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AIDS Care
Psychological and Socio-medical Aspects of AIDS/HIV
Volume 25, 2013 - Issue 12
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ORIGINAL ARTICLES

Antiretroviral therapy drug adherence in Rwanda: Perspectives from patients and healthcare workers using a mixed-methods approach

Joseph VyankandonderaKigali University Teaching Hospital, Kigali, Rwanda;INTERACT program at the Institute of HIV/AIDS and Disease Prevention and Control (IHDPC), Kigali, Rwanda
,
Kirstin MitchellLondon School of Hygiene and Tropical Medicine, London, UK
,
Brenda Asiimwe-KateeraINTERACT program at the Institute of HIV/AIDS and Disease Prevention and Control (IHDPC), Kigali, Rwanda
,
Kimberly BoerINTERACT program at the Institute of HIV/AIDS and Disease Prevention and Control (IHDPC), Kigali, Rwanda;Department of Global Health, Academic Medical Center and Amsterdam Institute of Global Health and Development, Amsterdam, The Netherlands;Royal Tropical Institute (KIT), Biomedical Research, Epidemiology Unit, Amsterdam, The Netherlands
,
Philippe MutwaKigali University Teaching Hospital, Kigali, Rwanda;INTERACT program at the Institute of HIV/AIDS and Disease Prevention and Control (IHDPC), Kigali, Rwanda
,
Jean-Paul BalindaINTERACT program at the Institute of HIV/AIDS and Disease Prevention and Control (IHDPC), Kigali, Rwanda
,
Masja van StratenDepartment of Global Health, Academic Medical Center and Amsterdam Institute of Global Health and Development, Amsterdam, The Netherlands
,
Peter ReissDepartment of Global Health, Academic Medical Center and Amsterdam Institute of Global Health and Development, Amsterdam, The Netherlands
&
Janneke van de WijgertDepartment of Global Health, Academic Medical Center and Amsterdam Institute of Global Health and Development, Amsterdam, The Netherlands;Institute of Infection and Global Health, University of Liverpool, Liverpool, UKCorrespondence[email protected]
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Pages 1504-1512 | Received 19 Aug 2012, Accepted 21 Feb 2013, Published online: 21 Mar 2013

References

  • Ammassari, A., Trotta, M. P., Murri, R., Castelli, F., Narciso, P., Noto, P., … for the AdlCoNA Study Group. (2002). Correlates and predictors of adherence to highly active antiretroviral therapy: Overview of published literature. JAIDS Journal of Acquired Immune Deficiency Syndromes, 31, S123–S127. doi:10.1097/00126334-200212153-00007
  • Au, J. T., Kayitenkore, K., Shutes, E., Karita, E., Peters, P. J., Tichacek, A., & Allen, S. A. (2006). Access to adequate nutrition is a major potential obstacle to antiretroviral adherence among HIV-infected individuals in Rwanda. AIDS, 20, 2116–2118. doi:10.1097/01.aids.0000247580.16073.1b
  • Bhat, V. G., Ramburuth, M., Singh, M., Titi, O., Antony, A. P., Chiya, L., … Msengana, M. (2010). Factors associated with poor adherence to anti-retroviral therapy in patients attending a rural health centre in South Africa. European Journal of Clinical Microbiology and Infectious Disease, 29, 947–953. doi:10.1007/s10096-010-0949-4
  • Binagwaho, A., & Ratnayake, N. (2009). The role of social capital in successful adherence to antiretroviral therapy in Africa. PLoS Medicine, 6, e18. doi:10.1371/journal.pmed.1000018
  • Cohen, M. S., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., Hakim, J. G., … HPTN 052 Study Team. (2011). Prevention of HIV-1 infection with early antiretroviral therapy. The New England Journal of Medicine, 365, 493–505. doi:10.1056/NEJMoa1105243
  • Do, N. T., Phiri, K., Bussmann, H., Gaolathe, T., Marlink, R. G., & Wester, C. W. (2010). Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana. AIDS Research and Human Retroviruses, 6, 685–691. doi:10.1089/aid.2009.0222
  • Fairley, C. K., Permana, A., & Read, T. R. H. (2005). Long-term utility of measuring adherence by self-report compared with pharmacy record in a routine clinic setting. HIV Medicine, 6, 366–369. doi:10.1111/j.1468-1293.2005.00322.x
  • Hamers, R., Derdelinckx, I., van Vugt, M., Stevens, W., Rinke de Wit, T. F., & Schuurman, R. (2008). The status of HIV-1 resistance to antiretroviral drugs in sub-Saharan Africa. Antiviral Therapy, 13, 625–639.
  • Hardon, A. P., Akurut, D., Comoro, C., Ekezie, C., Irunde, H. F., Gerrits, T., … Laing, R. (2007). Hunger, waiting time and transport costs: Time to confront challenges to ART adherence in Africa. AIDS Care, 5, 658–665. doi:10.1080/09540120701244943
  • Maughan-Brown, B. (2010). Stigma rises despite antiretroviral roll-out: A longitudinal analysis in South Africa. Social Science & Medicine, 3, 368–374. doi:10.1016/j.socscimed.2009.09.041
  • Merten, S., Kenter, E., McKenzie, O., Musheke, M., Ntalasha, H., & Martin-Hilber, A. (2010). Patient-reported barriers and drivers of adherence to antiretrovirals in sub-Saharan Africa: A meta-ethnography. Tropical Medicine & International Health, 15(suppl. 1), 16–33. doi:10.1111/j.1365-3156.2010.02510.x
  • Mills, E. J., Nachega, J. B., Buchan, I., Orbinski, J., Attaran, A., Singh, S., … Bangsberg, D. R. (2006). Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA, 296, 679–690. doi:10.1001/jama.296.6.679
  • Mocroft, A., Youle, M., Moore, A., Sabin, C. A., Madge, S., Lepri, A. C., … Phillips, A. N. (2001). Reasons for modification and discontinuation of antiretrovirals: results from a single treatment centre. AIDS, 15(2), 185–194. doi:10.1097/00002030-200101260-00007
  • Monforte, A. A., Lepri, A. C., Rezza, G., Pezzotti, P., Antinori, A., Phillips, A. N., … Moroni, M. (2000). Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naive patients. AIDS, 14(5), 499–507. doi:10.1097/00002030-200003310-00005
  • Ritchie, J., & Lewis, J., (Eds.). (2003). Qualitative research practice: A guide for social science students and researchers. London: Sage.
  • Rosen, S., Fox, M. P., & Gill, C. J. (2007). Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Medicine, 4, e298. doi:10.1371/journal.pmed.0040298
  • Ross-Degnan, D., Pierre-Jacques, M., Zhang, F., Tadeg, H., Gitau, L., Ntaganira, J., … Inrud, I. A. (2010). Measuring adherence to antiretroviral treatment in resource-poor settings: The clinical validity of key indicators. BMC Health Services Research, 10, 42. doi:10.1186/1472-6963-10-42
  • Van Tam, V., Pharris, A., Thorson, A., Alfven, T., & Larsson, M. (2011). “It is not that I forget, it's just that I don't want other people to know”: Barriers to and strategies for adherence to antiretroviral therapy among HIV patients in Northern Vietnam. AIDS Care, 2, 139–145. doi:10.1080/09540121.2010.507741
  • Vervoort, S. C., Grypdonck, M. H., de Grauwe, A., Hoepelman, A. I., & Borleffs, J. C. (2009). Adherence to HAART: Processes explaining adherence behavior in acceptors and non-acceptors. AIDS Care, 21, 431–438. doi:10.1080/09540120802290381
  • World Health Organization, UNAIDS, & UNICEF. (2012). Global HIV/AIDS response, epidemic update and health sector progress towards universal access, progress report 2011. Retrieved from: http://www.who.int/hiv/pub/progress_report2011/en/index.html

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