Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens

References

• Subbiah V. The next generation of evidence-based medicine. Nat Med. 2023;29(1):49–7. doi:10.1038/s41591-022-02160-z.
   PubMed Web of Science ®Google Scholar
• NRC:National Academies of Sciences, Engineering, and Medicine. Research at the Intersection of the Physical and Life Sciences. Washington (DC): The National Academies Press; 2010. doi:10.17226/12809.
   Google Scholar
• Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S. et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119–77. doi:10.1093/eurheartj/ehx393.
   PubMed Web of Science ®Google Scholar
• Gruberg L, Dangas G, Leon MB. Coronary artery stents: appropriate use of adjunctive pharmacotherapy to prevent stent thrombosis. Drugs Aging. 1999;15(5):341–8. doi:10.2165/00002512-199915050-00002.
   PubMed Web of Science ®Google Scholar
• Denardo SJ, Denardo BC, Carpinone PL, Dean WT, New DM, Estrada LE, Green CL, Yock PG, Karunasiri G. Validated model of platelet slip at stenosis and device surfaces. Platelets. 2020;31(3):373–82. doi:10.1080/09537104.2019.1636021.
   PubMed Web of Science ®Google Scholar
• Auton M, Zhu C, Cruz MA. The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 2010;99(4):1192–201. doi:10.1016/j.bpj.2010.06.002.
   PubMed Web of Science ®Google Scholar
• Dembo M, Torney DC, Saxman K, Hammer D. The reaction-limited kinetics of membrane-to-surface adhesion and detachment. Proc R Soc Lond B Biol Sci. 1988;234(1274):55–83. doi:10.1098/rspb.1988.0038.
   PubMed Web of Science ®Google Scholar
• Marshall BT, Long M, Piper JW, Yago T, McEver RP, Zhu C. Direct observation of catch bonds involving cell-adhesion molecules. Nature. 2003;423(6936):190–3. doi:10.1038/nature01605.
   PubMed Web of Science ®Google Scholar
• Turitto VT, Baumgartner HR. Platelet interaction with subendothelium in flowing rabbit blood: effect of blood shear rate. Microvasc Res. 1979;17(1):38–54. doi:10.1016/0026-2862(79)90006-2.
   PubMed Web of Science ®Google Scholar
• Denardo SJ, Davis KE, Tcheng JE. Elective percutaneous coronary intervention using broad-spectrum antiplatelet therapy (eptifibatide, clopidogrel, and aspirin) alone, without scheduled unfractionated heparin or other antithrombin therapy. Am Heart J. 2005;149(1):138–44. doi:10.1016/j.ahj.2004.06.002.
   PubMed Web of Science ®Google Scholar
• Denardo SJ, Davis KE, Tcheng JE. Effectiveness and safety of reduced-dose enoxaparin in non-ST-segment elevation acute coronary syndrome followed by antiplatelet therapy alone for percutaneous coronary intervention. Am J Cardiol. 2007;100(9):1376–82. doi:10.1016/j.amjcard.2007.06.024.
   PubMed Web of Science ®Google Scholar
• Arce NA, Cao W, Brown AK, Legan ER, Wilson MS, Xu ER, Berndt MC, Emsley J, Zhang XF, Li R. Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module. Nat Commun. 2021;12(1):2360. doi:10.1038/s41467-021-22634-x.
   PubMed Web of Science ®Google Scholar
• Schneider SW, Nuschele S, Wixforth A, Gorzelanny C, Alexander-Katz A, Netz RR, Schneider MF. Shear-induced unfolding triggers adhesion of von Willebrand factor fibers. Proc Natl Acad Sci USA. 2007;104(19):7899–903. doi:10.1073/pnas.0608422104.
   PubMed Web of Science ®Google Scholar
• Jen CJ, Li HM, Wang JS, Chen HI, Usami S. Flow-induced detachment of adherent platelets from fibrinogen-coated surface. Am J Physiol. 1996;270(1 Pt 2):H160–166. doi: 10.1152/ajpheart.1996.270.1.H160. PMID: 8769747.
   PubMedGoogle Scholar
• Denardo SJ, Parish A, Green CL, Oxendine-Phillips L, Tcheng JE. Antiplatelet therapy only, without anticoagulation, for percutaneous coronary intervention: a translational application of platelet slip. J Transl Sci. 2021;7(6):1–11. doi:10.15761/JTS.1000455.
   Google Scholar
• Zi W, Song J, Kong W, Huang J, Guo C, He W, Yu Y, Zhang B, Geng W, Tan, et al. Tirofiban for stroke without large or medium-sized vessel occlusion. N Engl J Med. 2023;388(22):2025–36. doi:10.1056/NEJMoa2214299.
   PubMed Web of Science ®Google Scholar
• Smith SC Jr, Dove JT, Jacobs AK, Kennedy JW, Kereiakes D, Kern MJ, Kuntz RE, Popma JJ, Schaff HV, Williams DO. et al. ACC/AHA guidelines for percutaneous coronary intervention (revision of the 1993 PTCA guidelines)-executive summary: a report of the American College of Cardiology/American heart association task force on practice guidelines (Committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty) endorsed by the society for cardiac angiography and interventions. Circulation. 2001;103(24):3019–41. doi:10.1161/01.cir.103.24.3019.
   PubMed Web of Science ®Google Scholar
• Chieffo A, Burzotta F, Pappalardo F, Briguori C, Garbo R, Masiero G, Nicolini E, Ribichini F, Trani C, Álvarez BC. et al. Clinical expert consensus document on the use of percutaneous left ventricular assist support devices during complex high-risk indicated PCI: Italian society of interventional cardiology working group endorsed by Spanish and Portuguese interventional cardiology societies. Int J Cardiol. 2019;293:84–90. doi:10.1016/j.ijcard.2019.05.065.
   PubMed Web of Science ®Google Scholar
• Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, Kaul S, Wiviott SD, Menon V, Nikolsky E. et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium. Circulation. 2011;123(23):2736–47. doi:10.1161/CIRCULATIONAHA.110.009449.
   PubMed Web of Science ®Google Scholar
• Denardo S. PLATELETS_JTS_RETROSPECTIVE_DATA_N228_Biomark_Pos_NSTE_ACS_12072023 [Data set]. Zenodo. 2023. https://doi.org/10.5281/zenodo.10277693.
   Google Scholar
• Bikdeli B, Erlinge D, Valgimigli M, Kastrati A, Han Y, Steg PG, Stables RH, Mehran R, James SK, Frigoli E. et al. Bivalirudin versus heparin during PCI in NSTEMI: individual patient data meta-analysis of large randomized trials. Circulation. 2023;148(16):1207–19. doi:10.1161/CIRCULATIONAHA.123.063946.
   PubMed Web of Science ®Google Scholar
• Sakariassen KS, Orning L, Turitto VT. The impact of blood shear rate on arterial thrombus formation. Future Sci OA. 2015;1(4):FSO30. doi:10.4155/fso.15.28.
   PubMedGoogle Scholar
• Wu YP, van Breugel HH, Lankhof H, Wise RJ, Handin RI, de Groot PG, Sixma JJ. Platelet adhesion to multimeric and dimeric von Willebrand factor and to collagen type III preincubated with von Willebrand factor. Arterioscler Thromb Vasc Biol. 1996;16(5):611–20. doi:10.1161/01.atv.16.5.611.
   PubMed Web of Science ®Google Scholar
• Speich HE, Earhart AD, Hill SN, Cholera S, Kueter TJ, Smith JN, White MM, Jennings LK. Variability of platelet aggregate dispersal with glycoprotein IIb-IIIa antagonists eptifibatide and abciximab. J Thromb Haemost. 2009;7(6):983–91. doi:10.1111/j.1538-7836.2009.03432.x.
   PubMed Web of Science ®Google Scholar
• Kajiya F, Matsuoka S, Ogasawara Y, Hiramatsu O, Kanazawa S, Wada Y, Tadaoka S, Tsujioka K, Fujiwara T, Zamir M. Velocity profiles and phasic flow patterns in the non-stenotic human left anterior descending coronary artery during cardiac surgery. Cardiovasc Res. 1993;27(5):845–50. doi:10.1093/cvr/27.5.845.
   PubMed Web of Science ®Google Scholar
• Sedaghat A, Kulka H, Sinning JM, Falkenberg N, Driesen J, Preisler B, Hammerstingl C, Nickenig G, Pötzsch B, Oldenburg J. et al. Transcatheter aortic valve implantation leads to a restoration of von Willebrand factor (VWF) abnormalities in patients with severe aortic stenosis - Incidence and relevance of clinical and subclinical VWF dysfunction in patients undergoing transfemoral TAVI. Thromb Res. 2017;151:23–8. doi:10.1016/j.thromres.2016.12.027.
   PubMed Web of Science ®Google Scholar
• Badimon L, Vilahur G. Platelets, arterial thrombosis and cerebral ischemia. Cerebrovasc Dis. 2007;24(Suppl 1):30–9. doi:10.1159/000107377.
   PubMedGoogle Scholar
• Storey RF, Judge HM, Wilcox RG, Heptinstall S. Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Thromb Haemost. 2002;88(3):488–94. doi: 10.1055/s-0037-1613242. PMID: 12353080.
   PubMed Web of Science ®Google Scholar
• Virchow RLK. Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Kapitel IV [Thrombose und Embolie]. Frankfurt, Germany: Meidinger Sohn & Co; 1856.
   Google Scholar
• Stevens SM, Woller SC, Baumann Kreuziger L, Bounameaux H, Doerschug K, Geersing GJ, Huisman MV, Kearon C, King CS, Knighton AJ. et al. Executive summary: antithrombotic therapy for vte disease: second update of the CHEST guideline and expert panel report. Chest. 2021;160(6):2247–59. doi:10.1016/j.chest.2021.07.056.
   PubMed Web of Science ®Google Scholar
• January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, Ellinor PT, Ezekowitz MD, Field ME, Furie KL. et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American college of cardiology/American heart association task force on clinical practice guidelines and the heart rhythm society in collaboration with the society of thoracic surgeons. Circulation. 2019;140(2):125–51. doi:10.1161/CIR.0000000000000665.
   PubMed Web of Science ®Google Scholar
• Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B. et al. 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American heart association/American stroke association. Stroke. 2018;49(3):46–110. doi:10.1161/STR.0000000000000158.
   PubMed Web of Science ®Google Scholar
• Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, Jaffe AS, Jneid H, Kelly RF, Kontos MC. et al. 2014 AHA/ACC Guideline for the management of patients with non–st-elevation acute coronary syndromes: executive summary. Circulation. 2014;130(25):2354–94. doi:10.1161/CIR.0000000000000133.
   PubMed Web of Science ®Google Scholar
• Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM. et al. 2011 ACCF/AHA/SCAI Guideline for percutaneous coronary intervention: a report of the American college of cardiology foundation/American heart association task force on practice guidelines and the society for cardiovascular angiography and interventions. Circulation. 2011;124(23):e574–651. doi:10.1161/CIR.0b013e31823ba622.
   PubMed Web of Science ®Google Scholar
• Chen JY, He PC, Liu YH, Wei XB, Jiang L, Guo W, Duan CY, Guo YS, Yu XP, Li J. et al. Association of parenteral anticoagulation therapy with outcomes in Chinese patients undergoing percutaneous coronary intervention for non-st-segment elevation acute coronary syndrome. JAMA Internal Medicine. 2019;179(2):186–94. doi:10.1001/jamainternmed.2018.5953.
   PubMed Web of Science ®Google Scholar
• Grüntzig A, Schneider HJ. Die perkutane Dilatation chronischer Koronarstenosen–Experiment und Morphologie [The percutaneous dilatation of chronic coronary stenoses–experiments and morphology]. Schweiz Med Wochenschr. 1977;107(44):1588. German. PMID: 918625.
   PubMedGoogle Scholar
• Stabile E, Nammas W, Salemme L, Sorropago G, Cioppa A, Tesorio T, Ambrosini V, Campopiano E, Popusoi G, Biondi Zoccai G. et al. The CIAO (Coronary Interventions Antiplatelet-based Only) study: a randomized study comparing standard anticoagulation regimen to absence of anticoagulation for elective percutaneous coronary intervention. J Am Coll Cardiol. 2008;52(16):1293–8. doi:10.1016/j.jacc.2008.07.026.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Théroux P. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor. Circulation. 1998 Jan 27;97(3):251–6. 10.1161/01.cir.97.3.251. PMID: 9462526.
   PubMed Web of Science ®Google Scholar
• Alexander KP, Chen AY, Roe MT, Newby LK, Gibson CM, Allen-LaPointe NM, Pollack C, Gibler WB, Ohman EM, Peterson ED. CRUSADE Investigators. Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. JAMA. 2005;294(24):3108–16. doi:10.1001/jama.294.24.3108.
   PubMed Web of Science ®Google Scholar
• Brieger DB, Mak KH, Kottke-Marchant K, Topol EJ. Heparin-induced thrombocytopenia. J Am Coll Cardiol. 1998 June;31(7):1449–59. doi:10.1016/s0735-1097(98)00134-x. PMID: 9626819.
   PubMed Web of Science ®Google Scholar
• [accessed 2023 December 7]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017029s140lbl.pdf.
   Google Scholar
• Sproul EP, Nandi S, Chee E, Sivadanam S, Igo BJ, Schreck L, Brown AC. Development of biomimetic antimicrobial platelet-like particles comprised of microgel nanogold composites. Regen Eng Transl Med. 2020;6(3):299–309. doi:10.1007/s40883-019-00121-6.
   PubMed Web of Science ®Google Scholar
• Raben JS, Hariharan P, Robinson R, Malinauskas R, Vlachos PP. Time-resolved particle image velocimetry measurements with Wall Shear Stress and uncertainty quantification for the FDA nozzle model. Cardiovasc Eng Technol. 2016;7(1):7–22. doi:10.1007/s13239-015-0251-9.
   PubMed Web of Science ®Google Scholar
• Zhu S, Diamond SL. Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay. Thromb Res. 2014;134(6):1335–43. doi:10.1016/j.thromres.2014.09.030.
   PubMed Web of Science ®Google Scholar
• Feller T, Connell SDA, Ras A. Why fibrin biomechanical properties matter for hemostasis and thrombosis. J Thromb Haemost. 2022;20(1):6–16. doi:10.1111/jth.15531.
   PubMed Web of Science ®Google Scholar
• Gaudino M, Yong CM, Chadow D, Lawton J, Tamis-Holland J. Coronary artery bypass surgery after transradial catheterization: Implementing 2021 ACC/AHA/SCAI revascularization guidelines into clinical practice. JACC Case Rep. 2022;4(1):27–30. doi:10.1016/j.jaccas.2021.09.026.
   PubMedGoogle Scholar
• Avvedimento M, Real C, Nuche J, Farjat-Pasos J, Galhardo A, Trinh KH, Robichaud M, Delarochellière R, Paradis JM, Poulin A. et al. Incidence, predictors, and prognostic impact of bleeding events after TAVR according to VARC-3 Criteria. JACC Cardiovasc Interv. 2023;16(18):2262–74. doi:10.1016/j.jcin.2023.07.005.
   PubMed Web of Science ®Google Scholar
• Généreux P, Piazza N, Alu MC, Nazif T, Hahn RT, Pibarot P, Bax JJ, Leipsic JA, Blanke P, Blackstone EH. et al. Valve academic research consortium 3: updated endpoint definitions for aortic valve clinical research. J Am Coll Cardiol. 2021;77(21):2717–46. doi:10.1016/j.jacc.2021.02.038.
   PubMed Web of Science ®Google Scholar
• Mehran R, Pocock SJ, Stone GW, Clayton TC, Dangas GD, Feit F, Manoukian SV, Nikolsky E, Lansky AJ, Kirtane A. et al. Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. Eur Heart J. 2009;30(12):1457–66. doi:10.1093/eurheartj/ehp110.
   PubMed Web of Science ®Google Scholar
• Coylewright M, Holmes DR, Kapadia SR, Hsu JC, Gibson DN, Freeman JV, Yeh RW, Piccini JP, Price MJ, Allocco DJ. et al. DAPT is comparable to OAC Following LAAC with WATCHMAN FLX: a national registry analysis. JACC Cardiovasc Interv. 2023;16(22):2708–18. doi:10.1016/j.jcin.2023.08.013.
   PubMed Web of Science ®Google Scholar
• Grigoriadis GI, Sakellarios AI, Kosmidou I, Naka KK, Ellis C, Michalis LK, Fotiadis DI. Wall shear stress alterations at left atrium and left atrial appendage employing abnormal blood velocity profiles. Annu Int Conf IEEE Eng Med Biol Soc. 2020;2020:2565–8. doi:10.1109/EMBC44109.2020.9175235.
   PubMedGoogle Scholar
• Mehra MR, Netuka I, Uriel N, Katz JN, Pagani FD, Jorde UP, Gustafsson F, Connors JM, Ivak P, Cowger J. et al. Aspirin and hemocompatibility events with a left ventricular assist device in advanced heart failure: The ARIES-HM3 randomized clinical trial. JAMA. 2023;330(22):2171–81. doi:10.1001/jama.2023.23204.
   PubMed Web of Science ®Google Scholar
• Bourque K, Cotter C, Dague C, Harjes D, Dur O, Duhamel J, Spink K, Walsh K, Burke E. Design rationale and preclinical evaluation of the HeartMate 3 left ventricular assist system for hemocompatibility. Asaio J. 2016;62(4):375–83. doi:10.1097/MAT.0000000000000388.
   PubMed Web of Science ®Google Scholar
• Tamez H, Généreux P, Yeh RW, Amin AP, Fan W, White HD, Kirtane AJ, Stone GW, Gibson CM, Harrington RA. et al. Cost implications of intraprocedural thrombotic events and bleeding in percutaneous coronary intervention: results from the CHAMPION PHOENIX ECONOMICS Study. Catheter Cardiovasc Interv. 2018;92(5):348–55. doi:10.1002/ccd.27638.
   PubMed Web of Science ®Google Scholar
• Jacobson KM, Hall Long K, McMurtry EK, Naessens JM, Rihal CS. The economic burden of complications during percutaneous coronary intervention. Qual Saf Health Care. 2007;16(2):154–9. doi:10.1136/qshc.2006.019331.
   PubMedGoogle Scholar
• Hershey D, Cho SJ. Blood flow in rigid tubes: thickness and slip velocity of plasma film at the wall. J Appl Physiol. 1966;21(1):27–32. doi:10.1152/jappl.1966.21.1.27.
   PubMed Web of Science ®Google Scholar