754
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Antiplatelet effects of the CEACAM1-derived peptide QDTT

ORCID Icon, , , , , , , , & ORCID Icon show all
Article: 2308635 | Received 29 Aug 2023, Accepted 17 Jan 2024, Published online: 12 Feb 2024

References

  • Nagareddy P, Smyth SS. Inflammation and thrombosis in cardiovascular disease. Curr Opin Hematol. 2013;20(5):457–12. doi:10.1097/MOH.0b013e328364219d. Epub.
  • Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as mediators of immunity, inflammation, and thrombosis. Circ Res. 2018;122(2):337–51. doi:10.1161/CIRCRESAHA.117.310795. Epub 2018/01/20.
  • Holinstat M. Normal platelet function. Cancer Metastasis Rev. 2017;36(2):195–98. doi:10.1007/s10555-017-9677-x. Epub 2017/07/02.
  • Mackman N, Bergmeier W, Stouffer GA, Weitz JI. Therapeutic strategies for thrombosis: new targets and approaches. Nat Rev Drug Discov. 2020;19(5):333–52. doi:10.1038/s41573-020-0061-0. Epub 2020/03/07.
  • Kim WM, Huang YH, Gandhi A, Blumberg RS. CEACAM1 structure and function in immunity and its therapeutic implications. Semin Immunol. 2019;42:101296. doi:10.1016/j.smim.2019.101296. Epub 2019/10/13.
  • Prall F, Nollau P, Neumaier M, Haubeck HD, Drzeniek Z, Helmchen U, Loning T, Wagener C. CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues. J Histochem Cytochem. 1996;44(1):35–41. doi:10.1177/44.1.8543780. Epub 1996/01/01.
  • Singer BB, Scheffrahn I, Obrink B. The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation. Cancer Res. 2000;60(5):1236–44. Epub 2000/03/23.
  • Schumann D, Chen CJ, Kaplan B, Shively JE. Carcinoembryonic antigen cell adhesion molecule 1 directly associates with cytoskeleton proteins actin and tropomyosin. J Biol Chem. 2001;276(50):47421–33. doi:10.1074/jbc.M109110200. Epub 2001/10/12.
  • Wong C, Liu Y, Yip J, Chand R, Wee JL, Oates L, Nieswandt B, Reheman A, Ni H, Beauchemin N. et al. CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 2009;113(8):1818–28. doi:10.1182/blood-2008-06-165043. Epub 2008/11/15.
  • Yip J, Alshahrani M, Beauchemin N, Jackson DE. CEACAM1 regulates integrin alphaIibbeta3-mediated functions in platelets. Platelets. 2016;27(2):168–77. doi:10.3109/09537104.2015.1064102. Epub 2015/07/22.
  • Comegys MM, Lin SH, Rand D, Britt D, Flanagan D, Callanan H, Brilliant K, Hixson DC. Two variable regions in carcinoembryonic antigen-related cell adhesion molecule1 N-terminal domains located in or next to monoclonal antibody and adhesion epitopes show evidence of recombination in rat but not in human. J Biol Chem. 2004;279(33):35063–78. doi:10.1074/jbc.M404431200. Epub 2004/06/09.
  • Skubitz KM, Campbell KD, Skubitz AP. Synthetic peptides of CD66a stimulate neutrophil adhesion to endothelial cells. J Immunol. 2000;164(8):4257–64. doi:10.4049/jimmunol.164.8.4257. Epub 2001/02/07.
  • Skubitz KM, Campbell KD, Skubitz AP. Synthetic peptides from the N-domains of CEACAMs activate neutrophils. J Pept Res. 2001;58(6):515–26. doi:10.1034/j.1399-3011.2001.00931.x. Epub 2002/05/15.
  • Wang J, Ye Y, Wei G, Hu W, Li L, Lu S, Meng Z. Matrix metalloproteinase12 facilitated platelet activation by shedding carcinoembryonic antigen related cell adhesion molecule1. Biochem Biophys Res Commun. 2017;486(4):1103–9. doi:10.1016/j.bbrc.2017.04.001. Epub 2017/04/08.
  • Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA. Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood. 2001;98(5):1469–79. doi:10.1182/blood.v98.5.1469. Epub 2001/08/25.
  • Stern N, Markel G, Arnon TI, Gruda R, Wong H, Gray-Owen SD, Mandelboim O. Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol. 2005;174(11):6692–701. doi:10.4049/jimmunol.174.11.6692. Epub 2005/05/21.
  • Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003;102(2):449–61. doi:10.1182/blood-2002-12-3882. Epub 2003/03/22.
  • Dawood BB, Wilde J, Watson SP. Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways. Platelets. 2007;18(5):329–45. doi:10.1080/09537100601024111. Epub 2007/07/27.
  • Jarvis GE, Best D, Watson SP. Differential roles of integrins alpha2beta1 and alphaIibbeta3 in collagen and CRP-induced platelet activation. Platelets. 2004;15(5):303–13. doi:10.1080/09537100410001710254. Epub 2004/09/17.
  • Stalker TJ, Newman DK, Ma P, Wannemacher KM, Brass LF. Platelet signaling. Handb Exp Pharmacol. 2012(210):59–85. doi:10.1007/978-3-642-29423-5_3. Epub.
  • Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost. 2005;3(8):1752–62. doi:10.1111/j.1538-7836.2005.01429.x. Epub 2005/08/17.
  • Bigalke B, Kramer BF, Seizer P, Fateh-Moghadam S, Gawaz M, Lindemann S. Diagnostic and therapeutic potentials of platelet glycoprotein VI. Semin Thromb Hemost. 2010;36(2):203–11. doi:10.1055/s-0030-1251505. Epub 2010/04/24.
  • Zahid M, Mangin P, Loyau S, Hechler B, Billiald P, Gachet C, Jandrot-Perrus M. The future of glycoprotein VI as an antithrombotic target. J Thromb Haemost. 2012;10(12):2418–27. doi:10.1111/jth.12009. Epub 2012/10/02.
  • Gawaz M, Vogel S, Pfannenberg C, Pichler B, Langer H, Bigalke B. Implications of glycoprotein VI for theranostics. Thromb Haemost. 2014;112(1):26–31. doi:10.1160/TH13-09-0756. Epub 2014/02/21.
  • Ye Y, Wan W, Wang J, Hu W, Wang H, Li L, Sang P, Gu Y, Li D, Wang Z. et al. The CEACAM1-derived peptide QLSN impairs collagen-induced human platelet activation through glycoprotein VI. Biosci Biotechnol Biochem. 2020;84(1):85–94. doi:10.1080/09168451.2019.1662277. Epub 2019/12/04.
  • Yu J, Sun G, Chen Y, Li L, Wang H, Tu D, Li L, Meng Z, Wang Y. CEACAM1 inhibited IkappaB-alpha/NF-kappaB signal pathway via targeting MMP-9/TIMP-1 axis in diabetic atherosclerosis. J Cardiovasc Pharmacol. 2020;76(3):329–36. doi:10.1097/FJC.0000000000000868. Epub 2020/06/23.
  • Wang Y, Chen Y, Yan Y, Li X, Chen G, He N, Shen S, Chen G, Zhang C, Liao W. et al. Loss of CEACAM1, a tumor-associated factor, attenuates post-infarction cardiac remodeling by inhibiting apoptosis. Sci Rep. 2016;6(1):21972. doi:10.1038/srep21972. Epub 2016/02/26.
  • Ergun S, Kilik N, Ziegeler G, Hansen A, Nollau P, Gotze J, Wurmbach JH, Horst A, Weil J, Fernando M. et al. CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Molecular Cell. 2000;5(2):311–20. doi:10.1016/s1097-2765(00)80426-8. Epub 2000/07/06.
  • Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ. et al. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation. Blood. 2014;124(14):2271–9. doi:10.1182/blood-2014-05-575878. Epub 2014/08/08.
  • Nam GS, Park HJ, Nam KS. The antithrombotic effect of caffeic acid is associated with a cAMP-dependent pathway and clot retraction in human platelets. Thromb Res. 2020;195:87–94. doi:10.1016/j.thromres.2020.07.024. Epub 2020/07/19.
  • Su X, Mi J, Yan J, Flevaris P, Lu Y, Liu H, Ruan Z, Wang X, Kieffer N, Chen S. et al. RGT, a synthetic peptide corresponding to the integrin β3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin αIIbβ3 with Src kinase. Blood. 2008;112(3):592–602. doi:10.1182/blood-2007-09-110437. Epub 2008/04/10.
  • Banfi C, Amadio P, Zara M, Brioschi M, Sandrini L, Barbieri SS. Prenylcysteine oxidase 1 (PCYOX1), a new player in thrombosis. Int J Mol Sci. 2022;23(5):2831. doi:10.3390/ijms23052831. Epub 2022/03/11.
  • Bansal AB, Sattar Y, Jamil RT. Eptifibatide. Treasure Island (FL): StatPearls; 2023.
  • Pan G, Chang L, Zhang J, Liu Y, Hu L, Zhang S, Zhang J, Qiao J, Jakopin Z, Hu H. et al. GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI. Biochem Pharmacol. 2021;183:114315. doi:10.1016/j.bcp.2020.114315. Epub 2020/11/06.
  • Bonnard T, Hagemeyer CE. Ferric chloride-induced thrombosis mouse model on carotid artery and mesentery vessel. J Vis Exp. 2015;2015(100):e52838. doi:10.3791/52838-v. Epub 2015/07/15.
  • Liu G, Xie W, He AD, Da XW, Liang ML, Yao GQ, Xiang JZ, Gao CJ, Ming ZY. Antiplatelet activity of chrysin via inhibiting platelet alphaIIbbeta3-mediated signaling pathway. Mol Nutr Food Res. 2016;60(9):1984–93. doi:10.1002/mnfr.201500801. Epub 2016/03/24.
  • Bye AP, Unsworth AJ, Gibbins JM. Platelet signaling: a complex interplay between inhibitory and activatory networks. J Thromb Haemost. 2016;14(5):918–30. doi:10.1111/jth.13302. Epub 2016/03/02.
  • Iyu D, Juttner M, Glenn JR, White AE, Johnson AJ, Fox SC, Heptinstall S. PGE1 and PGE2 modify platelet function through different prostanoid receptors. Prostaglandins Other Lipid Mediat. 2011;94(1–2):9–16. doi:10.1016/j.prostaglandins.2010.11.001. Epub 2010/11/26.
  • Moroi M, Jung SM. Platelet glycoprotein VI: its structure and function. Thromb Res. 2004;114(4):221–33. doi:10.1016/j.thromres.2004.06.046. Epub 2004/09/24.
  • Babur O, Melrose AR, Cunliffe JM, Klimek J, Pang J, Sepp AI, Zilberman-Rudenko J, Tassi Yunga S, Zheng T, Parra-Izquierdo I. et al. Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs. Blood. 2020;136(20):2346–58. doi:10.1182/blood.2020005496. Epub 2020/07/09.
  • Moroi AJ, Watson SP. Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy. Biochem Pharmacol. 2015;94(3):186–94. doi:10.1016/j.bcp.2015.02.004. Epub 2015/02/24.
  • Kim S, Mangin P, Dangelmaier C, Lillian R, Jackson SP, Daniel JL, Kunapuli SP. Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem. 2009;284(49):33763–72. doi:10.1074/jbc.M109.048553. Epub 2009/08/25.
  • Shen B, Delaney MK, Du X. Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction. Curr Opin Cell Biol. 2012;24(5):600–6. doi:10.1016/j.ceb.2012.08.011. Epub 2012/09/18.
  • Mach P, Andrikos D, Schmidt B, Gellhaus A, Rusch P, Birdir C, Andrikos A, Schmitt V, Kimmig R, Singer BB. et al. Evaluation of carcinoembryonic antigen-related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsia. Am J Reprod Immunol. 2021;85(5):e13375. doi:10.1111/aji.13375. Epub 2020/11/12.
  • Markel G, Gruda R, Achdout H, Katz G, Nechama M, Blumberg RS, Kammerer R, Zimmermann W, Mandelboim O. The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells. J Immunol. 2004;173(6):3732–9. doi:10.4049/jimmunol.173.6.3732. Epub 2004/09/10.
  • Oikawa S, Inuzuka C, Kuroki M, Arakawa F, Matsuoka Y, Kosaki G, Nakazato H. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. J Biol Chem. 1991;266(13):7995–8001. doi:10.1016/S0021-9258(18)92930-3. Epub 1991/05/05.
  • Zhou H, Stanners CP, Fuks A. Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion. Cancer Res. 1993;53(16):3817–22. Epub 1993/08/15.
  • Gray-Owen SD, Blumberg RS. CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 2006;6(6):433–46. doi:10.1038/nri1864. Epub 2006/05/26.
  • Rayes J, Watson SP, Nieswandt B. Functional significance of the platelet immune receptors GPVI and CLEC-2. J Clin Invest. 2019;129(1):12–23. doi:10.1172/JCI122955. Epub 2019/01/03.
  • Lee RH, Bergmeier W. Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development. J Thromb Haemost. 2016;14(4):645–54. doi:10.1111/jth.13250. Epub 2016/01/11.
  • Canobbio I, Stefanini L, Guidetti GF, Balduini C, Torti M. A new role for FcgammaRIIA in the potentiation of human platelet activation induced by weak stimulation. Cell Signal. 2006;18(6):861–70. doi:10.1016/j.cellsig.2005.07.014. Epub 2005/09/20.
  • Huang J, Li X, Shi X, Zhu M, Wang J, Huang S, Huang X, Wang H, Li L, Deng H. et al. Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting. J Hematol Oncol. 2019;12(1):26. doi:10.1186/s13045-019-0709-6. Epub 2019/03/09.