References
- Machlus KR, et al. The incredible journey: from megakaryocyte development to platelet formation. J Cell Biol 2013;201(6):785–796. DOI:https://doi.org/10.1083/jcb.201304054.
- van der Meijden PEJ, et al. Platelet biology and functions: new concepts and clinical perspectives. Nat Rev Cardiol 2019;16(3):166–179. DOI:https://doi.org/10.1038/s41569-018-0110-0.
- Ruggeri ZM. Platelet adhesion under flow. Microcirculation 2009;16(1):58–83. DOI:https://doi.org/10.1080/10739680802651477.
- Ruggeri ZM, Mendolicchio GL. Adhesion mechanisms in platelet function. Circ Res 2007;100(12):1673–1685. DOI:https://doi.org/10.1161/01.RES.0000267878.97021.ab.
- Barnes MJ, Knight CG, Farndale RW. The collagen-platelet interaction. Curr Opin Hematol 1998;5(5):314–320. DOI:https://doi.org/10.1097/00062752-199809000-00002.
- Herr AB, Farndale RW. Structural insights into the interactions between platelet receptors and fibrillar collagen. J Biol Chem 2009;284(30):19781–19785. DOI:https://doi.org/10.1074/jbc.R109.013219.
- Jarvis GE, Atkinson BT, Snell DC, Watson SP. Distinct roles of GPVI and integrin α2 β1 in platelet shape change and aggregation induced by different collagens. Br J Pharmacol 2002;137(1):107–117. DOI:https://doi.org/10.1038/sj.bjp.0704834.
- Li Z, Delaney MK, O’Brien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 2010;30(12):2341–2349. DOI:https://doi.org/10.1161/ATVBAHA.110.207522.
- Durrant TN, Van Den Bosch MT, Hers I. Integrin αIIbβ3 outside-in signaling. Blood 2017;130(14):1607–1619. DOI:https://doi.org/10.1182/blood-2017-03-773614.
- Estevez B, et al. New concepts and mechanisms of platelet activation signaling. Physiology 2017;32(2):162–177. DOI:https://doi.org/10.1152/physiol.00020.2016.
- Grover SP, Bergmeier W, Mackman N. Recent highlights of ATVB: platelet signaling pathways and new inhibitors. Arterioscler Thromb Vasc Biol 2018;38(4):e28–e35. DOI:https://doi.org/10.1161/ATVBAHA.118.310224.
- D’Souza SE, Ginsberg MH, Matsueda GR, Plow EF. A discrete sequence in a platelet integrin is involved in ligand recognition. Nature 1991;350(6313):66–68. DOI:https://doi.org/10.1038/350066a0.
- Bennett JS. Structural biology of glycoprotein IIb-IIIa. Trends Cardiovasc Med 1996;6(1):31–36. DOI:https://doi.org/10.1016/1050-1738(95)00126-3.
- Bennett JS. Structure and function of platelet integrin αIIbβ3. J Clin Invest 2005;115(12):3363–3369. DOI:https://doi.org/10.1172/JCI26989.
- Jackson SP, et al. The growing complexity of platelet aggregation. Blood 2007;109(12):5087–5095. DOI:https://doi.org/10.1182/blood-2006-12-027698.
- Lentz BR. Exposure of platelet membrane phosphatidylserine regulates blood coagulation. Prog Lipid Res 2003;42(5):423–438. DOI:https://doi.org/10.1016/S0163-7827(03)00025-0.
- Hoffman M, Monroe D. A cell-based model of hemostasis. Thromb Haemost 2001;85(6):958–965. DOI:https://doi.org/10.1055/s-0037-1615947.
- Monroe DM, Hoffman M, Roberts HR. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol 2002;22(9):1381–1389. DOI:https://doi.org/10.1161/01.ATV.0000031340.68494.34.
- van Meer G, Voelker DR, Feigenson GW. Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol 2008;9(2):112–124. DOI:https://doi.org/10.1038/nrm2330.
- Versteeg HH J, et al. New fundamentals in hemostasis. Physiol Rev 2013;93(1):327–358. DOI:https://doi.org/10.1152/physrev.00016.2011.
- Verma A, Agarwal P. Platelet utilization in the developing world: strategies to optimize platelet transfusion practices. Transfus Apher Sci 2009;41(2):145–149. DOI:https://doi.org/10.1016/j.transci.2009.07.005.
- Kumar A, Mhaskar R, Grossman BJ, Kaufman RM, Tobian AAR, Kleinman S, Gernsheimer T, Tinmouth AT, Djulbegovic B. AABB Platelet Transfusion Guidelines Panel, Platelet transfusion: a systematic review of the clinical evidence. Transfusion 2015;55(5):1116–1127. DOI:https://doi.org/10.1111/trf.12943.
- Etchill EW, Myers SP, Raval JS, Hassoune A, SenGupta A, Neal MD. Platelet transfusion in critical care and surgery: evidence-based review of contemporary practice and future directions. Shock 2017;47(5):537–549. DOI:https://doi.org/10.1097/SHK.0000000000000794.
- Newland A, Bentley R, Jakubowska A, Liebman H, Lorens J, Peck-Radosavljevic M, Taieb V, Takami A, Tateishi R, Younossi ZM, et al. A systematic literature review on the use of platelet transfusions in patients with thrombocytopenia. Hematology 2019;24(1):679–719. DOI:https://doi.org/10.1080/16078454.2019.1662200.
- Thiele T, et al. Platelet transfusion in perioperative medicine. Semin Thromb Hemost 2020;46(11):50–61. DOI:https://doi.org/10.1055/s-0039-1697951.
- Cohen MJ, et al. Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg 2013;75(1 Suppl 1):S40- S47. DOI:https://doi.org/10.1097/TA.0b013e31828fa43d.
- Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, Del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA 2015;313(5):471–482. DOI:https://doi.org/10.1001/jama.2015.12.
- Cardenas JC, Zhang X, Fox EE, Cotton BA, Hess JR, Schreiber MA, Wade CE, Holcomb JB. Platelet transfusions improve hemostasis and survival in a sub study of the prospective randomized PROPPR trial. Blood Adv 2018;2(14):1696–1704. DOI:https://doi.org/10.1182/bloodadvances.2018017699.
- Murphy S, et al. Effect of storage temperature on maintenance of platelet viability–deleterious effect of refrigerated storage. N Engl J Med 1969;280(20):1094–1098. DOI:https://doi.org/10.1056/NEJM196905152802004.
- Storch EK, et al. Review of current transfusion therapy and blood banking practices. Blood Rev 2019;38:100593. DOI:https://doi.org/10.1016/j.blre.2019.100593.
- Spinella PC, Dunne J, Beilman GJ, O’Connell RJ, Borgman MA, Cap AP, Rentas F. Constant challenges and evolution of US military transfusion medicine and blood operations in combat. Transfusion 2012;52(5):1146–1153. DOI:https://doi.org/10.1111/j.1537-2995.2012.03594.x.
- Lambert MP, Sullivan SK, Fuentes R, French DL, Poncz M. Challenges and promises for the development of donor-independent platelet transfusions. Blood 2013;121(17):3319–3324. DOI:https://doi.org/10.1182/blood-2012-09-455428.
- Humbrecht C, Kientz D, Gachet C. Platelet transfusion: current challenges. Transfus Clin Biol 2018;25(3):151–164. DOI:https://doi.org/10.1016/j.tracli.2018.06.004.
- Alcaina PS. Platelet transfusion: an update on challenges and outcomes. J Blood Med 2020;11:19–26. DOI:https://doi.org/10.2147/JBM.S234374.
- Magron A, Laugier J, Provost P, Boilard E. Pathogen reduction technologies: the pros and cons for platelet transfusion. Platelets 2018;29(1):2–8. DOI:https://doi.org/10.1080/09537104.2017.1306046.
- Levy JH, Neal MD, Herman JH. Bacterial contamination of platelets for transfusion: strategies for prevention. Crit Care 2018;22(1):271. DOI:https://doi.org/10.1186/s13054-018-2212-9.
- Alarhayem AQ, Myers JG, Dent D, Liao L, Muir M, Mueller D, Nicholson S, Cestero R, Johnson MC, Stewart R, et al. Time is the enemy: mortality in trauma patients with hemorrhage from torso injury occurs long before the ‘golden hour.’ Am J Surg 2016;212(6):1101–1105. DOI:https://doi.org/10.1016/j.amjsurg.2016.08.018.
- Shackelford SA, Del Junco DJ, Powell-Dunford N, Mazuchowski EL, Howard JT, Kotwal RS, Gurney J, Butler FK, Gross K, Stockinger ZT, et al. Association of prehospital blood product transfusion during medical evacuation of combat casualties in Afghanistan with acute and 30-day survival. JAMA 2017;318(16):1581–1591. DOI:https://doi.org/10.1001/jama.2017.15097.
- Sperry JL, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ, Adams PW, Daley BJ, Miller RS, Harbrecht BG, et al. Prehospital plasma during Air Medical transport in trauma patients at risk for hemorrhagic shock. N Engl J Med 2018;379(4):315–326. DOI:https://doi.org/10.1056/NEJMoa1802345.
- Guyette FX, Sperry JL, Peitzman AB, Billiar TR, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Putnam T, Duane TM, et al. Prehospital blood product and crystalloid resuscitation in the severely injured patient. Ann Surg 2021;273(2):358–364. DOI:https://doi.org/10.1097/SLA.0000000000003324.
- Hod E, Schwartz J. Platelet transfusion refractoriness. Br J Hematol 2008;142(3):348–360. DOI:https://doi.org/10.1111/j.1365-2141.2008.07189.x.
- Read MS, Reddick RL, Bode AP, Bellinger DA, Nichols TC, Taylor K, Smith SV, McMahon DK, Griggs TR, Brinkhous KM, et al. Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion. Proc Natl Acad Sci 1995;92(2):397–401. DOI:https://doi.org/10.1073/pnas.92.2.397.
- Bode AP, Fischer TH. Lyophilized platelets: fifty years in the making. Artif Cells Blood Substit Immobil Biotechnol 2007;35(1):125–133. DOI:https://doi.org/10.1080/10731190600974962.
- Cap AP, et al. Lyophilized platelets: challenges and opportunities. J Trauma 2011;70(5 Suppl):S59–S60.
- Snyder EL, Rinder HM. Platelet storage – time to come in from the cold? N Engl J Med 2003;348(20):2032–2033. DOI:https://doi.org/10.1056/NEJMcibr035099.
- Reddoch KM, Pidcoke HF, Montgomery RK, Fedyk CG, Aden JK, Ramasubramanian AK, Cap AP. Hemostatic function of apheresis platelets stored at 4°C and 22°C. Shock 2014;41(1):54–61. DOI:https://doi.org/10.1097/SHK.0000000000000082.
- Hegde S, Akbar H, Zheng Y, Cancelas JA. Towards increasing shelf-life and hemostatic potency of stored platelet concentrates. Curr Opin Hematol 2018;25(6):500–508. DOI:https://doi.org/10.1097/MOH.0000000000000456.
- Marks DC, Johnson L. Assays for phenotypic and functional characterization of cryopreserved platelets. Platelets 2019;30(1):48–55. DOI:https://doi.org/10.1080/09537104.2018.1514108.
- Milford EM, Reade MC. Comprehensive review of platelet storage methods for use in the treatment of active hemorrhage. Transfusion 2016;56(Suppl 2):S140–S148. DOI:https://doi.org/10.1111/trf.13504.
- Cohn CS, Dumont LJ, Lozano M, Marks DC, Johnson L, Ismay S, Bondar N, T’Sas F, Yokoyama APH, Kutner JM, et al. Vox Sanguinis international forum on platelet cryopreservation: summary. Vox Sang 2017;112(7):684–688. DOI:https://doi.org/10.1111/vox.12533.
- Hoffmeister KM, et al. Glycosylation restores survival of chilled blood platelets. Science 2003;301(5639):1531–1534. DOI:https://doi.org/10.1126/science.1085322.
- Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH, et al. The clearance mechanism of chilled blood platelets. Cell 2003;112(1):87–97. DOI:https://doi.org/10.1016/S0092-8674(02)01253-9.
- Bennett JS. Shedding new light on the platelet storage lesion. Arterioscler Thromb Vasc Biol 2016;36(9):1715–1716. DOI:https://doi.org/10.1161/ATVBAHA.116.308095.
- Getz TM. Physiology of cold-stored platelets. Transfus Apher Sci 2019;58(1):12–15. DOI:https://doi.org/10.1016/j.transci.2018.12.011.
- Quach ME, Chen W, Li R. Mechanisms of platelet clearance and translation to improve platelet storage. Blood 2018;131(14):1512–1521. DOI:https://doi.org/10.1182/blood-2017-08-743229.
- Reddoch-Cardenas KM, Bynum JA, Meledeo MA, Nair PM, Wu X, Darlington DN, Ramasubramanian AK, Cap AP. Cold-stored platelets: a product with function optimized for hemorrhage control. Transfus Apher Sci 2019;58(1):16–22. DOI:https://doi.org/10.1016/j.transci.2018.12.012.
- Cap AP. Platelet storage: a license to chill ! Transfusion 2016;56(1):13–16. DOI:https://doi.org/10.1111/trf.13433.
- Reade MC, Marks DC, Bellomo R, Deans R, Faulke DJ, Fraser JF, Gattas DJ, Holley AD, Irving DO, Johnson L, et al. A randomized, controlled pilot clinical trial of cryopreserved platelets for perioperative surgical bleeding: the CLIP-I trial (Editorial, p. 2759). Transfusion 2019;59(9):2794–2804. DOI:https://doi.org/10.1111/trf.15423.
- Kleinveld DJB, et al. The use of cryopreserved platelets in a trauma-induced hemorrhage model. Transfusion 2020;60(9):2079–2089.
- Seheult JN, Anto V, Alarcon LH, Sperry JL, Triulzi DJ, Yazer MH. Clinical outcomes among low-titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation. Transfusion 2018;58(8):1838–1845. DOI:https://doi.org/10.1111/trf.14779.
- Shea SM, Staudt AM, Thomas KA, Schuerer D, Mielke JE, Folkerts D, Lowder E, Martin C, Bochicchio GV, Spinella PC, et al. The use of low-titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage. Transfusion 2020;60(Suppl 3):S2–S9. DOI:https://doi.org/10.1111/trf.15696.
- Williams J, et al. Safety profile and impact of low-titer group O whole blood for emergency use in trauma. J Trauma Acute Care Surg 2020;88(1):87–93. DOI:https://doi.org/10.1097/TA.0000000000002498.
- Leeper CM, Yazer MH, Cladis FP, Saladino R, Triulzi DJ, Gaines BA. Cold-stored whole blood platelet function is preserved in injured children with hemorrhagic shock. J Trauma Acute Care Surg 2019;87(1):49–53. DOI:https://doi.org/10.1097/TA.0000000000002340.
- Assen S, Cardenas J, George M, Wang Y-W, Wade CE, Meyer D, Cotton BA. Hemostatic potential of cold-stored non-leukoreduced whole blood over time: an assessment of platelet function and thrombin generation for optimal shelf life. J Trauma Acute Care Surg 2020;89(3):429–434. DOI:https://doi.org/10.1097/TA.0000000000002799.
- Avanzi MP, Mitchell WB. Ex Vivo production of platelets from stem cells. Brit J Haematol 2014;165(2):237–247. DOI:https://doi.org/10.1111/bjh.12764.
- Thon JN, et al. Platelet bioreactor-on-a-chip. Blood 2014;124(12):1857–1867.
- Sugimoto N, Eto K. Platelet production from induced pluripotent stem cells. J Thromb Haemost 2017;15(9):1717–1727. DOI:https://doi.org/10.1111/jth.13736.
- Ito Y, et al. Turbulence activates platelet biogenesis to enable clinical scale ex vivo production. Cell 2018;174(3):636–648. DOI:https://doi.org/10.1016/j.cell.2018.06.011.
- Tozzi L, Laurent P-A, Di Buduo CA, Mu X, Massaro A, Bretherton R, Stoppel W, Kaplan DL, Balduini A. Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production. Biomaterials 2018;178:122–133. DOI:https://doi.org/10.1016/j.biomaterials.2018.06.018.
- Lawrence M, Mueller A, Ghevaert C. Using genome editing to engineer universal platelets. Emerg Top Life Sci 2019;3(3):301–311. DOI:https://doi.org/10.1042/ETLS20180153.
- Mookerjee S, Foster HR, Waller AK, Ghevaert CJ. In vitro-derived platelets: the challenges we will have to face to assess quality and safety. Platelets 2020;31(6):724–730. DOI:https://doi.org/10.1080/09537104.2020.1769051.
- Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, Akasaka M, Nakamura S, Higashi N, Xu H, et al. iPSC-Derived platelets depleted of HLA Class I are inert to anti-HLA Class I and natural killer cell immunity. Stem Cell Rep 2020;14(1):49–59. DOI:https://doi.org/10.1016/j.stemcr.2019.11.011.
- Rybak ME, Renzulli LA. A liposome based platelet substitute, the plateletsome, with hemostatic efficacy. Biomater Artif Cells Immobilization Biotechnol 1993;21(2):101–118. DOI:https://doi.org/10.3109/10731199309117350.
- Graham SS, Gonchoroff NJ, Miller JL. Infusible platelet membranes retain partial functionality of the platelet GPIb/IX/V receptor complex. Am J Clin Pathol 2001;115(1):144–147. DOI:https://doi.org/10.1309/CCDV-3BEP-XXKP-BKDM.
- Nasiri S, Graham SS, et al. Infusible platelet membrane as a platelet substitute for transfusion: an overview. Blood Transfus 2013;11(3):337–342.
- Hu C-M J, Fang RH, Wang K-C, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, et al. Nanoparticle biointerfacing by platelet membrane cloaking. Nature 2015;526(7571):118–121. DOI:https://doi.org/10.1038/nature15373.
- Hu Q, Sun W, Qian C, Wang C, Bomba HN, Gu Z. Anticancer platelet-mimicking nanovehicles. Adv Mater 2015;27(44):7043–7050. DOI:https://doi.org/10.1002/adma.201503323.
- Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q, Wun B, Roy S, Shen X, King MR, et al. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials 2016;76:52–65. DOI:https://doi.org/10.1016/j.biomaterials.2015.10.046.
- Hu Q, Qian C, Sun W, Wang J, Chen Z, Bomba HN, Xin H, Shen Q, Gu Z. Engineered nanoplatelets for enhanced treatment of multiple myeloma and thrombus. Adv Mater 2016;28(43):9573–9580. DOI:https://doi.org/10.1002/adma.201603463.
- Fitzpatrick GM, Cliff R, Tandon N. Thrombosomes: a platelet-derived hemostatic agent for control of noncompressible hemorrhage. Transfusion 2013;53(Suppl 1):100 S–106 S. DOI:https://doi.org/10.1111/trf.12043.
- Barroso J, Osborne B, Teramura G, Pellham E, Fitzpatrick M, Biehl R, Yu A, Pehta J, Slichter SJ. Safety evaluation of a lyophilized platelet-derived hemostatic product. Transfusion 2018;58(12):2969–2977. DOI:https://doi.org/10.1111/trf.14972.
- Bynum JA, Meledeo MA, Peltier GC, McIntosh CS, Taylor AS, Montgomery RK, Reddoch–Cardenas KM, Getz TM, Fitzpatrick MG, Cap AP, et al. Evaluation of a lyophilized platelet-derived hemostatic product. Transfusion 2019;59(S2):1490–1498. DOI:https://doi.org/10.1111/trf.15167.
- Agam G, Livne A. Passive participation of fixed platelets in aggregation facilitated by covalently bound fibrinogen. Blood 1983;61(1):186–191. DOI:https://doi.org/10.1182/blood.V61.1.186.186.
- Agam G, LIVNE AA. Erythrocytes with covalently-bound fibrinogen as a cellular replacement for the treatment of thrombocytopenia. Eur J Clin Invest 1992;22(2):105–112. DOI:https://doi.org/10.1111/j.1365-2362.1992.tb01943.x.
- Yen RCK, et al. A new haemostatic agent: thrombospheres shorten the bleeding time in thrombocytopenic rabbits. Thromb Haemost 1995;73:986.
- Levi M, Friederich PW, Middleton S, Groot PGD, Wu YP, Harris R, Biemond BJ, Heijnen HFG, Levin J, Cate JWT, et al. Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits. Nature Med 1999;5(1):107–111. DOI:https://doi.org/10.1038/4795.
- Davies AR, et al. Interactions of platelets with Synthocytes, a novel platelet substitute. Platelets 2002;13(4):197–205.
- Sung AD, Yen RC, Jiao Y, Bernanke A, Lewis DA, Miller SE, Li Z, Ross JR, Artica A, Piryani S, et al. Fibrinogen-coated albumin nanospheres prevent thrombocytopenia-related bleeding. Radiat Res 2020;194(2):162–172. DOI:https://doi.org/10.1667/RADE-20-00016.
- Verhoef C, Singla N, Moneta G, Muir W, Rijken A, Lockstadt H, De Wilt JHW, O-Yurvati A, Zuckerman LA, Frohna P, et al. Fibrocaps for surgical hemostasis: two randomized, controlled phase II trials. J Surg Res 2015;194(2):679–687. DOI:https://doi.org/10.1016/j.jss.2014.12.011.
- Takeoka S, et al. Rolling properties of rGPIbalpha-conjugated phospholipid vesicles with different membrane flexibilities on vWf surface under flow conditions. Biochem Biophys Res Commun 2002;296(3):765–770. DOI:https://doi.org/10.1016/S0006-291X(02)00934-8.
- Nishiya T, Kainoh M, Murata M, Handa M, Ikeda Y. Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ib alpha under flow conditions: specific synergy of receptor-ligand interactions. Blood 2002;100(1):136–142. DOI:https://doi.org/10.1182/blood.V100.1.136.
- Nishiya T, et al. Platelet interactions with liposomes carrying recombinant platelet membrane glycoproteins or fibrinogen: approach to platelet substitutes. Artif Cells Blood Substit Immobil Biotechnol 2001;29(6):453–464. DOI:https://doi.org/10.1081/BIO-100108550.
- Doshi N, et al. Platelet mimetic particles for targeting thrombi in flowing blood. Adv Mater 2012;24(28):3864–3869. DOI:https://doi.org/10.1002/adma.201200607.
- Kim OV, et al. Quantitative structural mechanobiology of platelet-driven blood clot contraction. Nat Commun 2017;8(1):1274. DOI:https://doi.org/10.1038/s41467-017-00885-x.
- Brown AC, et al. Ultrasoft microgels displaying emergent, platelet-like, behaviors. Nat Mater 2014;13(12):1108–1114. DOI:https://doi.org/10.1038/nmat4066.
- Chee E, et al. Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles. J Biomed Mater Res B Appl Biomater 2020;108(6):2599–2609. DOI:https://doi.org/10.1002/jbm.b.34592.
- Mihalko EP, et al. Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation. Blood Adv 2021;5(3):613–627. DOI:https://doi.org/10.1182/bloodadvances.2020003046.
- Coller BS, Springer KT, Beer JH, Mohandas N, Scudder LE, Norton KJ, West SM. In vitro studies of a potential autologous, semi-artificial alternative to platelet transfusions. J Clin Invest 1992;89(2):546–555. DOI:https://doi.org/10.1172/JCI115619.
- Pytela R, Pierschbacher M, Ginsberg M, Plow E, Ruoslahti E. Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp-specific adhesion receptors. Science 1986;231(4745):1559–1562. DOI:https://doi.org/10.1126/science.2420006.
- Plow EF, et al. Ligand binding to GPIIb-IIIa: a status report. Semin Thromb Hemost 1992;18(3):324–332. DOI:https://doi.org/10.1055/s-2007-1002571.
- Bertram JP, Williams CA, Robinson R, Segal SS, Flynn NT, Lavik EB. Intravenous hemostat: nanotechnology to halt bleeding. Sci Trans Med 2009;1(11):11ra22. DOI:https://doi.org/10.1126/scitranslmed.3000397.
- Lashof-Sullivan MM, Shoffstall E, Atkins KT, Keane N, Bir C, VandeVord P, Lavik EB. Intravenously administered nanoparticles increase survival following blast trauma. Proc Natl Acad Sci USA 2014;111(28):10293–10298. DOI:https://doi.org/10.1073/pnas.1406979111.
- Gkikas M, Peponis T, Mesar T, Hong C, Avery RK, Roussakis E, Yoo H-J, Parakh A, Patino M, Sahani DV, et al. Systemically administered hemostatic nanoparticles for identification and treatment of internal bleeding. ACS Biomat Sci Eng 2019;5(5):2563–2576. DOI:https://doi.org/10.1021/acsbiomaterials.9b00054.
- Ruoslahti E. RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol 1996;12(1):697–715. DOI:https://doi.org/10.1146/annurev.cellbio.12.1.697.
- Du X, Plow EF, Frelinger AL, O’Toole TE, Loftus JC, Ginsberg MH. Ligands activate integrin αIIbβ3 (Platelet GPIIb-IIIa). Cell 1991;65(3):409–416. DOI:https://doi.org/10.1016/0092-8674(91)90458-B.
- Bassler N, et al. A mechanistic model for paradoxical platelet activation by ligand-mimetic αIIbβ3 (GPIIb/IIIa) antagnists. Arterioscler Thomb Vascular Biol 2007;27(3):e9–e15.
- Okamura Y, Takeoka S, Teramura Y, Maruyama H, Tsuchida E, Handa M, Ikeda Y. Hemostatic effects of fibrinogen gamma-chain dodecapeptide-conjugated polymerized albumin particles in vitro and in vivo. Transfusion 2005;45(7):1221–1228. DOI:https://doi.org/10.1111/j.1537-2995.2005.00173.x.
- Okamura Y, Fujie T, Nogawa M, Maruyama H, Handa M, Ikeda Y, Takeoka S. Haemostatic effects of polymerized albumin particles carrying fibrinogen γ-chain dodecapeptide as platelet substitutes in severely thrombocytopenic rabbits. Transfusion Med 2008;18(3):158–166. DOI:https://doi.org/10.1111/j.1365-3148.2008.00860.x.
- Okamura Y, Maekawa I, Teramura Y, Maruyama H, Handa M, Ikeda Y, Takeoka S. Hemostatic effects of phospholipid vesicles carrying fibrinogen γ chain dodecapeptide in vitro and in vivo. Bioconj Chem 2005;16(6):1589–1596. DOI:https://doi.org/10.1021/bc050178g.
- Okamura Y, Katsuno S, Suzuki H, Maruyama H, Handa M, Ikeda Y, Takeoka S. Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute. J Control Rel 2010;148(3):373–379. DOI:https://doi.org/10.1016/j.jconrel.2010.09.013.
- del Carpio Munoz C, Campbell W, Constantinescu I, Gyongyossy-Issa MIC. Rational design of antithrombotic peptides to target the von Willebrand Factor (vWf) - GPIb integrin interaction. J Mol Model 2008;14(12):1191–1202. DOI:https://doi.org/10.1007/s00894-008-0375-z.
- Ravikumar M, Modery CL, Wong TL, Dzuricky M, Sen Gupta A. Mimicking adhesive functionalities of blood platelets using ligand-decorated liposomes. Bioconjug Chem 2012;23(6):1266–1275. DOI:https://doi.org/10.1021/bc300086d.
- Haji-Valizadeh H, Modery-Pawlowski CL, Sen Gupta A. A factor VIII-derived peptide enables von Willebrand factor (VWF)-binding of artificial platelet nanoconstructs without interfering with VWF-adhesion of natural platelets. Nanoscale 2014;6(9):4765–4773. DOI:https://doi.org/10.1039/C3NR06400J.
- Swieringa F, Spronk HMH, Heemskerk JWM, van der Meijden PEJ. Integrating platelet and coagulation activation in fibrin clot formation. Res Pract Thromb Haemost 2018;2(3):450–460. DOI:https://doi.org/10.1002/rth2.12107.
- Okamura Y, Handa M, Suzuki H, Ikeda Y, Takeoka S. New strategy of platelet substitutes for enhancing platelet aggregation at high shear rates: cooperative effects of a mixed system of fibrinogen gamma-chain dodecapeptide- or glycoprotein Ib alpha-conjugated latex beads under flow conditions. J Artif Organs 2006;9(4):251–258. DOI:https://doi.org/10.1007/s10047-006-0345-0.
- Cheng S, Craig WS, Mullen D, Tschopp JF, Dixon D, Pierschbacher MD. Design and synthesis of novel cyclic-RGD containing peptides as highly potent and selective integrin αIIbβ3 antagonists. J Med Chem 1994;37(1):1–8. DOI:https://doi.org/10.1021/jm00027a001.
- Ravikumar M, Modery CL, Wong TL, Sen Gupta A, et al. Peptide-decorated liposomes promote arrest and aggregation of activated platelets under flow on vascular injury relevant protein surfaces in vitro. Biomacromolecules 2012;13(5):1495–1502. DOI:https://doi.org/10.1021/bm300192t.
- Modery-Pawlowski CL, Tian LL, Ravikumar M, Wong TL, Gupta AS. In vitro and in vivo hemostatic capabilities of a functionally integrated platelet-mimetic liposomal nanoconstruct. Biomaterials 2013;34(12):3031–3041. DOI:https://doi.org/10.1016/j.biomaterials.2012.12.045.
- Shukla M, Sekhon UDS, Betapudi V, Li W, Hickman DA, Pawlowski CL, Dyer MR, Neal MD, McCrae KR, Sen Gupta A, et al. In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice. J Thromb Haemost 2017;15(2):375–387. DOI:https://doi.org/10.1111/jth.13579.
- Dyer MR, Hickman D, Luc N, Haldeman S, Loughran P, Pawlowski C, Sen Gupta A, Neal MD. Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis. J Trauma Acute Care Surg 2018;84(6):917–923. DOI:https://doi.org/10.1097/TA.0000000000001893.
- Hickman DA, Pawlowski CL, Shevitz A, Luc NF, Kim A, Girish A, Marks J, Ganjoo S, Huang S, Niedoba E, et al. Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve ‘golden hour’ survival in a porcine model of traumatic arterial hemorrhage. Sci Rep 2018;8(1):3118. DOI:https://doi.org/10.1038/s41598-018-21384-z.
- Girish A, Hickman DA, Banerjee A, Luc N, Ma Y, Miyazawa K, Sekhon UDS, Sun M, Huang S, Sen Gupta A, et al. Trauma-targeted delivery of Tranexamic Acid improves hemostasis and survival in rat liver hemorrhage model. J Thromb Haemost 2019;17(10):1632–1644. DOI:https://doi.org/10.1111/jth.14552.
- Anselmo AC, Modery-Pawlowski CL, Menegatti S, Kumar S, Vogus DR, Tian LL, Chen M, Squires TM, Sen Gupta A, Mitragotri S, et al. Platelet-like nanoparticles: mimicking shape, flexibility and surface biology of platelets to target vascular injuries. ACS Nano 2014;8(11):11243–11253. DOI:https://doi.org/10.1021/nn503732m.
- Gao Y, Sarode A, Kokoroskos N, Ukidve A, Zhao Z, Guo S, Flaumenhaft R, Gupta AS, Saillant N, Mitragotri S, et al. A polymer-based systemic hemostatic agent. Sci Adv 2020;6(31):eaba0588. DOI:https://doi.org/10.1126/sciadv.aba0588.
- Brass LF, Diamond SL, Stalker TJ. Platelets and hemostasis: a new perspective on an old subject. Blood Adv 2016;1(1):5–9. DOI:https://doi.org/10.1182/bloodadvances.2016000059.
- Majumder S, Liu AP. Bottom-up synthetic biology: modular design of making artificial platelets. Phys Biol 2017;15(1):013001. DOI:https://doi.org/10.1088/1478-3975/aa9768.
- Sen Gupta A. Synthetic platelets for treatment of traumatic hemorrhage and thrombocytopenia. Blood 2019;134(Supplement_1):SCI–37. DOI:https://doi.org/10.1182/blood-2019-121079.
- Sen Gupta A. Role of particle size, shape, and stiffness in design of intravascular drug delivery systems: insights from computations, experiments, and nature. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2016;8(2):255–270. DOI:https://doi.org/10.1002/wnan.1362.
- Cooley M, Sarode A, Hoore M, Fedosov DA, Mitragotri S, Sen Gupta A. Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale. Nanoscale 2018;10(32):15350–15364. DOI:https://doi.org/10.1039/C8NR04042G.
- Czaja B, Gutierrez M, Závodszky G, de Kanter D, Hoekstra A, Eniola-Adefeso O. The influence of red blood cell deformability on hematocrit profiles and platelet margination. PLoS Comput Biol 2020;16(3):e1007716. DOI:https://doi.org/10.1371/journal.pcbi.1007716.
- He Y, Xu J, Sun X, Ren X, Maharjan A, York P, Su Y, Li H, Zhang J. Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting. Theranostics 2019;9(9):2489–2504. DOI:https://doi.org/10.7150/thno.31159.
- Cap AP, Cannon JW, Reade MC. Synthetic blood and blood products for combat casualty care and beyond. J Trauma Acute Care Surg 2021;91(2S):S26–S32. DOI:https://doi.org/10.1097/TA.0000000000003248.
- Hagisawa K, Kinoshita M, Takikawa M, Takeoka S, Saitoh D, Seki S, Sakai H. Combination therapy using fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits. Transfusion 2019;59(10):2186–2196. DOI:https://doi.org/10.1111/trf.15427.
- Ware J, Corken A, Khetpal R. Platelet function beyond hemostasis and thrombosis. Curr Opin Hematol 2013;20(5):451–456. DOI:https://doi.org/10.1097/MOH.0b013e32836344d3.
- Modery-Pawlowski CL, Kuo -H-H, Baldwin WM, Gupta AS. A platelet-inspired paradigm for nanomedicine targeted to multiple diseases. Nanomedicine 2013;8(10):1709–1727. DOI:https://doi.org/10.2217/nnm.13.113.
- Van Regenmortel MH. Antigenicity and immunogenicity of synthetic peptides. Biologicals 2001;29(3–4):209–213.
- d’Avanzo N, Celia C, Barone A, Carafa M, Di Marzio L, Santos HA, Fresta M. Immunogenicity of polyethylene glycol-based nanomedicines: mechanisms, clinical implications and systematic approach. Advance Therapeutics 2020;3(3):1900170. DOI:https://doi.org/10.1002/adtp.201900170.