U.S. Hospitalization rates and reasons stratified by age among persons with HIV 2014–15

References

• 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. (1992). MMWR. Recommendations and Reports, 41(RR-17), 1–19.
   Google Scholar
• Althoff, K. N., McGinnis, K. A., Wyatt, C. M., Freiberg, M. S., Gilbert, C., Oursler, K. K., … Veterans Aging Cohort, S. (2015). Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults. Clinical Infectious Diseases, 60(4), 627–638. doi: 10.1093/cid/ciu869
   PubMed Web of Science ®Google Scholar
• Alvi, R. M., Tariq, N., Malhotra, A., Awadalla, M., Triant, V. A., Zanni, M. V., & Neilan, T. G. (2018). Sleep apnea and heart failure with a reduced ejection fraction among persons living with human Immunodeficiency Virus. Clinical Infectious Diseases, 67(3), 447–455. doi: 10.1093/cid/ciy216
   PubMed Web of Science ®Google Scholar
• Atashili, J., Kalilani, L., & Adimora, A. A. (2006). Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: A meta-analysis. BMC Infectious Diseases, 6, 138. doi: 10.1186/1471-2334-6-138
   PubMed Web of Science ®Google Scholar
• Bachhuber, M. A., & Southern, W. N. (2014). Hospitalization rates of people living with HIV in the United States, 2009. Public Health Reports, 129(2), 178–186. doi: 10.1177/003335491412900212
   PubMed Web of Science ®Google Scholar
• Berry, S. A., Fleishman, J. A., Moore, R. D., Gebo, K. A., & Network, H. I. V. R. (2012). Trends in reasons for hospitalization in a multisite United States cohort of persons living with HIV, 2001-2008. JAIDS Journal of Acquired Immune Deficiency Syndromes, 59(4), 368–375. doi: 10.1097/QAI.0b013e318246b862
   PubMed Web of Science ®Google Scholar
• Butler, J., Kalogeropoulos, A. P., Anstrom, K. J., Hsue, P. Y., Kim, R. J., Scherzer, R., … Braunwald, E. (2018). Diastolic dysfunction in individuals with human immunodeficiency virus infection: Literature review, rationale and design of the characterizing heart function on antiretroviral therapy (CHART) study. Journal of Cardiac Failure, 24(4), 255–265. doi: 10.1016/j.cardfail.2018.02.001
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. HIV Surveillance Report. (2015). vol. 27. Retrieved from http://www.cdc.gov/hiv/library/reports/hiv-surveillance.html. Published November 2016
   Google Scholar
• Crum-Cianflone, N. F., Grandits, G., Echols, S., Ganesan, A., Landrum, M., Weintrob, A., … Infectious Disease Clinical Research, P. (2010). Trends and causes of hospitalizations among HIV-infected persons during the late HAART era: What is the impact of CD4 counts and HAART use? JAIDS Journal of Acquired Immune Deficiency Syndromes, 54(3), 248–257. doi: 10.1097/QAI.0b013e3181c8ef22
   PubMed Web of Science ®Google Scholar
• Deeks, S. G. (2011). HIV infection, inflammation, immunosenescence, and aging. Annual Review of Medicine, 62, 141–155. doi: 10.1146/annurev-med-042909-093756
   PubMed Web of Science ®Google Scholar
• Edelman, E. J., Tetrault, J. M., & Fiellin, D. A. (2014). Substance use in older HIV-infected patients. Current Opinion in HIV and AIDS, 9(4), 317–324. doi: 10.1097/COH.0000000000000069
   PubMed Web of Science ®Google Scholar
• Elion, R. A., Althoff, K. N., Zhang, J., Moore, R. D., Gange, S. J., Kitahata, M. M., … ANorth American AIDS Cohort Collaboration on Research and Design of IeDEA. (2018). Recent Abacavir Use Increases risk of type 1 and type 2 Myocardial Infarctions Among adults With HIV. JAIDS Journal of Acquired Immune Deficiency Syndromes, 78(1), 62–72. doi: 10.1097/QAI.0000000000001642
   PubMed Web of Science ®Google Scholar
• Elixhauser, A., Steiner, C., & Palmer, L. (2008). Clinical Classifications Software (CCS). In U.S. Agency for Healthcare Research and Quality.
   Google Scholar
• Feikin, D. R., Feldman, C., Schuchat, A., & Janoff, E. N. (2004). Global strategies to prevent bacterial pneumonia in adults with HIV disease. The Lancet Infectious Diseases, 4(7), 445–455. doi: 10.1016/S1473-3099(04)01060-6
   PubMed Web of Science ®Google Scholar
• Free only searchable. (2009). ICD-9-CM. Retrieved from http://icd9.chrisendres.com/
   Google Scholar
• Gallant, J., Hsue, P. Y., Shreay, S., & Meyer, N. (2017). Comorbidities among US patients with prevalent HIV infection-A trend analysis. The Journal of Infectious Diseases, 216(12), 1525–1533. doi: 10.1093/infdis/jix518
   PubMed Web of Science ®Google Scholar
• Gebo, K. A., Diener-West, M., & Moore, R. D. (2001). Hospitalization rates in an urban cohort after the introduction of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 27(2), 143–152. doi: 10.1097/00042560-200106010-00009
   PubMed Web of Science ®Google Scholar
• Gebo, K. A., Diener-West, M., & Moore, R. D. (2003). Hospitalization rates differ by hepatitis C satus in an urban HIV cohort. JAIDS Journal of Acquired Immune Deficiency Syndromes, 34(2), 165–173. doi: 10.1097/00126334-200310010-00006
   PubMed Web of Science ®Google Scholar
• Gebo, K. A., Fleishman, J. A., Conviser, R., Hellinger, J., Hellinger, F. J., Josephs, J. S., … HIV Research Network. (2010). Contemporary costs of HIV healthcare in the HAART era. Aids (london, England), 24(17), 2705–2715. doi: 10.1097/QAD.0b013e32833f3c14
   PubMed Web of Science ®Google Scholar
• Green, T. C., Kershaw, T., Lin, H., Heimer, R., Goulet, J. L., Kraemer, K. L., … Justice, A. C. (2010). Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort. Drug and Alcohol Dependence, 110(3), 208–220. doi: 10.1016/j.drugalcdep.2010.02.020
   PubMed Web of Science ®Google Scholar
• Guaraldi, G., Malagoli, A., Calcagno, A., Mussi, C., Celesia, B. M., Carli, F., … Di Perri, G. (2018). The increasing burden and complexity of multi-morbidity and polypharmacy in geriatric HIV patients: A cross sectional study of people aged 65 - 74 years and more than 75 years. BMC Geriatrics, 18(1), 99. doi: 10.1186/s12877-018-0789-0
   PubMed Web of Science ®Google Scholar
• Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., … Palella, F. (2011). Premature age-related comorbidities among HIV-infected persons compared with the general population. Clinical Infectious Diseases, 53(11), 1120–1126. doi: 10.1093/cid/cir627
   PubMed Web of Science ®Google Scholar
• Heckman, B. D., Lovejoy, T. I., Heckman, T. G., Anderson, T., Grimes, T., Sutton, M., & Bianco, J. A. (2014). The moderating role of sexual identity in group teletherapy for adults aging with HIV. Behavioral Medicine, 40(3), 134–142. doi: 10.1080/08964289.2014.925417
   PubMed Web of Science ®Google Scholar
• Hsue, P. Y., & Waters, D. D. (2017). Heart failure in persons living with HIV infection. Current Opinion in HIV and AIDS, 12(6), 534–539. doi: 10.1097/COH.0000000000000409
   PubMed Web of Science ®Google Scholar
• Kim, D. J., Westfall, A. O., Chamot, E., Willig, A. L., Mugavero, M. J., Ritchie, C., … Willig, J. H. (2012). Multimorbidity patterns in HIV-infected patients: The role of obesity in chronic disease clustering. JAIDS Journal of Acquired Immune Deficiency Syndromes, 61(5), 600–605. doi: 10.1097/QAI.0b013e31827303d5
   PubMed Web of Science ®Google Scholar
• Kirk, G. D., Merlo, C., O'Driscoll, P., Mehta, S. H., Galai, N., Vlahov, D., … Engels, E. A. (2007). HIV infection is associated with an increased risk for lung cancer, independent of smoking. Clinical Infectious Diseases, 45(1), 103–110. doi: 10.1086/518606
   PubMed Web of Science ®Google Scholar
• Lazar, R., Kersanske, L., Xia, Q., Daskalakis, D., & Braunstein, S. L. (2017). Hospitalization rates among people with HIV/AIDS in New York City, 2013. Clinical Infectious Diseases, 65(3), 469–476. doi: 10.1093/cid/cix343
   PubMed Web of Science ®Google Scholar
• May, M. T., Gompels, M., Delpech, V., Porter, K., Orkin, C., Kegg, S., … UK Collaborative HIV Cohort (UK CHIC) Study. (2014). Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. Aids (london, England), 28(8), 1193–1202. doi: 10.1097/QAD.0000000000000243
   PubMed Web of Science ®Google Scholar
• McDermott KW (IBM Watson Health), E. A. A., Sun R (AHRQ). Trends in hospital inpatient stays in the United States, 2005-2014. HCUP Statistical Brief #225. June 2017. Agency for Healthcare Research and Quality, Rockville, MD. Retrieved from www.hcup-us.ahrq.gov/reports/statbriefs/sb225-Inpatient-US-Stays-Trends.pdf
   Google Scholar
• Mills, E. J., Barnighausen, T., & Negin, J. (2012). HIV and aging–preparing for the challenges ahead. New England Journal of Medicine, 366(14), 1270–1273. doi: 10.1056/NEJMp1113643
   PubMed Web of Science ®Google Scholar
• O'Connor, J., Vjecha, M. J., Phillips, A. N., Angus, B., Cooper, D., Grinsztejn, B., … INSIGHT START study group. (2017). Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per muL: Secondary outcome results from a randomised controlled trial. The Lancet HIV, 4(3), e105–e112. doi: 10.1016/S2352-3018(16)30216-8
   PubMed Web of Science ®Google Scholar
• Paisible, A. L., Chang, C. C., So-Armah, K. A., Butt, A. A., Leaf, D. A., Budoff, M., … Freiberg, M. S. (2015). HIV infection, cardiovascular disease risk factor profile, and risk for acute myocardial infarction. JAIDS Journal of Acquired Immune Deficiency Syndromes, 68(2), 209–216. doi: 10.1097/QAI.0000000000000419
   PubMed Web of Science ®Google Scholar
• Ryom, L., Lundgren, J. D., El-Sadr, W., Reiss, P., Kirk, O., Law, M., … D:A:D study group. (2018). Cardiovascular disease and use of contemporary protease inhibitors: The D:A:D international prospective multicohort study. The Lancet HIV, 5(6), e291–e300. doi: 10.1016/S2352-3018(18)30043-2
   PubMed Web of Science ®Google Scholar
• Salive, M. E. (2013). Multimorbidity in older adults. Epidemiologic Reviews, 35, 75–83. doi: 10.1093/epirev/mxs009
   PubMed Web of Science ®Google Scholar
• Schackman, B. R., Fleishman, J. A., Su, A. E., Berkowitz, B. K., Moore, R. D., Walensky, R. P., … Losina, E. (2015). The lifetime medical cost savings from preventing HIV in the United States. Medical Care, 53(4), 293–301. doi: 10.1097/MLR.0000000000000308
   PubMed Web of Science ®Google Scholar
• Schouten, J., Wit, F. W., Stolte, I. G., Kootstra, N. A., van der Valk, M., Geerlings, S. E., … AGEhIV Cohort Study Group. (2014). Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: The AGEhIV cohort study. Clinical Infectious Diseases, 59(12), 1787–1797. doi: 10.1093/cid/ciu701
   PubMed Web of Science ®Google Scholar
• Shafran, S. D. (2016). Live attenuated herpes zoster vaccine for HIV-infected adults. HIV Medicine, 17(4), 305–310. doi: 10.1111/hiv.12311
   PubMed Web of Science ®Google Scholar
• Siberry, G. K., Williams, P. L., Lujan-Zilbermann, J., Warshaw, M. G., Spector, S. A., Decker, M. D., … IMPAACT P1065 Protocol Team. (2010). Phase I/II, open-label trial of safety and immunogenicity of meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine in human immunodeficiency virus-infected adolescents. The Pediatric Infectious Disease Journal, 29(5), 391–396. doi: 10.1097/INF.0b013e3181c38f3b
   PubMed Web of Science ®Google Scholar
• Simonsen, L., Conn, L. A., Pinner, R. W., & Teutsch, S. (1998). Trends in infectious disease hospitalizations in the United States, 1980-1994. Archives of Internal Medicine, 158(17), 1923–1928. doi: 10.1001/archinte.158.17.1923
   PubMedGoogle Scholar
• Smit, M., Brinkman, K., Geerlings, S., Smit, C., Thyagarajan, K., Sighem, A., … ATHENA observational cohort. (2015). Future challenges for clinical care of an ageing population infected with HIV: A modelling study. The Lancet Infectious Diseases, 15(7), 810–818. doi: 10.1016/S1473-3099(15)00056-0
   PubMed Web of Science ®Google Scholar
• Smit, M., Cassidy, R., Cozzi-Lepri, A., Quiros-Roldan, E., Girardi, E., Mammone, A., … Hallett, T. B. (2017). Projections of non-communicable disease and health care costs among HIV-positive persons in Italy and the U. PLOS ONE, 12(10), e0186638. doi: 10.1371/journal.pone.0186638
   PubMed Web of Science ®Google Scholar
• Tasker, S. A., Treanor, J. J., Paxton, W. B., & Wallace, M. R. (1999). Efficacy of influenza vaccination in HIV-infected persons. A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine, 131(6), 430–433. doi: 10.7326/0003-4819-131-6-199909210-00006
   PubMed Web of Science ®Google Scholar
• Triant, V. A., Brown, T. T., Lee, H., & Grinspoon, S. K. (2008). Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. Healthcare system. The Journal of Clinical Endocrinology & Metabolism, 93(9), 3499–3504. doi: 10.1210/jc.2008-0828
   PubMed Web of Science ®Google Scholar
• Triant, V. A., Lee, H., Hadigan, C., & Grinspoon, S. K. (2007). Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. The Journal of Clinical Endocrinology & Metabolism, 92(7), 2506–2512. doi: 10.1210/jc.2006-2190
   PubMed Web of Science ®Google Scholar
• Vogeli, C., Shields, A. E., Lee, T. A., Gibson, T. B., Marder, W. D., Weiss, K. B., & Blumenthal, D. (2007). Multiple chronic conditions: Prevalence, health consequences, and implications for quality, care management, and costs. Journal of General Internal Medicine, 22(Suppl 3), 391–395. doi: 10.1007/s11606-007-0322-1
   PubMed Web of Science ®Google Scholar
• Ward, B. W., & Schiller, J. S. (2013). Prevalence of multiple chronic conditions among US adults: Estimates from the national health interview survey, 2010. Preventing Chronic Disease, 10, E65. doi: 10.5888/pcd10.120203
   PubMed Web of Science ®Google Scholar
• Wong, C., Gange, S. J., Moore, R. D., Justice, A. C., Buchacz, K., Abraham, A. G., … North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD. (2018). Multimorbidity Among persons living with Human Immunodeficiency Virus in the United States. Clinical Infectious Diseases, 66(8), 1230–1238. doi: 10.1093/cid/cix998
   PubMed Web of Science ®Google Scholar
• Yehia, B. R., Gebo, K. A., Hicks, P. B., Korthuis, P. T., Moore, R. D., Ridore, M., … Network, H. I. V. R. (2008). Structures of care in the clinics of the HIV Research Network. AIDS Patient Care and STDs, 22(12), 1007–1013. doi: 10.1089/apc.2008.0093
   PubMed Web of Science ®Google Scholar
• Yusuf, S., Hawken, S., Ounpuu, S., Dans, T., Avezum, A., Lanas, F., … INTERHEART Study Investigators. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet, 364(9438), 937–952. doi: 10.1016/S0140-6736(04)17018-9
   PubMed Web of Science ®Google Scholar