Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia

References

• Sokol L, Loughran TP Jr. Large granular lymphocyte leukemia. Oncologist. 2006;11(3):263–5. doi:10.1634/theoncologist.11-3-263.
   PubMed Web of Science ®Google Scholar
• Loughran TP Jr. Clonal diseases of large granular lymphocytes. Blood. 1993;82(1):1–14. doi:10.1182/blood.V82.1.1.bloodjournal8211.
   PubMed Web of Science ®Google Scholar
• Okuno SH, Tefferi A, Hanson CA, Katzmann JA, Li CY, Witzig TE. Spectrum of diseases associated with increased proportions or absolute numbers of peripheral blood natural killer cells. Br J Haematol. 1996;93(4):810–812.
   PubMed Web of Science ®Google Scholar
• Sabnani I, Tsang P. Are clonal T-cell large granular lymphocytes to blame for unexplained haematological abnormalities? Br J Haematol. 2007;136(1):30–37. doi:10.1111/j.1365-2141.2006.06374.x.
   PubMed Web of Science ®Google Scholar
• Oshimi K. Clinical features, pathogenesis, and treatment of large granular lymphocyte leukemias. Intern Med. 2017;56(14):1759–1769. doi:10.2169/internalmedicine.56.8881.
   PubMed Web of Science ®Google Scholar
• Rose MG, Berliner N. T-cell large granular lymphocyte leukemia and related disorders. Oncologist. 2004;9(3):247–258. doi:10.1634/theoncologist.9-3-247.
   PubMed Web of Science ®Google Scholar
• Lamy T, Loughran TP Jr. How I treat LGL leukemia [published correction appears in blood. 2014 Mar 27;123(13):1182]. Blood. 2011;117(10):2764–2774. doi:10.1182/blood-2010-07-296962.
   PubMed Web of Science ®Google Scholar
• Lamy T, Moignet A, Loughran TP Jr. LGL leukemia: from pathogenesis to treatment. Blood. 2017;129(9):1082–1094. doi:10.1182/blood-2016-08-692590.
   PubMed Web of Science ®Google Scholar
• Schwaneck EC, Renner R, Junker L, Einsele H, Gadeholt O, Geissinger E, Kleinert S, Gernert M, Tony H-P, Schmalzing M. Prevalence and characteristics of persistent clonal T cell large granular lymphocyte expansions in rheumatoid arthritis: a comprehensive analysis of 529 patients. Arthritis Rheumatol. 2018;70(12):1914–1922. doi:10.1002/art.40654.
   PubMed Web of Science ®Google Scholar
• Zhang R, Shah MV, Loughran TP Jr. The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders. Hematol Oncol. 2010;28(3):105–117. doi:10.1002/hon.917.
   PubMed Web of Science ®Google Scholar
• Neunert C, Terrell DR, Arnold DM, Buchanan G, Cines DB, Cooper N, Cuker A, Despotovic JM, George JN, Grace RF, et al. American society of hematology 2019 guidelines for immune thrombocytopenia [published correction appears in blood adv. 2020 Jan 28;4(2):252]. Blood Adv. 2019;3(23):3829–3866. doi:10.1182/bloodadvances.2019000966.
   PubMed Web of Science ®Google Scholar
• Stasi R, Del Poeta G, Stipa E, Evangelista ML, Trawinska MM, Cooper N, Amadori S. Response to B-cell–depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood. 2007;110(8):2924–2930. doi:10.1182/blood-2007-02-068999.
   PubMed Web of Science ®Google Scholar
• Page LK, Psaila B, Provan D, Michael Hamilton J, Jenkins JM, Elish AS, Lesser ML, Bussel JB. The immune thrombocytopenic purpura (ITP) bleeding score: assessment of bleeding in patients with ITP. Br J Haematol. 2007;138(2):245–248. doi:10.1111/j.1365-2141.2007.06635.x.
   PubMed Web of Science ®Google Scholar
• Moignet A, Lamy T. Latest advances in the diagnosis and treatment of large granular lymphocytic leukemia. Am Soc Clin Oncol Educ Book. 2018;38(38):616–625. doi:10.1200/EDBK_200689.
   PubMedGoogle Scholar
• Dhodapkar MV, Li CY, Lust JA, Tefferi A, Phyliky RL. Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance? Blood. 1994;84(5):1620–1627. doi:10.1182/blood.V84.5.1620.1620.
   PubMed Web of Science ®Google Scholar
• Sabnani I, Tsang P. Therapeutic implications of T-cell clonopathy of unknown significance in chronic immune thrombocytopenic purpura. Platelets. 2009;20(2):135–139. doi:10.1080/09537100802657727.
   PubMed Web of Science ®Google Scholar
• Vrbensky JR, Arnold DM, Kelton JG, Smith JW, Jaffer AM, Larché M, Clare R, Ivetic N, Nazy I. Increased cytotoxic potential of CD8+ T cells in immune thrombocytopenia. Br J Haematol. 2020;188(5):e72–76. doi:10.1111/bjh.16334.
   PubMed Web of Science ®Google Scholar
• Vrbensky JR, Nazy I, Clare R, Larché M, Arnold DM. T cell-mediated autoimmunity in immune thrombocytopenia. Eur J Haematol. 2022;108(1):18–27. doi:10.1111/ejh.13705.
   PubMed Web of Science ®Google Scholar
• Alekshun TJ, Tao J, Sokol L. Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Am J Hematol. 2007;82(6):481–485. doi:10.1002/ajh.20853.
   PubMed Web of Science ®Google Scholar
• Guo L, Kapur R, Aslam R, Speck ER, Zufferey A, Zhao Y, Kim M, Lazarus AH, Ni H, Semple JW. CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell–mediated immune thrombocytopenia. Blood. 2016;127(6):735–738. doi:10.1182/blood-2015-06-655126.
   PubMed Web of Science ®Google Scholar
• Li N, Heddle NM, Nazy I, Kelton JG, Arnold DM. Platelet variability index: a measure of platelet count fluctuations in patients with immune thrombocytopenia. Blood Adv. 2021;5(20):4256–4264. doi:10.1182/bloodadvances.2020004162.
   PubMed Web of Science ®Google Scholar
• Vrbensky JR, Nazy I, Toltl LJ, Ross C, Ivetic N, Smith JW, Kelton JG, Arnold DM. Megakaryocyte apoptosis in immune thrombocytopenia. Platelets. 2018;29(7):729–732. doi:10.1080/09537104.2018.1475637.
   PubMed Web of Science ®Google Scholar
• Nazy I, Kelton JG, Moore JC, Clare R, Horsewood P, Smith JW, Ivetic N, D’Souza V, Li N, Arnold DM. Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia. Br J Haematol. 2018;181(2):234–241. doi:10.1111/bjh.15165.
   PubMed Web of Science ®Google Scholar