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Platelets Volume 31, 2020 - Issue 3
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Short Communication

Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)

Rick KapurDepartment of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-1608-876XView further author information
ORCID Icon,
Rukhsana AslamKeenan Research Center, St. Michael’s Hospital, Toronto, ON, CanadaView further author information
,
Edwin R. SpeckKeenan Research Center, St. Michael’s Hospital, Toronto, ON, CanadaView further author information
,
Johan M. RebetzDivision of Hematology and Transfusion Medicine, Lund University, Lund, SwedenView further author information
&
John W. SempleKeenan Research Center, St. Michael’s Hospital, Toronto, ON, Canada;Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden;Department of Pharmacology, University of Toronto, Toronto, ON, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1510-0077View further author information
ORCID Icon
Pages 399-402 | Received 09 Apr 2019, Accepted 21 May 2019, Published online: 30 May 2019

References

  • Zufferey A, Kapur R, Semple JW. Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP). J Clin Med 2017;6(2):16. doi:10.3390/jcm6020016
  • McKenzie CG, Guo L, Freedman J, Semple JW. Cellular immune dysfunction in immune thrombocytopenia (ITP). Br J Haematol 2013;163(1):10–23. doi:10.1111/bjh.12480
  • Erickson-Miller CL, DeLorme E, Tian SS, Hopson CB, Stark K, Giampa L, Valoret EI, Duffy KJ, Luengo JL, Rosen J, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol 2005;33(1):85–93. doi:10.1016/j.exphem.2004.09.006
  • Cohn CS, Bussel JB. Romiplostim: a second-generation thrombopoietin agonist. Drugs Today (Barc) 2009;45(3):175–188. doi:10.1358/dot.2009.45.3.1343793
  • Bao W, Bussel JB, Heck S, He W, Karpoff M, Boulad N, Yazdanbakhsh K. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood 2010;116(22):4639–4645. doi:10.1182/blood-2010-04-281717
  • Liu XG, Liu S, Feng Q, Liu X-N, Li G-S, Sheng Z, Chen P, Liu Y, Wei Y, Dong X-Y, et al. Thrombopoietin receptor agonists shift the balance of Fcgamma receptors toward inhibitory receptor IIb on monocytes in ITP. Blood 2016;128(6):852–861. doi:10.1182/blood-2016-01-690727
  • Newland A, Godeau B, Priego V, Viallard J-F, López Fernández MF, Orejudos A, Eisen M. Remission and platelet responses with romiplostim in primary immune thrombocytopenia: final results from a phase 2 study. Br J Haematol 2016;172(2):262–273. doi:10.1111/bjh.13827
  • Chow L, Aslam R, Speck ER, Kim M, Cridland N, Webster ML, Chen P, Sahib K, Ni H, Lazarus AH, et al. A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. Blood 2010;115(6):1247–1253. doi:10.1182/blood-2009-09-244772
  • Aslam R, Hu Y, Gebremeskel S, Segel GB, Speck ER, Guo L, Kim M, Ni H, Freedman J, Semple JW. Thymic Retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia (ITP). Blood 2012;120(10):2127–2132. doi:10.1182/blood-2012-02-413526
  • Zufferey A, Speck ER, Aslam R, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, et al. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. Blood Adv 2017;1(20):1773–1785. doi:10.1182/bloodadvances.2017007021

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