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AIDS Care
Psychological and Socio-medical Aspects of AIDS/HIV
Volume 28, 2016 - Issue 12
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Articles

Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis

, , , , &
Pages 1481-1494 | Received 15 Jan 2016, Accepted 16 May 2016, Published online: 30 May 2016

References

  • Anand, P., Springer, S. A., Copenhaver, M. M., & Altice, F. L. (2010). Neurocognitive impairment and HIV risk factors: A reciprocal relationship. AIDS and Behavior, 14, 1213–1226. doi:10.1007/s10461-010-9684-1
  • Aronow, H. A., Weston, A. J., Pezeshki, B. B., & Lazarus, T. S. (2008). Effects of coinfection with HIV and hepatitis C virus on the nervous system. The AIDS Reader, 18, 43–48.
  • Becker, J. T., & Salthouse, T. A. (1999). Neuropsychological test performance in the acquired immunodeficiency syndrome: Independent effects of diagnostic group on functioning. Journal of the International Neuropsychological Society, 5, 41–47. doi:10.1017/S1355617799511065
  • Carey, C. L., Woods, S. P., Gonzalez, R., Conover, E., Marcotte, T. D., Grant, I., … HNRC Group. (2004). Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. Journal of Clinical and Experimental Neuropsychology, 26, 307–319. doi:10.1080/13803390490510031
  • Cherner, M., Letendre, S., Heaton, R. K., Durelle, J., Marquie-Beck, J., Gragg, B., … HIV Neurobehavioral Research Center Group. (2005). Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine. Neurology, 64, 1343–1347. doi:10.1212/01.WNL.0000158328.26897.0D
  • Ciccarelli, N., Fabbiani, M., Grima, P., Falasca, K., Tana, M., Baldonero, E., … Di Giambenedetto, S. (2013). Comparison of cognitive performance in HIV or HCV mono-infected and HIV-HCV co-infected patients. Infection, 41, 1103–1109. doi:10.1007/s15010-013-0503-2
  • Clifford, D. B., Evans, S. R., Yang, Y., & Gulick, R. M. (2005). The neuropsychological and neurological impact of hepatitis C virus co-infection in HIV-infected subjects. AIDS, 19(Suppl. 3), S64–S71. doi:10.1097/01.aids.0000192072.80572.43
  • Clifford, D. B., Smurzynski, M., Park, L. S., Yeh, T. M., Zhao, Y., Blair, L., … Evans, S. R. (2009). Effects of active HCV replication on neurologic status in HIV RNA virally suppressed patients. Neurology, 73, 309–314. doi:10.1212/WNL.0b013e3181af7a10
  • Cohen, R. A., de la Monte, S., Gongvatana, A., Ombao, H., Gonzalez, B., Devlin, K. N., … Tashima, K. T. (2011). Plasma cytokine concentrations associated with HIV/hepatitis C coinfection are related to attention, executive and psychomotor functioning. Journal of Neuroimmunology, 233(1–2), 204–210. doi:10.1016/j.jneuroim.2010.11.006
  • Córdoba, J., Flavià, M., Jacas, C., Sauleda, S., Esteban, J. I., Vargas, V., … Guardia, J. (2003). Quality of life and cognitive function in hepatitis C at different stages of liver disease. Journal of Hepatology, 39, 231–238. doi:10.1016/S0168-8278(03)00189-2
  • Crystal, H., Kleyman, I., Anastos, K., Lazar, J., Cohen, M., Liu, C., … Manly, J. (2012). Effects of hepatitis C and HIV on cognition in women: Data from the womens interagency HIV study. Journal of Acquired Immune Deficiency Syndromes, 59, 149–154. doi:10.1097/QAI.0b013e318240566b
  • Cysique, L. A., Vaida, F., Letendre, S., Gibson, S., Cherner, M., Woods, S. P., … Ellis, R. J. (2009). Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapy. Neurology, 73, 342–348. doi:10.1212/WNL.0b013e3181ab2b3b
  • Devlin, K. N., Gongvatana, A., Clark, U. S., Chasman, J. D., Westbrook, M. L., Tashima, K. T., … Cohen, R. A. (2012). Neurocognitive effects of HIV, hepatitis C, and substance use history. Journal of the International Neuropsychological Society, 18, 68–78. doi:10.1017/S1355617711001408
  • Fellows, R. P., Byrd, D. A., & Morgello, S. (2014). Effects of information processing speed on learning, memory, and executive functioning in people living with HIV/AIDS. Journal of Clinical and Experimental Neuropsychology, 36, 806–817. doi:10.1080/13803395.2014.943696
  • Foley, J. M., Ettenhofer, M. L., Kim, M. S., Behdin, N., Castellon, S. A., & Hinkin, C. H. (2012). Cognitive reserve as a protective factor in older HIV-positive patients at risk for cognitive decline. Applied Neuropsychology: Adult, 19, 16–25. doi:10.1080/09084282.2011.595601
  • Fontana, R. J., Bieliauskas, L. A., Back-Madruga, C., Lindsay, K. L., Kronfol, Z., Lok, A. S., … HALT-C Trial Group. (2005). Cognitive function in hepatitis C patients with advanced fibrosis enrolled in the HALT-C trial. Journal of Hepatology, 43, 614–622. doi:10.1016/j.jhep.2005.04.006
  • Foster, G. R., Goldin, R. D., & Thomas, H. C. (1998). Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology, 27, 209–212. doi:10.1002/hep.510270132
  • Garvey, L. J., Pavese, N., Ramlackhansingh, A., Thomson, E., Allsop, J. M., Politis, M., … Winston, A. (2012). Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. Plos ONE, 7(7), e38980. doi:10.1371/journal.pone.0038980
  • Gershon, A., Margulies, M., Gorczynski, R., & Heathcote, E. J. (2000). Serum cytokine values and fatigue in chronic hepatitis C infection. Journal of Viral Hepatitis, 7, 397–402. doi:10.1046/j.1365-2893.2000.00249.x
  • von Giesen, H.-J., Heintges, T., Abbasi-Boroudjeni, N., Kücükköylü, S., Köller, H., Haslinger, B. A., … Arendt, G. (2004). Psychomotor slowing in hepatitis C and HIV infection. Journal of Acquired Immune Deficiency Syndromes, 35, 131–137. doi:10.1097/00126334-200402010-00005
  • Gill, A. J., & Kolson, D. L. (2014). Chronic inflammation and the role for cofactors (hepatitis C, drug abuse, antiretroviral drug toxicity, aging) in HAND persistence. Current HIV/AIDS Reports, 11, 325–335. doi:10.1007/s11904-014-0210-3
  • Grant, I. (2008). Neurocognitive disturbances in HIV. International Review of Psychiatry, 20, 33–47. doi:10.1080/09540260701877894
  • Grant, I., Franklin, D. R., Deutsch, R., Woods, S. P., Vaida, F., Ellis, R. J., … Heaton, R. K. (2014). Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology, 82, 2055–2062. doi:10.1212/WNL.0000000000000492
  • Higgins, J. P. T., & Green, S. (2011). Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration. Retrieved from www.cochrane-handbook.org
  • Higgins, J. P. T., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 21, 1539–1558. doi:10.1002/sim.1186
  • Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. British Medical Journal 327, 557–560. doi:10.1136/bmj.327.7414.557
  • Hilsabeck, R. C., Castellon, S. A., & Hinkin, C. H. (2005). Neuropsychological aspects of coinfection with HIV and hepatitis C virus. Clinical Infectious Diseases, 41(Suppl. 1), S38–S44. doi:10.1086/429494
  • Hilsabeck, R. C., Perry, W., & Hassanein, T. I. (2002). Neuropsychological impairment in patients with chronic hepatitis C. Hepatology, 35, 440–446. doi:10.1053/jhep.2002.31257
  • Hinkin, C. H., Castellon, S. A., Levine, A. J., Barclay, T. R., & Singer, E. J. (2008). Neurocognition in individuals co-infected with HIV and hepatitis C. Journal of Addictive Diseases, 27, 11–17. doi:10.1300/J069v27n02_02
  • Hong, S., & Banks, W. A. (2015). Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications. Brain, Behavior, and Immunity, 45, 1–12. doi:10.1016/j.bbi.2014.10.008
  • Kumar, A. M., Borodowsky, I., Fernandez, B., Gonzalez, L., & Kumar, M. (2007). Human immunodeficiency virus type 1 RNA levels in different regions of human brain: Quantification using real-time reverse transcriptase-polymerase chain reaction. Journal of Neurovirology, 13, 210–224. doi:10.1080/13550280701327038
  • Kumar, A. M., Ownby, R. L., Waldrop-Valverde, D., Fernandez, B., & Kumar, M. (2011). Human immunodeficiency virus infection in the CNS and decreased dopamine availability: Relationship with neuropsychological performance. Journal of Neurovirology, 17, 26–40. doi:10.1007/s13365-010-0003-4
  • Kushner, L. E., Wendelboe, A. M., Lazzeroni, L. C., Chary, A., Winters, M. A., Osinusi, A., … Holodniy, M. (2013). Immune biomarker differences and changes comparing HCV mono-infected, HIV/HCV co-infected, and HCV spontaneously cleared patients. PLoS ONE, 8(4), e60387. doi:10.1371/journal.pone.0060387
  • Letendre, S. (2011). Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder. Topics in Antiviral Medicine, 19, 137–142.
  • Letendre, S. L., Cherner, M., Ellis, R. J., Marquie-Beck, J., Gragg, B., Marcotte, T., … HNRC Group. (2005). The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: Biological correlates of disease. AIDS, 19(Suppl. 3), S72–S78. doi:10.1097/01.aids.0000192073.18691.ff
  • Letendre, S., Paulino, A. D., Rockenstein, E., Adame, A., Crews, L., Cherner, M., … HIV Neurobehavioral Research Center Group. (2007). Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. Journal of Infectious Diseases, 196, 361–370. doi:10.1086/519285
  • Martin, E. M., Novak, R. M., Fendrich, M., Vassileva, J., Gonzalez, R., Grbesic, S., … Sworowski, L. (2004). Stroop performance in drug users classified by HIV and hepatitis C virus serostatus. Journal of the International Neuropsychological Society, 10, 298–300. doi:10.1017/S135561770410218X
  • Martin-Thormeyer, E. M., & Paul, R. H. (2009). Drug abuse and hepatitis C infection as comorbid features of HIV associated neurocognitive disorder: Neurocognitive and neuroimaging features. Neuropsychology Review, 19, 215–231. doi:10.1007/s11065-009-9101-6
  • McAfoose, J., & Baune, B. T. (2009). Evidence for a cytokine model of cognitive function. Neuroscience & Biobehavioral Reviews, 33, 355–366. doi:10.1016/j.neubiorev.2008.10.005
  • Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine, 6(6): e1000097. doi:10.1371/journal.pmed1000097
  • Morgan, E. E., Woods, S. P., Smith, C., Weber, E., Scott, J. C., Grant, I., & HIV Neurobehavioral Research Program (HNRP) Group. (2012). Lower cognitive reserve among individuals with syndromic HIV-associated neurocognitive disorders (HAND). AIDS and Behavior, 16, 2279–2285. doi:10.1007/s10461-012-0229-7
  • Morgello, S., Estanislao, L., Ryan, E., Gerits, P., Simpson, D., Verma, S., … Manhattan HIV Brain Bank. (2005). Effects of hepatic function and hepatitis C virus on the nervous system assessment of advanced-stage HIV-infected individuals. AIDS, 19(Suppl. 3), S116–S122. doi:10.1097/01.aids.0000192079.49185.f9
  • Nightingale, S., Winston, A., Letendre, S., Michael, B. D., Mcarthur, J. C., Khoo, S., … Street, W. D. (2014). Controversies in HIV-associated neurocognitive disorders. The Lancet Neurology, 13, 1139–1151. doi:10.1016/S1474-4422(14)70137-1
  • Parsons, T. D., Tucker, K. A., Hall, C. D., Robertson, W. T., Eron, J. J., Fried, M. W., & Robertson, K. R. (2006). Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection. AIDS, 20, 1591–1595. doi:10.1097/01.aids.0000238404.16121.47
  • Perry, W., Carlson, M. D., Barakat, F., Hilsabeck, R. C., Schiehser, D. M., Mathews, C., & Hassanein, T. I. (2005). Neuropsychological test performance in patients co-infected with hepatitis C virus and HIV. AIDS, 19(Suppl. 3), S79–S84. doi:10.1097/01.aids.0000192074.18691.31
  • Perry, W., Hilsabeck, R. C., & Hassanein, T. I. (2008). Cognitive dysfunction in chronic hepatitis C: A review. Digestive Diseases and Sciences, 53, 307–321. doi:10.1007/s10620-007-9896-z
  • Posada, C., Morgan, E. E., Moore, D. J., Woods, S. P., Letendre, S. L., Grant, I., & HIV Neurobehavioral Research Center Group. (2009). Neurocognitive effects of the hepatitis C virus. Current Hepatitis Reports, 8, 18–26. doi:10.1007/s11901-010-0085-8
  • Rempel, H., Sun, B., Calosing, C., Abadjian, L., Monto, A., & Pulliam, L. (2013). Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PloS One, 8(2), e55776. doi:10.1371/journal.pone.0055776
  • Richardson, J. L., Nowicki, M., Danley, K., Martin, E. M., Cohen, M. H., Gonzalez, R., … Levine, A. M. (2005). Neuropsychological functioning in a cohort of HIV- and hepatitis C virus-infected women. AIDS, 19, 1659–1667. doi:10.1097/01.aids.0000186824.53359.62
  • Rosca, E. C., Rosca, O., Chirileanu, R. D., & Simu, M. (2011). Neurocognitive disorders due to HIV infection. HIV & AIDS Review, 10, 33–37. doi:10.1016/j.hivar.2011.02.003
  • Ryan, E. L., Morgello, S., Isaacs, K., Naseer, M. G., Gerits, P., & Manhattan HIV Brain Bank. (2004). The neuropsychiatric impact of hepatitis C on advanced HIV. Neurology, 62, 957–962. doi:10.1212/01.WNL.0000115177.74976.6C
  • Sakamoto, M., Woods, S. P., Kolessar, M., Kriz, D., Anderson, J. R., Olavarria, H., … Huckans, M. (2013). Protective effects of higher cognitive reserve for neuropsychological and daily functioning among individuals infected with hepatitis C. Journal of Neurovirology, 19, 442–451. doi:10.1007/s13365-013-0196-4
  • Salthouse, T. A. (1996). The processing-speed theory of adult age differences in cognition. Psychological Review, 103, 403–428. doi:10.1037/0033-295X.103.3.403
  • Schouten, J., Cinque, P., Gisslen, M., Reiss, P., & Portegies, P. (2011). HIV-1 infection and cognitive impairment in the cART-era: A review. AIDS, 25, 561–575. doi:10.1097/QAD.0b013e3283437f9a
  • Simioni, S., Cavassini, M., Annoni, J. M., Rimbault Abraham, A., Bourquin, I., Schiffer, V., … Du Pasquier, R. A. (2010). Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS, 24, 1243–1250. doi:10.1097/QAD.0b013e3283354a7b
  • Stebbins, G. T., Smith, C. A., Bartt, R. E., Kessler, H. A., Adeyemi, O. M., Martin, E., … Moseley, M. E. (2007). HIV-associated alterations in normal-appearing White matter: a voxel-wise diffusion tensor imaging study. Journal of Acquired Immune Deficiency Syndromes, 46, 564–573. doi:10.1097/QAI.0b013e318159d807
  • Stern, Y. (2003). The concept of cognitive reserve: A catalyst for research. Journal of Clinical and Experimental Neuropsychology (Neuropsychology, Development and Cognition: Section A), 25, 589–593. doi:10.1076/jcen.25.5.589.14571
  • Sun, B., Abadjian, L., Rempel, H., Monto, A., & Pulliam, L. (2013). Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. Journal of Acquired Immune Deficiency Syndromes, 62, 190–196. doi:10.1097/QAI.0b013e31827b61f1
  • The Cochrane Collaboration. 2012. Review manager, Version 5.2. (RevMan 5.2) [Computer program]. Copenhagen, Denmark: The Nordic Cochrane Centre.
  • Thein, H., Maruff, P., Krahn, M., Kaldor, J., Koorey, D., Brew, B., & Dore, G. (2007). Cognitive function, mood and health-related quality of life in hepatitis C virus (HCV)-monoinfected and HIV/HCV-coinfected individuals commencing HCV treatment. HIV Medicine, 8, 192–202. doi:10.1111/j.1468-1293.2007.00452.x
  • Thiyagarajan, A., Garvey, L. J., Pflugrad, H., Maruffc, P., Scullard, G., Main, J., … Winston, A. (2010). Cerebral function tests reveal differences in HIV-infected subjects with and without chronic HCV co-infection. Clinical Microbiology and Infection, 16, 1579–1584. doi:10.1111/j.1469-0691.2010.03176.x
  • Vázquez-Justo, E., Piñón, A., Vergara-Moragues, E., Guillén-Gestoso, C., & Pérez-García, M. (2014). Influence of cognitive reserve on neuropsychological performance in HIV intravenous drug users. Applied Neuropsychology: Adult, 21, 288–296. doi:10.1080/23279095.2013.813852
  • Vigil, O., Posada, C., Woods, S. P., Atkinson, J. H., Heaton, R. K., Perry, W., … HIV Neurobehavioral Research Center (HNRC) Group. (2008). Impairments in fine-motor coordination and speed of information processing predict declines in everyday functioning in hepatitis C infection. Journal of Clinical and Experimental Neuropsychology, 30, 805–815. doi:10.1080/13803390701802354
  • Vivithanaporn, P., Maingat, F., Lin, L. T., Na, H., Richardson, C. D., Agrawal, B., … Power, C. (2010). Hepatitis C virus core protein induces neuroimmune activation and potentiates human immunodeficiency virus-1 neurotoxicity. PloS one, 5(9), e12856. doi:10.1371/journal.pone.0012856
  • Vivithanaporn, P., Nelles, K., DeBlock, L., Newman, S. C., Gill, M. J., & Power, C. (2012). Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV/AIDS. Journal of the Neurological Sciences, 312, 45–51. doi:10.1016/j.jns.2011.08.025
  • Winston, A., Garvey, L., Scotney, E., Yerrakalva, D., Allsop, J. M., Thomson, E. C., … Taylor-Robinson, SD. (2010). Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals? Journal of Viral Hepatitis, 17, 419–426. doi:10.1111/j.1365-2893.2009.01198.x
  • Woods, S. P., Moore, D. J., Weber, E., & Grant, I. (2009). Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychological Review, 19, 152–168. doi:10.1007/s11065-009-9102-5

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