Platelet-rich plasma loaded with antibiotics as an affiliated treatment for infected bone defect by combining wound healing property and antibacterial activity

References

• RO D. Antimicrobial approaches for preventing infections associated with surgical implants. Clin Infect Dis 2003;36:1284–1289. doi:10.1086/374842.
   PubMed Web of Science ®Google Scholar
• Deysine M. Infections associated with surgical implants. N Engl J Med 2004;351:193–195. author reply 193-195. Epub 2004/ 07/13.
   PubMed Web of Science ®Google Scholar
• Jain AK, Panchagnula R. Skeletal drug delivery systems. Int J Pharm 2000;206:1–12. Epub 2000/ 11/04. doi:10.1016/S0378-5173(00)00468-3.
   PubMed Web of Science ®Google Scholar
• Henry MW, Miller AO. A single dose of antibiotics before removal of orthopaedic implants used to treat below-the-knee fractures did not reduce surgical site infections at 30 days. J Bone Joint Surg Am 2018;100:1434. Epub 2018/ 08/15. doi:10.2106/JBJS.18.00634.
   PubMed Web of Science ®Google Scholar
• Matthews PC, Berendt AR, McNally MA, Byren I. Diagnosis and management of prosthetic joint infection. BMJ 2009;338:b1773. Epub 2009/ 06/02. doi:10.1136/bmj.b1773.
   PubMed Web of Science ®Google Scholar
• Singh K, Bauer JM, LaChaud GY, Bible JE, Mir HR. Surgical site infection in high-energy peri-articular tibia fractures with intra-wound vancomycin powder: a retrospective pilot study. J Orthop Traumatology 2015;16:287–291. Epub 2015/ 05/11. doi:10.1007/s10195-015-0352-0.
   PubMedGoogle Scholar
• Zilberman M, Elsner JJ. Antibiotic-eluting medical devices for various applications. J Controlled Release 2008;130:202–215. Epub 2008/ 08/09. doi:10.1016/j.jconrel.2008.05.020.
   PubMed Web of Science ®Google Scholar
• Buchholz HW, Gartmann HD. [Infection prevention and surgical management of deep insidious infection in total endoprosthesis]. Chirurg 1972;43:446–453. Epub 1972/ 10/01.
   PubMed Web of Science ®Google Scholar
• Tennent DJ, Shiels SM, Sanchez CJ Jr., Niece KL, Akers KS, Stinner DJ, Wenke JC. Time-dependent effectiveness of locally applied vancomycin powder in a contaminated traumatic orthopaedic wound model. J Orthop Trauma 2016;30:531–537. Epub 2016/ 04/29. doi:10.1097/BOT.0000000000000617.
   PubMed Web of Science ®Google Scholar
• Piccin A, Di Pierro AM, Canzian L, Primerano M, Corvetta D, Negri G, Mazzoleni G, Gastl G, Steurer M, Gentilini I, et al. Platelet gel: a new therapeutic tool with great potential. Blood Transfus 2017;15:333–340. doi:10.2450/2016.0038-16.
   PubMed Web of Science ®Google Scholar
• Cetinkaya RA, Yenilmez E, Petrone P, Yilmaz S, Bektore B, Simsek B, Kula Atik T, Ozyurt M, Unlu A. Platelet-rich plasma as an additional therapeutic option for infected wounds with multi-drug resistant bacteria: in vitro antibacterial activity study. Eur J Trauma Emergency Surg 2018. 45:555-565. Epub 2018/ 04/28.
   Web of Science ®Google Scholar
• Porter JR, Ruckh TT, Popat KC. Bone tissue engineering: a review in bone biomimetics and drug delivery strategies. Biotechnol Prog 2009;25:1539–1560. Epub 2009/ 10/14. doi:10.1002/btpr.246.
   PubMed Web of Science ®Google Scholar
• Breen A, O’Brien T, Pandit A. Fibrin as a delivery system for therapeutic drugs and biomolecules. Tissue Eng Part B Rev 2009;15:201–214. Epub 2009/ 03/03. doi:10.1089/ten.teb.2008.0527.
   PubMed Web of Science ®Google Scholar
• Miron RJ, Zhang Y. Autologous liquid platelet rich fibrin: a novel drug delivery system. Acta Biomater 2018;75:35–51. Epub 2018/ 05/18. doi:10.1016/j.actbio.2018.05.021.
   PubMed Web of Science ®Google Scholar
• Bayer A, Lammel J, Rademacher F, J G, Siggelkow M, Lippross S, Kluter T, Varoga D, Tohidnezhad M, Pufe T, et al. Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes. Exp Dermatol 2016;25:460–465. Epub 2016/ 02/05. doi:10.1111/exd.12966.
   PubMed Web of Science ®Google Scholar
• Nagae M, Ikeda T, Mikami Y, Hase H, Ozawa H, Matsuda KI, Sakamoto H, Tabata Y, Kawata M, Kubo T. Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres. Tissue Eng 2007;13:147–158. doi:10.1089/ten.2006.0042.
   PubMedGoogle Scholar
• Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, Nagae M, Arai Y, Kawata M, Kubo T. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 2008;215:837–845. Epub 2008/ 01/09. doi:10.1002/jcp.21368.
   PubMed Web of Science ®Google Scholar
• Hammond JW, Hinton RY, Curl LA, Muriel JM, Lovering RM. Use of autologous platelet-rich plasma to treat muscle strain injuries. Am J Sports Med 2009;37:1135–1142. Epub 2009/ 03/14. doi:10.1177/0363546508330974.
   PubMed Web of Science ®Google Scholar
• Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Krol W, Wielkoszynski T. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J Bone Joint Surg Br 2007;89:417–420. Epub 2007/ 03/16. doi:10.1302/0301-620X.89B3.18491.
   PubMed Web of Science ®Google Scholar
• Cetinkaya RA, Yilmaz S, Unlu A, Petrone P, Marini C, Karabulut E, Urkan M, Kaya E, Karabacak K, Uyanik M, et al. The efficacy of platelet-rich plasma gel in MRSA-related surgical wound infection treatment: an experimental study in an animal model. Eur J Trauma Emergency Surg 2018;44:859–867. Epub 2017/ 10/02. doi:10.1007/s00068-017-0852-0.
   PubMed Web of Science ®Google Scholar
• Cieslik-Bielecka A, Bold T, Ziolkowski G, Pierchala M, Krolikowska A, Reichert P. Antibacterial activity of leukocyte- and platelet-rich plasma: an in vitro study. Biomed Res Int 2018;2018:9471723. Epub 2018/ 07/28. doi:10.1155/2018/9471723.
   PubMed Web of Science ®Google Scholar
• Cao Z, Jiang D, Yan L, Wu J. In vitro and in vivo drug release and antibacterial properties of the novel vancomycin-loaded bone-like hydroxyapatite/poly amino acid scaffold. Int J Nanomedicine 2017;12:1841–1851. Epub 2017/ 03/24. doi:10.2147/IJN.S122864.
   PubMed Web of Science ®Google Scholar
• Li X, Wang C, Yang S, Liu P, Zhang B. Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications. Int J Nanomedicine 2018;13:5287–5299. Epub 2018/ 09/22. doi:10.2147/IJN.S177256.
   PubMed Web of Science ®Google Scholar
• Lima TD, Seba KS, Gonçalves JC, Cardoso FL, Estrela RD. Rapid and simple HPLC method for therapeutic monitoring of vancomycin. J Chromatogr Sci 2018;56:115–121. doi:10.1093/chromsci/bmx089.
   PubMed Web of Science ®Google Scholar
• Liu CM, Chen YK, Yang TH, Hsieh SY, Hung MH, Lin ET. High-performance liquid chromatographic determination of clindamycin in human plasma or serum: application to the bioequivalency study of clindamycin phosphate injections. J Chromatogr B Biomed Sci Appl 1997;696:298–302. Epub 1997/ 08/29. doi:10.1016/S0378-4347(97)00241-7.
   PubMed Web of Science ®Google Scholar
• Girondi NG, Barreto F, Pigatto MC, Dalla Costa T. Sensitive analytical method to quantify clindamycin in plasma and microdialysate samples: application in a preclinical pharmacokinetic study. J Pharm Biomed Anal 2018;153:57–62. Epub 2018/ 02/21. doi:10.1016/j.jpba.2018.02.005.
   PubMed Web of Science ®Google Scholar
• Legrand T, Vodovar D, Tournier N, Khoudour N, Hulin A. Simultaneous determination of eight beta-lactam antibiotics, amoxicillin, cefazolin, cefepime, cefotaxime, ceftazidime, cloxacillin, oxacillin, and piperacillin, in human plasma by using ultra-high-performance liquid chromatography with ultraviolet detection. Antimicrob Agents Chemother 2016;60:4734–4742. Epub 2016/ 05/25. doi:10.1128/AAC.00176-16.
   PubMed Web of Science ®Google Scholar
• Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Yaprak E, Toker H, Firatli E. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. Biomed Res Int 2014;2014:209548. Epub 2014/ 02/25. doi:10.1155/2014/209548.
   PubMed Web of Science ®Google Scholar
• Walker M, Sharareh B, Mitchell SA. Masquelet reconstruction for posttraumatic segmental bone defects in the forearm. J Hand Surg Am 2019;44:342.e341-342.e348. Epub 2018/ 08/28. doi:10.1016/j.jhsa.2018.07.003.
   PubMed Web of Science ®Google Scholar
• Devereaux J, Nurgali K, Kiatos D, Sakkal S, Apostolopoulos V. Effects of platelet-rich plasma and platelet-poor plasma on human dermal fibroblasts. Maturitas 2018;117:34–44. Epub 2018/ 10/14. doi:10.1016/j.maturitas.2018.09.001.
   PubMed Web of Science ®Google Scholar
• Gessmann J, Seybold D, Ayami F, Peter E, Baecker H, Schildhauer TA, Koller M. Peripheral blood plasma clot as a local antimicrobial drug delivery matrix. Tissue Eng Part A 2018;24:809–818. Epub 2017/ 11/04. doi:10.1089/ten.tea.2017.0319.
   PubMed Web of Science ®Google Scholar
• Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002;10:432–463. Epub 2002/ 06/12. doi:10.1053/joca.2002.0801.
   PubMed Web of Science ®Google Scholar
• Wang JH, Zhao K, Liu HL, Zhao HM, Yang J, Sun XK. Infected bone inactivation combined with transplantation of autologous platelet-rich plasma and bone marrow for treatment of chronic osteomyelitis. Eur Rev Med Pharmacol Sci 2015;19:4488–4493. Epub 2015/ 12/25.
   PubMed Web of Science ®Google Scholar
• Wang HF, Gao YS, Yuan T, Yu XW, Zhang CQ. Chronic calcaneal osteomyelitis associated with soft-tissue defect could be successfully treated with platelet-rich plasma: a case report. Int Wound J 2013;10:105–109. Epub 2012/ 03/01. doi:10.1111/j.1742-481X.2012.00951.x.
   PubMed Web of Science ®Google Scholar
• Pollak AN, Jones AL, Castillo RC, Bosse MJ, MacKenzie EJ. The relationship between time to surgical debridement and incidence of infection after open high-energy lower extremity trauma. J Bone Joint Surg Am 2010;92:7–15. Epub 2010/ 01/06. doi:10.2106/JBJS.H.00984.
   PubMed Web of Science ®Google Scholar
• Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364:369–379. Epub 2004/ 07/28. doi:10.1016/S0140-6736(04)16727-5.
   PubMed Web of Science ®Google Scholar
• Lindbloom BJ, James ER, McGarvey WC. Osteomyelitis of the foot and ankle: diagnosis, epidemiology, and treatment. Foot Ankle Clin 2014;19:569–588. Epub 2014/ 08/19. doi:10.1016/j.fcl.2014.06.012.
   PubMed Web of Science ®Google Scholar
• Crawford T, Rodvold KA, Solomkin JS. Vancomycin for surgical prophylaxis? Clin Infect Dis 2012;54:1474–1479. Epub 2012/ 02/14. doi:10.1093/cid/cis027.
   PubMed Web of Science ®Google Scholar
• Zalavras CG, Patzakis MJ, Holtom P. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res 2004;427:86–93. Epub 2004/ 11/24. doi:10.1097/01.blo.0000143571.18892.8d.
   PubMed Web of Science ®Google Scholar
• Nana A, Nelson SB, McLaren A, Chen AF. What’s new in musculoskeletal infection: update on biofilms. J Bone Joint Surg Am 2016;98:1226–1234. Epub 2016/ 07/22. doi:10.2106/JBJS.16.00300.
   PubMed Web of Science ®Google Scholar
• O’Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Scharfstein DO, Gary JL, Bosse MJ, Castillo RC. Local antibiotic therapy to reduce infection after operative treatment of fractures at high risk of infection: a multicenter, randomized, controlled trial (VANCO study). J Orthop Trauma 2017;31(Suppl 1):S18–s24. Epub 2017/ 03/23. doi:10.1097/BOT.0000000000000801.
   PubMed Web of Science ®Google Scholar
• Shi S, Zhang Z, Luo Z, Yu J, Liang R, Li X, Chen H. Chitosan grafted methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac. Sci Rep 2015;5:11337. Epub 2015/ 06/13. doi:10.1038/srep11337.
   PubMed Web of Science ®Google Scholar
• Loc-Carrillo C, Wang C, Canden A, Burr M, Agarwal J. Local intramedullary delivery of vancomycin can prevent the development of long bone staphylococcus aureus infection. PLoS One 2016;11:e0160187. Epub 2016/ 07/30. doi:10.1371/journal.pone.0160187.
   PubMed Web of Science ®Google Scholar
• Jones RN, Barry AL, Thornsberry C. Disk agar diffusion susceptibility testing with 30-micrograms ceftazidime disks: confirmation of interpretive breakpoints and quality control guidelines. J Clin Microbiol 1983;18:211–214. Epub 1983/ 07/01. doi:10.1128/JCM.18.1.211-214.1983.
   PubMed Web of Science ®Google Scholar
• Ludwig HC, Birdwhistell KE, Brainard BM, Franklin SP. Use of a cyclooxygenase-2 inhibitor does not inhibit platelet activation or growth factor release from platelet-rich plasma. Am J Sports Med 2017;45:3351–3357. Epub 2017/ 09/28. doi:10.1177/0363546517730578.
   PubMed Web of Science ®Google Scholar
• Lazzarini L, Mader JT, Calhoun JH. Osteomyelitis in long bones. J Bone Joint Surg Am 2004;86:2305–2318. Epub 2004/ 10/07. doi:10.2106/00004623-200410000-00028.
   PubMed Web of Science ®Google Scholar
• Doty HA, Leedy MR, Courtney HS, Haggard WO, Bumgardner JD. Composite chitosan and calcium sulfate scaffold for dual delivery of vancomycin and recombinant human bone morphogenetic protein-2. J Mater Sci Mater Med 2014;25:1449–1459. Epub 2014/ 02/08. doi:10.1007/s10856-014-5167-7.
   PubMed Web of Science ®Google Scholar
• Glatt V, Kwong FN, Park K, Parry N, Griffin D, Vrahas M, Evans CH, Harris M. Ability of recombinant human bone morphogenetic protein 2 to enhance bone healing in the presence of tobramycin: evaluation in a rat segmental defect model. J Orthop Trauma 2009;23:693–701. Epub 2009/ 10/28. doi:10.1097/BOT.0b013e3181b01b2f.
   PubMed Web of Science ®Google Scholar
• Etulain J. Platelets in wound healing and regenerative medicine. Platelets 2018;29:556–568. Epub 2018/ 02/15. doi:10.1080/09537104.2018.1430357.
   PubMed Web of Science ®Google Scholar
• Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A, Sawa S, Nitta T, Takayanagi H. Osteoimmunology: the conceptual framework unifying the immune and skeletal systems. Physiol Rev 2017;97:1295–1349. Epub 2017/ 08/18. doi:10.1152/physrev.00036.2016.
   PubMed Web of Science ®Google Scholar
• Heher P, Muhleder S, Mittermayr R, Redl H, Slezak P. Fibrin-based delivery strategies for acute and chronic wound healing. Adv Drug Deliv Rev 2018;129:134–147. Epub 2017/ 12/17. doi:10.1016/j.addr.2017.12.007.
   PubMed Web of Science ®Google Scholar