References
- Haniffa MA, Collin MP, Buckley CD, Dazzi F. Mesenchymal stem cells: the fibroblasts’ new clothes? Haematologica 2009;94(2).258–263. doi:https://doi.org/10.3324/haematol.13699.
- Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell. 4th ed. New York; Garland Science; 2002. 1616 p.
- Junker JPE, Sommar P, Skog M, Johnson H, Kratz G, et al. Adipogenic, chondrogenic and osteogenic differentiation of clonally derived human dermal fibroblasts. Cells Tissues Organs 2010;191(2).105–118. doi:https://doi.org/10.1159/000232157.
- Ichim TE, O’Heeron P, Kesari S. Fibroblasts as a practical alternative to mesenchymal stem cells. J Transl Med 2018;16(1):212. doi:https://doi.org/10.1186/s12967-018-1536-1.
- Wada N, Bartold PM, Gronthos S. Human foreskin fibroblasts exert immunomodulatory properties by a different mechanism to bone marrow stromal/stem cells. Stem Cells Dev 2011;20(4):647–659. doi:https://doi.org/10.1089/scd.2010.0246.
- Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004;95(1):9–20. doi:https://doi.org/10.1161/01.RES.0000135902.99383.6f.
- Cappellesso-Fleury S, Puissant-Lubrano B, Apoil P-A, Titeux M, Winterton P, Casteilla L, Bourin P, Blancher A. Human fibroblasts share immunosuppressive properties with bone marrow mesenchymal stem cells. J Clin Immunol 2010;30(4).607–619. doi:https://doi.org/10.1007/s10875-010-9415-4.
- Dominiak M, Saczko J, Gerber H, Rybak Z, Gredes T. Use of primary culture of human fibroblasts in gingiva augmentation procedure. Biomed Tech (Berl) 2010;55(6).331–334. doi:https://doi.org/10.1515/bmt.2010.052.
- Milinkovic I, Aleksic Z, Jankovic S, Popovic O, Bajic M, Cakic S, Lekovic V. Clinical application of autologous fibroblast cell culture in gingival recession treatment. J Periodontal Res 2015;50(3).363–370. doi:https://doi.org/10.1111/jre.12215.
- Ural IH, Alptekin K, Ketenci A, Solakoglu S, Alpak H, Özyalçın S. Fibroblast transplantation results to the degenerated rabbit lumbar intervertebral discs. Open Orthop J 2017;11(1).404–416. doi:https://doi.org/10.2174/1874325001711010404.
- Costa-Almeida R, Soares R, Granja PL. Fibroblasts as maestros orchestrating tissue regeneration. J Tissue Eng Regen Med 2018;12(1).240-251.doi:https://doi.org/10.1002/term.2405.
- Bieback K, Fernandez-Munoz B, Pati S, Schäfer R. Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the international society for cell & gene therapy. Cytotherapy 2019;21(9).911–924. doi:https://doi.org/10.1016/j.jcyt.2019.06.006.
- Burnouf T, Strunk D, Koh MBC, Schallmoser K. Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation? Biomaterials 2016;76:371–387. doi:https://doi.org/10.1016/j.biomaterials.2015.10.065.
- Agency EM. Guideline on the quality, non-clinical and clinical aspects of gene therapy medicinal products. Table of contents 2018;44.
- European Medicines Agency. Guideline on the use of bovine serum in the manufacture of human biological medicinal products. EMA/CHMP/BWP/457920/2012 rev.1. 2012.
- Choi YC, Morris GM, Sokoloff L. Effect of platelet lysate on growth and sulfated glycosaminoglycan synthesis in articular chondrocyte cultures. Arthritis Rheum 1980;23(2):220–224. doi:https://doi.org/10.1002/art.1780230213.
- Ministry of Health Social Services and Equality (Currently Ministry of Health Consumer Affairs and Social Welfare). Annual report on the national health system of Spain 2016. 2018.
- Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 2016;44(W1):W90–W97. doi:https://doi.org/10.1093/nar/gkw377.
- Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR, Ma’ayan A. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. J Eng Res 2013;14.128.
- Commission Directive 2003/94/EC of 8 October 2003. Laying down the principles and guidelines of good manufacturing practice in respect of medicinal products for human use and investigational medicinal products for human use. Off J Eur Union 2003;L 262:22–26.
- Commission Directive 2006/17/EC of 8 February 2006. Implementing Directive 2004/23/EC of the European Parliament and of the Council as regards certain technical requirements for the donation, procurement and testing of human tissues and cells. Off J Eur Union 2006;L 38:40–52.
- Directive 2004/23/EC of the European Parliament and of The Council of 31 March 2004 on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells. Off J Eur Union 2004;L 102:48–58.
- Directive 2002/98/EC of the European Parliament and of The Council of 27 January 2003 setting standards of quality and safety for the collection, testing, processing, storage and distribution of human blood and blood componentsand amending Directive 2001. Off J Eur Union 2003;L 33:30–40.
- Bieback K. Platelet lysate as replacement for fetal bovine serum in mesenchymal stromal cell cultures. Transfus Med Hemother 2013;40(5):326–335. doi:https://doi.org/10.1159/000354061.
- Kocaoemer A, Kern S, Kluter H, Bieback K. Human AB serum and thrombin-activated platelet-rich plasma are suitable alternatives to fetal calf serum for the expansion of mesenchymal stem cells from adipose tissue. Stem Cell 2007;25(5).1270–1278. doi:https://doi.org/10.1634/stemcells.2006-0627.
- Huang C-J, Sun Y-C, Christopher K, Pai AS-I, Lu C-J, Hu F-R, Lin S-Y, Chen W-L. Comparison of corneal epitheliotrophic capacities among human platelet lysates and other blood derivatives. PLoS One 2017;12(2).e0171008. doi:https://doi.org/10.1371/journal.pone.0171008.
- Pawitan JA. Platelet rich plasma in xeno-free stem cell culture: the impact of platelet count and processing method. Curr Stem Cell Res Ther 2012;7(5):329–335. doi:https://doi.org/10.2174/157488812802481508.
- European Directorate for the Quality of Medicines & HealthCare (EDQM). Guide to the preparation, use and quality assurance of blood components. 19th ed. Strasbourg; Council of Europe; 2017.
- Horn P, Bokermann G, Cholewa D, Bork S, Walenda T, Koch C, Drescher W, Hutschenreuther G, Zenke M, Ho AD, et al. Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells. Cytotherapy 2010;12(7).888–898. doi:https://doi.org/10.3109/14653249.2010.501788.
- Everts PAM, Knape JTA, Weibrich G, Schonberger JPAM, Hoffmann J, Overdevest EP, Box HAM, van Zundert A. Platelet-rich plasma and platelet gel: a review. J Extra Corpor Technol 2006;38:174–187.
- Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev 2009;23(4):177–189. doi:https://doi.org/10.1016/j.blre.2009.04.001.
- Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003;83(3):835–870. doi:https://doi.org/10.1152/physrev.2003.83.3.835.
- Azuma H, Hirayama J, Akino M, Ikeda H. Platelet additive solution - electrolytes. Transfus Apher Sci 2011;44(3).277–281. doi:https://doi.org/10.1016/j.transci.2011.03.002.
- Eriksson L, Hogman CF. Platelet concentrates in an additive solution prepared from pooled buffy coats. 1. In vitro studies. Vox Sang 1990;59:140–145.
- Mojica-Henshaw MP, Jacobson P, Morris J, Kelley L, Pierce J, Boyer M, Reems J-A. Serum-converted platelet lysate can substitute for fetal bovine serum in human mesenchymal stromal cell cultures. Cytotherapy 2013;15(12).1458–1468. doi:https://doi.org/10.1016/j.jcyt.2013.06.014.
- Pierce J, Benedetti E, Preslar A, Jacobson P, Jin P, Stroncek DF, Reems J-A. Comparative analyses of industrial-scale human platelet lysate preparations. Transfusion 2017;57(12).2858–2869. doi:https://doi.org/10.1111/trf.14324.
- Trojahn Kolle S-F, Oliveri RS, Glovinski PV, Kirchhoff M, Mathiasen AB, Elberg JJ, Andersen PS, Drzewiecki KT, Fischer-Nielsen A. Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use. Cytotherapy 2013;15(9).1086–1097. doi:https://doi.org/10.1016/j.jcyt.2013.01.217.
- Azouna N, Jenhani F, Regaya Z, Berraeis L, Othman T, Ducrocq E, Domenech J. Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum. Stem Cell Res Ther 2012;3(1).6. doi:https://doi.org/10.1186/scrt97.
- Bernardi M, Agostini F, Chieregato K, Amati E, Durante C, Rassu M, Ruggeri M, Sella S, Lombardi E, Mazzucato M, et al. The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro. J Transl Med 2017;15(1).1–9. doi:https://doi.org/10.1186/s12967-017-1185-9.
- Abdelrazik H, Spaggiari GM, Chiossone L, Moretta L. Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function. Eur J Immunol 2011;41(11).3281–3290. doi:https://doi.org/10.1002/eji.201141542.
- Schallmoser K, Bartmann C, Rohde E, Reinisch A, Kashofer K, Stadelmeyer E, Drexler C, Lanzer G, Linkesch W, Strunk D, et al. Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion 2007;47(8).1436–1446. doi:https://doi.org/10.1111/j.1537-2995.2007.01220.x.
- Fernandez-Rebollo E, Mentrup B, Ebert R, Franzen J, Abagnale G, Sieben T, Ostrowska A, Hoffmann P, Roux P-F, Rath B, et al. Human platelet lysate versus fetal calf serum: these supplements do not select for different mesenchymal stromal cells. Sci Rep 2017;7(1).5132. doi:https://doi.org/10.1038/s41598-017-05207-1.
- Schallmoser K, Bartmann C, Rohde E, Bork S, Guelly C, Obenauf AC, Reinisch A, Horn P, Ho AD, Strunk D, et al. Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions. Haematologica 2010;95(6).867–874. doi:https://doi.org/10.3324/haematol.2009.011692.
- Dessels C, Ambele MA, Pepper MS. The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro. Stem Cell Res Ther 2019;10(1):253. doi:https://doi.org/10.1186/s13287-019-1370-2.
- Torensma R, Prins H-J, Schrama E, Verwiel ETP, Martens ACM, Roelofs H, Jansen BJH. The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells. Stem Cells Dev 2013;22(7).1086–1096. doi:https://doi.org/10.1089/scd.2012.0384.
- Sondergaard RH, Follin B, Lund LD, Juhl M, Ekblond A, Kastrup J, Haack-Sørensen M. Senescence and quiescence in adipose-derived stromal cells: effects of human platelet lysate, fetal bovine serum and hypoxia. Cytotherapy 2017;19(1).95–106. doi:https://doi.org/10.1016/j.jcyt.2016.09.006.
- Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000;28(1):27–30. doi:https://doi.org/10.1093/nar/28.1.27.
- Kanehisa M, Sato Y, Furumichi M, Morishima K, Tanabe M. New approach for understanding genome variations in KEGG. Nucleic Acids Res 2019;47(D1).D590–D595. doi:https://doi.org/10.1093/nar/gky962.
- The Gene Ontology Consortium. The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res 2019;47(D1):D330–D338. doi:https://doi.org/10.1093/nar/gky1055.
- Jia M, Souchelnytskyi N, Hellman U, O’Hare M, Jat PS, Souchelnytskyi S. Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancer. Proteomics Clin Appl 2010;4(10–11).816–828. doi:https://doi.org/10.1002/prca.201000006.
- Purcell M, Kruger A, Tainsky MA. Gene expression profiling of replicative and induced senescence. Cell Cycle 2014;13(24):3927–3937. doi:https://doi.org/10.4161/15384101.2014.973327.
- Benatar T, Yang W, Amemiya Y, Evdokimova V, Kahn H, Holloway C, Seth A. IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways. Breast Cancer Res Treat 2012;133(2).563–573. doi:https://doi.org/10.1007/s10549-011-1816-4.
- Zunino R, Li Q, Rose SD, Romero-Benítez MMI, Lejen T, Brandan NC, Trifaró J-M. Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis. Blood 2001;98(7).2210–2219. doi:https://doi.org/10.1182/blood.V98.7.2210.
- Bhakkiyalakshmi E, Sireesh D, Rajaguru P, Paulmurugan R, Ramkumar KM. The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes. Pharmacol Res 2015;91:104–114. doi:https://doi.org/10.1016/j.phrs.2014.10.004.
- George MJ, Prabhakara K, Toledano-Furman NE, Wang Y-W, Gill BS, Wade CE, Olson SD, Cox CS. Clinical cellular therapeutics accelerate clot formation. Stem Cells Transl Med 2018;7(10):731–739. doi:https://doi.org/10.1002/sctm.18-0015.
- Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk H-D, Geissler S, Reinke P. Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines. Trends Mol Med 2019;25(2).149–163. doi:https://doi.org/10.1016/j.molmed.2018.12.006.
- European Directorate for the Quality of Medicines & HealthCare (EDQM). General chapter 5. 2.12. Raw materials for the production of cell-based and gene therapy products. European Pharmacopoeia; Strasbourg; Council of Europe; 2013.
- Park WB, Kwon NJ, Choi SJ, Kang CK, Choe PG, Kim JY, Yun J, Lee G-W, Seong M-W, Kim NJ, et al. Virus Isolation from the first patient with SARS-CoV-2 in Korea. J Korean Med Sci 2020;35(7).e84. doi:https://doi.org/10.3346/jkms.2020.35.e84.
- Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al. A novel coronavirus from patients with Pneumonia in China, 2019. N Engl J Med 2020;382(8).727–733. doi:https://doi.org/10.1056/NEJMoa2001017.