Molecular imaging of autism spectrum disorder

References

• Ajram, L.A., Horder, J., Mendez, M.A., Galanopoulos, A., Brennan, L.P., Wichers, R.H., …. McAlonan, G.M. (2017). Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder. Translational Psychiatry, 7, e1137. doi:https://doi.org/10.1038/tp.2017.104
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.) (DSM-5). Arlington, VA: Author.
   Google Scholar
• Aoki, Y., Kasai, K., & Yamasue, H. (2012). Age-related change in brain metabolite abnormalities in autism: A meta-analysis of proton magnetic resonance spectroscopy studies. Translational Psychiatry, 2, e69. doi:https://doi.org/10.1038/tp.2011.65
   PubMed Web of Science ®Google Scholar
• Attwood, T. (1997). Asperger’s syndrome: A guide for parents and professionals. London, UK: Jessica Kingsley Publishers.
   Google Scholar
• Balz, J., Keil, J., Roa Romero, Y., Mekle, R., Schubert, F., Aydin, S., … Senkowski, D. (2016). GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion. Neuroimage, 125, 724–730. doi:https://doi.org/10.1016/j.neuroimage.2015.10.087
   PubMed Web of Science ®Google Scholar
• Barker, P.B. (2001). N-acetyl aspartate-a neuronal marker? Annals of Neurology, 49, 423–424. doi:10.1002/ana.90
   PubMed Web of Science ®Google Scholar
• Baron-Cohen, S., & Wheelwright, S. (2004). The empathy quotient: An investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders, 34, 163–175. doi:10.1023/B:JADD.0000022607.19833.00
   PubMed Web of Science ®Google Scholar
• Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17. doi:10.1023/A:1005653411471
   PubMed Web of Science ®Google Scholar
• Beaty, H.W. (2006). Units, symbols, constants, definitions, and conversion factors. In H.W. Beaty (Ed.), Standard handbook for electrical engineers (pp. 1-1–1-57). Columbus, OH: McGraw Hill Companies. Retrieved from www.digitalengineeringlibrary.com
   Google Scholar
• Beversdorf, D.Q., Nordgren, R.E., Bonab, A.A., Fischman, A.J., Weise, S.B., Dougherty, D.D., … Bauman, M.L. (2012). 5-HT2 receptor distribution shown by [18F] setoperone PET in high-functioning autistic adults. The Journal of Neuropsychiatry and Clinical Neurosciences, 24, 191–197.
   PubMed Web of Science ®Google Scholar
• Blackstone, E.H. (2002). Comparing apples and oranges. The Journal of Thoracic and Cardiovascular Surgery, 123, 8–15. doi:10.1067/mtc.2002.120329
   PubMed Web of Science ®Google Scholar
• Blin, J., Sette, G., Fiorelli, M., Bletry, O., Elghozi, J.L., Crouzel, C., & Baron, J.C. (1990). A method for the in vivo investigation of the serotonergic 5-HT2 receptors in the human cerebral cortex using positron emission tomography and 18F-labeled setoperone. Journal of Neurochemisiry, 54, 1744–1754. doi:10.1111/j.1471-4159.1990.tb01229.x
   PubMed Web of Science ®Google Scholar
• Bottomley, P.A. (1987). Spatial localization in NMR spectroscopy in vivo. Annals of the New York Academy of Sciences, 508, 333–348. doi:10.1111/j.1749-6632.1987.tb32915.x
   PubMed Web of Science ®Google Scholar
• Brašić, J.R. (1999a). Asperger’s syndrome: A guide for parents and professionals. By Tony Attwood. London: Jessica Kingsley Publishers, Ltd. 1998. Neurology, 52, 1112. [book review]
   Google Scholar
• Brasić, J.R. (1999b). Movements in autistic disorder. Medical Hypotheses, 53, 48–49.
   PubMed Web of Science ®Google Scholar
• Brašić, J.R. (2003a). Documentation of demographic data. Psychological Reports, 9, 151–152.
   Google Scholar
• Brašić, J.R. (2003b). Treatment of movement disorders in autism spectrum disorders. In E. Hollander (Ed), Autism Spectrum Disorders. Volume 24 of the Medical Psychiatry Series (pp. 273–346). New York: Marcel Dekker, Inc.
   Google Scholar
• Brašić, J.R. (2004). Documentation of ethnicity. Psychological Reports, 95, 859–861.
   PubMed Web of Science ®Google Scholar
• Brašić, J.R. (2013). Neurotransmitter visualization in schizophrenia. Journal of Biomedical Graphics and Computing, 3, 30–45.
   Google Scholar
• Brasic, J.R. (2014, March 26). Asperger Syndrome. Medscape Drugs & Diseases. Retrieved from http://emedicine.medscape.com/article/912296-overview
   Google Scholar
• Brasic, J.R. (2016). Catatonia. Medscape Drugs & Diseases, November 3. Retrieved from http://emedicine.medscape.com/article/1154851-overview
   Google Scholar
• Brasic, J.R. (2017a). A 20-year-old man who stopped speaking. Medscape, July 31. Retrieved from http://reference.medscape.com/viewarticle/883207_6
   Google Scholar
• Brasic, J.R. (2017b). A 33-year-old woman with rigidity and stereotypies. Medscape, April 25. Retrieved from http://reference.medscape.com/viewarticle/878930
   Google Scholar
• Brasic, J.R. (2017c). Autism. Medscape Drugs & Diseases, April 21. Retrieved from http://emedicine.medscape.com/article/912781-overview
   Google Scholar
• Brasić, J.R., & Barnett, J.Y. (1997). Hyperkinesias in a prepubertal boy with autistic disorder treated with haloperidol and valproic acid. Psychological Reports, 80, 163–170.
   PubMed Web of Science ®Google Scholar
• Brasić, J.R., Barnett, J.Y., Ahn, S.C., Nadrich, R.H., Will, M.V., & Clair, A. (1997). Clinical assessment of self-injurious behavior. Psychological Reports, 80, 155–160.
   PubMed Web of Science ®Google Scholar
• Brasić, J.R., Barnett, J.Y., Aisemberg, P., Ahn, S.C., Nadrich, R.H., Kaplan, D., … Mendonça, M.F. (1997). Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation. Psychological Reports, 81, 755–767.
   PubMed Web of Science ®Google Scholar
• Brasić, J.R., Barnett, J.Y., Kaplan, D., Sheitman, B.B., Aisemberg, P., Lafargue, R.T., … Young, J.G. (1994). Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. Neurology, 44, 1309–1312.
   PubMed Web of Science ®Google Scholar
• Brašić, J.R., Barnett, J.Y., Kowalik, S., Tsaltas, M.O., & Ahmad, R. (2004). Neurobehavioral assessment of children and adolescents attending a developmental disabilities clinic. Psychological Reports, 95, 1079–1086.
   PubMed Web of Science ®Google Scholar
• Brasić, J.R., Barnett, J.Y., Sheitman, B.B., Lafargue, R.T., & Ahn, S.C. (1998). Clinical assessment of adventitious movements. Psychological Reports, 83, 739–750.
   PubMed Web of Science ®Google Scholar
• Brasić, J.R., Barnett, J.Y., Sheitman, B.B., Lafargue, R.T., Kowalik, S., Kaplan, D., … Mendonça, M.F. (1998). Behavioral effects of clomipramine on prepubertal boys with autistic disorder and severe mental retardation. CNS Spectrums, 3, 39–46.
   Google Scholar
• Brašić, J.R., Bibat, G., Kumar, A., Zhou, Y., Hilton, J., Yablonski, M.E., … Naidu, S. (2012). Correlation of the vesicular acetylcholine transporter densities in the striata to the clinical abilities of women with Rett syndrome. Synapse, 66, 471–482. doi:10.1002/syn.21515.
   PubMed Web of Science ®Google Scholar
• Brašić, J.R., Cascella, N., Kumar, A., Zhou, Y., Hilton, J., Raymont, V., … Wong, D.F. (2012). Positron emission tomography (PET) experience with 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]FA) in the living human brain of smokers with paranoid schizophrenia. Synapse, 66, 352–368.
   PubMed Web of Science ®Google Scholar
• Brasic, J.R., & Gianutsos, J.G. (2000). Neuromotor assessment and autistic disorder. Autism: The International Journal of Research and Practice, 4, 287–298. doi:10.1177/1362361300004003005
   Google Scholar
• Brašić, J.R., & Holland, J.A. (2006). Reliable classification of case-control studies of autistic disorder and obstetric complications. Journal of Developmental and Physical Disabilities, 18, 355–381.
   Web of Science ®Google Scholar
• Brašić, J.R., & Holland, J.A. (2007). A qualitative and quantitative review of obstetric complications and autistic disorder. Journal of Developmental and Physical Disabilities, 19, 337–364.
   Web of Science ®Google Scholar
• Brašić, J.R., & Kim, J. (2014). The nicotine hypothesis. In B. Madras & M. Kuhar (Eds.), The effects of drug abuse on the human nervous system (pp. 313–332). Oxford, UK: Academic Press, Elsevier Science.
   Google Scholar
• Brašić, J.R., & Mohamed, M. (2014). Human brain imaging of autism spectrum disorders. In P. Seeman & B. Madras (Eds.), Imaging of the human brain in health and disease (pp. 373–406). Oxford, UK: Academic Press, Elsevier Science.
   Google Scholar
• Brasic, J.R., & Wong, D.F. (2015). PET scanning in autism spectrum disorders. Medscape Drugs & Diseases, October 14. Retrieved from http://emedicine.medscape.com/article/1155568-overview
   Google Scholar
• Brasic, J.R., & Young, J.G. (1994). Research design, measures, and statistics. In K.S. Robson (Ed.), Manual of clinical child and adolescent psychiatry, revised edition (pp. 435–463). Washington, DC: American Psychiatric Press, Inc.
   Google Scholar
• Brašić, J.R., Zagzag, D., Kowalik, S., Prichep, L., John, E.R., Barnett, J.Y., … Brathwaite, C. (2000). Clinical manifestations of progressive catatonia. German Journal of Psychiatry, 3, 13–24. Retrieved from http://www.gwdg.de/∼bbandel/gjp-article-brasic.htm
   Google Scholar
• Brasić, J.R., Zagzag, D., Kowalik, S., Prichep, L., John, E.R., Liang, H.G., … Brathwaite, C. (1999). Progressive catatonia. Psychological Reports, 84, 239–246.
   PubMed Web of Science ®Google Scholar
• Brašić, J.R., Zhou, Y., Musachio, J.L., Hilton, J., Fan, H., Crabb, A., … Wong, D.F. (2009). Single photon emission computed tomography experience with (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers. Synapse, 63, 339–358.
   PubMed Web of Science ®Google Scholar
• Brix, M.K., Ersland, L., Hugdahl, K., Grüner, R., Posserud, M.B., Hammar, A., … Beyer, M.K. (2015). Brain MR spectroscopy in autism spectrum disorder-the GABA excitatory/inhibitory imbalance theory revisited. Frontiers of Human Neuroscience, 9, 365. doi:https://doi.org/10.3389/fnhum.2015.00365
   PubMed Web of Science ®Google Scholar
• Budimirovic, D.B., & Kaufmann, W.E. (2011). What can we learn about autism from studying fragile X syndrome? Developmental Neuroscience, 33, 379–394. doi:10.1159/000330213
   PubMed Web of Science ®Google Scholar
• Buxbaum, J.D. (2017). The Seaver Autism Center for Research and Treatment. Icahn School of Medicine at Mount Sinai, New York, New York, Treatment. Retrieved from http://icahn.mssm.edu/research/seaver/patients/treatment
   Google Scholar
• Cardin, J.A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., … Moore, C.I. (2009). Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature, 459, 663–667. doi:https://doi.org/10.1038/nature08002
   PubMed Web of Science ®Google Scholar
• Catana, C. (2017). Principles of simultaneous PET/MR imaging. Magnetic Resonance Imaging Clinics of North America, 25, 231–243. doi:10.1016/j.mric.2017.01.002
   PubMed Web of Science ®Google Scholar
• Chandana, S.R., Behen, M.E., Juhász, C., Muzik, O., Rothermel, R.D., Mangner, T.J., … Chugani, D.C. (2005). Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism. International Journal of Developmental Neuroscience, 23, 171–182.
   PubMed Web of Science ®Google Scholar
• Center for Molecular and Genomic Imaging, University of California Davis (UCDavis). (2017). Positron emission tomography (PET). Retrieved from https://bme.ucdavis.edu/cmgi/services/positron-emission-tomography-pet/
   Google Scholar
• Chen, M.K., Kuwabara, H., Zhou, Y., Adams, R.I., Brašić, J.R., McGlothan, J.L., & Guilarte, T.R. (2008). VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. Journal of Neurochemistry, 105, 78–90.
   PubMed Web of Science ®Google Scholar
• Chess, S. (1971). Autism in children with congenital rubella. Journal of Autism and Childhood Schizophrenia, 1, 33–47. doi:10.1007/BF01537741
   PubMedGoogle Scholar
• Chugani, D.C. (2012). Neuroimaging and neurochemistry of autism. Pediatric Clinics of North America, 59, 63–73. doi:10.1016/j.pcl.2011.10.002
   PubMed Web of Science ®Google Scholar
• Chugani, D.C., & Muzik, O. (2000). α-[C-11]methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. Journal of Cerebral Blood Flow and Metabolism, 20, 2–9.
   PubMed Web of Science ®Google Scholar
• Chugani, D.C., Muzik, O., Chakraborty, P., Mangner, T., & Chugani, H.T. (1998). Human brain serotonin synthesis capacity measured in vivo with α-[C-11]methyl-L-tryptophan. Synapse, 28, 33–43.
   PubMed Web of Science ®Google Scholar
• Chugani, D.C., Muzik, O., Behen, M., Rothermel, R., Janisse, J.J., Lee, J., & Chugani, H.T. (1999). Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of Neurology, 45, 287–295.
   PubMed Web of Science ®Google Scholar
• Chugani, D.C., Muzik, O., Rothermel, R., Behen, M., Chakraborty, P., Mangner, T., … Chugani, H.T. (1997). Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Annals of Neurology, 142, 666–669.
   Google Scholar
• Cohen, S. (2006). Targeting autism: What we know, don't know, and can do to help young children with autism spectrum disorders. Oakland, CA: University of California Press.
   Google Scholar
• Corrigan, N.M., Shaw, D.W.W., Estes, A.M., Richards, T.L., Munson, J., Friedman, S.D., … Dager, S.R. (2013). Atypical developmental patterns of brain chemistry in children with autism spectrum disorder. JAMA Psychiatry, 70, 964–974. doi:https://doi.org/10.1001/jamapsychiatry.2013.1388
   PubMed Web of Science ®Google Scholar
• Cox, R.W. (1996). AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Computers and Biomedical Research, 29, 162–173. doi:10.1006/cbmr.1996.0014
   PubMedGoogle Scholar
• De Volder, A., Bol, A., Michel, C., Cogneau, M., & Goffinet, A.M. (1987). Brain glucose metabolism in children with the autistic syndrome: Positron tomography analysis. Brain. & Development, 9, 581–587. doi:10.1016/S0387-7604(87)80089-X
   PubMed Web of Science ®Google Scholar
• Doyle-Thomas, K.A.R., Card, D., Soorya, L.V., Wang, A.T., Fan, J., & Anagnostou, E. (2014). Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders. Research in Autism Spectrum Disorders, 8, 44–51. doi:https://doi.org/10.1016/j.rasd.2013.10.003
   PubMed Web of Science ®Google Scholar
• Drenthen, G.S., Barendse, E.M., Aldenkamp, A.P., van Veenendaal, T.M., Puts, N.A., Edden, R.A., … Jansen, J.F. (2016). Altered neurotransmitter metabolism in adolescents with high-functioning autism. Psychiatry Research, 256, 44–49. doi:https://doi.org/10.1016/j.pscychresns.2016.09.007
   PubMed Web of Science ®Google Scholar
• Durieux, A.M., Fernandes, C., Murphy, D., Labouesse, M.A., Giovanoli, S., Meyer, U., … McAlonan, G. (2015). Targeting glia with N-Aacetylcysteine modulates brain glutamate and behaviors relevant to neurodevelopmental disorders in C57BL/6J Mice. Frontiers in Behavioral Neuroscience, 9, 343. doi:https://doi.org/10.3389/fnbeh.2015.00343
   PubMed Web of Science ®Google Scholar
• Ehlers, S., Gillberg, C., & Wing, L. (1999). A screening questionnaire for Asperger syndrome and other high-functioning autism spectrum disorders in schoolage children. Journal of Autism and Developmental Disorders, 29, 129–141. doi:10.1023/A:1023040610384
   PubMed Web of Science ®Google Scholar
• Eckelman, W.C. (2006). Imaging of muscarinic receptors in the central nervous system. Current Pharmaceutical Design, 12, 3901–3913. doi:10.2174/138161206778559678
   PubMed Web of Science ®Google Scholar
• Elze, M.C., Gregson, J., Baber, U., Williamson, E., Sartori, S., Mehran, R., … Pocock, S.J. (2017). Comparison of propensity score methods and covariate adjustment. Evaluation in 4 cardiovascular studies. Journal of the American College of Cardiology, 69, 345–357. doi:10.1016/j.jacc.2016.10.060
   PubMed Web of Science ®Google Scholar
• Endres, D., Tebartz van Elst, L., Meyer, S.A., Feige, B., Nickel, K., Bubl, A., … Perlov, E. (2017). Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: An MRS study. Molecular Autism, 8, 10. doi:https://doi.org/10.1186/s13229-017-0122-3
   PubMed Web of Science ®Google Scholar
• Fatemi, S.H. (2008). The hyperglutamatergic hypothesis of autism. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32, 911. [letter] doi:10.1016/j.pnpbp.2007.11.004
   PubMed Web of Science ®Google Scholar
• Frahm, J., Bruhn, H., Gyngell, M.L., Merboldt, K.D., Hänicke, W., & Sauter, R. (1989). Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo. Magnetic Resonance in Medicine, 9, 79–93. doi:10.1002/mrm.1910090110
   PubMed Web of Science ®Google Scholar
• Fukai, M., Hirosawa, T., Kikuchi, M., Ouchi, Y., Takahashi, T., Yoshimura, Y., … Minabe, Y. (2017). Oxytocin effects on emotional response to others’ faces via serotonin system. Psychiatry Research: Neuroimaging, 167, 45–50.
   Google Scholar
• Gellar, J.E., Colantuoni, E., Needham, D.M., & Crainiceanu, C.M. (2014). Variable-domain functional regression for modeling ICU data. Journal of the American Statistical Association, 109, 1425–1439. doi:10.1080/01621459.2014.940044
   PubMed Web of Science ®Google Scholar
• Gellar, J.E., Colantuoni, E., Needham, D.M., & Crainiceanu, C.M. (2015). Cox regression models with functional covariates for survival data. Statistical Modelling, 15, 256–278. doi:10.1177/1471082X14565526
   PubMed Web of Science ®Google Scholar
• George, N., Gean, E.G., Nandi, A., Frolov, B., Zaidi, E., Lee, H., … Wong, D.F. (2015). Advances in CNS imaging agents: Focus on PET and SPECT tracers in experimental and clinical use. CNS Drugs, 29, 313–330.
   PubMed Web of Science ®Google Scholar
• Gharib, A., Balende, C., Sarda, N., Weissmann, D., Plenevaux, A., Luxen, A., … Pujol, J.-F. (1999). Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: A reexaminations of the α-methyl-L-tryptophan method. Journal of Neurochemistry, 72, 2593–2600. doi:10.1046/j.1471-4159.1999.0722593.x.
   PubMed Web of Science ®Google Scholar
• Ginovart, N., Wilson, A.A., Meyer, J.H., Hussey, D., & Houle, S. (2001). Positron emission tomography quantification of [11C]-DASB binding to the human serotonin transporter: Modeling strategies. Journal of Cerebral Blood Flow and Metabolism, 21, 1342–1353. doi:10.1097/00004647-200111000-00010
   PubMed Web of Science ®Google Scholar
• Girgis, R.R., Slifstein, M., Xu, X., Frankle, W.G., Anagnostou, E., Wasserman, S., … Hollander, E. (2011). The 5-HT2A receptor and serotonin transporter in Asperger's disorder: A PET studywith [11C]MDL 100907 and [11C]DASB. Psychiatry Research: Neuroimaging, 194, 230–234.
   PubMed Web of Science ®Google Scholar
• Goji, A., Ito, H., Mori, K., Harada, M., Hisaoka, S., Toda, Y., … Kagami, S. (2017). Assessment of anterior cingulate cortex (ACC) and left cerebellar metabolism in Asperger's syndrome with proton magnetic resonance spectroscopy (MRS). PLoS One, 12, e0169288. doi:https://doi.org/10.1371/journal.pone.0169288
   PubMed Web of Science ®Google Scholar
• Golding, J. (2016). Commentary: Continuum of reproductive casualty-or causality? International Journal of Epidemiology, 45, 317–318. doi:10.1093/ije/dyw065
   PubMed Web of Science ®Google Scholar
• Goldberg, J., Anderson, G.M., Zwaigenbaum, L., Hall, G.B.C., Nahmias, C., Thompson, A., & Szatmari, P. (2009). Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 97–104. doi:10.1007/s10803-008-0604-4
   PubMed Web of Science ®Google Scholar
• Govindaraju, V., Young, K., & Maudsley, A.A. (2000). Proton NMR chemical shifts and coupling constants for brain metabolites. NMR in Biomedicne, 13, 129–153. doi:10.1002/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V
   PubMed Web of Science ®Google Scholar
• Hardan, A.Y., Fung, L.K., Frazier, T., Berquist, S.W., Minshew, N.J., Keshavan, M.S., & Stanley, J.A. (2016). A proton spectroscopy study of white matter in children with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 66, 48–53. doi:https://doi.org/10.1016/j.pnpbp.2015.11.005
   PubMed Web of Science ®Google Scholar
• Herold, S., Frackowiak, R.S.J., Le Couteur, A., Rutter, M., & Howlin, P. (1988). Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults. Psychological Medicine, 18, 823–831. doi:10.1017/S0033291700009752
   PubMed Web of Science ®Google Scholar
• Hirosawa, T., Kikuchi, M., Ouchi, Y., Takahashi, T., Yoshimura, Y., Kosaka, H., … Minabe, Y. (2017). A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder. Autism Research, 10, 821–828.
   PubMed Web of Science ®Google Scholar
• Hsu, D.F.C., Ilan, E., Peterson, W.T., Uribe, J., Lubberink, M., & Levin, C.S. (2017). Studies of a next-generation silicon-photomultiplier–based time-of-flight PET/CT system. Journal of Nuclear Medicine, 58, 1511–1518. doi:10.2967/jnumed.117.189514
   PubMedGoogle Scholar
• Huang, Y., Hwang, D.-R., Narendran, R., Sudo, Y., Chatterjee, R., Bae, S.-A., … Laruelle, M. (2002). Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. Journal of Cerebral Blood Flow & Metabolism, 22, 1377–1398.
   PubMed Web of Science ®Google Scholar
• Janik, R., Thomason, L.A., Stanisz, A.M., Forsythe, P., Bienenstock, J., & Stanisz, G.J. (2016). Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate. Neuroimage, 125, 988–995. doi:https://doi.org/10.1016/j.neuroimage.2015.11.018
   PubMed Web of Science ®Google Scholar
• Katsanis, N. (2016). The continuum of causality in human genetic disorders. Genome Biology, 17, 233. doi10.1186/s13059-016-1107-9
   PubMed Web of Science ®Google Scholar
• Kim, J., Horti, A.G., Mathews, W.B., Pogorelov, V., Valentine, H., Brasic, J.R., … Wong, D.F. (2015). Quantitative multi-modal brain autoradiography of glutamatergic, dopaminergic, cannabinoid, and nicotinic receptors in mutant Disrupted-In-Schizophrenia-1 (DISC1) mice. Molecular Imaging and Biology, 17, 355–363.
   PubMed Web of Science ®Google Scholar
• Knobloch, H., & Pasamanick, B. (1962). Etiologic factors in early infantile autism and childhood schizophrenia. Presented at the 10th International Congress of Paediatrics, Lisbon, Portugal, September, 1962 (Cited in M. Pollack, and M.G. Woerner. (1966). Pre- and perinatal complications and “childhood schizophrenia”: A comparison of five controlled studies. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 7, 235–242.
   Google Scholar
• Knobloch, H., & Pasamanick, B. (1975). Some etiologic and prognostic factors in early infantile autism and psychosis. Pediatrics, 55, 182–191.
   PubMed Web of Science ®Google Scholar
• Kumar, B.N.A., Malhotra, S., Bhattacharya, A., Grover, S., & Batra, Y.K. (2017). Regional cerebral glucose metabolism and its association with phenotype and cognitive functioning in patients with autism. Indian Journal of Psychological Medicine, 39, 262–270. doi:10.4103/0253-7176.207344
   PubMedGoogle Scholar
• Kurland, B.F., Johnson, L.L., Egleston, B.L., & Diehr, P.H. (2009). Longitudinal data with follow-up truncated by death: Match the analysis method to research aims. Statistical Science, 24, 211–222. doi:10.1214/09-STS293
   PubMed Web of Science ®Google Scholar
• Lam, K.S.L., & Aman, M.G. (2007). The repetitive behavior scale-revised: Independent validation in individuals with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 855–866. doi:10.1007/s10803-006-0213-z
   PubMed Web of Science ®Google Scholar
• LeBlanc, H. (2017). Brain abnormality findings in F18-FDG PET/CT imaging and its role in the clinical diagnosis of autism. Journal of Nuclear Medicine, 58(Suppl 1), 828. [abstract]
   Web of Science ®Google Scholar
• Le Couteur, A., Lord, C., & Rutter, M. (2003). The autism diagnostic interview-revised (ADI-R). Los Angeles, CA: Western Psychological Services.
   Google Scholar
• Li, L., & Greene, T. (2013). A weighting analogue to pair matching in propensity score analysis. International Journal of Biostatistics, 9, 215–234. doi:10.1515/ijb-2012-0030
   Web of Science ®Google Scholar
• Liu, X., Brašić, J.R., & Zhou, Y. (2011). Differentiation of non-pharmacological from pharmacological dopamine release in the living human brain. Current Medical Imaging Reviews, 7, 104–106.
   Web of Science ®Google Scholar
• Lord, C., Rutter, M., DiLavore, P.C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule: ADOS-2. Los Angeles, CA: Western Psychological Services.
   Google Scholar
• Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185–212. doi:10.1007/BF02211841
   PubMed Web of Science ®Google Scholar
• Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. doi:10.1007/BF02172145
   PubMed Web of Science ®Google Scholar
• Makkonen, I., Riikonen, R., Kokki, H., Airaksinen, M.M., & Kuikka, J.T. (2008). Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental Medicine & Child Neurology, 50, 593–597. doi:10.1111/j.1469-8749.2008.03027.x
   PubMed Web of Science ®Google Scholar
• Martin-Facklam, M., Pizzagalli, F., Zhou, Y., Ostrowitzki, S., Raymont, V., Brašić, J.R., … Wong, D.F. (2013). Glycine transporter type 1 occupancy by bitopertin: A positron emission tomography study in healthy volunteers. Neuropsychopharmacology, 38, 504–512.
   PubMed Web of Science ®Google Scholar
• McBride, P.A., Anderson, G.M., Hertzig, M.E., Sweeney, J.A., Kream, J., Cohen, D.J., & Mann, J.J. (1989). Serotonergic responsivity in male young adults with autistic disorder: Results of a pilot study. Archives of General Psychiatry, 46, 213–221. doi:10.1001/archpsyc.1989.01810030019003
   PubMed Web of Science ®Google Scholar
• Mikkelsen, M., Wodka, E.L., Mostofsky, S.H., & Puts, N.A.J. (2017). Autism spectrum disorder in the scope of tactile processing. Developmental Cognitive Neuroscience, Advance online publication. doi:https://doi.org/10.1016/j.dcn.2016.12.005
   Google Scholar
• Mitelman, S.A., Bralet, M.-C., Haznedar, M.M., Hollander, E., Shihabuddin, L., Hazlett, E.A., & Buchsbaum, M.S. (2017). Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. Brain Imaging and Behavior, DOI 10.1007/s11682-017-9721-z
   Google Scholar
• Mudd, A.T., Berding, K., Wang, M., Donovan, S.M., & Dilger, R.N. (2017). Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig. Gut Microbes, 1–12. doi:https://doi.org/10.1080/19490976.2017.1353849
   Google Scholar
• Munro, C.A., McCaul, M.E., Wong, D.F., Oswald, L.M., Zhou, Y., Brasic, J., … Wand, G.S. (2006). Sex differences in striatal dopamine release in healthy adults. Biological Psychiatry, 59, 966–974.
   PubMed Web of Science ®Google Scholar
• Nakamura, K., Sekine, Y., Ouchi, Y., Tsujii, M., Yoshikawa, E., Futatsubashi, M., … Mori, N. (2010). Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. Archives of General Psychiatry, 67, 59–68.
   PubMed Web of Science ®Google Scholar
• Page, L.A., Daly, E., Schmitz, N., Simmons, A., Toal, F., Deeley, Q., … Murphy, D.G. (2006). In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism. American Journal of Psychiatry, 163, 2189–2192.
   PubMed Web of Science ®Google Scholar
• Pasamanick, B., & Knobloch, H. (1966). Retrospective studies on the epidemiology of reproductive casuality: old and new. Merrill-Palmer Quarterly of Behavior and Development, 12, 7–26.
   Google Scholar
• Pasamanick, B., Rogers, M.E., & Lilienfeld, A.M. (1956). Pregnancy experience and the development of behavior disorders in children. American Journal of Psychiatry, 112, 613–618. doi:10.1176/ajp.112.8.613
   PubMed Web of Science ®Google Scholar
• Port, R.G., Gaetz, W., Bloy, L., Wang, D.-J., Blaskey, L., Kuschner, E.S., … Roberts, T.P.L. (2017). Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD. Autism Research, 10, 593–607. doi:https://doi.org/10.1002/aur.1686
   PubMed Web of Science ®Google Scholar
• Puts, N.A.J., Wodka, E.L., Harris, A.D., Crocetti, D., Tommerdahl, M., Mostofsky, S.H., & Edden, R.A.E. (2017). Reduced GABA and altered somatosensory function in children with autism spectrum disorder. Autism Research, 10, 608–619. doi:https://doi.org/10.1002/aur.1691
   PubMed Web of Science ®Google Scholar
• Rahmim, A., Cheng, J.C., Blinder, S., Camborde, M.L., & Sossi, V. (2005). Statistical dynamic image reconstruction in state-of-the-art high-resolution PET. Physics in Medicine and Biology, 50, 4887–4912. doi:10.1088/0031-9155/50/20/010
   PubMed Web of Science ®Google Scholar
• Robertson, C.E., Ratai, E.M., & Kanwisher, N. (2016). Reduced GABAergic action in the autistic brain. Current Biology, 26, 80–85. doi:https://doi.org/10.1016/j.cub.2015.11.019
   PubMed Web of Science ®Google Scholar
• Rosenberg, P.B., Wong, D.F., Edell, S.L., Ross, J.S., Joshi, A.D., Brašić, J.R., … Lyketsos, C.G. (2013). Cognition and amyloid load in Alzheimer Disease imaged with florbetapir F 18 (AV-45) positron emission tomography. American Journal of Geriatric Psychiatry, 21, 272–278.
   PubMed Web of Science ®Google Scholar
• Ross, B., & Bluml, S. (2001). Magnetic resonance spectroscopy of the human brain. Anatomical Record, 265, 54–84. doi:10.1002/ar.1058
   PubMedGoogle Scholar
• Rumsey, R.M., Duara, R., Grady, C., Rapoport, J.L., Margolin, R.A., Rapoport, S.I., & Cutler, N.R. (1985). Brain metabolism in autism. Archives of General Psychiatry, 42, 448–455. doi:10.1001/archpsyc.1985.01790280026003
   PubMedGoogle Scholar
• Schain, R.J., & Freedman, D.X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. Journal of Pediatrics, 58, 315–320. doi:10.1016/S0022-3476(61)80261-8
   PubMed Web of Science ®Google Scholar
• Schür, R.R., Draisma, L.W., Wijnen, J.P., Boks, M.P., Koevoets, M.G.J.C., Joëls, M., … Vinkers, C.H. (2016). Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of 1H-MRS studies. Human Brain Mapping, 37, 3337–3352. doi:https://doi.org/10.1002/hbm.23244
   PubMed Web of Science ®Google Scholar
• Shoaf, S.E., Carson, R., Hommer, D., Williams, W., Higley, J.D., Schmall, B., … Linnoila, M. (1998). Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations. Neuropsychopharmacology, 19, 345–353.
   PubMed Web of Science ®Google Scholar
• Shoaf, S.E., Carson, R., Hommer, D., Williams, W., Higley, J.D., Schmall, B., … Linnoila, M. (2000). The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: Studies with dual administration of [11C] and [14C] labeled tracer. Journal of Cerebral Blood Flow and Metabolism, 20, 244–252.
   PubMed Web of Science ®Google Scholar
• Simpao, A.F., Ahumada, L.M., & Rehman, M.A. (2015). Big data and visual analytics in anaesthesia and health care. British Journal of Anaesthesia, 115, 350–356. doi:10.1093/bja/aeu552
   PubMed Web of Science ®Google Scholar
• Singer, H.S., Szymanski, S., Giuliano, J., Yokoi, F., Dogan, A.S., Brasic, J.R., … Wong, D.F. (2002). Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET. American Journal of Psychiatry, 159, 1329–1336.
   PubMed Web of Science ®Google Scholar
• Sossi, V., de Jong, H.W.A.M., Barker, W.C., Bloomfield, P., Burbar, Z., Camborde, M.-L., …, Wong, D.F. (2005). The second generation HRRT: A multi-centre scanner performance investigation. IEEE Nuclear Science Symposium Conference Record, 4, 2195–2199.
   Google Scholar
• Spielberger, C.D.G.R., & Lushene, R.E. (1970). STAI manual for the state-trait anxiety inventory. Palo Alto, CA: Consulting Psychologist Press.
   Google Scholar
• Stanley, J.A. (2002). In vivo magnetic resonance spectroscopy and its application to neuropsychiatric disorders. Canadian Journal of Psychiatry, 47, 315–326. doi:10.1177/070674370204700402
   PubMed Web of Science ®Google Scholar
• Tebartz van Elst, L., Maier, S., Fangmeier, T., Endres, D., Mueller, G.T., Nickel, K., … Perlov, E. (2014). Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: Evidence in support of the excitatory/inhibitory imbalance hypothesis. Molecular Psychiatry, 19, 1314–1325. doi:https://doi.org/10.1038/mp.2014.62
   PubMed Web of Science ®Google Scholar
• Van Audenhaege, K., Van Holen, R., Vandenberghe, S., Vanhove, C., Metzler, S.D., & Moore, S.C. (2015). Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging. Medical Physics, 42, 4796–4813. doi:10.1118/1.4927061
   PubMed Web of Science ®Google Scholar
• van Elst, L.T., Maier, S., Fangmeier, T., Endres, D., Mueller, G.T., Nickel, K., … Perlov, E. (2014). Magnetic resonance spectroscopy comparing adults with high functioning autism and above average IQ. Molecular Psychiatry, 19, 1251. doi:https://doi.org/10.1038/mp.2014.160
   PubMed Web of Science ®Google Scholar
• Walton, E., Turner, J.A., & Ehrlich, S. (2013). Neuroimaging as a potential biomarker to optimize psychiatric research and treatment. International Review of Psychiatry, 25, 619–631. doi:10.3109/09540261.2013.816659
   PubMed Web of Science ®Google Scholar
• Watanabe, K. (2016). [Autism and Autism-associated Metabolites]. Brain Nerve, 68, 623–631. doi:https://doi.org/10.11477/mf.1416200452
   PubMedGoogle Scholar
• The WHOQOL Group. (1998). The World Health Organization Quality of Life Assessment (WHOQOL): Development and general psychometric properties. Social Science & Medicine, 46, 1569–1585. doi:10.1016/S0277-9536(98)00009-4
   PubMed Web of Science ®Google Scholar
• Wong, D.F., & Brašić, J.R. (2001). In vivo imaging of neurotransmitter systems in neuropsychiatry. Clinical Neuroscience Research, 1, 35–45.
   Web of Science ®Google Scholar
• Wong, D.F., Brašić, J.R., Singer, H.S., Schretlen, D.J., Kuwabara, H., Zhou, Y., … Grace, A.A. (2008). Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette Syndrome: Clues from an in vivo neurochemistry study with PET. Neuropsychopharmacology, 33, 1239–1251.
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Gründer, G., & Brašić, J.R. (2007). Brain imaging research: Does the science serve clinical practice?. International Review of Psychiatry, 19, 541–558.
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Kuwabara, H., Horti, A.G., Raymont, V., Brasic, J., Guevara, M., … Cascella, N. (2010). Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [(11)C]OMAR. NeuroImage, 52, 1505–1513.
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Kuwabara, H., Kim, J., Brašić, J.R., Chamroonrat, W., Gao, Y., … Horti, A.G. (2013). PET imaging of high-affinity α4β2 nicotinic acetylcholine receptors in humans with 18F-AZAN, a radioligand with optimal brain kinetics. Journal of Nuclear Medicine, 54, 1308–1314.
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Kuwabara, H., Pomper, M., Holt, D.P., Brasic, J.R., George, N., … Horti, A.G. (2014). Human brain imaging of α7 nAChR with [18F]ASEM: A new PET radiotracer for neuropsychiatry and determination of drug occupancy. Molecular Imaging and Biology, 16, 730–738.
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Maini, A., Rousset, O.G., & Brašić, J.R. (2003). Positron emission tomography–a tool for identifying the effects of alcohol dependence on the brain. Alcohol Research and Health, 27, 161–173.
   Google Scholar
• Wong, D.F., Moghekar, A.R., Rigamonti, D., Brašić, J.R., Rousset, O., Willis, W., … Grachev, I.D. (2013). An in vivo evaluation of cerebral cortical amyloid with [18F]flutemetamol using positron emission tomography compared with parietal biopsy samples in living normal pressure hydrocephalus patients. Molecular Imaging and Biology, 15, 230–237.
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Nandi, A., Zaidi, E., Gean, E., Horti, A., Frolov, B., … Brasic, J.R. (2014). Brain PET imaging in the cannabinoid system. In P. Seeman & B. Madras (Eds.), Imaging of the human brain in health and disease (pp. 27–36). Oxford, UK: Academic Press, Elsevier Science.
   Google Scholar
• Wong, D., Ostrowitzki, S., Zhou, Y., Alberati, D., Pinard, E., Raymont, V., … Borroni, E. (2014). [11C]-RO5013853: A new PET radioligand for the glycine transporter type 1. Neuropsychopharmacology, 39, 2272. [corrigeum].
   Google Scholar
• Wong, D.F., Ostrowitzki, S., Zhou, Y., Raymont, V., Hofmann, C., Borroni, E., … Martin-Facklam, M. (2013). Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans. NeuroImage, 75, 282–290.
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Potter, W.Z., & Brasic, J.R. (2002). Proof of concept: functional models for drug development in humans. In K.L. Davis, D. Charney, J.T. Coyle & C. Nemeroff (Eds.), Neuropsychopharmacology: The Fifth Generation of Progress (pp. 457–473). Baltimore, MD: The American College of Neuropsychopharmacology and Lippincott Williams & Wilkins.
   Google Scholar
• Wong, D.F., Rosenberg, P.B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H.T., … Pontecorvo, M.J. (2010). In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). Journal of Nuclear Medicine, 51, 913–920. erratum in: Journal of Nuclear Medicine, 51 (8), 1327).
   PubMed Web of Science ®Google Scholar
• Wong, D.F., Waterhouse, R., Kuwabara, H., Kim, J., Brašić, J.R., Chamroonrat, W., … Mozley, P.D. (2013). 18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: A first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry. Journal of Nuclear Medicine, 54, 388–396.
   PubMed Web of Science ®Google Scholar
• Young, J.G., Brasic, J.R., & Leven, L.I. (1990). Genetic causes of autism and the pervasive developmental disorders. In S.I. Deutsch, A. Weizman, & R. Weizman (Eds.), Application of basic neuroscience to child psychiatry (pp. 183–216). New York: Plenum Medical Book Company.
   Google Scholar
• Zung, W.W.K. (1965). A self-rating depression scale. Archives of General Psychiatry, 12, 63–70. doi:10.1001/archpsyc.1965.01720310065008
   PubMed Web of Science ®Google Scholar
• Zürcher, N.R., Bhanot, A., McDougle, C.J., & Hooker, J.M. (2015). A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: Current state and future research opportunities. Neuroscience and Biobehavioral Reviews, 52, 56–73.
   PubMed Web of Science ®Google Scholar