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Research Article

The neurobiology of anxiety in children and adolescents

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Pages 114-128 | Published online: 11 Jul 2009

  • ABELSON, J.L. & NEESE, R.M. (1990). Cholecystokinen-4 and panic. Archives of General Psychiatry, 47, 395.
  • ABELSON, J.L., GLTTZ, D., et al (1991). Blunted growth hormone response to clonidine in patients with generalized anxiety disorder. Archives of General Psychiatry, 48, 157-162.
  • ABELSON, J.L, GLITZ, D., et al (1992). Endocrine, cardiovascular and behavioral responses to clonidine in patients with panic disorder. Biological Psychiatry, 32, 18-25.
  • AGGLETON, J.P. (1985). A description of intra-amygdaloid connections in the old-world monkeys. Experiments in Brain Research, 57, 390-399.
  • ALLEN, N.B., LEWTNSOHN, P.M., et al (1998). Prenatal and postnatal influences on risk for psychopathology in childhood and adolescence. Developments in Psychopathology, 10, 513-529.
  • AMARAL, D. (1987). Memory, anatomical organization of candidate brian regions. Handbook of Physiology (Vol. 5, pp. 211-294). Bethesda, MD, American Physiological Society.
  • APOSTALOPOULUS, M., JUDD, F.K., et al (1993). Prolactin response to DL-fenfluramine in panic disorder. Psychoneuroendocrinology, 18, 337-342.
  • ARONSON, T., CARASITI, I., et al (1989). Biological correlates of lactate sensitivity in panic disorder. Biological Psychiatry, 26, 463-477.
  • AVERY, D.H., OSGOOD, T.B., et al (1985). The DST in psychiatric outpatients with generalized anxiety disorder, panic disorder or primary affective disorder. American Journal of Psychiatry, 142, 844-848.
  • BALDESSARINI, R.J. & MARCH, E. (1990). Fluoxetine and side effects. Archives of General Psychiatry, 47, 191-192.
  • BALLENGER, J.C. (1998). Translational implications of the amygdala-stria terminalis model for the clinical anxiety disorders. Biological Psychiatry, 44, 1204-1207.
  • BALON, R., POHL, R., et al (1988). Lactate and isoproterenol induced panic attacks in panic disorder patients and controls. Psychiatry Research, 23, 153-160.
  • BARKLEY, R.A. (1997). Behavioral inhibition, sustained attention and executive functions, constructing a unifing theory of ADHD. Psychology Bulletin, 121, 65-94.
  • BATTAGLIA, M., BERTELLA, S., et al (1995). Age at onset of panic disorder, influence of familial liability to the disease and of childhood separation anxiety disorder. American Journal of Psychiatry, 152, 1362-1364.
  • BAXTER, L.R., SCHWARTZ, J.M., et al (1988). Cerebral glucose metabolic rates in non-depressed patients with obsessive compulsive disorder. American Journal of Psychiatry, 145, 1560-1563.
  • BAXTER, L.R., SCHWARTZ, J.M., et al (1992). Caudate glucose metaboloic rate changes with both drug and behavior therapy for obsessive compulsive disorder. Archives of General Psychiatry, 49, 681-689.
  • BELL, C.J., MALIZZIA, A.L., et al (1999). The neurobiology of social phobia. European Archives of Psychiatry Clinical Neuroscience, 249(Suppl. 1), S11-S18.
  • BENKELFAT, C., NORDAHL, T.E., et al (1990). Local cerebral glucose metabolic activity in obsessive-compulsive disorder, patients treated with clomipramine. Archives of General Psychiatry, 141, 840-848.
  • BIEDERMAN, J., ROSENBAUM, J.F., et al (1990). Psychiatric correlates of behavioral inhibition in young children of parents with and without psychiatric disorders. Archives of General Psychiatry, 47, 21-26.
  • BLACK, B. (1993). Neurobiology of anxiety disorders. Child and Adolescent Psychiatric Clinics of North America, 2(4), 749-762.
  • BRADWEJN, J., KOSZCYKI, D., et al (1992). A dose ranging study of the behavioral and cardiovascular effects of CCK-tetrapeptide in panic disorder. Biological Psychiatry, 32, 903-912.
  • BRAMBILLA, F., PERNA, G., et al. (1995).Alpha-2-adrenergic receptor sensitivity in panic disorder, I. GH response to GHRH and clonidine stimulation in panic disorder. Psychoneuroendocrinology, 20(1), 1-9.
  • BRAMBILLA, F., PERNA, G., et al (1997). Noradrenergic receptor sensitivity in obsessive-compulsive disorders, I, growth hormone response to clonidine stimulation. Psychiatry Research, 69, 155-162.
  • BREMNER, J., LICINO, J., et al (1997a). Elevated CSF corticotropin-releasing factor concentrations in post-traumatic stress disorder. American Journal of Psychiatry, 154, 624-629.
  • BREMNER, J.D., RANDALL, P., et al (1995). MRI based measurement of hippocampal volume in patients with combat related posttraumatic stress disorder. American Journal of Psychiatry, 152, 973-981.
  • BREMNER, J.D., RANDALL, P., et al (1997b). MRI based measurement of hippocampal volume in PTSD related childhood physical and sexual abuse, a preliminary report. British Journal of Psychiatry, 41, 23-32.
  • BREWERTON, T. (1989). Seasonal variation of serotonin function. Annuals of Clinical Psychiatry, 1, 153-164.
  • BREWERTON, T.D., LYDIARD, R.B., et al (1995). CSF serotonin, diagnostic and seasonal differences, 148th Meeting of the American Psychiatric Association. Washington, DC: American Psychiatric Press.
  • BURWELL, R.D., WITTER, M.P., et al (1995). Perirhinal and postrhinal cortices of the rat, a review of the neuroanatomical literature and comparison withfindings from the monkey brain. Hippocampus, 5, 390-408.
  • BUTLER, R.W., BRAFF, D.L., et al (1990). Physiologic evidence of exaggerated startle response in a subgroup of Vietnam veterans with combat-related posttraumatic stress disorder. American Journal of Psychiatry, 147, 1308-1312.
  • CALDIROLA, D., PERNA, G., et al (1997). The 35% CO2 challenge test in patients with social phobia. Psychiatry Research, 71, 41-48.
  • CAMERON, H., McEWEN, B., et al (1995). Regulation of adult neurogenesis by excitatory input and NMDA receptor activity in the dentate gyms. Journal of Neuroscience, 15, 4687-4692.
  • CAMERON, H., WOOLLEY, C., et al (1993). Adrenal steroid receptor immunoreactivity in cells bom in the adult rat dentate gyms. Brain Research, 611, 342-346.
  • CAMERON, O.G., SMITH, C.B., et al (1990). Adrenergic status in anxiety disorders, platelet alpha two-adrenergic receptor binding, blood pressure, pulse and plasma catecholamines in panic and generalized anxiety disorder patients and in normal subjects. Biological Psychiatry, 28, 3-20.
  • CAFPS, L., SIGMAN, M., et al (1996). Fear, anxiety, and perceived control in children of agoraphobic patients. Journal of Child Psychology & Psychiatry, 37, 445-452.
  • CARB, O.E., SHEEHAN, D.V., et al (1986). Neuroendocrine correlates of lactate induced anxiety and their response to chronic alprazolam therapy. American Journal Psychiatry, 143, 483-494.
  • CASPI, A., MOFFITT, T.E., et al (1996). Behavioral observations at age 3 years predict adult psychiatric disorders. Archives of General Psychiatry, 53, 1033-1039.
  • CHARNEY, D.S. & DEUTCH, A. (1996). A functional neuroanatomy of anxiety and fear, implications for the pathophysiology and treatment of anxiety disorders. Critical Reviews in Neurobiology, 10, 419-446.
  • CHARNEY, D.S. & HENINGER, G.B. (1986). Abnormal regulation of noradrenergic function in panic disorders. Archives of General Psychiatry, 43, 1042-1054.
  • CHARNEY, D.S., GOODMAN, W., et al (1988). Serotonin function in obsessive compulsive disorder, a comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Archives of General Psychiatry, 45, 177-185.
  • CHANEY, D.S., HENINGER, G.B., et al (1984). Noradrenergic function in panic anxiety, effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder. Archives of General Psychiatry, 41, 751-763.
  • CHARNEY, D.S., WOODS, S., et al. (1987a). Neurobiological mechanisms of panic anxiety, biochemical and behavioral correlates of yohimbine induced panic attacks. American Journal Psychiatry, 144, 1030-1036.
  • CHARNEY, D.S., WOODS, S., et al (1987b). Serotonin function in anxiety, II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology, 92, 14-24.
  • CHARNEY, D.S., WOODS, S.W., et al. (1989). Noradrenergic function in generalized anxiety disorder, effects of yohimbine in healthy subjects and patients with generalized anxiety disorder. Psychiatry Research, 27, 173-182.
  • CHARNEY, D.S., WOODS, S.W., et al (1992). Noradrenergic neuronal deregulation in panic disorder, the effects of intravenous yohimbine and clonidine in panic disorder patients. Acta Psychiatrica Scandinavica, 86, 273-282.
  • CONNOR, K.M. & DAVIDSON, J.R. (1998). Generalized anxiety disorder, neurobiological and pharmacotherapeutic perspectives. Biological Psychiatry, 44, 1286-1294.
  • COPLAN, J.D., PAPP, L.A., et al (1995). Persistence of blunted human growth hormone response to clonidine in panic disorder following fluoxetine treatment. American Journal Psychiatry, 152, 619-622.
  • COWLEY, D. & ARANA, G. (1990). The diagnostic utility of lactate sensitivity in panic disorder. Archives of General Psychiatry, 47, 277-284.
  • COWLEY, D., DAGER, S. et al (1988). Response to lactate infusion in generalized anxiety disorder. Biological Psychiatry, 24, 409-414.
  • COWLEY, D., DAGER, S. et al (1991a). Lactate vulnerability after alprazolam versus placebo treatment of panic disorder. Biological Psychiatry, 30, 49-56.
  • COWLEY, D., ROY-BYRNE, P., et al (1991b). Benzodiazepine sensitivity in anxiety disorders. Biological Psychiatry, 29, 57 A.
  • CREESE, I. & IVERSON, S.D. (1974). The role of forebrain dopamine systems in amphetamine induced stereotyped behavior in the rat. Psychopharmacologia, 39, 345-357.
  • DAVIDSON, J.R., KRISHNAN, K.R., et al (1993). Magnetic resonance spectroscopy in social phobia, preliminary findings. Journal of Clinical Psychiatry, 54(Suppl), 19-25.
  • DAVIDSON, R., MARSHALL, J., et al (2000). While a phobic waits, regional brain electrical and autonomie activity in social phobies during anticipation of public speaking. Biological Psychiatry, 47, 85-95.
  • DAVIDSON, R.J. (1995). Cerebral asymmetry, emotion and affective syle. In: R.J. DAVIDSON & K. HUGHDAL (Eds), Brain asymmetry (pp. 361-388). Cambridge: MIT Press.
  • DAVIS, M. (1992). The role of the amygdala in conditioned fear. In: J.P. AGGLETON (Ed.), Neurbiological aspects of emotion, memory and mental dysfunction (pp. 255-305). New York Wiley.
  • DAVIS, M. (1998). Are different parts of the extended amygdala involved in fear versus anxiety. Biological Psychiatry, 44, 1239-1247.
  • DEBELLIS, M.D., CASEY, B.J., et al (2000). A pilot study of amygdala volumes in pediatric generalized anxiety disorder. Biological Psychiatry, 48, 51-57.
  • DEBELLIS, M.D., KESHAVAN, M.S., et al (1999). Developmental traumatology part II, brain development Biological Psychiatry, 45, 1271-1284.
  • DECRISTOFORO, M., SESSAREGO, A., et al (1993). Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients, a SPECT study. Biological Psychiatry, 33, 505-512.
  • DIAMOND, A. & GOLDMAN-RAKIC, P.S. (1989). Comparison of human infants and rhesus monkeys on Piagets AB task, evidence for dependence on dorso lateral prefrontal cortex. Experimental Brain Research, 74, 24-40.
  • DILLON, D., GORMAN, J., et al (1987). Measurement of lactate induced panic and anxiety. Psychiatry Research, 20, 97-105.
  • EILAM, D., GOLANI, I., et al (1989). D2-agonist quinpirole induces perseveration of routes and hyperactivity but no perseveration of movements. Brain Research, 490, 225-267.
  • FERRARESE, C., APOLLONIO, I., et al (1990). Decreased density of benzodiazepine receptors in lymphocytes of anxious patients, reversal after chronic diazepam treatment. Acta Psychiatrica Scandinavica, 82, 169-173.
  • FILE, S.E. (1990). Preclinical studies of the mechanisms of anxiety and its treatment. In: J.C. BALLENGER (Ed.), Neurobiology of panic disorder (pp. 31-48). New York: Alan R. Liss.
  • FLAMENT, M.F., RAPOPORT, J.L., et al. (1987). Biochemical changes during clomipramine treatment of childhood obsessive compulsive disorder. Archives of General Psychiatry, 44, 219-225.
  • FRYE, P.E. & ARNOLD, L.E. (1981). Persistent amphetamine-induced compulsive rituals, response to pyridoxine. Biological Psychiatry, 16, 583-587.
  • FYER, A., LIEBOEITZ, M.R., et al (1985). Lactate vulnerability of remitted panic patients. Psychiatry Research, 14, 143-148.
  • GARVEY, M.A., GIEDD, J., et al (1998). PANDAS, the search for environmental triggers of pediatric neuropsychiatrie disorders. Lessons from rheumatic fever. Journal of Child Neurology, 13, 413-423.
  • GEORGE, M.S. & BALLENGER, J.C. (1992). The neuroanatomy of panic disorder, the emerging role of the right parahippocampal region. Journal of Anxiety Disorders, 6, 181-188.
  • GERMINE, M., GODDARD, A.W., et al (1992). Anger and anxiety responses to m-chlororphenylpiperazinein generalized anxiety disorder. Biological Psychiatry, 32, 457-467.
  • GIEDD, J.N., RAPOPORT, J.L., et al (2000). MRI assessment of children with obssessive compulsive disorder or tics associated with streptococcal infection. American Journal Psychiatry, 157, 281-283.
  • GLOOR, P. (1960). Amygdala. In: J. Field (Ed.), Handbook in Physiology (pp. 1395-1420). Washington, DC: American Physiological Society.
  • GOBNJIAN, A.K., YEHUDA, R., et al. (1996). Basal cortisol and dexamethasone suppression of cortisol among adolescents after the, 1988 earthquake in Armenia. American Journal Psychiatry, 153, 929-934.
  • GOLDMAN-RAKIC, P.S. & BROWN, R.M. (1982). Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys. Brain Research, 25, 339-349.
  • GOODGLASS, H. & KAPLAN, E. (1972). An assessment of aphasia and related disorders. Philadelphia, PA: Lea and Fibiger.
  • GORMAN, J., FYER, R., et al (1988). Ventilatory physiology of patients with panic disorder. Archives of General Psychiatry, 45, 31-39.
  • GORMAN, J., PAPP, L.A., et al (1994). Anxiogenic effects of carbon dioxide and hyperventilation in patients with panic disorder. American Journal Psychiatry, 151, 547-553.
  • GORMAN, J.M., PAPP, L.A., et al (1990). High dose carbon dioxide challenge test in anxiety disorder patients. Biological Psychiatry, 28, 743-757.
  • GOULD, E., CAMERON, H., et al (1994). Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyms. Journal of Comp Neurology, 340, 551-565.
  • GRAY, T.S. (1989). Autonomie neuropeptide connections of the amygdala. In: Y. TACHE, J.E. MORLEY & M.R. BROWN (Eds), Neuropeptides and stress (pp. 92-106). New York: Springer-Verlag.
  • GREENHILL, L.L., PINE, D.S., et al (1998). Assessment issues in treatment research on pediatric anxiety disorders, what is working, what is not working, and what needs improvement. Psychology Bulletin, 34, 155-164.
  • GRIEZ, E., DELOOF, C., et al (1990). Specific sensitivity of patients with panic attacks to carbon dioxide inhalation. Psychiatry Research, 31, 193-199.
  • GRILLON, C., DIERKER, L., et al (1998). Fear-potentiated startle in adolescent offspring of parents with anxiety disorders. Biological Psychiatry, 44, 990-997.
  • GURGUIN, G.N. & UHDE, T.W. (1990). Plasma 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and growth hormone responses to yohimbine in panic disorder patients and normal controls. Psychoneuroendocrinology, 15, 217-224.
  • GURVTTS, T.G., SHELTON, M.R., et al (1996). Magnetic resonance imaging study of hippocampal volume in chronic, combat-related PTSD. Biological Psychiatry, 40, 1091-1099.
  • HANNA, G.L., YUWILER, A., et al (1991). Whole blood serotonin in juvenile obsessive compulsive disorder. Biological Psychiatry, 29, 738-744.
  • HAYWARD, C., KILLEN, J., et al (1992). Pubertal stage and panic attack history in sixth- and sevent-grade girls. American Journal Psychiatry, 149, 1239-1243.
  • HIRSHFELD, D.R., ROSENBAUM, J.F., et al (1992). Stable behavioral inhibition and its association with anxiety disorder. Journal of American Academy of Chad Adolescence Psychiatry, 31, 103-111.
  • HOEHN-SARIC, R., PEARLSON, G., et al (1991). Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients. American Journal Psychiatry, 148, 1243-1245.
  • HOLLANDER, E., DECARIA, C.M., et al (1991). 5-HT function and neurology of social phobia. 144th Annual Meeting of the American Psychiatric Association, New Orleans.
  • HOLLANDER, E., LIEBOWITZ, M.R., er al (1990). Fenflluramine, cortisol and anxiety (letter; comment). Psychiatry Research, 31, 211-213.
  • HOLT, P.E. & ANDREWS, G. (1989a). Hyperventilation and anxiety in panic disorder, social phobia, GAD and normal controls. Behavioural Research Therapy, 27, 453-460.
  • HOLT, P.E. & ANDREWS, G. (1989b). Provocation of panic, three elements of the panic reaction in four anxiety disorders. Behavioural Research Therapy, 27, 253-261.
  • HUTTENLOCHER, P.R. (1979). Synaptic density of human frontal cortex, developmental changes and effects of aging. Brain Research, 163, 195-205.
  • INSEL, T.R. (1992). Toward a neuroanatomy of obsessive-compulsive disorder. Archives of General Psychiatry, 49, 739-744.
  • INY, L.J., PECKNOLD, J., et al (1994). Studies of a neurochemical link between depression, anxiety and stress from 3H-imipramine and 3H-paroxetine binding on human platelets. Biological Psychiatry, 36, 281-291.
  • JUDD, F.K., APOSTALOPOULUS, M., et al (1994). Serotonergic function in panic disorder, endocrine responses to D-fenfluramine. Progress in Neuropsychopharmacology Biology Psychiatry, 18, 329-337.
  • KAGAN, J. & SNIDMAN, N. (1999). Early childhood predictors of adult anxiety disorders. Biological Psychiatry, 46, 1536-1541.
  • KAGAN, J., REZNICK, J.,et al. (1984). Behavioral inhibition to the unfamiliar. Child Development, 55, 2212-2225.
  • KAGAN, J., REZNICK, J.S., et al (1987). The physiology and psychology of behavioral inhibition in children. Child Development, 58, 1459-1473.
  • KAGAN, J., REZNICK, J.S., et al (1988). Biological bases of childhood shyness. Science, 240, 167-171.
  • KAHN, R.S., WETZLER, S., et al (1988). Behavioral indications for serotonin receptor hypersensitivity in panic disorder. Psychiatry Research, 25, 101-104.
  • KALIN, N.H. (1993). The neurobiology of fear. Scientific American, 268, 94-101.
  • KAPP, B.S., PASCOE, J.P., et al (1984). The amygdala, a neuroanatomical systems approach to its contribution to aversive conditioning. In: N. BUTTER & L. S. SQUIRES (Eds), The Neuropsychology of Memory (pp. 473-488). New York Guilford.
  • KAPP, B.S., SUPPLE, W.F., et al (1994). Effects of electrical stimulation of the amygdaloid central nucleus on neurocortical arousal in the rabbit. Behavioural Neuroscience, 108, 81-93.
  • KELLNER, M., BAKER, D., et al (1997). Salivary cortisol in Operation Desert Storm returnees. Biological Psychiatry, 41, 849-850.
  • KHANNA, S. (1988). Obsessive-compulsive disorder, is there frontal lobe dysfunction? Biological Psychiatry, 24, 602-613.
  • KLEIN, R.G. (1995a). Anxiety disorders. In: M. RUTTER, E. TAYLOR & L. HERSOV (Eds), Chad and adolescent psychiatry, modern approaches (pp. 351-374). London: Blackwell Scientific Publications.
  • KLEIN, R.G. (1995b). Is panic disorder associated with childhood separation anxiety disorder. Clinical Neuropharmacology, 18(Suppl. 2), S7-S14.
  • KOOB, G.F., HEINRICHS, S.C., et al (1998). Animal models of anxiety disorders. In: A.F. SCHATZBERG & C.B. NEMEROFF (Eds), Textbook of Psychopharmacology (pp. 133-144). Washington, DC: American Psychiatric Press.
  • LANDIS, C. & HUNT, W.A. (1939). The startle pattern. New York: Farrar and Rhinehart.
  • LAPIERRE, Y., KNOTT, V., er ai (1984). Psychophysiological correlates of sodium lactate. Psychopharmacology Bulletin, 20, 50-57.
  • LEDOUX, J.E. (1987). Emotion. In: F. PLUM (Ed.), Handbook of physiology (vol. 5, pp. 416-459). Bethesda, MD: American Physiological Society.
  • LEE, M.A., CAMERON, O.G., et al. (1990). Alpha2-adrenoreceptor status in obsessive-compulsive disorder. Biological Psychiatry, 27, 1083-1093.
  • LEMIEUX, A.M. & COE, C.L. (1995). Abuse-related post-traumatic stress disorder, evidence for chronic neuroendocrine activation in women. Psychosomatic Medecine, 57, 105-115.
  • LESCH, K.P., WIESMANN, M., et al (1992). 5-HT1A receptor-effector system responsivity in panic disorder. Psychopharmacology, 106, 111-117.
  • LIEBOWITZ, M.R., FYER, A.J., et al (1985). Specificity of lactate infusions in social phobia versus panic disorder. American Journal of Psychiatry, 142, 947-950.
  • LLOYD, R.L. & KLING, A.S. (1991). Delta activity from amygdala in squirrel monkeys, influence of social and environmental contexts. Behavioural Neuroscience, 105, 223-229.
  • LURIA, A.R. (1966). Higher cortical Junction in man. New York: Basic Books.
  • MALIZZIA, A.L. (1997). PET studies in experimental andpathological anxiety. Journal of Psychopharmacology, 11, A88.
  • McBRIDE, P., TIERNEY, H., et al (1990). Effects of age and gender on CNS serotonergic responsivity in normal adults. Biological Psychiatry, 27, 1143-1155.
  • McDOUGLE, C.J., GOODMAN, W., et al (1989). Pathophysiology of obsessive-compulsive disorder. American Journal Psychiatry, 146, 1350-1351.
  • McEWEN, B.S. (1994). The plasticity of the hippocampus is the reason for its vulnerability. Seminal Neuroscience, 6, 239-246.
  • McFALL, M., MURBURG, M., et al (1990). Autonomie response to stress in Vietnam combat veterans with posttraumatic stress disorder. Biological Psychiatry, 27, 1165-1175.
  • MERKANGAS, K.R., AVENEVOLI, S., et al (1999). Vulnerability factors among children at risk for anxiety disorders. Biological Psychiatry, 46, 1523-1535.
  • MODELL, J.G., MOUNTZ, J.M. et al (1989). Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. Journal of Neuropsychiatry, 1, 27-36.
  • MOREAU, D. & FOLLETT, C. (1993). Panic disorder in children and adolescents. Child and Adolescent Psychiatric Clinics of North America, 2, 581-602.
  • MORGAN, C.A., GRILLON, C., et al (1995). Fearpotentiated startle in posttraumatic stress disorder. Biological Psychiatry, 38, 378-385.
  • MORGAN, C.A., GRILLON, C., et al (1996). Exaggerated acoustic startle reflex in Gulf War veterans with posttraumatic stress disorder. American Journal Psychiatry, 153, 64-68.
  • MORGAN, M.A. & LBDOUX, J.E. (1995). Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear. Behavioral Neuroscience, 109, 681-688.
  • MORGAN, M.A., ROMANSKI, L.M. et al (1993). Extinction of emotional learning, contribution of the prefrontal cortex. Neuroscience Letters, 163, 109-113.
  • MUNJACK, D.J., BALTAZAR, P.L., et al. (1990). Generalized anxiety disorder, some biological aspects. Psychiatry Research, 32, 35-43.
  • NINAN, P.T. (1999). The functional anatomy, neurochemistry, and pharmacology of anxiety. Journal of Clinical Psychiatry, 60(Suppl. 22), 12-17.
  • NUTT, D.J. (1989). Altered central alpha-2 sensitivity in panic disorder. Archives of General Psychiatry, 46, 165-169.
  • ORR, S.P., LASKO, N.B., et ai. (1995). Physiologie responses to loud tones in Vietnam veterans with posttraumatic stress disorder. Journal of Abnormal Psychology, 104, 75-82.
  • PALMOUR, R., ERVIN, R., et al. (1991). The anxiogenic and cardiovascular effects of CCK-4 are blocked by CCK-B antagonists LY 262,691. Neuroscience, 17, 1602.
  • PAPP, L.A., KLEIN, D.F., et al. (1993). Diagnostic and substance specificity in carbon dioxide-induced panic. American Journal Psychiatry, 150, 250-257.
  • PASSINGHAM, R.E. (1972). Visual discrimination learning after selective prefrontal ablations in monkeys. Neuropsychologia, 10, 27-39.
  • PATARROYO, M.E., WINCHESTER, R.J., et al (1979). Association of a B-cell alloantigen with susceptibility to rheumatic fever. Nature, 278, 173-174.
  • PAULS, D.L., ALSOBROOK, J.P., et al (1995). A family study of obsessive-compulsive disorder. American Journal Psychiatry, 152, 76-84.
  • PERNA, G., BATTAGLIA, M., et al. (1993). Carbon dioxide/oxygen challenge test in panic disorder. Psychiatry Research, 52, 159-171.
  • PERNA, G., BERTANI, A., et al (1995). Laboratory responses of patients with panic and obsessive compulsive disorders to 35% CO2 challenges. American Journal Psychiatry, 152, 85-89.
  • PIERRI, J.N., KESHAVAN, M.S., et al (1996). Neurological soft signs, OCD and offspring at risk for schizophrenia. 43rd Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Philadelphia.
  • PIGOTT, T.A., HILL, J.L., et al (1993). A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to IV mCPP. Biological Psychiatry, 33, 3-14.
  • PINE, D.S. (1999). Pathophysiology of childhood anxiety disorders. Biological Psychiatry, 46, 1555-1566.
  • PINE, D.S., COHEN, P., et al (1996). Emotional problems in youth as predictors of stature in early adulthood, results from a prospective epidemiologic study. Pediatrics, 97(6), 856-863.
  • PINE, D.S., COHEN, P., et al (1998a). The risk for early adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Archives of General Psychiatry, 55, 56-64.
  • PINE, D.S., COPLAN, J.D., et al (1995). Noradrenergic function in youth and adults with anxiety disorders. 42nd Annual Meeting of the American Academy of Child and Adolescent Psychiatry, New York.
  • PINE, D.S., COPLAN, J.D., et al (1998b). Ventilatory physiology of children and adolescents with anxiety disorders. Archives of General Psychiatry, 55, 123-129.
  • PINE, D.S., KLEIN, R.G., et al (2000). Differential carbon dioxide sensitivity in childhood anxiety disorders and nonill comparison group. Archives of General Psychiatry, 57, 960-967.
  • PITKANEN, A., STEFANACI, L., et al (1995). Intrinsic connections of the rat amygdaloid complex, projections originating in the basolateral nucleus. Journal of Comp. Neurology, 356, 288-310.
  • PLOTSKY, P.M. & MEANEY, M.J. (1993). Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) release in adult rats. Molecular Brain Research, 18, 195-200.
  • POHL, R., YERAGANI, V.K., et al (1988). Isoproterenol inducedpanic attacks. Biological Psychiatry, 24, 891-902.
  • RAPEE, R.M., BROWN, T.A., et al (1992). Response to hyperventilation and inhalation of 5.5% carbon dioxide enriched air across the DSM-III-R anxiety disorders. Journal of Abnormal Psychology, 101, 538-552.
  • RAUCH, S.L., JENICKE, M.A., et al. (1994). Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labelled carbon dioxide and positron emission tomography. Archives of General Psychiatry, 51, 62-70.
  • REIMAN, E.M., RAICHLE, M.E., et al (1989). Neuroanatomical correlates of a lactate-induced anxiety attack. Archives of General Psychiatry, 46, 469-477.
  • RESNICK, H.S., YEHUDA, R., et al (1995). Effect of prior trauma on acute hormonal response to rape. American Journal Psychiatry, 152, 1675-1677.
  • REZNICK, J.S., KAGAN, J., et al (1986). Inhibited and uninhibited children, a follow up study. Chad Development, 57, 660-680.
  • RIFKIN, A., KLEIN, D.F., et al (1981). Blockade by imipramine or desipramine of panic induced by sodium lactate. American Journal Psychiatry, 138, 676-677.
  • ROCCA, P., FERRERO, P., et al (1991). Peripheral-type benzodiazepine receptors in anxiety disorders. Acta Psychiatrica Scandtnavica, 84, 537-544.
  • ROSENBAUM, A.H., SCHATZBERG, A.F., et al (1983). Urinary free cortisol levels in anxiety. Psychosomatics, 24, 835-837.
  • ROSENBERG, D. & LEWIS, D. (1994). Changes in the dopaminergic innervation of monkey prefrontal cortex during late postnatal development, a tyrosine hydroxylase immunohistochemical study. Biological Psychiatry, 46, 272-277.
  • ROSENBERG, D. & LEWIS, D. (1995). The postnatal development of the dopaminergic innervation of monkey prefrontal cortex and motor cortices, a tyrosine hydroxylase immunohistochemical analysis. Journal of Comp. Neurology, 36, 272-277.
  • ROSENBERG, D.R. & KESHAVAN, M.S. (1998). Toward a neurodevelopmental model of obsessive-compulsive disorder. Biological Psychiatry, 43, 623-640.
  • ROSENBERG, D.R., AVERBACH, D.H., et al. (1997a). Oculomotor response inhibition abnormalities in pediatric obsessive-compulsive disorder. Archives of General Psychiatry, 54, 831-838.
  • ROSENBERG, D.R., KESHAVAN, M.S., et al (1997b). Fronto-striatal morphology of treatment-naive pediatric obsessive compulsive disorder. Archives of General Psychiatry, 54, 824-830.
  • ROSENBERG, D.R., MACMASTER, F.F., et al (2000). Decrease in caudate glutamatergic concentrations in pediatric obsessive compulsive disorder patients taking paroxetine. Journal of American Academy of Chad and Adolescent Psychiatry, 39, 1096-1103.
  • ROSVOLD, H.E. & MISHKIN, M. (1961). Non-sensory effects of frontal lesions on discrimination learning and performance. In: J.F. DELAFRESNAYE (Ed.), Brain Mechanisms and Learning (pp. 555-576). Oxford, B lackwell.
  • SALLEE, F.R. & GREENWALD, J. (1995). Neurobiology. In: J. MARCH (Ed.), Anxiety disorders in children and adolescents (pp. 3-34). New York, Guilford.
  • SALLEE, F.R., RICHMAN, H., et al. (1996). Platelet serotonin transporter in children and adolescents with obsessive compulsive disorder and Tourelles syndrome. Journal of American Academy of Child and Adolescent Psychiatry, 35, 1647-1656.
  • SALLEE, F.R., RICHMAN, H., et al (1998). Clonidine challenge in childhood anxiety disorder. Journal of American Academy of Child and Adolescent Psychiatry, 37(6), 655-662.
  • SANDERSON, M. & WETZLER, S. (1990). Five percent carbon dioxide challenge, valid analogue and marker of panic disorder? Biological Psychiatry, 27, 689-701.
  • SAPOLSKY, M., KREY, L.C., et al (1986). The neuroendocrinology of stress and aging, the glucocorticoid cascade hypothesis. Endocrinology Review, 7, 284-306.
  • SARTER, M. & MARKOWITSCH, H.J. (1985). Involvement of the amygdala in learning and memory. Behavioral Neuroscience, 99, 342-380.
  • SAVANDER, V., GO, C.-G., et al. (1995). Intrinsic connections of the rat amygadaloid complex, projections originating in the basal nucleus. Journal of Comp. Neurology, 361, 345-368.
  • SCHNEIER, F., LIEBOWITZ, M.R., et al (2000). Low dopamine D2 binding potential in social phobia. American Journal Psychiatry, 157, 457-459.
  • SELYE, H. (1976). The stress of life. NewYork, McGraw-Hill.
  • SEVY, S., PAPADIMITRIOU, G.N., et al (1989). Noradrenergic function in generalized anxiety disorder, major depressive disorder, and healthy subjects. Biological Psychiatry, 25, 141-152.
  • SHALEV, A.Y., ORR, S.P., et al (1992). Physiologic responses to loud tones in Israeli patients with posttraumatic stress disorder. Archives of General Psychiatry, 49, 870-875.
  • SHALEV, A.Y., SAHAR, T., et al (1998). A prospective study of heart rate responses following trauma and the subsequent development of PTSD. Archives of General Psychiatry, 55, 553-559.
  • SHIN, L.M., McNALLY, R.J., et al (1999). Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD, a PET investigation. American Journal Psychiatry, 156, 575-584.
  • SIEGEL, D.J. (2001). Memory, an overview with emphasis on developmental, interpersonal and neurobiological aspects. Journal of American Academy of Child and Adolescent Psychiatry, 40, 997-1011.
  • SIEIVER, L.J., INSEL, T.R., et al (1983). Growth hormone response to clonidine in obsessive-compulsive patients. British Journal of Psychiatry, 142, 184-187.
  • SOUTHWICK, S.M., KRYSTAL, J.H., et al. (1993). Abnormal noradrenergic function in posttraumatic stress disorder. Archives of General Psychiatry, 50, 266-274.
  • STEIN, M.B. (1998). Neurobiological perspectives on social phobia, from affiliation to zoology. Biological Psychiatry, 44, 1277-1285.
  • STEIN, M.B. & LESLIE, W.D. (1996). A brain single photon emission computed tomography study of generalized social phobia. Biological Psychiatry, 39, 825-828.
  • STEIN, M.B., KOVEROLA, C., et al. (1997a). Hippocampal volume in women victimized by childhood sexual abuse. Psychology Medicine, 27, 951-960.
  • STEIN, M.B., YEHUDA, R., et al (1997b). Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biological Psychiatry, 42, 680-686.
  • STUSS, D.T. & BENSON, D.F. (1983). Frontal lobe lesions and behavior. In: A. KERTESZ (Ed.), Localization in neuropsychology (pp. 429-449). New York: Academic Press.
  • SUOMI, S.J. (1986). Anxiety-like disorders in young nonhuman primates. In: R. GITTLEMAN (Ed.), Anxiety disorders of childhood (pp. 1-23). New York: Guilford Press.
  • SUOMI, S.J. (1987). Genetic and maternal contributions to individual differences in rhesus monkey biobehavioral development. In: N.A. KRASNEGOR, E.M. BLASS, M.A. HOFER & W.P. SMOTHERMAN (Eds), Perinatal development, a psychobiological perspective (pp. 397-419). Orlando, FL: Academic Press.
  • SUOMI, S.J., KRAEMER, G.W., et al (1981). Inherited and experiential factors associated with individual differences in anxious behavior displayed by rhesus monkeys. In: D.F. KLEIN & J. RABKIN (Eds), Anxiety, new research and changing concepts (pp. 179-199). New York: Raven Press.
  • SWEDO, S.E., KILPATRICK, K., et al. (1991). Antineuronal antibodies in Sydenhams chorea and obsessive compulsive disorder. Pediatric Research, 29, 364A.
  • SWEDO, S.E., LEONARD, H.L., et al (1997). Identification of children with pediatric autoimmune neuropsychiatrie disorders associated with streptococcal infections by a marker associated with rheumatic fever. American Journal Psychiatry, 154, 110-112.
  • SWEDO, S.E., PIETRINI, P., et al (1992). Cerebral glucose metabolism in childhood-onset obsessive compulsive disorder, revisualization during pharmacotherapy. Archives of General Psychiatry, 49, 690-694.
  • SWEENEY, J.A., MINTUN, M.A., et al (1996). A positron emission tomography study of voluntary saccadic eye movements and spatial working memory. Journal of Nuerophysiology, 75, 454-468.
  • SZESZKO, P.R., ROBINSON, D., et al (1999). Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Archives of General Psychiatry, 56, 913-919.
  • TANCER, M.E. (1993). Neurobiology of social phobia. Journal of Clinical Psychiatry, 54(Suppl. 12), 26-30.
  • TANCER, M. E., MAILMAN, R.B., et al (1994/1995). Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia. Anxiety, 1, 216-223.
  • TANCER, M.E., STEIN, M.B., et al (1993). Growth hormone response to intravenous clonidine in social phobia, comparison to patients with panic disorder and healthy volunteers. Biological Psychiatry, 34, 591-595.
  • TARGUM, S.D. (1990). Differential responses to anxiogenic challenge studies in patients with major depressive disorder and panic disorder. Biological Psychiatry, 28, 21-34.
  • TARGUM, S.D. (1992). Cortisol response during different anxiogenic challenges in panic disorder patients. Psychoneuroendocrinology, 17, 453-458.
  • TARGUM, S.D. & MARSHALL, L.E. (1989). Fenfluramine provocation of anxiety in patients with panic disorder. Psychiatry Research, 28, 295-306.
  • TIEN, A.Y., PEARLSON, G.D., et al (1992). Oculomotor performance in obsessive compulsive disorder. American Journal Psychiatry, 149, 641-646.
  • TIIHONEN, J., KUIKKA, J., et al (1997). Dopamine reuptake site densities in patients with social phobia. American Journal Psychiatry, 154, 239-242.
  • TILLER, J.G., BIDDLE, N., et al (1988). The dexamethasone suppression test and plasma dexamethasone in generalized anxiety disorder. Biological Psychiatry, 23, 261-270.
  • TUPLER, LA., DAVIDSON, J.R.T., et al (1997). A repeat magnetic resonance spectroscopy study in social phobia. Biological Psychiatry, 42, 419-424.
  • UHDE, T.W., STEIN, M.B., et al (1989). Behavioral and physiologic effects of short-term and long-term administration of clonidine in panic disorder. Archives of General Psychiatry, 46, 170-177.
  • WAHLESTEDT, C., PICH, E., et al (1993). Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science, 259, 528-531.
  • WALLACH, M.B. (1974). Drug-induced stereotyped behavior, similarities and differences. Psychology Bulletin, 10, 12-13.
  • WEIZMAN, R., TANNE, Z., et al (1987). Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients. European Journal of Pharmacology, 138, 289-292.
  • WOODS, S., CHARNEY, D.S., et al (1986). Carbon dioxide sensitivity in panic anxiety. Ventilatory and anxiogenic response to carbon dioxide in healthy subjects and patients with panic anxiety before and after alprazolam treatment. Archives of General Psychiatry, 43, 900-909.
  • WOODS, S., CHARNEY, D.S., et al (1988). Carbon dioxide induced anxiety. Archives of General Psychiatry, 45, 43-52.
  • WOODS, S., CHARNEY, D.S., et al (1990). The effects of long term imipramine treatment on carbon dioxide induced anxiety in panic disorder patients. Journal of Clinical Psychiatry, 51, 505-507.
  • WOODS, S.W. (1992). Regional cerebral blood flow imaging with SPECT in psychiatric disease, focus on schizophrenia, anxiety disorders, and substance abuse. Journal of Clinical Psychiatry, 53(Suppl. 11), 20-25.
  • YEHUDA, R. (1999). Parental PTSD as a risk factor for PTSD. In: R. YEHUDA (Ed.), Progress in Psychiatry Series. Washington, DC: American Psychiatric Association.
  • YEHUDA, R. (2000). Biology of posttraumatic stress disorder. Journal of Clinical Psychiatry, 61(Suppl. 7), 14-21.
  • YEHUDA, R., BOISONEAU, D., et al (1995a). Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Archives of General Psychiatry, 52, 583-593.
  • YEHUDA, R., KAHANA, B., et al (1995b). Low urinary cortisol excretion in Holocaust survivors with posttraumatic stress disorder. American Journal Psychiatry, 152, 982-986.
  • YEHUDA, R., MCFARLANE, A.C., et al. (1998). Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event. Biological Psychiatry, 44, 1305-1313.
  • YEHUDA, R., SIEVER, L.J., et al (1998). Plasma norepinephrine and MHPG concentrations and severity of depression in combat PTSD and major depressive disorder. Biological Psychiatry, 44, 56-63.
  • YEHUDA, R., SOUTHWICK, S.M., et al. (1990). Low urinary cortisol excretion in PTSD. Journal of Nervous Mental Disorder, 178, 366-369.
  • YEHUDA, R., SOUTHWICK, S.M., et al (1993). Enhanced suppression of cortisol following dexamethasone administration in combat veterans with posttraumatic stress disorder and major depressive disorder. American Journal Psychiatry, 150, 83-86.
  • YERAGANI, V.K., POHL, R., et al (1988). Sodium lactate infusions after treatments with tricyclic antidepressants, behavioral and physiological findings. Biological Psychiatry, 24, 767-774.
  • ZOHAR, J. & INSEL, T. (1987). Obsessive compulsive disorder, psychobiological approaches to diagnosis, treatment and pathophysiology. Biological Psychiatry, 22, 667-687.

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