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Original Research

Altitude and risk of depression and anxiety: findings from the intern health study

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Pages 637-645 | Received 18 Nov 2018, Accepted 12 Feb 2019, Published online: 14 May 2019

References

  • Ågren, H., & Niklasson, F. (1988). Creatinine and creatine in CSF: Indices of brain energy metabolism in depression. Journal of Neural Transmission, 74(1), 55–59. doi:10.1007/BF01243575
  • Alameda-Palacios, J., Ruiz-Ramos, M., & García-Robredo, B. (2015). Suicide mortality in Andalusia, Spain: Geographical distribution and relationship with antidepressants, altitude and socioeconomic inequalities. Revista Española de Salud Pública, 89(3), 283–293. doi:10.4321/S1135-57272015000300006
  • Bardwell, W. A., Ensign, W. Y., & Mills, P. J. (2003). Mood disturbances endure after completion of high-altitude military training. Defense Technical Information Center Report No. NHRC-03-32. Naval Health Research Center, San Diego, CA.
  • Bogdanova, O. V., Abdullah, O., Kanekar, S., Bogdanov, V. B., Prescot, A. P., & Renshaw, P. F. (2014). Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia. Behavioural Brain Research, 263, 203–209. doi:10.1016/j.bbr.2014.01.027
  • Brenner, B., Cheng, D., Clark, S., & Camargo, C. A. (2011). Positive association between altitude and suicide in 2584 U.S. counties. High Altitude Medicine & Biology, 12(1), 31–35. doi:10.1089/ham.2010.1058
  • Brenner, B. E., Cheng, D., Muller, E., Clark, S., & Camargo, C. A. (2006). Suicide rates strongly correlate with altitude: A study of 3,060 U.S. counties. Academic Emergency Medicine, 13(5 Supplement 1), S195. doi:10.1197/j.aem.2006.03.496
  • Cheng, D. C., Mendenhall, T. I., & Brenner, B. E. (2005). Suicide rates strongly correlate with altitude. Academic Emergency Medicine, 12(Supplement 1), 141. doi:10.1197/j.aem.2005.03.397
  • Crapo, R. O., Jensen, R. L., Hegewald, M., & Tashkin, D. P. (1999). Arterial blood gas reference values for sea level and an altitude of 1,400 meters. American Journal of Respiratory and Critical Care Medicine, 160(5 Pt 1), 1525–1531. doi:10.1164/ajrccm.160.5.9806006
  • DelMastro, K., Hellem, T., Kim, N., Kondo, D., Sung, Y. H., & Renshaw, P. F. (2011). Incidence of major depressive episode correlates with elevation of substate region of residence. Journal of Affective Disorders, 129(1–3), 376–379. doi:10.1016/j.jad.2010.10.001
  • Fagenholz, P. J., Murray, A. F., Gutman, J. A., Findley, J. K., & Harris, N. S. (2007). New-onset anxiety disorders at high altitude. Wilderness and Environmental Medicine, 18(4), 312–316. doi:10.1580/07-WEME-BR-102R1.1
  • Gamboa, J. L., Caceda, R., & Arregui, A. (2011). Is depression the link between suicide and high altitude? High Altitude Medicine &Amp; Biology, 12(4), 403–404. doi:10.1089/ham.2011.1014
  • Haws, C. A., Gray, D. D., Yurgelun-Todd, D. A., Moskos, M., Meyer, L. J., & Renshaw, P. F. (2009). The possible effect of altitude on regional variation in suicide rates. Medical Hypotheses, 73(4), 587–590. doi:10.1016/j.mehy.2009.05.040
  • Huber, R. S., Coon, H., Kim, N., Renshaw, P. F., & Kondo, D. G. (2014). Altitude is a risk factor for completed suicide in bipolar disorder. Medical Hypotheses, 82(3), 377–381. doi:10.1016/j.mehy.2014.01.006
  • Iosifescu, D. V., Bolo, N. R., Nierenberg, A. A., Jensen, J. E., Fava, M., & Renshaw, P. F. (2008). Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder. Biological Psychiatry, 63(12), 1127–1134. doi:10.1016/j.biopsych.2007.11.020
  • Jain, K., Prasad, D., Singh, S. B., & Kohli, E. (2015). Hypobaric hypoxia imbalances mitochondrial dynamics in rat brain hippocampus. Neurology Research International, 2015, 742–759. doi:10.1155/2015/742059
  • Joiner, T. E., Brown, J. S., & Wingate, L. R. (2005). The psychology and neurobiology of suicidal behavior. Annual Review of Psychology, 56, 287–314. doi:10.1146/annurev.psych.56.091103.070320
  • Katz, I. R. (1980). Oxygen affinity of tyrosine and tryptophan hydroxylases in synaptosomes. Journal of Neurochemistry, 35(3), 760–763. doi:10.1111/j.1471-4159.1980.tb03721.x
  • Katz, I. R. (1981). Interaction between the oxygen and tryptophan dependence of synaptosomal tryptophan hydroxylase. Journal of Neurochemistry, 37(2), 447–451. doi:10.1111/j.1471-4159.1981.tb00476.x
  • Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6), 593–602. doi:10.1001/archpsyc.62.6.593
  • Kessler, R. C., Chiu, W. T., Demler, O., Merikangas, K. R., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6), 617–627. doi:10.1001/archpsyc.62.6.617
  • Kim, J., Choi, N., Lee, Y. J., An, H., Kim, N., Yoon, H. K., & Lee, H. J. (2014). High altitude remains associated with elevated suicide rates after adjusting for socioeconomic status: A study from South Korea. Psychiatry Investigation, 11(4), 492–494. doi:10.4306/pi.2014.11.4.492
  • Kim, N., Mickelson, J. B., Brenner, B. E., Haws, C. A., Yurgelun-Todd, D. A., & Renshaw, P. F. (2011). Altitude, gun ownership, rural areas, and suicide. The American Journal of Psychiatry, 168(1), 49–54. doi:10.1176/appi.ajp.2010.10020289
  • Kondo, D. G., Forrest, L. N., Shi, X., Sung, Y. H., Hellem, T. L., Huber, R. S., & Renshaw, P. F. (2016). Creatine target engagement with brain bioenergetics: A dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression. Amino Acids, 48(8), 1941–1954. doi:10.1007/s00726-016-2194-3
  • Kroenke, K., Spitzer, R. L., & Williams, J. B. (2001). The PHQ-9: Validity. Journal of General Internal Medicine, 16(9), 606–613. doi:10.1046/j.1525-1497.2001.016009606.x
  • Kumar, G. K. (2011). Hypoxia and neurotransmitter synthesis. American Journal of Physiology, 300(4), C743–C751. doi:10.1152/ajpcell.00019.2011
  • Lilienthal, J. L., Riley, R. L., Proemmel, D. D., & Franke, R. E. (1946). An experimental analysis in man of the oxygen pressure gradient from alveolar air to arterial blood during rest and exercise at sea level and at altitude. American Journal of Physiology, 147(1), 199–216. doi:10.1152/ajplegacy.1946.147.1.199
  • Malone, K. M., Haas, G. L., Sweeney, J. A., & Mann, J. J. (1995). Major depression and the risk of attempted suicide. Journal of Affective Disorders, 34(3), 173–185. doi:10.1016/0165-0327(95)00015-F
  • Mark, T. L., Shern, D. L., Bagalman, J. E., & Cao, Z. (2007). Ranking America’s mental health: An analysis of depression across the states. Alexandria, VA: Mental Health America.
  • Markkula, N., Härkänen, T., Nieminen, T., Peña, S., Mattila, A. K., Koskinen, S., … Suvisaari, J. (2016). Prognosis of depressive disorders in the general population: Results from the longitudinal Finnish Health 2011 Study. Journal of Affective Disorders, 190, 687–696. doi:10.1016/j.jad.2015.10.043
  • Mata, D. A., Ramos, M. A., Bansal, N., Khan, R., Guille, C., Di Angelantonio, E., & Sen, S. (2015). Prevalence of depression and depressive symptoms among resident physicians: A systematic review and meta-analysis. Journal of the American Medical Association, 314(22), 2373–2383. doi:10.1001/jama.2015.15845
  • Mathur, R., Cox, I. J., Oatridge, A., Shephard, D. T., Shaw, R. J., & Taylor-Robinson, S. D. (1999). Cerebral bioenergetics in stable chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 160(6), 1994–1999. doi:10.1164/ajrccm.160.6.9810069
  • Muthuraju, S., & Pati, S. (2014). Effect of hypobaric hypoxia on cognitive functions and potential therapeutic agents. Malaysian Journal of Medical Sciences, 21(Special Issue), 41–45.
  • National Center for Health Statistics. (2017). Suicide Mortality by State: 2015. Retrieved from https://www.cdc.gov/nchs/pressroom/sosmap/suicide-mortality/suicide.htm
  • Nicolas, M., Thullier-Lestienne, F., Bouquet, C., Gardette, B., Gortan, C., Joulia, F., … Abraini, J. H. (1999). An anxiety, personality, and altitude symptomatology study during a 31-day period of hypoxia in a hypobaric chamber experiment (Everest-COMEX 1997). Journal of Environmental Psychology, 19(4), 407–414. doi:10.1006/jevp.1999.0139
  • Nicolas, M., Thullier-Lestienne, F., Bouquet, C., Gardette, B., Gortan, C., Richalet, J. P., & Abraini, J. H. (2000). A study of mood changes and personality during a 31-day period of chronic hypoxia in a hypobaric chamber (Everest-Comex 97). Psychological Reports, 86(1), 119–126. doi:10.2466/pr0.2000.86.1.119
  • Nussbaumer-Ochsner, Y., Ursprung, J., Siebenmann, C., Maggiorini, M., & Bloch, K. E. (2012). Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing. Sleep, 35(3), 419–423. doi:10.5665/sleep.1708
  • Olson, E. B., Vidruk, E. H., McCrimmon, D. R., & Dempsey, J. A. (1983). Monoamine neurotransmitter metabolism during acclimatization to hypoxia in rats. Respiratory Physiology, 54(1), 79–96. doi:10.1016/0034-5687(83)90115-9
  • Peacock, A. J. (1998). ABC of oxygen: Oxygen at high altitude. BMJ (Clinical Research ed.), 317(7165), 1063–1066. doi:10.1136/bmj.317.7165.1063
  • Posner, K., Brown, G. K., Stanley, B., Brent, D. A., Yershova, K. V., Oquendo, M. A., … Mann, J. J. (2011). The Columbia–Suicide Severity Rating Scale: Initial validity and internal consistency findings from three multisite studies with adolescents and adults. American Journal of Psychiatry, 168(12), 1266–1277. doi:10.1176/appi.ajp.2011.10111704
  • Prioux-Guyonneau, M., Mocaer-Cretet, E., Redjimi-Hafsi, F., & Jacquot, C. (1982). Changes in brain 5-hydroxytryptamine metabolism induced by hypobaric hypoxia. General Pharmacology, 13(3), 251–254. doi:10.1016/0306-3623(82)90097-0
  • Radha, T. G., Venkitasubramanian, T. A., & Viswanathan, R. (1976). Effect of acute hypoxia on blood serotonin in human beings and rats. Respiration; International Review of Thoracic Diseases, 33(1), 64–69. doi:10.1159/000193689
  • Rahn, H., & Otis, A. B. (1949). Man's respiratory response during and after acclimatization to high altitude. American Journal of Physiology, 157(3), 445–462. doi:10.1152/ajplegacy.1949.157.3.445
  • Raman, L., Tkac, I., Ennis, K., Georgieff, M. K., Gruetter, R., & Rao, R. (2005). In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus. Brain Research. Developmental Brain Research, 156(2), 202–209. doi:10.1016/j.devbrainres.2005.02.013
  • Ray, K., Dutta, A., Panjwani, U., Thakur, L., Anand, J. P., & Kumar, S. (2011). Hypobaric hypoxia modulates brain biogenic amines and disturbs sleep architecture. Neurochemistry International, 58(1), 112–118. doi:10.1016/j.neuint.2010.11.003
  • Sen, S., Kranzler, H. R., Krystal, J. H., Speller, H., Chan, G., Gelernter, J., & Guille, C. (2010). A prospective cohort study investigating factors associated with depression during medical internship. Archives of General Psychiatry, 67(6), 557–565. doi:10.1001/archgenpsychiatry.2010.41
  • Shi, X.-F., Carlson, P. J., Kim, T.-S., Sung, Y.-H., Hellem, T. L., Fiedler, K. K., … Kondo, D. G. (2014). Effect of altitude on brain intracellular pH and inorganic phosphate levels. Psychiatry Research: Neuroimaging, 222(3), 149–156. doi:10.1016/j.pscychresns.2014.04.002
  • Shi, X.-F., Kondo, D. G., Sung, Y.-H., Hellem, T. L., Fiedler, K. K., Jeong, E.-K., … Renshaw, P. F. (2012). Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: A phosphorus-31 magnetic resonance spectroscopy study. Bipolar Disorders, 14(6), 607–617. doi:10.1111/j.1399-5618.2012.01040.x
  • Spitzer, R. L., Kroenke, K., Williams, J. W., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine, 166(10), 1092–1097. doi:10.1001/archinte.166.10.1092
  • van der Voort, T. Y., Seldenrijk, A., van Meijel, B., Goossens, P. J., Beekman, A. T., Penninx, B. W., & Kupka, R. W. (2015). Functional versus syndromal recovery in patients with major depressive disorder and bipolar disorder. Journal of Clinical Psychiatry, 76(6), 809–814.
  • Young, S. N. (2013). Elevated incidence of suicide in people living at altitude, smokers and patients with chronic obstructive pulmonary disease and asthma: Possible role of hypoxia causing decreased serotonin synthesis. Journal of Psychiatry & Neuroscience, 38(6), 423–426. doi:10.1503/jpn.130002

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