Effects of the Fusarium toxin zearalenone and/or deoxynivalenol on the serum IL-1, IL-4, and C3 levels in miceFootnote

† Z. H. Ren and Y. T. Deng contributed equally to this work and should be considered co-first authors.

References

• Abbès, S., Ouanes, Z., Salah-Abbès, B. J., Houas, Z., Oueslati, R., Bacha, H., & Othman, O. (2006). The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by zeralenone in mice. Toxicon, 47, 567–574. doi:10.1016/j.toxicon.2006.01.016
   PubMed Web of Science ®Google Scholar
• Abid-Essefi, S., Zaied, C., Bouaziz, C., Sale, I. B., Kaderi, R., & Bacha, H. (2012). Protective effect of aqueous extract of allium sativum against zearalenone toxicity mediated by oxidative stress. Experimental and Toxicologic Pathology, 64, 689–595. doi:10.1016/j.etp.2010.12.012
   PubMed Web of Science ®Google Scholar
• Azcona-Olivera, J. I., Ouyang, Y. L., Warner, R. L., Linz, J. E., & Pestka, J. J. (1995). Effects of vomitoxin(deoxynivalenol) and cycloheximide on IL-2, 4, 5 and 6 secretion and mRNA levels in murine CD4+ cells. Food and Chemical Toxicology, 33, 433–441. doi: 10.1016/0278-6915(95)00012-Q
   PubMed Web of Science ®Google Scholar
• Cavaillon, J. M. (1994). Cytokines and macrophages. Biomedicine & Pharmacotherapy, 48, 445–453. doi: 10.1016/0753-3322(94)90005-1
   PubMed Web of Science ®Google Scholar
• Cotler, S. J., Wartelle, C. F., Larson, A. M., Gretch, D. R., Jensen, D. M., & Carithers, R. L. Jr. (2000). Pretreatment symptoms and dosing regimen predict side effects of interferon therapy for hepatitis C. Journal of Viral Hepatitis, 7, 211–217. doi: 10.1046/j.1365-2893.2000.00215.x
   PubMed Web of Science ®Google Scholar
• Dong, W. M., Azconaolivera, J. I., Brooks, K. H., Linz, J. E., & Pestka, J. J. (1994). Elevated gene expression and production of Interleukins 2, 4, 5 and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma. Toxicology and Applied Pharmacology, 127, 282–290. doi: 10.1006/taap.1994.1163
   PubMed Web of Science ®Google Scholar
• Fink-Gremmels, J., & Malekinejad, H. (2007). Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone. Animal Feed Science and Technology, 137, 326–341. doi:10.1016/j.anifeedsci.2007.06.008
   Web of Science ®Google Scholar
• Girish, C. K., Smith, T. K., Boermans, H. J., Kumar, A., & Girgis, G. N. (2010). Effects of dietary Fusarium mycotoxins on intestinal lymphocyte subset populations, cell proliferation and histological changes in avian lymphoid organs. Food and Chemical Toxicology, 48, 3000–3007. doi:10.1016/j.fct.2010.07.040
   PubMed Web of Science ®Google Scholar
• Green, T. D., Montefiori, D. C., & Ross, T. M. (2003). Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d. Journal of Virology, 77, 2046–2055. doi: 10.1128/JVI.77.3.2046-2055.2003
   PubMed Web of Science ®Google Scholar
• Islam, Z., & Pestka, J. J. (2003). Role of IL-1β in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. Toxicology Science, 74, 93–102. doi: 10.1093/toxsci/kfg119
   PubMed Web of Science ®Google Scholar
• Madrigal-Estebas, L., Doherty, D. G., O'Donoghue, D. P., Feighery, C., & O'Farrelly, C. (2002). Differential expression and upregulation of inteleukin-1alpha, interleukin-1 beta and interleukin-6 by freshly isolated human small intestinal epithelial cells. Mediators of Inflammation, 11, 313–319. doi: 10.1080/09629350210000015728
   PubMed Web of Science ®Google Scholar
• Meky, F. A., Hardie, L. J., Evans, S. W., & Wild, C. P. (2001). Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production. Food and Chemical Toxicology, 39(8), 827–836. doi: 10.1016/S0278-6915(01)00029-1
   PubMed Web of Science ®Google Scholar
• Ouyang, Y. L., Azcona-Olivera, J. I., & Pestka, J. J. (1995). Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. Toxicology, 104, 187–202. doi: 10.1016/0300-483X(95)03147-8
   PubMed Web of Science ®Google Scholar
• Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998). The pathophysiologic roles of interleukin-6 in human disease. Annals of Internal Medicine, 128, 127–137. doi: 10.7326/0003-4819-128-2-199801150-00009
   PubMed Web of Science ®Google Scholar
• Ren, Z. H., Wang, Y. C., Deng, H. D., Deng, Y. T., Deng, J. L., Zuo, Z. C., … Shen, L. H. (2015a). Deoxynivalenol induces apoptosis in chicken splenic lymphocytes via the reactive oxygen species-mediated mitochondrial pathway. Enviromental Toxicology and Pharmacology, 39, 339–346. doi: 10.1016/j.etap.2014.11.028
   PubMed Web of Science ®Google Scholar
• Ren, Z. H., Wang, Y. C., Deng, H. D., Deng, Y. T., Deng, J. L., Zuo, Z. C., … Fang, J. (2015b). Deoxynivalenol-induced cytokines and related genes in concanavalin A-stimulated primary chicken splenic lumphocytes. Toxicology in Vitro, 29, 558–563. doi: 10.1016/j.tiv.2014.12.006
   PubMed Web of Science ®Google Scholar
• Vlata, Z., Porichis, F., Tzanakakis, G., Tsatsakis, A., & Krambovitis, E. (2006). A study of zearalenone cytotoxicity on human peripheral blood mononuclear cells. Toxicology Letters, 165, 274–281. doi:10.1016/j.toxlet.2006.02.001
   PubMed Web of Science ®Google Scholar
• Warner, R. L., Brooks, K., & Peskta, J. J. (1994). In vitro effects of vomitoxin (deoxynivalenol) on T-cell interleukin production and IgA secretion. Food and Chemical Toxicology, 32, 617–625. doi: 10.1016/0278-6915(94)90005-1
   PubMed Web of Science ®Google Scholar
• Zhou, H. R., Yan, D., & Pestka, J. J. (1997). Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Dose-response and time course. Toxicology and Applied Pharmacology, 144(2), 294–305. doi: 10.1006/taap.1997.8132
   PubMed Web of Science ®Google Scholar