Publication Cover
AIDS Care
Psychological and Socio-medical Aspects of AIDS/HIV
Volume 27, 2015 - Issue 7
3,861
Views
158
CrossRef citations to date
0
Altmetric
Original Articles

Factors associated with adherence to antiretroviral therapy among adolescents living with HIV/AIDS in low- and middle-income countries: a systematic review

&
Pages 805-816 | Received 15 Sep 2014, Accepted 20 Jan 2015, Published online: 23 Feb 2015

References

  • Ajose, O., Mookerjee, S., Mills, E. J., Boulle, A., & Ford, N. (2012). Treatment outcomes of patients on second-line antiretroviral therapy in resource-limited settings: A systematic review and meta-analysis. AIDS, 26, 929–938. doi:10.1097/QAD.0b013e328351f5b2
  • Arrivillaga, M., Martucci, V., Hoyos, P. A., & Arango, A. (2013). Adherence among children and young people living with HIV/AIDS: A systematic review of medication and comprehensive interventions. Vulnerable Children and Youth Studies, 8, 321–337. doi:10.1080/17450128.2013.764031
  • Bain-Brickley, D., Butler, L. M., Kennedy, G. E., & Rutherford, G. W. (2011). Interventions to improve adherence to antiretroviral therapy in children with HIV infection. Cochrane Database of Systematic Reviews, (12), CD009513. doi:10.1002/14651858.CD009513
  • Bangsberg, D. R., Charlebois, E. D., Grant, R. M., Holodniy, M., Deeks, S. G., Perry, S., … Zolopa, A. (2003). High levels of adherence do not prevent accumulation of HIV drug resistance mutations. AIDS, 17, 1925–1932. doi:10.1097/00002030-200309050-00011
  • Bangsberg, D. R., Perry, S., Charlebois, E. D., Clark, R. A., Roberston, M., Zolopa, A. R., & Moss, A. (2001). Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS, 15, 1181–1183. doi:10.1097/00002030-200106150-00015
  • Berg, K. M., & Arnsten, J. H. (2006). Practical and conceptual challenges in measuring antiretroviral adherence. Journal of Acquired Immune Deficiency Syndromes (1999), 43(Suppl. 1), S79–S87. doi:10.1097/01.qai.0000248337.97814.66
  • Biadgilign, S., Deribew, A., Amberbir, A., & Deribe, K. (2008). Adherence to highly active antiretroviral therapy and its correlates among HIV infected pediatric patients in Ethiopia. BMC Pediatrics, 8(1), 53.
  • Binagwaho, A., Fuller, A., Kerry, V., Dougherty, S., Agbonyitor, M., Wagner, C., … Farmer, P. (2012). Adolescents and the right to health: Eliminating age-related barriers to HIV/AIDS services in Rwanda. AIDS Care, 24, 936–942. doi:10.1080/09540121.2011.648159
  • Biressaw, S., Abegaz, W. E., Abebe, M., Taye, W. A., & Belay, M. (2013). Adherence to antiretroviral therapy and associated factors among HIV infected children in Ethiopia: Unannounced home-based pill count versus caregivers’ report. BMC Pediatrics, 13, 132. doi:10.1186/1471-2431-13-132
  • Cardorelle, A. M., Toussoungamana-Peka, S. A., Miakassissa, C. M., & Okoko, A. (2014). Compliance with antiretroviral therapy in HIV-infected adolescents in Brazzaville, Congo. Archives De Pediatrie, 21(1), 105–107. doi:10.1016/j.arcped.2013.10.011
  • Carlson, M. D. A., & Morrison, R. S. (2009). Study design, precision, and validity in observational studies. Journal of Palliative Medicine, 12(1), 77–82. doi:10.1089/jpm.2008.9690
  • Cochrane Review Group on HIV/AIDS. (2012, May 25). Searching archives of HIV/AIDS conference abstracts. Retrieved July 1, 2013, from http://hiv.cochrane.org/node/59
  • Cupsa, A., Gheonea, C., Bulucea, D., & Dinescu, S. (2006). Factors with a negative influence on compliance to antiretroviral therapies. Annals of the New York Academy of Sciences, 918, 351–354. doi:10.1111/j.1749-6632.2000.tb05504.x
  • Ernesto, A. S., Lemos, R. M., Huehara, M. I., Morcillo, A. M., Dos Santos Vilela, M. M., & Silva, M. T. (2012). Usefulness of pharmacy dispensing records in the evaluation of adherence to antiretroviral therapy in Brazilian children and adolescents. The Brazilian Journal of Infectious Diseases, 16, 315–320. doi:10.1016/j.bjid.2012.06.006
  • Filho, A. C., Nogueira, S. A., Machado, E. S., Abreu, T. F., de Oliveira, R. H., Evangelista, L., & Hofer, C. B. (2008). Factors associated with lack of antiretroviral adherence among adolescents in a reference centre in Rio de Janeiro, Brazil. International Journal of STD & AIDS, 19, 685–688. doi:10.1258/ijsa.2008.008017
  • Fongkaew, W., Viseskul, N., Suksatit, B., Settheekul, S., Chontawan, R, Grimes, R. M., & Grimes, D. E. (2014). Verifying quantitative stigma and medication adherence scales using qualitative methods among thai youth living with HIV/AIDS. Journal of the International Association of Providers of AIDS Care, 13(1), 69–77. doi:10.1177/1545109712463734
  • Greenhalgh, T. (1999). Narrative based medicine in an evidence based world. BMJ, 318, 323–325. doi:10.1136/bmj.318.7179.323
  • Haberer, J., & Mellins, C. (2009). Pediatric adherence to HIV antiretroviral therapy. Current HIV/AIDS Reports, 6, 194–200. doi:10.1007/s11904-009-0026-8
  • Havens, P. L., & Gibb, D. M. (2007). Increasing antiretroviral drug access for children with HIV infection. Pediatrics, 119, 838–845. doi:10.1542/peds.2007-0273
  • Hazra, R., Siberry, G. K., & Mofenson, L. M. (2010). Growing up with HIV: Children, adolescents, and young adults with perinatally acquired HIV infection. Annual Review of Medicine, 61, 169–185.
  • Holmes, W. C., Bilker, W. B., Wang, H., Chapman, J., & Gross, R. (2007). HIV/AIDS-specific quality of life and adherence to antiretroviral therapy over time. JAIDS Journal of Acquired Immune Deficiency Syndromes, 46, 323–327. doi:10.1097/QAI.0b013e31815724fe
  • Kalichman, S. C., Cherry, C., White, D., Jones, M., Grebler, T., Kalichman, M. O., … Schinazi, R. F. (2011). Sexual HIV transmission and antiretroviral therapy: A prospective cohort study of behavioral risk factors among men and women living with HIV/AIDS. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine, 42(1), 111–119. doi:10.1007/s12160-011-9271-3
  • Kikuchi, K., Poudel, K. C., Muganda, J., Majyambere, A., Otsuka, K., Sato, T., … Jimba, M. (2012). High risk of ART non-adherence and delay of ART initiation among HIV positive double orphans in Kigali, Rwanda. PLoS One, 7, e41998. doi:10.1371/journal.pone.0041998.t005
  • Kim, S.-H., Gerver, S. M., Fidler, S., & Ward, H. (2014). Adherence to antiretroviral therapy in adolescents living with HIV: Systematic review and meta-analysis. AIDS, 28(13), 1945–1956. doi:10.1097/QAD.0000000000000316
  • Lowenthal, E., Lawler, K., Harari, N., Moamogwe, L., Masunge, J., Masedi, M., … Gross, R. (2012). Rapid psychosocial function screening test identified treatment failure in HIV plus African youth. AIDS Care-Psychological and Socio-Medical Aspects of AIDS/HIV, 24, 722–727. doi:10.1080/09540121.2011.644233
  • Lowenthal, E. D., Bakeera-Kitaka, S., Marukutira, T., Chapman, J., Goldrath, K., & Ferrand, R. A. (2014). Perinatally acquired HIV infection in adolescents from sub-Saharan Africa: A review of emerging challenges. The Lancet Infectious Diseases, 14, 627–639.
  • Machado, J. K. C., Sant’Anna, M. J. C., Coates, V., Almeida, F. J., Berezin, E. N., & Omar, H. A. (2009). Brazilian adolescents infected by HIV: Epidemiologic characteristics and adherence to treatment. The Scientific World Journal, 9, 1273–1285. doi:10.1100/tsw.2009.136
  • Martin, M., Del Cacho, E., Codina, C., Tuset, M., De Lazzari, E., Mallolas, J., … Ribas, J. (2008). Relationship between adherence level, type of the antiretroviral regimen, and plasma HIV type 1 RNA viral load: A prospective cohort study. AIDS Research and Human Retroviruses, 24, 1263–1268. doi:10.1089/aid.2008.0141
  • Mavhu, W., Berwick, J., Chirawu, P., Makamba, M., Copas, A., Dirawo, J., … Frances M. Cowan. (2013). Enhancing psychosocial support for HIV positive adolescents in Harare, Zimbabwe. PLoS One, 8(7), e70254. doi:10.1371/journal.pone.0070254.t003
  • Mills, E. J., Nachega, J. B., Bangsberg, D. R., Singh, S., Rachlis, B., Wu, P., … Cooper, C. (2006). Adherence to HAART: A systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Medicine, 3(11), e438. doi:10.1371/journal.pmed.0030438.t007
  • Mills, E. J., Nachega, J. B., Buchan, I., Orbinski, J., Attaran, A., Singh, S., … Cooper, C. (2006). Adherence to antiretroviral therapy in sub-Saharan Africa and North America. JAMA: The Journal of the American Medical Association, 296, 679–690. doi:10.1001/jama.296.6.679
  • Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine, 6(7), e1000097. doi:10.1371/journal.pmed.1000097
  • Musiime, V., Kayiwa, J., Kiconco, M., Tamale, W., Alima, H., Mugerwa, H., … Kizito, H. (2012). Response to antiretroviral therapy of HIV type 1-infected children in urban and rural settings of Uganda. AIDS Research and Human Retroviruses, 28, 1647–1657. doi:10.1089/aid.2011.0313
  • Nabukeera-Barungi, N., Kalyesubula, I., Kekitiinwa, A., Byakika-Tusiime, J., & Musoke, P. (2007). Adherence to antiretroviral therapy in children attending Mulago hospital, Kampala. Annals of Tropical Paediatrics: International Child Health, 27(2), 123–131. doi:10.1179/146532807X192499
  • Nachega, J. B., Hislop, M., Nguyen, H., Dowdy, D. W., Chaisson, R. E., Regensberg, L., … Maartens, G. (2009). Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in Southern Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 51(1), 65–71. doi:10.1097/QAI.0b013e318199072e
  • Nachega, J. B., Mills, E. J., & Schechter, M. (2010). Antiretroviral therapy adherence and retention in care in middle-income and low-income countries: Current status of knowledge and research priorities. Current Opinion in HIV and AIDS, 5(1), 70–77. doi:10.1097/COH.0b013e328333ad61
  • Ndiaye, M., Nyasulu, P., Nguyen, H., Lowenthal, E. D., Gross, R., Mills, E. J., & Nachega, J. B. (2013). Risk factors for suboptimal antiretroviral therapy adherence in HIV-infected adolescents in Gaborone, Botswana: A pilot cross-sectional study. Patient Preference and Adherence, 7, 891–895.
  • Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., … Singh, N. (2000). Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine, 133(1), 21–30. doi:10.7326/0003-4819-133-1-200007040-00004
  • Reda, A. A., & Biadgilign, S. (2012). Determinants of adherence to antiretroviral therapy among HIV-infected patients in Africa. AIDS Research and Treatment, 2012. doi:10.1155/2012/574656
  • Reisner, S. L., Mimiaga, M. J., Skeer, M., Perkovich, B., Johnson, C. V., & Safren, S. A. (2009). A review of HIV antiretroviral adherence and intervention studies among HIV-infected youth. Topics in HIV Medicine: A Publication of the International AIDS Society, USA, 17(1), 14–25.
  • San-Andrés, F.-J., Rubio, R., Castilla, J., Pulido, F., Palao, G., de Pedro, I., … del Palacio, A. (2003). Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989–1997. Clinical Infectious Diseases, 36, 1177–1185.
  • Sanderson, S., Tatt, I. D., & Higgins, J. P. T. (2007). Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: A systematic review and annotated bibliography. International Journal of Epidemiology, 36, 666–676. doi:10.1093/ije/dym018
  • Sawyer, S. M., Afifi, R. A., Bearinger, L. H., Blakemore, S.-J., Dick, B., Ezeh, A. C., & Patton, G. C. (2012). Adolescence: A foundation for future health. The Lancet, 379, 1630–1640. doi:10.1016/S0140-6736(12)60072-5
  • Scanlon, M. L., & Vreeman, R. C. (2013). Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings. HIV/AIDS (Auckland, NZ), 5, 1–17.
  • Simoni, J. M., Montgomery, A., Martin, E., New, M., Demas, P. A., & Rana, S. (2007). Adherence to antiretroviral therapy for pediatric HIV infection: A qualitative systematic review with recommendations for research and clinical management. Pediatrics, 119, e1371–e1383. doi:10.1542/peds.2006-1232
  • Sirikum, C., Sophonphan, J., Chuanjaroen, T., Lakonphon, S., Srimuan, A., Chusut, P., … HIV-NAT 015 study team. (2014). HIV disclosure and its effect on treatment outcomes in perinatal HIV-infected Thai children. AIDS care, 26(9), 1144–1149.
  • Tanner, A. E., Philbin, M. M., Duval, A., Ellen, J., Kapogiannis, B., & Fortenberry, J. D. (2014). “Youth friendly” clinics: Considerations for linking and engaging HIV-infected adolescents into care. AIDS Care, 26, 199–205. doi:10.1080/09540121.2013.808800
  • UNAIDS. (2013). Global report: UNAIDS report on the global AIDS epidemic. Geneva: Author.
  • UNICEF. (2011). Opportunity in crisis: Preventing HIV from early adolescence to young adulthood. New York: Author.
  • Van Dyke, R. B., Lee, S., Johnson, G. M., Wiznia, A., Mohan, K., Stanley, K., … Nachman, S. (2002). Reported adherence as a determinant of response to highly active antiretroviral therapy in children who have human immunodeficiency virus infection. Pediatrics, 109(4), e61.
  • van Rossum, A., Fraaij, P. L. A., & de Groot, R. (2002). Efficacy of highly active antiretroviral therapy in HIV-1 infected children. The Lancet Infectious Diseases, 2(2), 93–102. doi:10.1016/S1473-3099(02)00183-4
  • Vreeman, R. C., Wiehe, S. E., Pearce, E. C., & Nyandiko, W. M. (2008). A systematic review of pediatric adherence to antiretroviral therapy in low-and middle-income countries. The Pediatric Infectious Disease Journal, 27, 686–691. doi:10.1097/INF.0b013e31816dd325
  • Wales, H. E. B. (2004, January). Questions to assist with the critical appraisal of an observational study eg cohort, case-control, cross-sectional. Health Evidence Bulletin p. 26. Retrieved from http://hebw.cf.ac.uk/projectmethod/Project%20Methodology%205.pdf
  • WHO. (2013a). HIV and adolescents: Guidance for HIV testing and counselling and care for adolescents living with HIV (pp. viii). Geneva: Author.
  • WHO. (2013b, July 8). WHO/Adolescent health. WHO. Retrieved July 8, 2013, from http://www.who.int/topics/adolescent_health/en/files/431/en.html
  • World Bank. (2013). World bank list of economiesJuly 2013. Retrieved July 3, 2013, from http://data.worldbank.org/about/country-classifications/country-and-lending-groups
  • Young, S., Wheeler, A. C., McCoy, S. I., & Weiser, S. D. (2014). A review of the role of food insecurity in adherence to care and treatment among adult and pediatric populations living with HIV and AIDS. AIDS and Behavior, 5, S505–15. doi:10.1007/s10461-013-0547-4

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.