonen L, Onley DJ, Herr AB, Farndale RW, Ouwehand WH. Selective blockade of glycoprotein VI clustering on collagen helices. J Biol Chem 2006;281:33505–33510. DOI:10.1074/jbc.M606480200.
  • Miura Y, Takahashi T, Jung SM, Moroi M. Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. J Biol Chem 2002;277:46197–46204. DOI:10.1074/jbc.M204029200.
  • Loyau S, Dumont B, Ollivier V, Boulaftali Y, Feldman L, Ajzenberg N, Jandrot-Perrus M. Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity. Arterioscler Thromb Vasc Biol 2012;32:778–785. DOI:10.1161/ATVBAHA.111.241067.
  • Gardiner EE, Arthur JF, Kahn ML, Berndt MC, Andrews RK. Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood 2004;104:3611–3617. DOI:10.1182/blood-2004-04-1549.
  • Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP. Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem 2002;277:21561–21566. DOI:10.1074/jbc.M201012200.
  • Bori-Sanz T, Inoue KS, Berndt MC, Watson SP, Tulasne D. Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain. J Biol Chem 2003;278:35914–35922. DOI:10.1074/jbc.M301826200.
  • Watkins NA, O’Connor MN, Rankin A, Jennings N, Wilson E, Harmer IJ, Davies L, Smethurst PA, Dudbridge F, Farndale RW, et al. Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in-depth exon resequencing and genotyping with tag single nucleotide polymorphisms. J Thrombosis and Haemostasis: JTH 2006;4:1197–1205. DOI:10.1111/j.1538-7836.2006.01937.x.
  • Croft SA, Samani NJ, Teare MD, Hampton KK, Steeds RP, Channer KS, Daly ME. Novel platelet membrane glycoprotein VI dimorphism is a risk factor for myocardial infarction. Circulation 2001;104:1459–1463.
  • Best D, Senis YA, Jarvis GE, Eagleton HJ, Roberts DJ, Saito T, Jung SM, Moroi M, Harrison P, Green FR, et al. GPVI levels in platelets: relationship to platelet function at high shear. Blood 2003;102:2811–2818. DOI:10.1182/blood-2003-01-0231.
  • Joutsi-Korhonen L, Smethurst PA, Rankin A, Gray E, Ij M, Cm O, Na W, Lm W, Ah G, Pg DG, et al. The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression. Blood 2003;101:4372–4379. DOI:10.1182/blood-2002-08-2591.
  • Dumont B, Lasne D, Rothschild C, Bouabdelli M, Ollivier V, Oudin C, Ajzenberg N, Grandchamp B, Jandrot-Perrus M. Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood 2009;114:1900–1903. DOI:10.1182/blood-2009-03-213504.
  • Hermans C, Wittevrongel C, Thys C, Smethurst PA, Van Geet C, Freson K. A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder. J Thrombosis and Haemostasis: JTH 2009;7:1356–1363. DOI:10.1111/j.1538-7836.2009.03520.x.
  • Matus V, Valenzuela G, Saez CG, Hidalgo P, Lagos M, Aranda E, Panes O, Pereira J, Pillois X, Nurden AT, et al. An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families. J Thrombosis and Haemostasis: JTH 2013;11:1751–1759. DOI:10.1111/jth.12334.
  • Zilberman-Rudenko J, McCarty OJT. Utility and development of microfluidic platforms for platelet research. Platelets 2017;28:425–426. DOI:10.1080/09537104.2017.1325187.
  • Onselaer MB, Hardy AT, Wilson C, Sanchez X, Babar AK, Miller JLC, Watson CN, Watson SK, Bonna A, Philippou H, et al. Fibrin and D-dimer bind to monomeric GPVI. Blood Adv 2017;1:1495–1504. DOI:10.1182/bloodadvances.2017007732.
  • Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. J Biol Chem 2000;275:23998–24002. DOI:10.1074/jbc.M003803200.
  • Bellucci S, Huisse MG, Boval B, Hainaud P, Robert A, Fauvel-Lafève F, Jandrot-Perrus M. Defective collagen-induced platelet activation in two patients with malignant haemopathies is related to a defect in the GPVI-coupled signalling pathway. Thromb Haemost 2005;93:130–138. DOI:10.1160/TH04-05-0312.
  • Gardiner EE, Al-Tamimi M, Mu F-T, Karunakaran D, Thom JY, Moroi M, Andrews RK, Berndt MC, Baker RI. Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura. J Thrombosis and Haemostasis: JTH 2008;6:1175–1182. DOI:10.1111/j.1538-7836.2008.03016.x.
  • Nurden P, Tandon N, Takizawa H, Couzi L, Morel D, Fiore M, Pillois X, Loyau S, Jandrot-Perrus M, Nurden AT An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis. J Thrombosis and Haemostasis: JTH 2009;7:1541–1549. DOI:10.1111/j.1538-7836.2009.03537.x.
  • Quiroga T, Goycoolea M, Muñoz B, Morales M, Aranda E, Panes O, Pereira J, Mezzano D Pereira J and Mezzano D. Template bleeding time and PFA-100 have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study in 148 patients. J Thrombosis and Haemostasis: JTH 2004;2:892–898. DOI:10.1111/j.1538-7836.2004.00693.x.
  • Rabbolini DJ, Gardiner EE, Morel-Kopp M-C, Dunkley S, Jahangiri A, Lee CS-M, Stevenson WS, Ward CM Stevenson Ws and Ward CM. Anti-glycoprotein VI mediated immune thrombocytopenia: an under-recognized and significant entity? Res Pract Thromb Haemost 2017;1:291–295. DOI:10.1002/rth2.12033.
  • Boulaftali Y, Mawhin M-A, Jandrot-Perrus M, Ho-Tin-Noé B. Glycoprotein VI in securing vascular integrity in inflamed vessels. Res Pract Thromb Haemost 2018;2:228–239. DOI:10.1002/rth2.12092.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.