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AIDS Care
Psychological and Socio-medical Aspects of AIDS/HIV
Volume 35, 2023 - Issue 7
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Research Article

Levels of adherence to contemporary antiretroviral regimens and the likelihood of viral suppression: a cohort study in a Brazilian metropolis

Vanessa Aracele Rodriguesa Post-Graduate Program in Drug Utilization and Pharmaceutical Policy. Department of Social Pharmacy, Universidade Federal de Minas Gerais. School of Pharmacy, Belo Horizonte, BrazilCorrespondence[email protected]
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Maria das Graças Braga Ceccatoa Post-Graduate Program in Drug Utilization and Pharmaceutical Policy. Department of Social Pharmacy, Universidade Federal de Minas Gerais. School of Pharmacy, Belo Horizonte, BrazilORCID Iconhttps://orcid.org/0000-0002-4340-0659View further author information
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Juliana de Oliveira Costab Post-Graduate Program in Public Health. Department of Social and Preventive Medicine, Universidade Federal de Minas Gerais. School of Medicine, Belo Horizonte, Brazil;c Centre for Big Data Research in Health, University of New South Wales, Sydney, AustraliaORCID Iconhttps://orcid.org/0000-0002-8355-023XView further author information
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Celline Cardoso Almeida-Brasila Post-Graduate Program in Drug Utilization and Pharmaceutical Policy. Department of Social Pharmacy, Universidade Federal de Minas Gerais. School of Pharmacy, Belo Horizonte, Brazil;d Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, CanadaORCID Iconhttps://orcid.org/0000-0002-6324-4702View further author information
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Micheline Rosa Silveiraa Post-Graduate Program in Drug Utilization and Pharmaceutical Policy. Department of Social Pharmacy, Universidade Federal de Minas Gerais. School of Pharmacy, Belo Horizonte, BrazilORCID Iconhttps://orcid.org/0000-0001-7002-4428View further author information
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Edna Afonso Reise Statistics Department, Universidade Federal de Minas Gerais. Institute of Exact Sciences, Belo Horizonte, BrazilORCID Iconhttps://orcid.org/0000-0003-1465-9167View further author information
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Pages 976-981 | Received 31 Mar 2021, Accepted 27 Apr 2022, Published online: 29 May 2022

References

  • Bangsberg, D. R. (2006). Less than 95% adherence to nonnucleoside reverse-transcriptase inhibitor therapy can lead to viral suppression. Clinical Infectious Diseases, 43(7), 939–941. https://doi.org/10.1086/507526
  • Bezabhe, W. M., Chalmers, L., Bereznicki, L. R., & Peterson, G. M. (2016). Adherence to antiretroviral therapy and Virologic Failure: A meta-analysis. Medicine (Baltimore), 95(15), e3361. https://doi.org/10.1097/MD.0000000000003361
  • Gordon, L. L., Gharibian, D., Chong, K., & Chun, H. (2015). Comparison of HIV Virologic Failure rates between patients with variable adherence to three antiretroviral regimen types. AIDS Patient Care and STDs, 29(7), 384–388. https://doi.org/10.1089/apc.2014.0165
  • Hanna, D. B., Hessol, N. A., Golub, E. T., Cocohoba, J. M., Cohen, M. H., Levine, A. M., Wilson, T. E., Young, M., Anastos, K., & Kaplan, R. C. (2014). Increase in single-tablet regimen use and associated improvements in adherence-related outcomes in HIV-infected women. JAIDS Journal of Acquired Immune Deficiency Syndromes, 65(5), 587–596. https://doi.org/10.1097/QAI.0000000000000082
  • Instituto de Pesquisa Economica Aplicada (IPEA). (2018). Perfil Regiao Metropolitana Belo Horizonte. http://brasilmetropolitano.ipea.gov.br/#perfil/cod=3101
  • Kobin, A. B., & Sheth, N. U. (2011). Levels of adherence required for virologic suppression among newer antiretroviral medications. Annals of Pharmacotherapy, 45(3), 372–379. https://doi.org/10.1345/aph.1P587
  • Meireles, M. V., Pascom, A. R. P., Duarte, E. C., & McFarland, W. (2019). Comparative effectiveness of first-line antiretroviral therapy: Results from a large real-world cohort after the implementation of dolutegravir. Aids (london, England), 33(10), 1663–1668. https://doi.org/10.1097/QAD.0000000000002254
  • Min, S., Sloan, L., DeJesus, E., Hawkins, T., McCurdy, L., Song, I., Stroder, R., Chen, S., Underwood, M., Fujiwara, T., Piscitelli, S., & Lalezari, J. (2011). Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of dolutegravir as 10-day monotherapy in HIV-1-infected adults. Aids (london, England), 25(14), 1737–1745. https://doi.org/10.1097/QAD.0b013e32834a1dd9
  • Ministério da Saúde. (2018). Protocolo Clínico e Diretrizes Terapêuticas para Manejo da Infecção pelo HIV em Adultos. Ministry of Health (Brazil). Secretaria de Vigilância em Saúde. http://www.aids.gov.br/pt-br/tags/publicacoes/protocolo-clinico-e-diretrizes-terapeuticas
  • Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., Wagener, M. M., & Singh, N. (2000). Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine, 133(1), 21–30. https://doi.org/10.7326/0003-4819-133-1-200007040-00004
  • Stellbrink, H. J., Reynes, J., Lazzarin, A., Voronin, E., Pulido, F., Felizarta, F., Almond, S., St Clair, M., Flack, N., Min, S., & Team, S. (2013). Dolutegravir in antiretroviral-naive adults with HIV-1: 96-week results from a randomized dose-ranging study. Aids (london, England), 27(11), 1771–1778. https://doi.org/10.1097/QAD.0b013e3283612419
  • Sutton, S. S., Magagnoli, J., & Hardin, J. W. (2017). Odds of viral suppression by single-tablet regimens, multiple-tablet regimens, and adherence level in HIV/AIDS patients receiving antiretroviral therapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 37(2), 204–213. https://doi.org/10.1002/phar.1889
  • Tennant, S. J., Hester, E. K., Caulder, C. R., Lu, Z. K., & Bookstaver, P. B. (2015). Adherence among rural HIV-infected patients in the deep south: A comparison between single-tablet and multi-tablet once-daily regimens. Journal of the International Association of Providers of AIDS Care (JIAPAC), 14(1), 64–71. https://doi.org/10.1177/2325957414555228
  • van Lunzen, J., Maggiolo, F., Arribas, J. R., Rakhmanova, A., Yeni, P., Young, B., Rockstroh, J. K., Almond, S., Song, I., Brothers, C., & Min, S. (2012). Once daily dolutegravir (S/GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: Planned interim 48 week results from SPRING-1, a dose-ranging, randomised, phase 2b trial. The Lancet Infectious Diseases, 12(2), 111–118. https://doi.org/10.1016/S1473-3099(11)70290-0
  • Viswanathan, S., Detels, R., Mehta, S. H., Macatangay, B. J., Kirk, G. D., & Jacobson, L. P. (2015a). Level of adherence and HIV RNA suppression in the current era of highly active antiretroviral therapy (HAART). AIDS and Behavior, 19(4), 601–611. https://doi.org/10.1007/s10461-014-0927-4
  • Viswanathan, S., Justice, A. C., Alexander, G. C., Brown, T. T., Gandhi, N. R., McNicholl, I. R., Rimland, D., Rodriguez-Barradas, M. C., & Jacobson, L. P. (2015b). Adherence and HIV RNA suppression in the Current Era of highly active antiretroviral therapy. JAIDS Journal of Acquired Immune Deficiency Syndromes, 69(4), 493–498. https://doi.org/10.1097/QAI.0000000000000643
  • Walmsley, S. L., Antela, A., Clumeck, N., Duiculescu, D., Eberhard, A., Gutierrez, F., Hocqueloux, L., Maggiolo, F., Sandkovsky, U., Granier, C., Pappa, K., Wynne, B., Min, S., Nichols, G., & Investigators, S. (2013). Dolutegravir plus Abacavir-lamivudine for the treatment of HIV-1 infection. New England Journal of Medicine, 369(19), 1807–1818. https://doi.org/10.1056/NEJMoa1215541
  • Westergaard, R. P., Ambrose, B. K., Mehta, S. H., & Kirk, G. D. (2012). Provider and clinic-level correlates of deferring antiretroviral therapy for people who inject drugs: A survey of north American HIV providers. Journal of the International AIDS Society, 15(1), 10. https://doi.org/10.1186/1758-2652-15-10

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