Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure

References

• Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, Long D, Yu L. Association between platelet parameters and mortality in coronavirus disease 2019: retrospective cohort study. Platelets 2020;31(4):490–496. doi:10.1080/09537104.2020.1754383
   PubMed Web of Science ®Google Scholar
• Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, Zhang Z. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost 2020;18(6):1324–1329.
   PubMed Web of Science ®Google Scholar
• Carsana L, Sonzogni A, Nasr A, Rossi RS, Pellegrinelli A, Zerbi P, Rech R, Colombo R, Antinori S, Corbellino M, et al. Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study. Lancet Infect Dis 2020;20(10):1135–1140. doi:10.1016/S1473-3099(20)30434-5
   PubMed Web of Science ®Google Scholar
• Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, et al. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol 2020;7(8):e575–e582. doi:10.1016/S2352-3026(20)30216-7
   PubMed Web of Science ®Google Scholar
• Martinod K, Deppermann C. Immunothrombosis and thromboinflammation in host defense and disease. Platelets 2020 Sep 8:1–11. Epub ahead of print.;.. doi:10.1080/09537104.2020.1817360
   PubMed Web of Science ®Google Scholar
• Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben CJ, Petrey AC, Tolley ND, Guo L, Cody MJ, et al. Platelet gene expression and function in COVID-19 patients. Blood 2020;136(11):1317–1329. doi:10.1182/blood.2020007214
   PubMed Web of Science ®Google Scholar
• Hottz ED, Azevedo-Quintanilha IG, Palhinha L, Teixeira L, Barreto EA, Pão CRR, Righy C, Franco S, Souza TML, Kurtz P, et al. Platelet activation and platelet-monocyte aggregates formation trigger tissue factor expression in severe COVID-19 patients. Blood 2020;136(11):1330–1341. doi:10.1182/blood.2020007252
   PubMed Web of Science ®Google Scholar
• Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M, Khalki L, Limami Y, Zaid N, Sadki K, Ben El Haj R, et al. Platelets can associate with SARS-Cov-2 RNA and are hyperactivated in COVID-19. Circ Res 2020 Sep 17;127(11):1404–1418. Epub ahead of print. doi:10.1161/CIRCRESAHA.120.317703
   PubMed Web of Science ®Google Scholar
• Campo G, Pavasini R, Biscaglia S, Ferri A, Andrenacci E, Tebaldi M, Ferrari R. Platelet aggregation values in patients with cardiovascular risk factors are reduced by verbascoside treatment. A randomized study. Pharmacol Res 2015;97:1–6. doi:10.1016/j.phrs.2015.03.020
   PubMed Web of Science ®Google Scholar
• Campo G, Valgimigli M, Gemmati D, Percoco G, Tognazzo S, Cicchitelli G, Catozzi L, Malagutti P, Anselmi M, Vassanelli C, et al. Value of platelet reactivity in predicting response to treatment and clinical outcome in patients undergoing primary coronary intervention: insights into the STRATEGY Study. J Am Coll Cardiol 2006;48:2178–2185. doi:10.1016/j.jacc.2005.12.085
   PubMed Web of Science ®Google Scholar
• Fogagnolo A, Taccone FS, Campo G, Montanari G, Capatti B, Ferraro G, Erriquez A, Ragazzi R, Creteur J, Volta CA, et al. Impaired platelet reactivity in patients with septic shock: a proof-of-concept study. Platelets 2020;31(5):652–660. doi:10.1080/09537104.2019.1663807
   PubMed Web of Science ®Google Scholar
• Cangemi R, Casciaro M, Rossi E, Calvieri C, Bucci T, Calabrese CM, Taliani G, Falcone M, Palange P, Bertazzoni G, et al. Platelet activation is associated with myocardial infarction in patients with pneumonia. J Am Coll Cardiol 2014;64(18):1917–1925. doi:10.1016/j.jacc.2014.07.985
   PubMed Web of Science ®Google Scholar
• Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol 2018;72:2231–2264. doi:10.1016/j.jacc.2018.08.1038
   PubMed Web of Science ®Google Scholar
• Kinasewitz GT, Yan SB, Basson B, Comp P, Russell JA, Cariou A, Um SL, Utterback B, Laterre PF, Dhainaut JF. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care 2004;8(2):R82–90. doi:10.1186/cc2459
   PubMed Web of Science ®Google Scholar
• Zhang S, Liu Y, Wang X, Yang L, Li H, Wang Y, Liu M, Zhao X, Xie Y, Yang Y, et al. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol 2020;13(1):120. doi:10.1186/s13045-020-00954-7
   PubMed Web of Science ®Google Scholar
• Maree AO, Fitzgerald DJ. Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation. 2007;115:2196–2207. doi:10.1161/CIRCULATIONAHA.106.675991
   PubMed Web of Science ®Google Scholar
• Heeschen C, Dimmeler S, Hamm CW, van den Brand MJ, Boersma E, Zeiher AM, Simoons ML. CAPTURE Study Investigators. Soluble CD40 ligand in acute coronary syndromes. N Engl J Med 2003;348(12):1104–1111. doi:10.1056/NEJMoa022600
   PubMed Web of Science ®Google Scholar
• André P. P-selectin in haemostasis. Br J Haematol 2004;126(3):298–306. doi:10.1111/j.1365-2141.2004.05032.x
   PubMed Web of Science ®Google Scholar
• Lala A, Johnson KW, Januzzi JL, Russak AJ, Paranjpe I, Richter F, Zhao S, Somani S, Van Vleck T, Vaid A, et al. Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection. J Am Coll Cardiol 2020;76:533–546. doi:10.1016/j.jacc.2020.06.007
   PubMed Web of Science ®Google Scholar
• Lindner D, Fitzek A, Bräuninger H, Aleshcheva G, Edler C, Meissner K, Scherschel K, Kirchhof P, Escher F, Schultheiss HP, Blankenberg S, Püschel K, Westermann D. Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol. 2020 Nov 1;5(11):1281-1285. doi: 10.1001/jamacardio.2020.3551. PMID: 32730555; PMCID: PMC7385672.
   Google Scholar
• Fox SE, Li G, Akmatbekov A, Harbert JL, Lameira FS, Brown JQ, Vander Heide RS. Unexpected features of cardiac pathology in COVID-19 infection. Circulation 2020;142(11):1123–1125. doi:10.1161/CIRCULATIONAHA.120.049465
   PubMed Web of Science ®Google Scholar
• Lê VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, et al. Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis. Am J Respir Crit Care Med 2015;191(7):804–819. doi:10.1164/rccm.201406-1031OC
   PubMed Web of Science ®Google Scholar
• Rondina MT, Brewster B, Grissom CK, Zimmerman GA, Kastendieck DH, Harris ES, Weyrich AS. In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1). Chest 2012;141(6):1490–1495. doi:10.1378/chest.11-2860
   PubMed Web of Science ®Google Scholar
• Falcone M, Russo A, Cangemi R, Farcomeni A, Calvieri C, Barillà F, Scarpellini MG, Bertazzoni G, Palange P, Taliani G, et al. Lower mortality rate in elderly patients with community-onset pneumonia on treatment with aspirin. J Am Heart Assoc 2015;4(1):e001595. doi:10.1161/JAHA.114.001595
   PubMed Web of Science ®Google Scholar
• Sexton TR, Zhang G, Macaulay TE, Callahan LA, Charnigo R, Vsevolozhskaya OA, Li Z, Smyth S. Ticagrelor reduces thromboinflammatory markers in patients with Pneumonia. JACC Basic Transl Sci 2018;3(4):435–449. doi:10.1016/j.jacbts.2018.05.005
   PubMedGoogle Scholar
• Viecca M, Radovanovic D, Forleo GB, Santus P. Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study. Pharmacol Res 2020;158:104950. doi:10.1016/j.phrs.2020.104950
   PubMed Web of Science ®Google Scholar
• Chandler AB, Earhart AD, Speich HE, Kueter TJ, Hansen J, White MM, Jennings LK. Regulation of CD40L (CD154) and CD62P (p-selectin) surface expression upon GPIIb-IIIa blockade of platelets from stable coronary artery disease patients. Thromb Res 2010;125(1):44–52. doi:10.1016/j.thromres.2009.04.017
   PubMed Web of Science ®Google Scholar