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Research Article

Introduction of direct-acting antiviral agents alters frequencies of anti-GPIIb/IIIa antibody-producing B cells in chronic hepatitis C patients with thrombocytopenia

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Article: 2161498 | Received 03 Jun 2022, Accepted 16 Dec 2022, Published online: 03 Jan 2023

References

  • Peck-Radosavljevic M. Thrombocytopenia in chronic liver disease. Liver Int. 2017;37(6):778–9. doi:10.1111/liv.13317. PMID: 27860293.
  • Rawi S, Wu GY. Pathogenesis of thrombocytopenia in chronic HCV infection: a review. J Clin Transl Hepatol. 2020;8(2):184–191. doi:10.14218/JCTH.2020.00007. PMID: 32832399.
  • Kuwana M, Okazaki Y, Ikeda Y. Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia. PLoS One. 2014;9(1):e86943. doi:10.1371/journal.pone.0086943. PMID: 24466297.
  • Nazy I, Kelton JG, Moore JC, Clare R, Horsewood P, Smith JW, Ivetic N, D’Souza V, Li N, Arnold DM. Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia. Br J Haematol. 2018;181(2):234–241. doi:10.1111/bjh.15165. PMID: 29532903.
  • Liebman H. Other immune thrombocytopenias. Semin Hematol. 2007;44:S24–34. doi:10.1053/j.seminhematol.2007.11.004. PMID: 18096469.
  • Chiao EY, Engels EA, Kramer JR, Pietz K, Henderson L, Giordano TP, Landgren O. Risk of immune thrombocytopenic purpura and autoimmune hemolytic anemia among 120 908 US veterans with hepatitis C virus infection. Arch Intern Med. 2009;169(4):357–363. doi:10.1001/archinternmed.2008.576. PMID: 19237719.
  • Ioannou GN, Feld JJ. What are the benefits of a sustained virologic response to direct-acting antiviral therapy for hepatitis c virus infection? Gastroenterology. 2019;156(2):446–460. doi:10.1053/j.gastro.2018.10.033.
  • Ishizu Y, Ishigami M, Hayashi K, Honda T, Kuzuya T, Ito T, Fujishiro M. Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection. Hepatol Res. 2020;50(1):47–56. doi:10.1111/hepr.13426. PMID: 31496023.
  • Chen YC, Tseng CW, Tseng KC. Rapid platelet count improvement in chronic hepatitis C patients with thrombocytopenia receiving direct-acting antiviral agents. Med (Baltimore). 2020;99(19):e20156. doi:10.1097/MD.0000000000020156. PMID: 32384505.
  • Saif-Al-Islam M, Abdelaal UM, Younis MA, Alghany Algahlan HA, Khalaf S. Effect of direct-acting antiviral therapy on thrombocytopenic patients with hepatitis C virus-related chronic liver disease. Gastroenterol Res Pract. 2021;2021:8811203. doi:10.1155/2021/8811203. PMID: 34122539.
  • Chen YC, Chang TS, Chen CH, Cheng PN, Lo CC, Mo LR, Chen CT, Huang CF, Kuo HT, Huang YH, et al. Factors associated with significant platelet count improvement in thrombocytopenic chronic hepatitis c patients receiving direct-acting antivirals. Viruses. 2022;14(2):333. doi:10.3390/v14020333. PMID: 35215926.
  • Huang CE, Chen WM, Wu YY, Shen CH, Hsu CC, Li CP, Chen MC, Chang JJ, Chen YY, Lu CH, et al. Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia. Platelets. 2021;32(8):1043–1050. doi:10.1080/09537104.2020.1820975. PMID: 32967492.
  • Aref S, Sleem T, El Menshawy N, Ebrahiem L, Abdella D, Fouda M, Samara NA, Menessy A, Abdel-Ghaffar H, Bassam A, et al. Antiplatelet antibodies contribute to thrombocytopenia associated with chronic hepatitis C virus infection. Hematology. 2009;14(5):277–281. doi:10.1179/102453309X439818. PMID: 19843383.
  • Satoh T, Kuwana M. Differential Diagnosis: Secondary ITP. In: Ishida Y Tomiyama Y, editors. Autoimmune thrombocytopenia. Singapore: Springer Nature; 2017; pp. 97–105.
  • Zhang W, Nardi MA, Borkowsky W, Li Z, Karpatkin S. Role of molecular mimicry of hepatitis C virus protein with platelet GPIIIa in hepatitis C–related immunologic thrombocytopenia. Blood. 2009;113(17):4086–4093. doi:10.1182/blood-2008-09-181073. PMID: 19023115.
  • Kajihara M, Kato S, Okazaki Y, Kawakami Y, Ishii H, Ikeda Y, Kuwana M. A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis. Hepatology. 2003;37(6):1267–1276. doi:10.1053/jhep.2003.50209. PMID: 12774004.
  • Wada N, Uojima H, Satoh T, Okina S, Iwasaki S, Shao X, Takiguchi H, Arase Y, Itokawa N, Atsukawa M, et al. Impact of anti-GPIIb/IIIa antibody-producing B cells as a predictor of the response to lusutrombopag in thrombocytopenic patients with liver disease. Dig Dis. 2021;39(3):234–242. doi:10.1159/000510692. PMID: 32759604.
  • Baert L, Manfroi B, Casez O, Sturm N, Huard B. The role of APRIL - a proliferation inducing ligand - in autoimmune diseases and expectations from its targeting. J Autoimmun. 2018;95:179–190. doi:10.1016/j.jaut.2018.10.016. PMID: 30385081.
  • Long D, Chen Y, Wu H, Zhao M, Lu Q. Clinical significance and immunobiology of IL-21 in autoimmunity. J Autoimmun. 2019;99:1–14. doi:10.1016/j.jaut.2019.01.013. PMID: 30773373.
  • Zhang Y, Tian J, Xiao F, Zheng L, Zhu X, Wu L, Zhao C, Wang S, Rui K, Zou H, et al. B cell-activating factor and its targeted therapy in autoimmune diseases. Cytokine Growth Factor Rev. 2022;64:57–70. doi:10.1016/j.cytogfr.2021.11.004. PMID: 34916133.
  • Kuwana M, Okazaki Y, Satoh T, Asahi A, Kajihara M, Ikeda Y. Initial laboratory findings useful for predicting the diagnosis of idiopathic thrombocytopenic purpura. Am J Med. 2005;118(9):1026–1033. doi:10.1016/j.amjmed.2004.12.027. PMID: 16164890.
  • Kuwana M, Kurata Y, Fujimura K, Fujisawa K, Wada H, Nagasawa T, Nomura S, Kojima T, Yagi H, Ikeda Y. Preliminary laboratory based diagnostic criteria for immune thrombocytopenic purpura: evaluation by multi-center prospective study. J Thromb Haemost. 2006;4(9):1936–1943. doi:10.1111/j.1538-7836.2006.02091.x. PMID: 16961601.
  • Soliman Z, El Kassas M, Elsharkawy A, Elbadry M, Hamada Y, ElHusseiny R, El-Nahaas SM, Fouad R, Esmat G, Abdel Alem S. Improvement of platelet in thrombocytopenic HCV patients after treatment with direct-acting antiviral agents and its relation to outcome. Platelets. 2021;32(3):383–390. doi:10.1080/09537104.2020.1742313. PMID: 32250721.
  • Kuwana M, Nomura S, Fujimura K, Nagasawa T, Muto Y, Kurata Y, Tanaka S, Ikeda Y. Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura. Blood. 2004;103(4):1229–1236. doi:10.1182/blood-2003-06-2167. PMID: 14551140.
  • Honma Y, Shibata M, Hayashi T, Kusanaga M, Ogino N, Minami S, Kumei S, Oe S, Miyagawa K, Senju M, et al. Effect of direct-acting antivirals on platelet-associated immunoglobulin G and thrombocytopenia in hepatitis C virus-related chronic liver disease. Liver Int. 2019;39(9):1641–1651. doi:10.1111/liv.14120. PMID: 31009141.
  • George JN, Woolf SH, Raskob GE, Wasser JS, Aledort LM, Ballem PJ, Blanchette VS, Bussel JB, Cines DB, Kelton JG, et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American society of hematology. Blood. 1996;88(1):3–40. doi:10.1182/blood.V88.1.3.3. PMID: 8704187.
  • Pockros PJ, Duchini A, McMillan R, Nyberg LM, McHutchison J, Viernes E. Immune thrombocytopenic purpura in patients with chronic hepatitis C virus infection. Am J Gastroenterol. 2002;97(8):2040–2045. doi:10.1111/j.1572-0241.2002.05845.x. PMID: 12190174.
  • Chan H, Moore JC, Finch CN, Warkentin TE, Kelton JG. The IgG subclasses of platelet-associated autoantibodies directed against platelet glycoproteins IIb/IIIa in patients with idiopathic thrombocytopenic purpura. Br J Haematol. 2003;122(5):818–824. doi:10.1046/j.1365-2141.2003.04509.x. PMID: 12930395.
  • Porcelijn L, Huiskes E, Maatman R, de Kreuk A, de Haas M. Acquired glanzmann’s thrombasthenia caused by glycoprotein IIb/IIIa autoantibodies of the immunoglobulin G1 (IgG1), IgG2 or IgG4 subclass: a study in six cases. Vox Sang. 2008;95(4):324–330. doi:10.1111/j.1423-0410.2008.01093.x. PMID: 19138263.
  • Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014;5:520. doi:10.3389/fimmu.2014.00520. PMID: 25368619.
  • Lake-Bakaar G, Jacobson I, Talal A. B cell activating factor (BAFF) in the natural history of chronic hepatitis C virus liver disease and mixed cryoglobulinaemia. Clin Exp Immunol. 2012;170(2):231–237. doi:10.1111/j.1365-2249.2012.04653.x. PMID: 23039894.
  • Toubi E, Gordon S, Kessel A, Rosner I, Rozenbaum M, Shoenfeld Y, Zuckerman E. Elevated serum B-lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: association with autoimmunity. J Autoimmun. 2006;27(2):134–139. doi:10.1016/j.jaut.2006.07.005. PMID: 17029886.
  • Himoto T, Fujita K, Nomura T, Tani J, Morishita A, Yoneyama H, Haba R, Masaki T. Verification of B-lymphocyte activating factor’s involvement in the exacerbation of insulin resistance as well as an autoimmune response in patients with nonalcoholic steatohepatitis and patients with HCV-related chronic liver disease. Diabetol Metab Syndr. 2017;9(1):45. doi:10.1186/s13098-017-0243-z. PMID: 28630652.
  • Satoh T, Takiguchi H, Uojima H, Kubo M, Tanaka C, Yokoyama F, Wada N, Miyazaki K, Hidaka H, Kusano C, et al. B cell-activating factor is involved in thrombocytopenia in patients with liver cirrhosis. Ann Hematol. 2022;101(11):2433–2444. doi:10.1007/s00277-022-04973-x. PMID: 36098792.
  • Hegazy MT, Allam WR, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF, Ragab G. Mediterranean consortium for the study of cryoglobulinemic vasculitis. Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. EBioMedicine.2018;35:106–113. doi:10.1016/j.ebiom.2018.08.007. PMID: 30139628.
  • Hao YF, Bi H, Li HY, Yin LM, Yu JX, Tao W, Mu HL, Yang RC, Zhou ZP, Tai WL, et al. Aberrant expression of a proliferation-inducing ligand underlies autoimmune mechanisms in immune thrombocytopenia. J Immunology Res. 2021;2021:3676942. doi:10.1155/2021/3676942. PMID: 33564689.
  • Yoshio S, Kanto T. Host–virus interactions in hepatitis B and hepatitis C infection. J Gastoenterol. 2016;51(5):409–420. doi:10.1007/s00535-016-1183-3. PMID: 26894594.
  • Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol. 2002;2(7):465–475. doi:10.1038/nri844. PMID: 12094221.
  • Litinskiy MB, Nardelli B, Hillbert DM, He B, Scheffer A, Casali P, Cerutti A. Dcs induce CD40-independent immunoglobulin class switching through BLys and APRIL. Nat Immunol. 2002;3(9):822–829. doi:10.1038/ni829. PMID: 12154359.
  • Nabeel MM, Darwish RK, Alakel W, Maher R, Mostafa H, Hashem A, Elbeshlawy M, Abul-Fotouh A, Shousha HI, Saeed Marie M. Changes in serum interferon gamma and interleukin-10 in relation to direct-acting antiviral therapy of chronic hepatitis C genotype 4: a pilot study. J Clin Exp Hepatol. 2022;12(2):428–434. doi:10.1016/j.jceh.2021.06.018. PMID: 35535108.