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Letter

Smoking, clopidogrel and platelet reactivity: are we still missing something?

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References

  • Gupta R, Kirtane AJ, Liu Y, Crowley A, Witzenbichler B, Rinaldi MJ, Metzger DC, Weisz G, Stuckey TD, Brodie BR, et al. Impact of smoking on platelet reactivity and clinical outcomes after percutaneous coronary intervention: findings from the ADAPT-DES study. Circ Cardiovasc Interv 2019;12(11):e007982. doi:10.1161/CIRCINTERVENTIONS.119.007982
  • Stone GW, Witzenbichler B, Weisz G, Rinaldi MJ, Neumann FJ, Metzger DC, Henry TD, Cox DA, Duffy PL, Mazzaferri E, et al. Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study. Lancet 2013;382:614–623. doi:10.1016/S0140-6736(13)61170-8
  • Kim YG, Suh J-W, Kang S-H, Park JJ, Yoon C-H, Cho Y-S, Youn T-J, Chae I-H, Choi D-J, Kim H-S. Cigarette smoking does not enhance clopidogrel responsiveness after adjusting VerifyNow P2Y12 reaction unit for the influence of hemoglobin level. JACC Cardiovasc Interv 2016;16:1680–1690. doi:10.1016/j.jcin.2016.05.036
  • Crimi G, Somaschini A, Cattaneo M, Angiolillo DJ, Piscione F, Palmerini T, De Servi S. Cigarette smoking reduces platelet reactivity independently of clopidogrel treatment in patients with non-ST elevation acute coronary syndromes. Platelets 2018;29:309–311. doi:10.1080/09537104.2017.1394452
  • Cornel JH, Ohman EM, Neely B, Clemmensen P, Sritara P, Zamoryakhin D, Armstrong PW, Prabhakaran D, White HD, Fox KA, et al. Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. clopidogrel in patients with acute coronary syndromes managed without revascularization: insights from the TRILOGY ACS trial. Am Heart J 2014;168:76–87. doi:10.1016/j.ahj.2014.04.011

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