Comorbidity patterns among people living with HIV: a hierarchical clustering approach through integrated electronic health records data in South Carolina

References

• Aberg, J. A., Gallant, J. E., Ghanem, K. G., Emmanuel, P., Zingman, B. S., Horberg, M. A. (2014). Executive summary: Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV medicine association of the infectious diseases society of America. Clinical Infectious Diseases, 58(1), 1–10. https://doi.org/10.1093/cid/cit665
   Web of Science ®Google Scholar
• Althoff, K. N., McGinnis, K. A., Wyatt, C. M., Freiberg, M. S., Gilbert, C., Oursler, K. K., Rimland, D., Rodriguez-Barradas, M. C., Dubrow, R., Park, L. S., Skanderson, M., Shiels, M. S., Gange, S. J., Gebo, K. A., & Justice, A. C. (2015). Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults. Clinical Infectious Diseases, 60(4), 627–638. https://doi.org/10.1093/cid/ciu869
   PubMed Web of Science ®Google Scholar
• Bacik, L., BeLue, R., & Seck, F. (2016). Spectrum of comorbid conditions and their relationship to CD4T-lymphocyte counts in HIV-infected patients in Mbour, Senegal. The Journal of Global Health at Columbia University, 6(2), 7–10. https://doi.org/10.7916/thejgh.v6i2.4982
   Google Scholar
• Bitar, A. N., Syed Sulaiman, S. A., Ali, I. A. H., Khan, I., & Khan, A. H. (2019). Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes. Journal of Pharmacy And Bioallied Sciences, 11(4), 310–320. https://doi.org/10.4103/jpbs.JPBS_126_19
   PubMed Web of Science ®Google Scholar
• Bower, M., Fisher, M., Hill, T., Reeves, I., Walsh, J., Orkin, C., Phillips, A. N., Bansi, L., Gilson, R., Easterbrook, P., Johnson, M., Gazzard, B., Leen, C., Pillay, D., Schwenk, A., Anderson, J., Porter, K., Gompels, M., & Sabin, C. A. (2009). CD4 counts and the risk of systemic non-Hodgkin’s lymphoma in individuals with HIV in the UK. Haematologica, 94(6), 875–880. https://doi.org/10.3324/haematol.2008.002691
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. (2006). Missed opportunities for earlier diagnosis of HIV infection–South Carolina, 1997–2005. MMWR. Morbidity and Mortality Weekly Report, 55(47), 1269–1272.
   PubMedGoogle Scholar
• Chen, H., & Boutros, P. C. (2011). Venndiagram: A package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinformatics, 12(1), 35. https://doi.org/10.1186/1471-2105-12-35
   PubMed Web of Science ®Google Scholar
• Choi, H. K., De Vera, M. A., & Krishnan, E. (2008). Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profile. Rheumatology, 47(10), 1567–1570. https://doi.org/10.1093/rheumatology/ken305
   PubMed Web of Science ®Google Scholar
• Cook, R. L., Zhu, F., Belnap, B. H., Weber, K. M., Cole, S. R., Vlahov, D., Cook, J. A., Hessol, N. A., Wilson, T. E., Plankey, M., Howard, A. A., Sharp, G. B., Richardson, J. L., & Cohen, M. H. (2013). Alcohol consumption trajectory patterns in adult women with HIV infection. AIDS and Behavior, 17(5), 1705–1712. https://doi.org/10.1007/s10461-012-0270-6
   PubMed Web of Science ®Google Scholar
• Cornell, J. E., Pugh, J. A., Williams, J. W., Jr., Kazis, L., Lee, A. F., Parchman, M. L., Zeber, J., Pederson, T., Montgomery, K. A., & Hitchcock Noël, P. (2008). Multimorbidity clusters: Clustering binary data from multimorbidity clusters: Clustering binary data from a large administrative medical database. Applied Multivariate Research, 12(3), 163–182. https://doi.org/10.22329/amr.v12i3.658
   Google Scholar
• dos Santos Marcon, P., Tovo, C. V., Kliemann, D. A., Fisch, P., & de Mattos, A. A. (2018). Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study. World Journal of Gastroenterology, 24(5), 613–622. https://doi.org/10.3748/wjg.v24.i5.613
   PubMed Web of Science ®Google Scholar
• Dubrow, R., Qin, L., Lin, H., Hernández-Ramírez, R. U., Neugebauer, R. S., Leyden, W., Althoff, K. N., Achenbach, C. J., Hessol, N. A., Modur, S. P., D'Souza, G., Bosch, R. J., Grover, S., Horberg, M. A., Kitahata, M. M., Mayor, A. M., Novak, R. M., Rabkin, C. S., Sterling, T. R., … Silverberg, M. J. (2017). Association of CD4+ T-cell count, HIV-1 RNA viral load, and antiretroviral therapy with Kaposi Sarcoma risk among HIV-infected persons in the United States and Canada. JAIDS Journal of Acquired Immune Deficiency Syndromes, 75(4), 382–390. https://doi.org/10.1097/QAI.0000000000001394
   PubMed Web of Science ®Google Scholar
• Everitt, B. S., Landau, S., & Leese, M. (2001). Cluster analysis (4th ed.). Oxford University Press.
   Google Scholar
• Fischer, M. J., Wyatt, C. M., Gordon, K., Gibert, C. L., Brown, S. T., Rimland, D., Rodriguez-Barradas, M. C., Justice, A. C., & Parikh, C. R. (2010). Hepatitis C and the risk of kidney disease and mortality in veterans with HIV. JAIDS Journal of Acquired Immune Deficiency Syndromes, 53(2), 222–226. https://doi.org/10.1097/QAI.0b013e3181b980d4
   PubMed Web of Science ®Google Scholar
• Floriani, C., Feller, M., Aubert, C. E., M’Rabet-Bensalah, K., Collet, T. H., den Elzen, W. P. J., Bauer, D. C., Angelillo-Scherrer, A., Aujesky, D., & Rodondi, N. (2018). Thyroid dysfunction and anemia: A prospective cohort study and a systematic review. Thyroid, 28(5), 575–582. https://doi.org/10.1089/thy.2017.0480
   PubMed Web of Science ®Google Scholar
• Fortin, M., Lapointe, L., Hudon, C., Vanasse, A., Ntetu, A. L., & Maltais, D. (2004). Multimorbidity and quality of life in primary care: A systematic review. Health and Quality of Life Outcomes, 2(1), 51. https://doi.org/10.1186/1477-7525-2-51
   PubMedGoogle Scholar
• Gebo, K. A. (2008). Epidemiology of HIV and response to antiretroviral therapy in the middle aged and elderly. Aging Health, 4(6), 615–627. https://doi.org/10.2217/1745509X.4.6.615
   PubMedGoogle Scholar
• Gijsen, R., Hoeymans, N., Schellevis, F. G., Ruwaard, D., Satariano, W. A., & van den Bos, G. A. (2001). Causes and consequences of comorbidity: A review. Journal of Clinical Epidemiology, 54(7), 661–674. https://doi.org/10.1016/s0895-4356(00)00363-2
   PubMed Web of Science ®Google Scholar
• Goulet, J. L., Fultz, S. L., McGinnis, K. A., & Justice, A. C. (2005). Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. Aids (London, England), 19(Suppl. 3), S99–S105. https://doi.org/10.1097/01.aids.0000192077.11067.e5
   PubMed Web of Science ®Google Scholar
• Gower, J. C., & Legendre, P. (1986). Metric and Euclidean properties of dissimilarity coefficients. Journal of Classification, 3(1), 5–48. https://doi.org/10.1007/BF01896809
   Web of Science ®Google Scholar
• Green, T. C., Kershaw, T., Lin, H., Heimer, R., Goulet, J. L., Kraemer, K. L., Gordon, A. J., Maisto, S. A., Day, N. L., Bryant, K., Fiellin, D. A., & Justice, A. C. (2010). Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort. Drug and Alcohol Dependence, 110(3), 208–220. https://doi.org/10.1016/j.drugalcdep.2010.02.020
   PubMed Web of Science ®Google Scholar
• Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., Berti, A., Rossi, E., Roverato, A., & Palella, F. (2011). Premature age-related comorbidities among HIV-infected persons compared with the general population. Clinical Infectious Diseases, 53(11), 1120–1126. https://doi.org/10.1093/cid/cir627
   PubMed Web of Science ®Google Scholar
• High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., Justice, A. C., Landay, A., Levin, J., Miotti, P. G., Munk, R. J., Nass, H., Rinaldo, C. R., Shlipak, M. G., Tracy, R., … Volberding, P. (2012). HIV and aging: State of knowledge and areas of critical need for research. A report to the NIH office of AIDS research by the HIV and aging working group. JAIDS Journal of Acquired Immune Deficiency Syndromes, 60(Suppl. 1), S1–S18. https://doi.org/10.1097/QAI.0b013e31825a3668
   PubMed Web of Science ®Google Scholar
• Hughes, C. A., Robinson, L., Tseng, A., & MacArthur, R. D. (2009). New antiretroviral drugs: A review of the efficacy, safety, pharmacokinetics, and resistance profile of tipranavir, darunavir, etravirine, rilpivirine, maraviroc, and raltegravir. Expert Opinion on Pharmacotherapy, 10(15), 2445–2466. https://doi.org/10.1517/14656560903176446
   PubMed Web of Science ®Google Scholar
• Kalaria, R. N., Akinyemi, R., & Ihara, M. (2016). Stroke injury, cognitive impairment and vascular dementia. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(5), 915–925. https://doi.org/10.1016/j.bbadis.2016.01.015
   PubMed Web of Science ®Google Scholar
• Kim, D. J., Westfall, A. O., Chamot, E., Willig, A. L., Mugavero, M. J., Ritchie, C., Burkholder, G. A., Crane, H. M., Raper, J. L., Saag, M. S., & Willig, J. H. (2012). Multimorbidity patterns in HIV-infected patients: The role of obesity in chronic disease clustering. JAIDS Journal of Acquired Immune Deficiency Syndromes, 61(5), 600–605. https://doi.org/10.1097/QAI.0b013e31827303d5
   PubMed Web of Science ®Google Scholar
• Laux, G., Kuehlein, T., Rosemann, T., & Szecsenyi, J. (2008). Co- and multimorbidity patterns in primary care based on episodes of care: Results from the German content project. BMC Health Services Research, 8(1), 14. https://doi.org/10.1186/1472-6963-8-14
   PubMed Web of Science ®Google Scholar
• Lesko, C. R., Moore, R. D., Tong, W., & Lau, B. (2016). Association of injection drug use with incidence of HIV-associated non-AIDS-related morbidity by age, 1995–2014. Aids (London, England), 30(9), 1447–1455. https://doi.org/10.1097/QAD.0000000000001087
   PubMed Web of Science ®Google Scholar
• Lucas, G. M., Mehta, S. H., Atta, M. G., Kirk, G. D., Galai, N., Vlahov, D., & Moore, R. D. (2007). End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004. Aids (London, England), 21(18), 2435–2443. https://doi.org/10.1097/QAD.0b013e32827038ad
   PubMed Web of Science ®Google Scholar
• Marengoni, A., Rizzuto, D., Wang, H. X., Winblad, B., & Fratiglioni, L. (2009). Patterns of chronic multimorbidity in the elderly population. Journal of the American Geriatrics Society, 57(2), 225–230. https://doi.org/10.1111/j.1532-5415.2008.02109.x
   PubMed Web of Science ®Google Scholar
• Mocroft, A., Reiss, P., Gasiorowski, J., Ledergerber, B., Kowalska, J., Chiesi, A., Gatell, J., Rakhmanova, A., Johnson, M., Kirk, O., & Lundgren, J. (2010). Serious fatal and nonfatal non-AIDS-defining illnesses in Europe. JAIDS Journal of Acquired Immune Deficiency Syndromes, 55(2), 262–270. https://doi.org/10.1097/QAI.0b013e3181e9be6b
   PubMed Web of Science ®Google Scholar
• Nachega, J. B., Hsu, A. J., Uthman, O. A., Spinewine, A., & Pham, P. A. (2012). Antiretroviral therapy adherence and drug-drug interactions in the aging HIV population. Aids (London, England), 26(Suppl. 1), S39–S53. https://doi.org/10.1097/QAD.0b013e32835584ea
   PubMedGoogle Scholar
• Ng, S. K., Tawiah, R., Sawyer, M., & Scuffham, P. (2018). Patterns of multimorbid health conditions: A systematic review of analytical methods and comparison analysis. International Journal of Epidemiology, 47(5), 1687–1704. https://doi.org/10.1093/ije/dyy134
   PubMed Web of Science ®Google Scholar
• Olatosi, B., Probst, J., Stoskopf, C., Martin, A., & Duffus, W. (2009). Patterns of engagement in care by HIV-infected adults: South Carolina, 2004–2006. Aids (London, England), 23(6), 725–730. https://doi.org/10.1097/QAD.0b013e328326f546
   PubMed Web of Science ®Google Scholar
• Olatosi, B., Zhang, J., Weissman, S., Hu, J., Haider, M. R., & Li, X. (2019). Using big data analytics to improve HIV medical care utilisation in South Carolina: A study protocol. BMJ Open, 9(7), Article 027688. https://doi.org/10.1136/bmjopen-2018-027688
   Google Scholar
• Palella, F. J., Hart, R., Armon, C., Tedaldi, E., Yangco, B., Novak, R., Battalora, L., Ward, D., Li, J., & Buchacz, K. (2019). Non-AIDS comorbidity burden differs by sex, race, and insurance type in aging adults in HIV care. Aids (London, England), 33(15), 2327–2335. https://doi.org/10.1097/QAD.0000000000002349
   PubMed Web of Science ®Google Scholar
• Palfai, T. P., Cheng, D. M., Coleman, S. M., Bridden, C., Krupitsky, E., & Samet, J. H. (2014). The influence of depressive symptoms on alcohol use among HIV-infected Russian drinkers. Drug and Alcohol Dependence, 134, 85–91. https://doi.org/10.1016/j.drugalcdep.2013.09.014
   PubMed Web of Science ®Google Scholar
• Parekh, A. K., & Barton, M. B. (2010). The challenge of multiple comorbidity for the US health care system. JAMA, 303(13), 1303–1304. https://doi.org/10.1001/jama.2010.381
   PubMed Web of Science ®Google Scholar
• Patel, P., Rose, C. E., Collins, P. Y., Nuche-Berenguer, B., Sahasrabuddhe, V. V., Peprah, E., Vorkoper, S., Pastakia, S. D., Rausch, D., & Levitt, N. S. (2018). Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries: A systematic review and meta-analysis. Aids (London, England), 32, S5–S20. https://doi.org/10.1097/Qad.0000000000001888
   PubMed Web of Science ®Google Scholar
• Petrie, J. R., Guzik, T. J., & Touyz, R. M. (2018). Diabetes, hypertension, and cardiovascular disease: Clinical insights and vascular mechanisms. Canadian Journal of Cardiology, 34(5), 575–584. https://doi.org/10.1016/j.cjca.2017.12.005
   PubMed Web of Science ®Google Scholar
• Prados-Torres, A., Calderón-Larranaga, A., Hancco-Saavedra, J., Poblador-Plou, B., & van den Akker, M. (2014). Multimorbidity patterns: A systematic review. Journal of Clinical Epidemiology, 67(3), 254–266. https://doi.org/10.1016/j.jclinepi.2013.09.021
   PubMed Web of Science ®Google Scholar
• Rawat, A., Uebel, K., Moore, D., Cingl, L., & Yassi, A. (2018). Patient responses on quality of care and satisfaction with staff after integrated HIV care in South African primary health care clinics. Journal of the Association of Nurses in AIDS Care, 29(5), 698–711. https://doi.org/10.1016/j.jana.2018.04.014
   PubMed Web of Science ®Google Scholar
• Schafer, I., von Leitner, E. C., Schon, G., Koller, D., Hansen, H., Kolonko, T., Kaduszkiewicz, H., Wegscheider, K., Glaeske, G., van den Bussche, H., & Ross, J. S. (2010). Multimorbidity patterns in the elderly: A new approach of disease clustering identifies complex interrelations between chronic conditions. PLoS One, 5(12), Article 15941. https://doi.org/10.1371/journal.pone.0015941
   Google Scholar
• Schouten, J., Wit, F. W., Stolte, I. G., Kootstra, N. A., van der Valk, M., Geerlings, S. E., Reiss, P., Reiss, P., Wit, F. W. N. M., van der Valk, M., Schouten, J., Kooij, K. W., van Zoest, R. A., Elsenga, B. C., Prins, M., Stolte, I. G., Martens, M., Moll, S., Berkel, J., … Mulder, W. M. C. (2014). Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: The AGEhIV cohort study. Clinical Infectious Diseases, 59(12), 1787–1797. https://doi.org/10.1093/cid/ciu701
   PubMed Web of Science ®Google Scholar
• Shiels, M. S., Pfeiffer, R. M., Gail, M. H., Hall, H. I., Li, J., Chaturvedi, A. K., Bhatia, K., Uldrick, T. S., Yarchoan, R., Goedert, J. J., & Engels, E. A. (2011). Cancer burden in the HIV-infected population in the United States. JNCI: Journal of the National Cancer Institute, 103(9), 753–762. https://doi.org/10.1093/jnci/djr076
   PubMedGoogle Scholar
• Starfield, B., Lemke, K. W., Bernhardt, T., Foldes, S. S., Forrest, C. B., & Weiner, J. P. (2003). Comorbidity: Implications for the importance of primary care in ‘case’ management. The Annals of Family Medicine, 1(1), 8–14. https://doi.org/10.1370/afm.1
   PubMedGoogle Scholar
• Stevens, S. L., Wood, S., Koshiaris, C., Law, K., Glasziou, P., Stevens, R. J., & McManus, R. J. (2016). Blood pressure variability and cardiovascular disease: Systematic review and meta-analysis. BMJ, 354, i4098. https://doi.org/10.1136/bmj.i4098
   PubMed Web of Science ®Google Scholar
• Sulkowski, M. S., & Thomas, D. L. (2003). Hepatitis C in the HIV-infected person. Annals of Internal Medicine, 138(3), 197–207. https://doi.org/10.7326/0003-4819-138-3-200302040-00012
   PubMed Web of Science ®Google Scholar
• Valdez, A. N., Rubin, L. H., & Neigh, G. N. (2016). Untangling the Gordian knot of HIV, stress, and cognitive impairment. Neurobiology of Stress, 4, 44–54. https://doi.org/10.1016/j.ynstr.2016.02.005
   PubMed Web of Science ®Google Scholar
• Vance, D. E., Mugavero, M., Willig, J., Raper, J. L., & Saag, M. S. (2011). Aging with HIV: A cross-sectional study of comorbidity prevalence and clinical characteristics across decades of life. Journal of the Association of Nurses in AIDS Care, 22(1), 17–25. https://doi.org/10.1016/j.jana.2010.04.002
   PubMed Web of Science ®Google Scholar
• van den Bussche, H., Koller, D., Kolonko, T., Hansen, H., Wegscheider, K., Glaeske, G., von Leitner, E.-C., Schäfer, I., & Schön, G. (2011). Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany. BMC Public Health, 11(1), 101. https://doi.org/10.1186/1471-2458-11-101
   PubMed Web of Science ®Google Scholar
• Vermunt, J., & Magidson, J. (2002). Latent class cluster analysis. In J. A. Hagenaars & A. L. McCutcheon (Eds.), Applied latent class analysis (pp. 89–106). Cambridge University Press.
   Google Scholar
• Vijayan, M., & Reddy, P. H. (2016). Stroke, vascular dementia, and Alzheimer’s disease: Molecular links. Journal of Alzheimer's Disease, 54(2), 427–443. https://doi.org/10.3233/JAD-160527
   PubMed Web of Science ®Google Scholar
• Wandeler, G., Johnson, L. F., & Egger, M. (2016). Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: Comparisons with general population. Current Opinion in HIV and AIDS, 11(5), 492–500. https://doi.org/10.1097/COH.0000000000000298
   PubMed Web of Science ®Google Scholar
• Wong, C., Gange, S. J., Moore, R. D., Justice, A. C., Buchacz, K., Abraham, A. G., Rebeiro, P. F., Koethe, J. R., Martin, J. N., Horberg, M. A., Boyd, C. M., Kitahata, M. M., Crane, H. M., Gebo, K. A., Gill, M. J., Silverberg, M. J., Palella, F. J., Patel, P., Samji, H., … Sterling, T. R. (2018). Multimorbidity among persons living with human immunodeficiency virus in the United States. Clinical Infectious Diseases, 66(8), 1230–1238. doi:10.1093/cid/cix998
   PubMed Web of Science ®Google Scholar