191
Views
7
CrossRef citations to date
0
Altmetric
Article

Impaired platelet reactivity in patients with septic shock: a proof-of-concept study

ORCID Icon, ORCID Icon, ORCID Icon, , , , , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 652-660 | Received 03 Jul 2019, Accepted 22 Aug 2019, Published online: 13 Sep 2019

References

  • Tsirigotis P, Chondropoulos S, Frantzeskaki F, Stamouli M, Gkirkas K, Bartzeliotou A, Papanikolaou N, Atta M, Papassotiriou I, Dimitriadis G, et al. Thrombocytopenia in critically ill patients with severe sepsis/septic shock: prognostic value and association with a distinct serum cytokine profile. J Crit Care 2016;32:9–15. doi:10.1016/j.jcrc.2015.11.010.
  • Daviaud F, Grimaldi D, Dechartres A, Charpentier J, Geri G, Marin N, Chiche JD, Cariou A, Mira JP, Pène F. Timing and causes of death in septic shock. Ann Intensive Care 2015;5(1):16. doi:10.1186/s13613-015-0058-8.
  • Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche J-D, Coopersmith CM, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315(8):801. doi:10.1001/jama.2016.0287.
  • Drews RE, Weinberger SE. Thrombocytopenic disorders in critically ill patients. Am J Respir Crit Care Med 2000:162:347-351.
  • Venkata C, Kashyap R, Farmer JC, Afessa B. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J Intensive Care 2013;1(1):9. doi:10.1186/2052-0492-1-9.
  • Sharma B, Sharma M, Majumder M, Steier W, Sangal A, Kalawar M. Thrombocytopenia in septic shock patients- a prospective observational study of incidence, risk factors and correlation with clinical outcome. Anaesth Intensive Care 2007;35(6):874–880. doi:10.1177/0310057X0703500604.
  • Ali RA, Wuescher LM, Dona KR, Worth RG. Platelets mediate host defense against staphylococcus aureus through direct bactericidal activity and by enhancing macrophage activities. J Immunol 2016;198(1):344–351. doi:10.4049/jimmunol.1601178.
  • de Stoppelaar SF, van ‘t Veer C, Claushuis TA, Albersen BJ, Roelofs JJ, van der Poll T. Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice. Blood 2014;124(25):3781–3790. doi:10.1182/blood-2014-05-573915.
  • Watson CN, Kerrigan SW, Cox D, Henderson I, Watson SP, Arman M. Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets 2016Sep;27(6):535–540. doi:10.3109/09537104.2016.1148129.
  • Youssefian T, Drouin A, Masse JM, Guichard J, Cramer EM. Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 2002;99:11. doi:10.1182/blood-2001-12-0191.
  • Vanderschueren S, De Weerdt A, Malbrain M, Vankersschaever D, Frans E, Wilmer A, Bobbaers H. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000;28:6. doi:10.1097/00003246-200001000-00003.
  • Thiery-Antier N, Binquet C, Vinault S, Meziani F, Boisramé-Helms J, Quenot JP. Thrombocytopenia an early prognostic marker in septic shock?. Crit Care Med 2016;44(4):764-772.
  • Koyama K, Madoiwa S, Nunomiya S, Koinuma T, Wada M, Sakata A, Ohmori T, Mimuro J, Sakata Y. Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study. Crit Care 2014;18(1):R13. doi:10.1186/cc13712.
  • Wada H, Sakuragawa N, Mori Y, Takagi M, Nakasaki T, Shimura M, Hiyoyama K, Nisikawa M, Gabazza EC, Deguchi K, et al. Hemostatic molecular markers before the onset of disseminated intravascular coagulation. Am J Hematol 1999;60:4. doi:10.1002/(SICI)1096-8652(199904)60:4<273::AID-AJH4>3.0.CO;2-N.
  • Cattaneo M, Cerletti C, Harrison P, Hayward CP, Kenny D, Nugent D, Nurden P, Rao AK, Schmaier AH, Watson SP, et al. Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology Subcommittee of SSC/ISTH. J Thromb Haemost 2013;11:1183-1189.
  • Femia EA, Scavone M, Lecchi A, Cattaneo M. Effect of platelet count on platelet aggregation measured with impedance aggregometry (Multiplate™ analyzer) and with light transmission aggregometry. J Thromb Haemost 2013;11:12. doi:10.1111/jth.12432.
  • Jagroop IA, Clatworthy I, Lewin J, Mikhailidis DP. Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy. Platelets 2000;11:1.
  • Zampieri FG, Ranzani OT, Sabatoski V, de Souza HP, Barbeiro H, Da Neto L, Park M, Da Silva FP. An increase in mean platelet volume after admission is associated with higher mortality in critically ill patients. Ann Intensive Care 2014;4:20. doi:10.1186/s13613-014-0020-1.
  • Yilmaz Z, Eralp O, Ilcol YO. Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia. Vet Clin Path 2008;37:159–163. doi:10.1111/j.1939-165X.2008.00023.x.
  • Akca S, Haji-Michael P, de Mendonça A, Suter P, Levi M, Vincent JL. Time course of platelet counts in critically ill patients. Crit Care Med 2002;30(4):753–756. doi:10.1097/00003246-200204000-00005.
  • Greinacher A, Selleng S. How I evaluate and treat thrombocytopenia in the intensive care unit patient. Blood 2016;128(26):3032–3042. doi:10.1182/blood-2016-09-693655.
  • Campo G, Valgimigli M, Gemmati D, Percoco G, Tognazzo S, Cicchitelli G, Catozzi L, Malagutti P, Anselmi M, Vassanelli C, et al. Value of platelet reactivity in predicting response to treatment and clinical outcome in patients undergoing primary coronary intervention: insights into the STRATEGY study. J Am Coll Cardiol 2006;48:11. doi:10.1016/j.jacc.2005.12.085.
  • Williamson DR, Albert M, Heels-Ansdell D, Arnold DM, Lauzier F, Zarychanski R, Crowther M, Warkentin TE, Dodek P, Cade J, et al. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest 2013;144(4):1207–1215. doi:10.1378/chest.13-0121.
  • Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the european society of intensive care medicine. Intensive Care Med 1996;22(7):707–710. doi:10.1007/BF01709751.
  • Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol 2009Apr;145(1):24–33. doi:10.1111/bjh.2009.145.issue-1.
  • Evans JD. Straightforward statistics for the behavioral sciences. Pacific Grove, CA: Brooks/Cole Publishing; 1996.
  • Kieser M, Wassmer G. On the use of the upper confidence limit for the variance from a pilot sample for sample size determination. Biom J 1996;8:941–949. doi:10.1002/bimj.4710380806.
  • Lancaster GA, Dodd S, Williamson PR. Design and analysis of pilot studies: recommendations for good practice. J Eval Clin Pract 2004:10(02).
  • Adamzik M, Görlinger K, Peters J, Hartmann M. Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis. Crit Care 2012;16(5):R204. doi:10.1186/cc11816.
  • Würtz M, Hvas AM, Kristensen SD, Grove EL. Platelet aggregation is dependent on platelet count in patients with coronary artery disease. Thromb Res 2012;129(1):56–61. doi:10.1016/j.thromres.2011.08.019.
  • Wohlauer MVL, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg 2012;214(5):739–746. doi:10.1016/j.jamcollsurg.2012.01.050.
  • Davis PK, Musunuru H, Walsh M, Cassady R, Yount R, Losiniecki A, Moore EE, Wohlauer MV, Howard J, Ploplis VA, et al. Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocrit Care 2013;18(2):201–208. doi:10.1007/s12028-012-9745-6.
  • Lieberman L, Bercovitz RS, Sholapur NS, Heddle NM, Stanworth SJ, Arnold DM. Platelet transfusions for critically ill patients with thrombocytopenia. Blood 2014;123(8):1146–51; quiz 1280. doi:10.1182/blood-2013-02-435693.
  • Vincent J-L, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, et al. A randomized, double-blind, placebo-controlled, phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med 2013;41(9):2069–2079. doi:10.1097/CCM.0b013e31828e9b03.
  • Claushuis TAM, Van Der Veen AIP, Horn J, Schultz MJ, Houtkooper RH, Van ‘t Veer C, Van Der Poll T. Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis. Platelets 2019;30:296–304. doi:10.1080/09537104.2018.1445841.
  • Shannon O. Platelet interaction with bacterial toxins and secreted products. Platelets 2015;26(4):302–308. doi:10.3109/09537104.2015.1014471.
  • Cotoia A, Franchi F, De Fazio C, Vincent JL, Creteur J, Taccone FS. Platelet indices and outcome after cardiac arrest. BMC Emerg Med 2018;18(1):31. doi:10.1186/s12873-018-0183-4.
  • Spadaro S, Taccone FS, Fogagnolo A, Franchi F, Scolletta S, Ragazzi R, Fanni A, Marangoni E, Govoni M, Reverberi R, et al. The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study. Transfusion 2018;58(8):1863–1869. doi:10.1111/trf.14759.
  • Ouyang Y, Wang Y, Liu B, Ma X, Ding R. Effects of antiplatelet therapy on the mortality rate of patients with sepsis: a meta-analysis. J Crit Care 2019;50:162–168. doi:10.1016/j.jcrc.2018.12.004.
  • Adly AAM, Ragab IA, Ismail EAR, Farahat MM. Evaluation of the immature platelet fraction in the diagnosis and prognosis of childhood immune thrombocytopenia. Platelets 2015;26:645–650. doi:10.3109/09537104.2014.969220.
  • De Blasi RA, Cardelli P, Costante A, Sandri M, Mercieri M, Arcioni R. Immature platelet fraction in predicting sepsis in critically ill patients. Intensive Care Med 2013;39:4. doi:10.1007/s00134-012-2725-7.
  • Valgimigli M, Tebaldi M, Campo G, Gambetti S, Bristot L, Monti M, Parrinello G, Ferrari R. Prasugrel versus tirofiban bolus with or without short post-bolus infusion with or without concomitant prasugrel administration in patients with myocardial infarction undergoing coronary stenting: the FABOLUS PRO (Facilitation through aggrastat by drOpping or shortening infusion line in patients with ST-segment elevation myocardial infarction compared to or on top of PRasugrel given at loading dOse) trial. JACC Cardiovasc Interv 2012;5(3):266-277.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.