1,848
Views
1
CrossRef citations to date
0
Altmetric
Article

Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach

ORCID Icon, , , , , , , , , & show all
Pages 911-917 | Received 30 Sep 2021, Accepted 08 Nov 2021, Published online: 14 Dec 2021

References

  • Brown MA, Lindheimer MD, de Swiet V, van Assche A, Mountquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001;20:9–143. doi:10.1081/PRG-100104165.
  • Atallah A, Lecarpentier E, Goffinet F, Doret-Dion M, Gaucherand P, Tsatsaris V . Aspirin for prevention of preeclampsia. Drugs 2017;77(17):1819–1831. doi:10.1007/s40265-017-0823-0.
  • Rolnik DL, Wright D, Poon LC, O’Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, et al. Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N Engl J Med 2017;377(7):613–622. doi:10.1056/NEJMoa1704559.
  • Fitzgerald R, Pirohamed M. Aspirin resistance: effect of clinical, biochemical and genetic factors. Pharmacol Ther 2011;130(2):213–225. doi:10.1016/j.pharmthera.2011.01.011.
  • Bhala N, Emberson J, Merhi A, Abramson S, Arber, N, Baron, JA, Bombardier, C, Cannon, C, Farkouh, ME, FitzGerald, GA, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet 2013;382:769–779.
  • Navaratnam K, Alfirevic A, Alfirevic Z. Low dose aspirin and pregnancy: how important is aspirin resistance?. BJOG 2016;123(9):1481–1487. doi:10.1111/1471-0528.13914.
  • Patrono C, Coller B, Dalen JE, Fuster V, Gent M, Harker LA, Hirsh J, Roth G . Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest 1998;114:470s–488s. doi:10.1378/chest.114.5_Supplement.470S.
  • Hutt R, Ogunniyi SO, Sullivan MH, Elder MG. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol 1994;83:146–149.
  • Walsh SW. Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. Am J Obstet Gynecol 1985;152(3):335–340. doi:10.1016/S0002-9378(85)80223-4.
  • Schiff E, Peleg E, Goldenberg M, Rosenthal T, Ruppin E, Tamarkin M, Barkai G, Ben-Baruch G, Yahal I, Blankstein J, et al. The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. N Eng J Med 1989;321(6):351–356. doi:10.1056/NEJM198908103210603.
  • Sibai BM, Mirro R, Chesney CM, Leffler C. Low-dose aspirin in pregnancy. Obstet Gynecol 1989;74:551–557.
  • Spitz B, Magness RR, Cox SM, Brown CEL, Rosenfeld CR, Gant NF . Low-dose aspirin. I. Effect on angiotensin II pressor responses and blood prostaglandin concentrations in pregnant women sensitive to angiotensin II. Am J Obstet Gynecol 1988;159(5):1035–1043. doi:10.1016/0002-9378(88)90406-1.
  • Thorp JA, Walsh SW, Brath PC. Low-dose aspirin inhibits thromboxane, but not prostacyclin, production by human placental arteries. Am J Obstet Gynecol 1988;159:1381–1384. doi:10.1016/0002-9378(88)90560-1.
  • Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S, Forest J-C, Giguère Y . Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol 2010;116(2):402–414. doi:10.1097/AOG.0b013e3181e9322a.
  • Lindsay D, Levine LD, Holland TL, Kim K, Mumford SL, Schisterman EF . The role of aspirin and inflammation on reproduction: the EAGeR trial. Can J Physiol Pharmacol 2019;97(3):187–192. doi:10.1139/cjpp-2018-0368.
  • Giannakou K, Evangelou E, Papathedorou SI. Genetic and non-genetic risk factors for preeclampsia: umbrella review of systematic reviews and meta-analyses of observational studies. Ultrasound Obstet Gynecol 2018;51:720–730. doi:10.1002/uog.18959.
  • Eudy AM, Voora D, Myers RA, Clowse MEB. Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study. Lupus 2019;28(14):1640–1647. doi:10.1177/0961203319886069.
  • Mone F, Mulcahy C, McParland P, Breathnach F, Downey P, McCormack D, Culliton M, Stanton A, Cody F, Morrison JJ, et al. Trial of feasibility and acceptability of routine low-dose aspirin versus Early Screening Test indicated aspirin for preeclampsia prevention (TEST study): a multicentre randomised controlled trial. BMJ Open 2018;8:e022056. doi:10.1136/bmjopen-2018-022056.
  • Fox SC, May JA, Shah A, Neubert U, Heptinstall S. Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin. Platelets 2009;20:250–259. doi:10.1080/09537100902912451.
  • Dovlatova N, May JA, Fox SC. Remote platelet function testing–Significant progress towards widespread testing in clinical practice. Platelets 2015;26:399–401. doi:10.3109/09537104.2015.1043880.
  • Navaratnam K, Alfirevic A, Jorgensen A, Alfirevic Z. Aspirin non-responsiveness in pregnant women at high-risk of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2018;221:144–150. doi:10.1016/j.ejogrb.2017.12.052.
  • Grove EL, Hvas A-M, Johnsen HL, Hedegaard SS, Pedersen SB, Mortensen J, Kristensen SD . A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease. Thromb Haemost 2010;103(6):1245–1253. doi:10.1160/TH09-08-0527.
  • Cattaneo M. Laboratory detection of ‘aspirin resistance’: what test should we use (if any)?. Eur Heart J 2007;28:1673–1675. doi:10.1093/eurheartj/ehm232.
  • Pandey CP, Misra A, Negi MS, Kanuri BN, Chhonker YS, Bhatta R, Narain V, Dikshit M . Aspirin & clopidogrel non-responsiveness & its association with genetic polymorphisms in patients with myocardial infarction. Indian J Med Res 2019;150(1):50–61. doi:10.4103/ijmr.IJMR_782_17.
  • Lewis JP, Riaz M, Xie S, Polekhina G, Wolfe R, Nelson M, Tonkin AM, Reid CM, Murray AM, McNeil JJ, et al. Genetic variation in PEAR1, cardiovascular outcomes and effects of aspirin in a healthy elderly population. Clin Pharmacol Ther 2020;108:1289–1298. doi:10.1002/cpt.1959.
  • Ferreira M, Freitas-Silva M, Assis J, Pinto R, Nunes JP, Medeiros R . The emergent phenomenon of aspirin resistance: insights from genetic association studies. Pharmacogenomics 2020;21:125–140. doi:10.2217/pgs-2019-0133.
  • Liu WW, Wang H, Chen XH, Fu SW, Liu ML. miR-34b-3p may promote antiplatelet efficiency of aspirin by inhibiting thromboxane synthase expression. Thromb Haemost 2019;119:1451–1460. doi:10.1055/s-0039-1692681.
  • Massimi I, Alemanno L, Guarino ML, Guerriero R, Mancone M, Ceccacci A, Frati L, Angiolillo D, Pulcinelli F . aspirin-dependent effects on purinergic P2Y1 receptor expression. Thromb Haemost 2019;119(5):726–734. doi:10.1055/s-0039-1678707.
  • Lewis JP. Implementation of genotype-guided antiplatelet therapy: feasible but not without obstacles. Circ Genom Precis Med 2018;11:e002118. doi:10.1161/CIRCGEN.118.002118.
  • Zhou Y, Yan X, Feng X, Bu J, Dong Y, Lin P, Hayashi Y, Huang R, Olsson A, Andreassen PR, et al. Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation. Haematologica 2018;103(7):1110–1123. doi:10.3324/haematol.2018.187708.
  • Gao Z, Chen X, Zhu K, Zeng P, Ding G. Dab1 contributes to angiotensin II-induced apoptosis via p38 signaling pathway in podocytes. Biomed Res Int 2017;2484303. doi:10.1155/2017/2484303.
  • Navaratnam K, Alfirevic Z, Pirmohamed M, Alfirevic A. How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?. Eur J Obstet Gynecol Reprod Biol 2017;219:1–9. doi:10.1016/j.ejogrb.2017.10.004.
  • Shanmugalingam R, Wang X, Munch G, Fulcher I, Lee G, Chau K, Xu B, Kumar R, Hennessy A, Makris A, et al. A pharmacokinetic assessment of optimal dosing, preparation, and chronotherapy of aspirin in pregnancy. Am J Obstet Gynecol 2019;221:255.e1–255.e9. doi:10.1016/j.ajog.2019.04.027.
  • Mone F, Mulcahy C, McParland P, McAuliffe FM. Should we recommend universal aspirin for all pregnant women?. Am J Obstet Gynecol 2017;216:141.e1–141.e5. doi:10.1016/j.ajog.2016.09.086.
  • Hastie R, Tong S, Wikstrom A-K, Sandstrom A, Hesselman S, Bergman L. Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-based cohort study. Am J Obstet Gynecol 2021;224(1):95.e1–95.e12. doi:10.1016/j.ajog.2020.07.023.