Mass cytometry of platelet-rich plasma: a new approach to analyze platelet surface expression and reactivity

References

• Blair TA, Michelson AD, Frelinger AL. Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia. Sci Rep-uk. 2018;8:10300. DOI: 10.1038/s41598-018-28211-5
   PubMed Web of Science ®Google Scholar
• Bernlochner I, Klug M, Larasati D, Scheidt MV, Santovito D, Hristov M, Weber C, Laugwitz K-L, Bongiovanni D. Sorting and magnetic-based isolation of reticulated platelets from peripheral blood. Platelets. 2020:1–7. DOI: 10.1080/09537104.2020.1724923
   Web of Science ®Google Scholar
• Bongiovanni D, Santamaria G, Klug M, Santovito D, Felicetta A, Hristov M, Scheidt M, Von, Aslani M, Cibella J, Weber C, et al. Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile. Thromb Haemostasis. 2019;119:1795–1806. DOI: 10.1055/s-0039-1695009
   PubMed Web of Science ®Google Scholar
• Blair TA. Platelet surface marker analysis by mass cytometry. Platelets. 2019;31:1–8.
   Web of Science ®Google Scholar
• Hagberg IA, Roald HE, Lyberg T. Platelet Activation in Flowing Blood Passing Growing Arterial Thrombi. Arteriosclerosis Thrombosis Vasc Biol. 1997;17:1331–1336. DOI: 10.1161/01.ATV.17.7.1331
   PubMed Web of Science ®Google Scholar
• Spurgeon BEJ, Michelson AD, Frelinger AL. Platelet mass cytometry: optimization of sample, reagent, and analysis parameters. Cytom Part A. 2021. DOI: 10.1002/cyto.a.24300
   PubMed Web of Science ®Google Scholar
• Schulz AR, Baumgart S, Schulze J, Urbicht M, Grützkau A, Mei HE. Stabilizing Antibody Cocktails for Mass Cytometry. Cytom Part A. 2019;95:910–916.
   PubMedGoogle Scholar
• Bongiovanni D, Klug M, Lazareva O, Weidlich S, Biasi M, Ursu S, Warth S, Buske C, Lukas M, Spinner CD, et al. SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotype. Cell Death Dis. 2021;12:50. DOI: 10.1038/s41419-020-03333-9
   PubMed Web of Science ®Google Scholar
• Chevrier S, Crowell HL, Zanotelli VRT, Engler S, Robinson MD, Bodenmiller B. Compensation of Signal Spillover in Suspension and Imaging Mass Cytometry. Cell Syst. 2018;6612–620.e5. DOI: 10.1016/j.cels.2018.02.010
   PubMedGoogle Scholar
• Amir ED, Davis KL, Tadmor MD, Simonds EF, Levine JH, Bendall SC, Shenfeld DK, Krishnaswamy S, Nolan GP, Pe’er D. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat Biotechnol. 2013;31:545–552. DOI: 10.1038/nbt.2594
   PubMed Web of Science ®Google Scholar
• McInnes L, Healy J, Saul N, Großberger L. UMAP: uniform Manifold Approximation and Projection. J Open Source Softw. 2018;3:861. DOI: 10.21105/joss.00861
   Google Scholar
• Nowicka M, Krieg C, Weber LM, Hartmann FJ, Guglietta S, Becher B, Levesque MP, Robinson MD. CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets. F1000research. 2017;6:748. DOI: 10.12688/f1000research.11622.1
   PubMedGoogle Scholar
• Arend L, Bernett J, Manz Q, Klug M, Lazareva O, Baumbach J, Bongiovanni D, List M. A systematic comparison of novel and existing differential analysis methods for CyTOF data. Brief Bioinform. 2021. DOI: 10.1093/bib/bbab471
   PubMed Web of Science ®Google Scholar
• Siess W, Grünberg B. Phosphorylation of rap1B by protein kinase a is not involved in platelet inhibition by cyclic AMP. Cell Signal. 1993;5:209–214. DOI: 10.1016/0898-6568(93)90071-S
   PubMed Web of Science ®Google Scholar
• Bonhomme F, Bonvini R, Reny J-L, Poncet A, Fontana P. Impact of non-inhibited platelet supplementation on platelet reactivity in patients treated with prasugrel or ticagrelor for an acute coronary syndrome: an ex vivo study. Platelets. 2015;26:324–330. DOI: 10.3109/09537104.2015.1035247
   PubMed Web of Science ®Google Scholar
• Mourikis P, Helten C, Dannenberg L, Hohlfeld T, Stegbauer J, Petzold T, Levkau B, Zeus T, Kelm M, Polzin A. Platelet reactivity in patients with chronic kidney disease and hemodialysis. J Thromb Thrombolys. 2020;49:168–172. DOI: 10.1007/s11239-019-01983-x
   PubMed Web of Science ®Google Scholar
• Tokuda H, Kuroyanagi G, Tsujimoto M, Matsushima-Nishiwaki R, Akamatsu S, Enomoto Y, Iida H, Otsuka T, Ogura S, Iwama T, et al. Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients. Int J Mol Sci. 2016;17:737. DOI: 10.3390/ijms17050737
   PubMed Web of Science ®Google Scholar
• Klug M, Lazareva O, Kirmes K, Rosenbaum M, Lukas M, Weidlich S, Spinner CD, Scheidt M, Von, Gosetti R, Baumbach J, et al. Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination. Thromb Haemostasis. 2021. DOI: 10.1055/s-0041-1733934
   PubMed Web of Science ®Google Scholar
• Subrahmanyam PB, Maecker HT. CyTOF Measurement of Immunocompetence Across Major Immune Cell Types. Curr Protoc Cytom. 2017;82:12. DOI: 10.1002/cpcy.29
   PubMedGoogle Scholar
• Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, et al. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017;20:984–998. DOI: 10.1016/j.celrep.2017.06.087
   PubMed Web of Science ®Google Scholar
• Weber LM, Soneson C. HDCytoData: collection of high-dimensional cytometry benchmark datasets in Bioconductor object formats. F1000research. 2019;8:1459. DOI: 10.12688/f1000research.20210.2
   PubMedGoogle Scholar
• Weber LM, Nowicka M, Soneson C, Robinson MD. diffcyt: differential discovery in high-dimensional cytometry via high-resolution clustering. Commun Biol. 2019;2:183. DOI: 10.1038/s42003-019-0415-5
   PubMed Web of Science ®Google Scholar
• Sumatoh HR, Teng KWW, Cheng Y, Newell EW. Optimization of mass cytometry sample cryopreservation after staining. Cytom Part A. 2017;91:48–61. DOI: 10.1002/cyto.a.23014
   PubMedGoogle Scholar
• Pararasa C, Zhang N, Tull TJ, Chong MHA, Siu JHY, Guesdon W, Chavele KM, Sanderson JD, Langmead L, Kok K, et al. Reduced CD27−IgD− B Cells in Blood and Raised CD27−IgD− B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease. Front Immunol. 2019;10:361. DOI: 10.3389/fimmu.2019.00361
   PubMed Web of Science ®Google Scholar