Signaling mechanisms of the platelet glycoprotein Ib-IX complex

References

• Ware J. Molecular analyses of the platelet glycoprotein Ib-IX-V receptor. Thromb Haemost 1998;79(3):466–478. doi:10.1055/s-0037-1614928.
   PubMed Web of Science ®Google Scholar
• Quach ME, Li R. Structure-function of platelet glycoprotein Ib-IX. J Thromb Haemost 2020;18(12):3131–3141. Epub 2020/08/01. doi:10.1111/jth.15035.
   PubMed Web of Science ®Google Scholar
• Ramakrishnan V, Reeves PS, DeGuzman F, Deshpande U, Ministri-Madrid K, DuBridge RB, Phillips DR. Increased thrombin responsiveness in platelets from mice lacking glycoprotein V. Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13336–13341. doi:10.1073/pnas.96.23.13336.
   PubMed Web of Science ®Google Scholar
• Ramakrishnan V, DeGuzman F, Bao M, Hall SW, Leung LL, Phillips DR. A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V. Proc Natl Acad Sci U S A 2001;98(4):1823–1828. Epub 2001/02/15. doi:10.1073/pnas.98.4.1823.
   PubMed Web of Science ®Google Scholar
• Caen JP, Nurden AT, Jeanneau C, Michel H, Tobelem G, Levy-Toledano S, Sultan Y, Valensi F, Bernard J. Bernard-Soulier syndrome: a new platelet glycoprotein abnormality. Its relationship with platelet adhesion to subendothelium and with the factor VIII von Willebrand protein. J Lab Clin Med 1976;87(4):586–596. Epub 1976/04/01.
   PubMed Web of Science ®Google Scholar
• Clemetson KJ, Clemetson JM. Molecular abnormalities in Glanzmann’s thrombasthenia, Bernard-Soulier syndrome, and platelet-type von Willebrand’s disease. Curr Opin Hematol 1994;1(5):388–393. Epub 1994/09/01.
   PubMedGoogle Scholar
• Sakariassen KS, Nievelstein PFEM, Coller BS, Sixma JJ. The role of platelet membrane glycoproteins Ib and IIb-IIIa in platelet adherence to human artery subendothelium. Br J Haematol 1986;63(4):681–691. doi:10.1111/j.1365-2141.1986.tb07552.x.
   PubMed Web of Science ®Google Scholar
• Cosemans JM, Schols SE, Stefanini L, de Witt S, Feijge MA, Hamulyak K, Deckmyn H, Bergmeier W, Heemskerk JW. Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood 2011;117(2):651–660. Epub 2010/11/03. doi:10.1182/blood-2010-01-262683.
   PubMed Web of Science ®Google Scholar
• Du X. Signaling and regulation of the platelet glycoprotein Ib–IX–V complex. Curr Opin Hematol 2007;14(3):262–269. Epub 2007/04/07. 10.1097/MOH.0b013e3280dce51a.
   PubMed Web of Science ®Google Scholar
• Li Z, Delaney MK, O’Brien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 2010;30(12):2341–2349. Epub 2010/11/13. doi:10.1161/ATVBAHA.110.207522.
   PubMed Web of Science ®Google Scholar
• Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate–receptor interactions in platelet thrombus formation under flow. Cell 1998;94(5):657–666. doi:10.1016/S0092-8674(00)81607-4.
   PubMed Web of Science ®Google Scholar
• Estevez B, Du X. New concepts and mechanisms of platelet activation signaling. Physiology (Bethesda) 2017;32(2):162–177. Epub 2017/02/24. doi:10.1152/physiol.00020.2016.
   PubMed Web of Science ®Google Scholar
• Zhang W, Deng W, Zhou L, Xu Y, Yang W, Liang X, Wang Y, Kulman JD, Zhang XF, Li R. Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex. Blood 2015;125(3):562–569. doi:10.1182/blood-2014-07-589507.
   PubMed Web of Science ®Google Scholar
• Ju L, Chen Y, Xue L, Du X, Zhu C. Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals. eLife 2016;5:e15447. doi:10.7554/eLife.15447.
   PubMed Web of Science ®Google Scholar
• Ruggeri ZM, Mendolicchio GL. Adhesion mechanisms in platelet function. Circ Res 2007;100(12):1673–1685. Epub 2007/06/23. doi:10.1161/01.RES.0000267878.97021.ab.
   PubMed Web of Science ®Google Scholar
• Springer TA. von Willebrand factor, Jedi knight of the bloodstream. Blood 2014;124(9):1412–1425. Epub 2014/06/15. doi:10.1182/blood-2014-05-378638.
   PubMed Web of Science ®Google Scholar
• Li Z, Lin J, Sulchek T, Cruz MA, Wu J, Dong JF, Zhu C. Domain-specific mechanical modulation of VWF-ADAMTS13 interaction. Mol Biol Cell 2019;30(16):1920–1929. Epub 2019/05/09. doi:10.1091/mbc.E19-01-0021.
   PubMed Web of Science ®Google Scholar
• Fu H, Jiang Y, Yang D, Scheiflinger F, Wong WP, Springer TA. Flow-induced elongation of von Willebrand factor precedes tension-dependent activation. Nat Commun 2017;8(1):324. Epub 2017/08/24. doi:10.1038/s41467-017-00230-2.
   PubMedGoogle Scholar
• Doggett TA, Girdhar G, Lawshe A, Schmidtke DW, Laurenzi IJ, Diamond SL, Diacovo TG. Selectin-like kinetics and biomechanics promote rapid platelet adhesion in flow: the GPIbα-vWF tether bond. Biophys J 2002;83(1):194–205. Epub 2002/06/25. doi:10.1016/S0006-3495(02)75161-8.
   PubMed Web of Science ®Google Scholar
• Li J, Kim K, Jeong S-Y, Chiu J, Xiong B, Petukhov PA, Dai X, Li X, Andrews RK, Du X, et al. Platelet protein disulfide isomerase promotes glycoprotein Ibα–mediated platelet-neutrophil interactions under thromboinflammatory conditions. Circulation 2019;139(10):1300–1319. Epub 2018/12/28. doi:10.1161/CIRCULATIONAHA.118.036323.
   PubMed Web of Science ®Google Scholar
• Chen Y, Ruggeri ZM, Du X. 14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling. Blood 2018;131(22):2436–2448. Epub 2018/04/07. doi:10.1182/blood-2017-09-742650.
   PubMed Web of Science ®Google Scholar
• Uff S, Clemetson JM, Harrison T, Clemetson KJ, Emsley J. Crystal structure of the platelet glycoprotein Ibα N-terminal domain reveals an unmasking mechanism for receptor activation. J Biol Chem 2002;277(38):35657–35663. Epub 2002/06/28. doi:10.1074/jbc.M205271200.
   PubMed Web of Science ®Google Scholar
• Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science 2002;297(5584):1176–1179. Epub 2002/08/17. doi:10.1126/science.107355.
   PubMed Web of Science ®Google Scholar
• Yago T, Lou J, Wu T, Yang J, Miner JJ, Coburn L, López JA, Cruz MA, Dong J-F, McIntire LV, et al. Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest 2008;118(9):3195–3207. Epub 2008/08/30. doi:10.1172/JCI35754.
   PubMed Web of Science ®Google Scholar
• Ju L, Dong J-F, Cruz MA, Zhu C. The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα. J Biol Chem 2013;288(45):32289–32301. Epub 2013/09/26. doi:10.1074/jbc.M113.504001.
   PubMed Web of Science ®Google Scholar
• Kim J, Zhang C-Z, Zhang X, Springer TA. A mechanically stabilized receptor–ligand flex-bond important in the vasculature. Nature 2010;466(7309):992–995. Epub 2010/08/21. doi:10.1038/nature09295.
   PubMed Web of Science ®Google Scholar
• McEver RP, Zhu C. Rolling cell adhesion. Annu Rev Cell Dev Biol 2010;26(1):363–396. Epub 2009/07/07. doi:10.1146/annurev.cellbio.042308.113238.
   PubMedGoogle Scholar
• Yin H, Stojanovic A, Hay N, Du X. The role of Akt in the signaling pathway of the glycoprotein Ib-IX–induced platelet activation. Blood 2008;111(2):658–665. Epub 2007/10/05. doi:10.1182/blood-2007-04-085514.
   PubMed Web of Science ®Google Scholar
• De Marco L, Girolami A, Russell S, Ruggeri ZM. Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation. J Clin Invest 1985;75(4):1198–1203. doi:10.1172/JCI111816.
   PubMed Web of Science ®Google Scholar
• Grainick HR, Williams SB, Coller BS. Asialo von Willebrand factor interactions with platelets. Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation. J Clin Invest 1985;75(1):19–25. doi:10.1172/JCI111673.
   PubMed Web of Science ®Google Scholar
• Kroll MH, Harris TS, Moake JL, Handin RI, Schafer AI. von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. J Clin Invest 1991;88(5):1568–1573. doi:10.1172/JCI115468.
   PubMed Web of Science ®Google Scholar
• Chen Y, Ju LA, Zhou F, Liao J, Xue L, Su QP, Jin D, Yuan Y, Lu H, Jackson SP, et al. An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation. Nat Mater 2019;18(7):760–769. Epub 2019/03/27. doi:10.1038/s41563-019-0323-6.
   PubMed Web of Science ®Google Scholar
• Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, et al. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood 2010;115(16):3364–3373. Epub 2010/02/09. doi:10.1182/blood-2009-09-242271.
   PubMed Web of Science ®Google Scholar
• Ju L, Lou J, Chen Y, Li Z, Zhu C. Force-induced unfolding of leucine-rich repeats of glycoprotein Ibα strengthens ligand interaction. Biophys J 2015;109(9):1781–1784. Epub 2015/11/05. doi:10.1016/j.bpj.2015.08.050.
   PubMed Web of Science ®Google Scholar
• Zhang XF, Zhang W, Quach ME, Deng W, Li R. Force-regulated refolding of the mechanosensory domain in the platelet glycoprotein Ib-IX complex. Biophys J 2019;116(10):1960–1969. Epub 2019/04/30. doi:10.1016/j.bpj.2019.03.037.
   PubMed Web of Science ®Google Scholar
• Mazzucato M, Pradella P, Cozzi MR, De Marco L, Ruggeri ZM. Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibα mechanoreceptor. Blood 2002;100(8):2793–2800. Epub 2002/09/28. doi:10.1182/blood-2002-02-0514.
   PubMed Web of Science ®Google Scholar
• Nesbitt WS, Kulkarni S, Giuliano S, Goncalves I, Dopheide SM, Yap CL, Harper IS, Salem HH, Jackson SP. Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow. J Biol Chem 2002;277(4):2965–2972. Epub 2001/11/20. doi:10.1074/jbc.M110070200.
   PubMed Web of Science ®Google Scholar
• Deng W, Xu Y, Chen W, Paul DS, Syed AK, Dragovich MA, Liang X, Zakas P, Berndt MC, Di Paola J, et al. Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor. Nat Commun 2016;7(1):12863. Epub 2016/09/28. doi:10.1038/ncomms12863.
   PubMedGoogle Scholar
• Wang Y, Chen W, Zhang W, Lee-Sundlov MM, Casari C, Berndt MC, Lanza F, Bergmeier W, Hoffmeister KM, Zhang XF, et al. Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance. Haematologica 2020;106(1):220–229. Epub 2020/01/25. doi:10.3324/haematol.2019.240440.
   Web of Science ®Google Scholar
• Yap CL, Hughan SC, Cranmer SL, Nesbitt WS, Rooney MM, Giuliano S, Kulkarni S, Dopheide SM, Yuan Y, Salem HH, et al. Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3. J Biol Chem 2000;275(52):41377–41388. Epub 2000/09/01. doi:10.1074/jbc.M005590200.
   PubMed Web of Science ®Google Scholar
• Kasirer-Friede A, Cozzi MR, Mazzucato M, De Marco L, Ruggeri ZM, Shattil SJ. Signaling through GP Ib-IX-V activates αIIbβ3 independently of other receptors. Blood 2004;103(9):3403–3411. doi:10.1182/blood-2003-10-3664.
   PubMed Web of Science ®Google Scholar
• De Candia E, Hall SW, Rutella S, Landolfi R, Andrews RK, De Cristofaro R. Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets. J Biol Chem 2001;276(7):4692–4698. Epub 2000/11/21. doi:10.1074/jbc.M008160200.
   PubMed Web of Science ®Google Scholar
• Adam F, Guillin M-C, Jandrot-Perrus M. Glycoprotein Ib-mediated platelet activation. Eur J Biochem 2003;270(14):2959–2970. Epub 2003/07/09. doi:10.1046/j.1432-1033.2003.03670.x.
   PubMedGoogle Scholar
• Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood 2016;127(5):626–636. Epub 2015/11/21. doi:10.1182/blood-2015-04-638387.
   PubMed Web of Science ®Google Scholar
• Bradford HN, Dela Cadena RA, Kunapuli SP, Dong J-F, López JA, Colman RW. Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. Blood 1997;90(4):1508–1515. Epub 1997/08/15. doi:10.1182/blood.V90.4.1508.
   PubMed Web of Science ®Google Scholar
• Bradford HN, Pixley RA, Colman RW. Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation. J Biol Chem 2000;275(30):22756–22763. Epub 2000/05/10. doi:10.1074/jbc.M002591200.
   PubMed Web of Science ®Google Scholar
• Romo GM, Dong J-F, Schade AJ, Gardiner EE, Kansas GS, Li CQ, McIntire LV, Berndt MC, López JA. The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med 1999;190(6):803–814. Epub 1999/09/28. doi:10.1084/jem.190.6.803.
   PubMed Web of Science ®Google Scholar
• Wang Y, Gao H, Shi C, Erhardt PW, Pavlovsky AA, Soloviev D, Bledzka K, Ustinov V, Zhu L, Qin J, et al. Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα. Nat Commun 2017;8(1):15559. doi:10.1038/ncomms15559.
   PubMedGoogle Scholar
• Köhler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Bakchoul T, Eggstein C, et al. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat Commun 2020;11(1):1315. doi:10.1038/s41467-020-14958-x.
   PubMed Web of Science ®Google Scholar
• Gowert NS, Kruger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Kober S, Langer H, et al. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal 2017;40:210–221. Epub 2017/09/26. doi:10.1016/j.cellsig.2017.09.016.
   PubMed Web of Science ®Google Scholar
• Jurk K, Clemetson KJ, de Groot PG, Brodde MF, Steiner M, Savion N, Varon D, Sixma JJ, Van Aken H, Kehrel BE. Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor. FASEB J 2003;17(11):1490–1492. Epub 2003/06/26. doi:10.1096/fj.02-0830fje.
   PubMedGoogle Scholar
• Prakash P, Kulkarni PP, Chauhan AK. Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice. Blood 2015;125(2):399–406. Epub 2014/10/26. doi:10.1182/blood-2014-06-581942.
   PubMed Web of Science ®Google Scholar
• Pluskota E, Woody NM, Szpak D, Ballantyne CM, Soloviev DA, Simon DI, Plow EF. Expression, activation, and function of integrin αMβ2 (Mac-1) on neutrophil-derived microparticles. Blood 2008;112(6):2327–2335. Epub 2008/05/30. doi:10.1182/blood-2007-12-127183.
   PubMed Web of Science ®Google Scholar
• Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ. Lateral clustering of platelet GP Ib-IX complexes leads to Up-regulation of the adhesive function of integrin αIIbβ3. J Biol Chem 2002;277(14):11949–11956. Epub 12002 Jan 11925. doi:10.1074/jbc.M108727200.
   PubMed Web of Science ®Google Scholar
• Perrault C, Moog S, Rubinstein E, Santer M, Baas M-J, de la Salle C, Ravanat C, Dambach J, Freund M, Santoso S, et al. A novel monoclonal antibody against the extracellular domain of GPIbβ modulates vWF mediated platelet adhesion. Thromb Haemost 2001;86(11):1238–1248. Epub 2002/01/31. doi:10.1055/s-0037-1616057.
   PubMedGoogle Scholar
• Quach ME, Chen W, Wang Y, Deckmyn H, Lanza F, Nieswandt B, Li R. Differential regulation of the platelet GPIb-IX complex by anti-GPIbβ antibodies. J Thromb Haemost 2021;19(8):2044–2055. Epub 2021/04/30. doi:10.1111/jth.15359.
   PubMed Web of Science ®Google Scholar
• Andrews RK, Fox JE. Interaction of purified actin-binding protein with the platelet membrane glycoprotein Ib-IX complex. J Biol Chem 1991;266(11):7144–7147. 10.1016/S0021-9258(20)89622-7.
   PubMed Web of Science ®Google Scholar
• Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC. Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex. J Biol Chem 1994;269(28):18287–18290. Epub 1994/07/15. doi:10.1016/S0021-9258(17)32301-3.
   PubMed Web of Science ®Google Scholar
• Mu F-T, Andrews RK, Arthur JF, Munday AD, Cranmer SL, Jackson SP, Stomski FC, Lopez AF, Berndt MC. A functional 14-3-3ζ–independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. Blood 2008;111(9):4580–4587. Epub 2008/02/27. doi:10.1182/blood-2007-09-111096.
   PubMed Web of Science ®Google Scholar
• Mangin P, David T, Lavaud V, Cranmer SL, Pikovski I, Jackson SP, Berndt MC, Cazenave J-P, Gachet C, Lanza F. Identification of a novel 14-3-3ζ binding site within the cytoplasmic tail of platelet glycoprotein Ibα. Blood 2004;104(2):420–427. doi:10.1182/blood-2003-08-2881.
   PubMed Web of Science ®Google Scholar
• Wu Y, Asazuma N, Satoh K, Yatomi Y, Takafuta T, Berndt MC, Ozaki Y. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3–kinase. Blood 2003;101(9):3469–3476. Epub 2002/10/24. doi:10.1182/blood-2002-03-0806.
   PubMed Web of Science ®Google Scholar
• Arthur JF, Shen Y, Gardiner EE, Coleman L, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost 2011;9(1):163–172. Epub 2010/10/16. doi:10.1111/j.1538-7836.2010.04091.x.
   PubMed Web of Science ®Google Scholar
• Kim CM, Son Y-J, Kim S, Kim SY, Park HH. Molecular basis for unique specificity of human TRAF4 for platelets GPIbβ and GPVI. Proc Natl Acad Sci U S A 2017;114(43):11422–11427. Epub 2017/10/27. doi:10.1073/pnas.1708688114.
   PubMed Web of Science ®Google Scholar
• Andrews RK, Munday AD, Mitchell CA, Berndt MC. Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. Blood 2001;98(3):681–687. Epub 2001/07/27. doi:10.1182/blood.V98.3.681.
   PubMed Web of Science ®Google Scholar
• Kanaji T, Ware J, Okamura T, Newman PJ. GPIbα regulates platelet size by controlling the subcellular localization of filamin. Blood 2012;119(12):2906–2913. Epub 2011/12/17. doi:10.1182/blood-2011-08-376566.
   PubMed Web of Science ®Google Scholar
• Englund GD, Bodnar RJ, Li Z, Ruggeri ZM, Du X. Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal. J Biol Chem 2001;276(20):16952–16959. Epub 2001/03/30. doi:10.1074/jbc.M008048200.
   PubMed Web of Science ®Google Scholar
• Feng S, Reséndiz JC, Lu X, Kroll MH. Filamin A binding to the cytoplasmic tail of glycoprotein Ibα regulates von Willebrand factor–induced platelet activation. Blood 2003;102(6):2122–2129. Epub 2003/06/07. doi:10.1182/blood-2002-12-3805.
   PubMed Web of Science ®Google Scholar
• Rosa J-P, Raslova H, Bryckaert M. Filamin A: key actor in platelet biology. Blood 2019;134(16):1279–1288. Epub 2019/09/01. doi:10.1182/blood.2019000014.
   PubMed Web of Science ®Google Scholar
• Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med 2010;207(9):1967–1979. Epub 2010/08/18. doi:10.1084/jem.20100222.
   PubMed Web of Science ®Google Scholar
• Dutting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, et al. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Nat Commun 2017;8(1):15838. Epub 2017/06/24. doi:10.1038/ncomms15838.
   PubMedGoogle Scholar
• Mangin PH, Receveur N, Wurtz V, David T, Gachet C, Lanza F. Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets. J Thromb Haemost 2009;7(9):1550–1555. Epub 2009/06/30. 10.1111/j.1538-7836.2009.03530.x.
   PubMed Web of Science ®Google Scholar
• Dai K, Bodnar R, Berndt MC, Du X. A critical role for 14-3-3ζ protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications. Blood 2005;106(6):1975–1981. Epub 2005/06/09. doi:10.1182/blood-2005-01-0440.
   PubMed Web of Science ®Google Scholar
• Feng S, Christodoulides N, Reseéndiz JC, Berndt MC, Kroll MH. Cytoplasmic domains of GpIbα and GpIbβ regulate 14-3-3ζ binding to GpIb/IX/V. Blood 2000;95(2):551–557. Epub 2000/01/11. doi:10.1182/blood.V95.2.551.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zhang W, Yan R, Liao Y, Zhao L, Ruan C, Du X, Dai K. Identification of a novel 14-3-3ζ binding site within the cytoplasmic domain of platelet glycoprotein Ibα that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib-IX. Circ Res 2009;105(12):1177–1185. Epub 2009/10/31. doi:10.1161/CIRCRESAHA.109.204669.
   PubMed Web of Science ®Google Scholar
• Andrews RK, Harris SJ, McNally T, Berndt MC. Binding of purified 14-3-3 ζ signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. Biochemistry 1998;37(2):638–647. Epub 1998/02/21. doi:10.1021/bi970893g.
   PubMed Web of Science ®Google Scholar
• Bodnar RJ, Xi X, Li Z, Berndt MC, Du X. Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at ser 166 of glycoprotein Ibβ. J Biol Chem 2002;277(49):47080–47087. doi:10.1074/jbc.M208329200.
   PubMed Web of Science ®Google Scholar
• Constantinescu-Bercu A, Wang YA, Woollard KJ, Mangin P, Vanhoorelbeke K, Crawley JTB, Salles II II. The GPIbα intracellular tail – role in transducing VWF- and collagen/GPVI-mediated signaling. Haematologica 2021. Epub 2021/06/18. doi:10.3324/haematol.2020.278242.
   Web of Science ®Google Scholar
• Gu M, Xi X, Englund GD, Berndt MC, Du X. Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX–mediated activation of integrin αIIbβ3 using a reconstituted mammalian cell expression model. J Cell Biol 1999;147(5):1085–1096. doi:10.1083/jcb.147.5.1085.
   PubMed Web of Science ®Google Scholar
• Jain S, Zuka M, Liu J, Russell S, Dent J, Guerrero JA, Forsyth J, Maruszak B, Gartner TK, Felding-Habermann B, et al. Platelet glycoprotein Ibα supports experimental lung metastasis. Proc Natl Acad Sci U S A 2007;104(21):9024–9028. Epub 2007/05/15. doi:10.1073/pnas.0700625104.
   PubMed Web of Science ®Google Scholar
• Ruan CG, Du XP, Xi XD, Castaldi PA, Berndt MC. A murine antiglycoprotein Ib complex monoclonal antibody, SZ 2, inhibits platelet aggregation induced by both ristocetin and collagen. Blood 1987;69(2):570–577. doi:10.1182/blood.V69.2.570.570.
   PubMed Web of Science ®Google Scholar
• Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX–induced platelet activation via the cGMP signaling pathway. Blood 2008;112(4):1139–1146. Epub 2008/06/14. doi:10.1182/blood-2008-02-140970.
   PubMed Web of Science ®Google Scholar
• Delaney MK, Liu J, Zheng Y, Berndt MC, Du X. The role of Rac1 in glycoprotein Ib-IX–mediated signal transduction and Integrin activation. Arterioscler Thromb Vasc Biol 2012;32(11):2761–2768. Epub 2012/09/22. doi:10.1161/ATVBAHA.112.254920.
   PubMed Web of Science ®Google Scholar
• Munday AD, Berndt MC, Mitchell CA. Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ. Blood 2000;96(2):577–584. Epub 2000/07/11. doi:10.1182/blood.V96.2.577.014k15_577_584.
   PubMed Web of Science ®Google Scholar
• Mu F-T, Cranmer SL, Andrews RK, Berndt MC. Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibα, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex. J Thromb Haemost 2010;8(2):324–330. Epub 2009/10/31. doi:10.1111/j.1538-7836.2009.03672.x.
   PubMedGoogle Scholar
• Yap CL, Anderson KE, Hughan SC, Dopheide SM, Salem HH, Jackson SP. Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin αIIbβ3. Blood 2002;99(1):151–158. Epub 2002/01/05. doi:10.1182/blood.V99.1.151.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang G, Feil R, Han J, Du X. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin αIIbβ3. Blood 2006;107(3):965–972. Epub 2005/10/08. doi:10.1182/blood-2005-03-1308.
   PubMed Web of Science ®Google Scholar
• Li Z, Xi X, Du X. A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin αIIbβ3. J Biol Chem 2001;276(45):42226–42232. Epub 2001/08/28. doi:10.1074/jbc.M106129200.
   PubMed Web of Science ®Google Scholar
• Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofmann F, Du X. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 2003;112(1):77–86. doi:10.1016/S0092-8674(02)01254-0.
   PubMed Web of Science ®Google Scholar
• Cheng Z, Gao W, Fan X, Chen X, Mei H, Liu J, Luo X, Hu Y. Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway. J Thromb Haemost 2017;15(8):1679–1688. Epub 2017/06/13. doi:10.1111/jth.13755.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang G, Marjanovic JA, Ruan C, Du X. A platelet secretion pathway mediated by cGMP-dependent protein kinase. J Biol Chem 2004;279(41):42469–42475. doi:10.1074/jbc.M401532200.
   PubMed Web of Science ®Google Scholar
• Wen L, Feil S, Wolters M, Thunemann M, Regler F, Schmidt K, Friebe A, Olbrich M, Langer H, Gawaz M, et al. Publisher Correction: a shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis. Nat Commun 2018;9(1):4969. Epub 2018/11/22. doi:10.1038/s41467-018-07409-1.
   PubMedGoogle Scholar
• Edwards DC, Sanders LC, Bokoch GM, Gill GN. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1999;1(5):253–259. Epub 1999/11/13. doi:10.1038/12963.
   PubMed Web of Science ®Google Scholar
• Estevez B, Stojanovic-Terpo A, Delaney MK, O’Brien KA, Berndt MC, Ruan C, Du X. LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA2 synthesis, platelet activation, and thrombosis. Blood 2013;121(22):4586–4594. Epub 2013/04/27. doi:10.1182/blood-2012-12-470765.
   PubMed Web of Science ®Google Scholar
• Mangin P, Yuan Y, Goncalves I, Eckly A, Freund M, Cazenave J-P, Gachet C, Jackson SP, Lanza F. Signaling role for phospholipase Cγ2 in platelet glycoprotein Ibα calcium flux and cytoskeletal reorganization. J Biol Chem 2003;278(35):32880–32891. Epub 2003/06/19. doi:10.1074/jbc.M302333200.
   PubMed Web of Science ®Google Scholar
• Klier M, Gowert NS, Jäckel S, Reinhardt C, Elvers M. Phospholipase D1 is a regulator of platelet-mediated inflammation. Cell Signal 2017;38:171–181. Epub 2017/07/18. doi:10.1016/j.cellsig.2017.07.007.
   PubMed Web of Science ®Google Scholar
• Falati S, Edmead CE, Poole AW. Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to activate human platelets. Blood 1999;94(5):1648–1656. Epub 1999/09/09. doi:10.1182/blood.V94.5.1648.
   PubMed Web of Science ®Google Scholar
• Wu Y, Suzuki-Inoue K, Satoh K, Asazuma N, Yatomi Y, Berndt MC, Ozaki Y. Role of Fc receptor γ-chain in platelet glycoprotein Ib–mediated signaling. Blood 2001;97(12):3836–3845. Epub 2001/06/05. doi:10.1182/blood.V97.12.3836.
   PubMed Web of Science ®Google Scholar
• Liu J, Pestina TI, Berndt MC, Jackson CW, Gartner TK. Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an αIIbβ3- and aggregation-independent manner. Blood 2005;106(8):2750–2756. doi:10.1182/blood-2005-04-1667.
   PubMed Web of Science ®Google Scholar
• Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is dispensable for platelet GP1b-IX-V signaling. Int J Mol Sci 2017;18(6):1238. Epub 2017/06/10. doi:10.3390/ijms18061238.
   PubMed Web of Science ®Google Scholar
• Xu Z, Liang Y, Delaney MK, Zhang Y, Kim K, Li J, Bai Y, Cho J, Ushio-Fukai M, Cheng N, et al. Shear and integrin outside-in signaling activate NADPH-Oxidase 2 to Promote platelet activation. Arterioscler Thromb Vasc Biol 2021;41(5):1638–1653. Epub 2021/03/12. doi:10.1161/ATVBAHA.120.315773.
   PubMed Web of Science ®Google Scholar
• Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC, Metharom P. Thrombin-induced reactive oxygen species generation in platelets: a novel role for protease-activated receptor 4 and GPIbα. Redox Biol 2015;6:640–647. Epub 2015/11/17. doi:10.1016/j.redox.2015.10.009.
   PubMed Web of Science ®Google Scholar