References
- Agbabiaka, T. B., Guo, R., & Ernst, E. (2008). Pelargonium sidoides for acute bronchitis: A systematic review and meta-analysis. Phytomedicine, 15, 378–385. doi: https://doi.org/10.1016/j.phymed.2007.11.023
- Ayrle, H., Mevissen, M., Kaske, M., Nathues, H., Gruetzner, N., Melzig, M., & Walkenhorst, M. (2016). Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review BMC Veterinary Research, 12, 31. doi: https://doi.org/10.1186/s12917-016-0714-8
- Bähler, C., Steiner, A., Luginbuhl, A., Ewy, A., Posthaus, H., Strabel, D., … Regula, G. (2012). Risk factors for death and unwanted early slaughter in Swiss veal calves kept at a specific animal welfare standard. Research in Veterinary Science, 92(1), 162–168. doi: https://doi.org/10.1016/j.rvsc.2010.10.009
- Bałan, B. J., Sokolnicka, I., Skopińska-Różewska, E., & Skopiński, P. (2016). The modulatory influence of some Echinacea-based remedies on antibody production and cellular immunity in mice. Central European Journal of Immunology, 1(1), 12–18. doi: https://doi.org/10.5114/ceji.2016.58813
- Barbour, E. K., Assi, C. A., Shaib, H., Hamadeh, S., Murtada, M., Mahmoud, G., … Kumosani, T. (2015). Evaluation of a Salmonella Enteritidis vaccine and related ELISA for respective induction and assessment of acquired immunity to the vaccine and/or Echinacea purpurea in Awassi Ewes. Vaccine, 33(19), 2228–2231. doi: https://doi.org/10.1016/j.vaccine.2015.03.035
- Barrett, B. (2003). Medicinal properties of Echinacea: A critical review. Phytomedicine, 10, 66–86. doi: https://doi.org/10.1078/094471103321648692
- Baruh, ÜA, & Kacabağlı, N. (2017). Effect of different levels of oregano essential Oil on some rumen parameters in lambs. İstanbul Üniv. Vet. Fak. Derg. / J. Fac. Vet. Med. Istanbul Univ, 43(2), 116–122. doi: https://doi.org/10.16988/iuvfd.322369
- Basmacioğlu Malayoğlu, H., Baysal, S., Misirlioğlu, Z., Polat, M., Yilmaz, H., & Turan, N. (2010). Effects of oregano essential oil with or without feed enzymes on growth performance, digestive enzyme, nutrient digestibility, lipid metabolism and immune response of broilers fed on wheat-soybean meal diets. British Poultry Science, 51(1), 67–80. doi: https://doi.org/10.1080/00071660903573702
- Beil, W., & Kilian, P. (2007). EPs® 7630, an extract from Pelargonium sidoides roots inhibits adherence of helicobacter pylori to gastric epithelial cells. Phytomedicine, 14(6), 5–8. doi: https://doi.org/10.1016/j.phymed.2006.11.024
- Bodinet, C., Lindequist, U., Teuscher, E., & Freudenstein, J. (2002). Effect of an orally applied herbal immunomodulator on cytokine induction and antibody response in normal and immunosuppressed mice. Phytomedicine, 9, 606–613. doi: https://doi.org/10.1078/094471102321616418
- Brendler, T., & van Wyk, B. E. (2008). A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae). Journal of Ethnopharmacology, 119, 420–433. doi: https://doi.org/10.1016/j.jep.2008.07.037
- Brodzki, P., Kostro, K., Krakowski, L., & Marczuk, J. (2015). Inflammatory cytokine and acute phase protein concentrations in the peripheral blood and uterine washings of cows with subclinical endometritis in the late postpartum period. Veterinary Research Communications, 39(2), 143–149. doi: https://doi.org/10.1007/s11259-015-9635-4
- Cho, Y. I., & Yoon, K. J. (2014). An overview of calf diarrhea – infectious etiology, diagnosis, and intervention. Journal of Veterinary Science, 15(1), 1–17. doi: https://doi.org/10.4142/jvs.2014.15.1.1
- Conrad, A., & Frank, U. (2008). Extract of Pelargonium sidoides (EPs® 7630) displays anti-infective properties by enhanced phagocytosis and differential modulation of host-bacteria interactions. Planta Medica, 74(6), 682–685. doi: https://doi.org/10.1055/s-2008-1034287
- Cundell, D. R., Matrone, M. A., Ratajczak, P., & Jr, P. J. (2003). The effect of aerial parts of Echinacea on the circulating white cell levels and selected immune functions of the aging male Sprague-Dawley rat. International Immunopharmacology, 3, 1041–1048. doi: https://doi.org/10.1016/S1567-5769(03)00114-0
- Currier, N. L., & Miller, S. C. (2001). Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span. The Journal of Alternative and Complementary Medicine, 7, 241–251. doi: https://doi.org/10.1089/107555301300328115
- Dapas, B., Dall’Acqua, S., Bulla, R., Agostinis, C., Perissutti, B., Invernizzi, S., … Voinovich, D. (2014). Immunomodulation mediated by a herbal syrup containing a standardized Echinacea root extract: A pilot study in healthy human subjects on cytokine gene expression. Phytomedicine, 21(11), 1406–1410. doi: https://doi.org/10.1016/j.phymed.2014.04.034
- Dar, P. A., Hajam, I. A., Suryanarayana, V. S., Kishore, S., & Kondabattula, G. (2015). Kinetics of cytokine expression in bovine PBMCs and whole blood after in vitro stimulation with foot-and-mouth disease virus (FMDV) antigen. Cytokine, 72(1), 58–62. doi: https://doi.org/10.1016/j.cyto.2014.12.011
- Fast, D. J., Balles, J. A., Scholten, J. D., Mulder, T., & Rana, J. (2015). Echinacea purpurea root extract inhibits TNF release in response to Pam3Csk4 in a phosphatidylinositol-3-kinase dependent manner. Cellular Immunology, 297(2), 94–99. doi: https://doi.org/10.1016/j.cellimm.2015.07.003
- Freier, D. O., Wright, K., Klein, K., Voll, D., Dabiri, K., Cosulich, K., & George, R. (2003). Enhancement of the humoral immune response by Echinacea purpurea in female Swiss mice. Immunopharmacology and Immunotoxicology, 25, 551–560. doi: https://doi.org/10.1081/IPH-120026440
- Goel, V., Chang, C., Slama, J., Barton, R., Bauer, R., Gahler, R., & Basu, T. (2002). Echinacea stimulates macrophage function in the lung and spleen of normal rats. The Journal of Nutritional Biochemistry, 13, 487–492. doi: https://doi.org/10.1016/S0955-2863(02)00190-0
- Hall, H., Fahlman, M. M., & Engels, H. J. (2007). Echinacea purpurea and mucosal immunity. International Journal of Sports Medicine, 28(9), 792–797. doi: https://doi.org/10.1055/s-2007-964895
- Hayashi, I., Ohotsuki, M., Suzuki, I., & Watanabe, T. (2001). Effects of oral administration of Echinacea purpurea (American herb) on incidence of spontaneous leukemia caused by recombinant leukemia viruses in AKR/J mice. Japanese Journal of Clinical Immunology, 24, 10–20. doi: https://doi.org/10.2177/jsci.24.10
- Helfer, M., Koppensteiner, H., Schneider, M., Rebensburg, S., Forcisi, S., Muller, C., … Brack-Werner, R. (2014). The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor. PLoS One, 9, e87487. doi: https://doi.org/10.1371/journal.pone.0087487
- Hu, S., Concha, C., Lin, F., & Persson Waller, K. (2003). Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle. Veterinary Immunology and Immunopathology, 91(1), 29–37. doi: https://doi.org/10.1016/S0165-2427(02)00264-7
- Kayser, O., Kolodziej, H., & Kiderlen, A. F. (2001). Immunomodulatory principles of Pelargonium sidoides. Phytotherapy Research, 15(2), 122–126. doi: https://doi.org/10.1002/ptr.785
- Kim, C. E., Griffiths, W. J., & Taylor, P. W. (2009). Components derived from Pelargonium stimulate macrophage killing of mycobacterium species. Journal of Applied Microbiology, 106(4), 1184–1193. doi: https://doi.org/10.1111/j.1365-2672.2008.04085.x
- Kolodziej, H., & Kiderlen, A. F. (2007). In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs® 7630. Phytomedicine, 14, 18–26. doi: https://doi.org/10.1016/j.phymed.2006.11.020
- Konnai, S., Usui, T., Ohashi, K., & Onuma, M. (2003). The rapid quantitative analysis of bovine cytokine genes by real-time RT-PCR. Veterinary Microbiology, 94(4), 283–294. doi: https://doi.org/10.1016/S0378-1135(03)00119-6
- LaLone, C. A., Hammer, K. D., Wu, L., Bae, J., Leyva, N., Liu, Y., … Wurtele, E. S. (2007).Echinacea species and alkamides inhibit prostaglandin E 2 production in RAW264.7 mouse macrophage cells. Journal of Agricultural and Food Chemistry, 55, 7314–7322. doi: https://doi.org/10.1021/jf063711a
- Lorenz, I., Earley, B., Gilmore, J., Hogan, I., Kennedy, E., & More, S. J. (2011). Calf health from birth to weaning. III. Housing and management of calf pneumonia. Irish Veterinary Journal, 64(1), 14. doi: https://doi.org/10.1186/2046-0481-64-14
- Matthys, H., Pliskevich, D. A., Bondarchuk, O. M., Malek, F. A., Tribanek, M., & Kieser, M. (2013). Randomised, doubleblind, placebo-controlled trial of EPs 7630 in adults with COPD. Respiratory Medicine, 107, 691–701. doi: https://doi.org/10.1016/j.rmed.2013.02.011
- Meganck, V., Hoflack, G., & Opsomer, G. (2014). Advances in prevention and therapy of neonatal dairy calf diarrhoea: A systematical review with emphasis on colostrum management and fluid therapy. Acta Veterinaria Scandinavica, 56, 231. doi: https://doi.org/10.1186/s13028-014-0075-x
- Michaelis, M., Doerr, H. W., & Cinatl, J. (2011). Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. Phytomedicine, 18(5), 384–386. doi: https://doi.org/10.1016/j.phymed.2010.09.008
- Mishima, S., Saito, K., Maruyama, H., Inoue, M., Yamashita, T., Ishida, T., & Gu, Y. (2004). Antioxidant and immuno-enhancing effects of Echinacea purpurea. Biological & Pharmaceutical Bulletin, 27(7), 1004–1009. doi: https://doi.org/10.1248/bpb.27.1004
- Moyo, M., & Van Staden, J. (2014). Medicinal properties and conservation of Pelargonium sidoides DC. Journal of Ethnopharmacology, 152(2), 243–255. doi: https://doi.org/10.1016/j.jep.2014.01.009
- Mukherjee, R., De, U. K., & Ram, G. C. (2010). Evaluation of mammary gland immunity and therapeutic potential of Tinospora cordifolia against bovine subclinical mastitis. Tropical Animal Health and Production, 42(4), 645–651. doi: https://doi.org/10.1007/s11250-009-9471-z
- O’Neill, W., McKee, S., & Clarke, A. F. (2002). Immunological and haematinic consequences of feeding a standardised Echinacea (Echinacea angustifolia) extract to healthy horses. Equine Veterinary Journal, 34, 222–227. doi: https://doi.org/10.2746/042516402776186001
- Pacheco, J. M., Smoliga, G. R., O’Donnell, V., Brito, B. P., Stenfeldt, C., Rodriguez, L. L., & Arzt, J. (2015). Persistent foot-and-mouth disease virus infection in the nasopharynx of cattle; tissue-specific distribution and local cytokine expression. PLoS One, 10(5), e0125698. doi: https://doi.org/10.1371/journal.pone.0125698
- Pfützner, M., & Ozsvari, L. (2017). The financial impact of decreased milk production due to subclinical mastitis in German dairy herds. İstanbul Üniv. Vet. Fak. Derg. / J. Fac. Vet. Med. Istanbul Univ., 43(2), 110–115. doi: https://doi.org/10.16988/iuvfd.322545
- Prohl, A., Wolf, K., Weber, C., Müller, K. E., Menge, C., Sachse, K., … Berndt, A. (2015). Kinetics of local and systemic leucocyte and cytokine reaction of calves to intrabronchial infection with chlamydia psittaci. PLoS One., 10(8), e0135161. doi: https://doi.org/10.1371/journal.pone.0135161
- Puech, C., Dedieu, L., Chantal, I., & Rodrigues, V. (2015). Design and evaluation of a unique SYBR green real-time RT-PCR assay for quantification of five major cytokines in cattle, sheep and goats. BMC Veterinary Research, 11, 65. doi: https://doi.org/10.1186/s12917-015-0382-0
- Rehman, J., Dillow, J. M., Carter, S. M., Chou, J., Le, B., & Maisel, A. S. (1999). Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and hydrastis canadensis. Immunology Letters, 68, 391–395. doi: https://doi.org/10.1016/S0165-2478(99)00085-1
- Rininger, J. A., Kickner, S., Chigurupati, P., McLean, A., & Franck, Z. (2000). Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. Leukoc Biol, 68, 503–510.
- Robbers, J. E., & Tyler, V. E. (1999). Herbs of choise: The therapeutic use of phytomedicinals. New York, NY: Haworth Herbal Press.
- Roesler, J., Steinmuller, C., Kiderlen, A., Emmendorffer, A., Wagner, H., & Lohmann-Matthes, M. L. (1991). Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans. International Journal of Immunopharmacology, 13, 27–37. doi: https://doi.org/10.1016/0192-0561(91)90022-Y
- Schmittgen, T. D., & Livak, K. J. (2008). Analyzing real-time PCR data by the comparative CT method. Nature Protocols, 3(6), 1101–1108. doi: https://doi.org/10.1038/nprot.2008.73
- Senchina, D. S., Wu, L., Flinn, G. N., Konopka del, N., McCoy, J. A., Widrlechner, M. P., … Kohut, M. L. (2006). Year-and-a-Half Old, Dried Echinacea roots retain cytokine-modulating capabilities in an in vitro human older adult model of influenza vaccination. Planta Medica, 72(13), 1207–1215. doi: https://doi.org/10.1055/s-2006-947254
- Steinmuller, C., Roesler, J., Grottrup, E., Franke, G., Wagner, H., & Lohmann-Matthes, M. L. (1993). Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with candida albicans and listeria monocytogenes. International Journal of Immunopharmacology, 15, 605–614. doi: https://doi.org/10.1016/0192-0561(93)90078-D
- Stevenson, L. M., Matthias, A., Banbury, L., Penman, K. G., Bone, K. M., Leach, D., & Lehmann, R. P. (2005). Modulation of macrophage immune responses by Echinacea. Molecules, 10, 1279–1285. doi: https://doi.org/10.3390/10101279
- Tahan, F., & Yaman, M. (2013). Can the Pelargonium sidoides root extract EPs® 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children?. Phytomedicine, 20(2), 148–150. doi: https://doi.org/10.1016/j.phymed.2012.09.022
- Thale, C., Kiderlen, A. F., & Kolodziej, H. (2011). Anti-infective activities of Pelargonium sidoides (EPS® 7630): effects of induced NO production on leishmania major in infected macrophages and antiviral effects as assessed in a fibroblast-virus protection assay. Planta Medica, 77, 718–725. doi: https://doi.org/10.1055/s-0030-1250567
- Theisen, L. L., & Muller, C. P. (2012). EPs® 7630 (umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo. Antiviral Research, 94, 147–156. doi: https://doi.org/10.1016/j.antiviral.2012.03.006
- Timmer, A., Günther, J., Motschall, E., Rücker, G., Antes, G., & Kern, W. V. (2013). Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database of Systematic Reviews, 10, CD006323.
- Torkan, S., Khamesipour, F., & Katsande, S. (2015). Evaluating the effect of oral administration of Echinacea hydroethanolic extract on the immune system in dog. Autonomic and Autacoid Pharmacology, 35(1-2), 9–13. doi: https://doi.org/10.1111/aap.12024
- Trun, W., Kiderlen, A. F., & Kolodziej, H. (2006). Nitric oxide synthase and cytokines gene expression analyses in leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (Eps® 7630). Phytomedicine, 13, 570–575. doi: https://doi.org/10.1016/j.phymed.2005.07.004
- Uluısık, D., & Keskin, E. (2012). Effects of ginseng and Echinacea on cytokine mRNA expression in rats. ScientificWorldJournal, 2012. doi:10.1100/2012/942025. Epub 2012 May 22.
- Wagner, L., Cramer, H., Klose, P., Lauche, R., Gass, F., Dobos, G., & Langhorst, J. (2015). Herbal medicine for cough: A systematic review and meta-analysis. Forschende Komplementarmedizin (2006), 22(6), 359–368.
- Windeyer, M. C., Leslie, K. E., Godden, S. M., Hodgins, D. C., Lissemore, K. D., & LeBlanc, S. J. (2014). Factors associated with morbidity, mortality, and growth of dairy heifer calves up to 3 months of age. Preventive Veterinary Medicine, 113(2), 231–240. doi: https://doi.org/10.1016/j.prevetmed.2013.10.019
- Wu, M., He, M., & Kang, Y. (2017). Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine. Food and Agricultural Immunology, 1, 14. doi: https://doi.org/10.1080/09540105.2017.1406459
- Wu, H., Nardone, A., & Lacetera, N. (2009). Effects of a standardized purified dry extract from Echinacea angustifolia on proliferation and interferon gamma secretion of peripheral blood mononuclear cells in dairy heifers. Research in Veterinary Science, 87(3), 396–398. doi: https://doi.org/10.1016/j.rvsc.2009.05.005
- Xiong, Q., Kadota, S., Tani, T., & Namba, T. (1996). Antioxidative effects of phenylethanoids from Cistanche deserticola. Biological & Pharmaceutical Bulletin, 19, 1580–1585. doi: https://doi.org/10.1248/bpb.19.1580
- Yuan, J. S., Reed, A., Chen, F., & Stewart Jr, C. N. (2006). Statistical analysis of real-time PCR data. BMC Bioinformatics, 7, 85. doi: https://doi.org/10.1186/1471-2105-7-85
- Zhai, Z., Haney, D., Wu, L., Solco, A., Murphy, P. A., Wurtele, E. S., … Cunnick, J. E. (2007b). Alcohol extracts of Echinacea inhibit production of nitric oxide and tumor necrosis factor-alpha by macrophages in vitro. Food and Agricultural Immunology, 18(3-4), 221–236. doi: https://doi.org/10.1080/09540100701797363
- Zhai, Z., Liu, Y., Wu, L., Senchina, D. S., Wurtele, E. S., Murphy, P. A., … Cunnick, J. E. (2007a). Enhancement of innate and adaptive immune functions by multiple Echinacea species. Journal of Medicinal Food, 10(3), 423–434. doi: https://doi.org/10.1089/jmf.2006.257