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Review Articles

The outcome of early intervention in first episode psychosis

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Pages 413-424 | Received 14 May 2019, Accepted 11 Jul 2019, Published online: 28 Aug 2019

References

  • Addington, D. E., McKenzie, E., Norman, R., Wang, J., & Bond, G. R. (2013). Essential evidence-based components of first-episode psychosis services. Psychiatric Services (Washington, D.C.), 64(5), 452–457. doi:10.1176/appi.ps.201200156
  • Albert, N., Melau, M., Jensen, H., Emborg, C., Jepsen, J. R. M., Fagerlund, B., … Nordentoft, M. (2017). Five years of specialised early intervention versus two years of specialised early intervention followed by three years of standard treatment for patients with a first episode psychosis: Randomised, superiority, parallel group trial in Denmark. BMJ (Online), 356, i6681. doi:10.1136/bmj.i6681.
  • Albert, N., Melau, M., Jensen, H., Hastrup, L. H., Hjorthøj, C., & Nordentoft, M. (2017). The effect of duration of untreated psychosis and treatment delay on the outcomes of prolonged early intervention in psychotic disorders. Npj Schizophrenia, 3(1), 34. doi:10.1038/s41537-017-0034-4
  • Bertelsen, M., Jeppesen, P., Petersen, L., Thorup, A., Øhlenschlaeger, J., Le Quach, P., … Nordentoft, M. (2008). Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness: The OPUS trial. Archives of General Psychiatry, 65(7), 762–771. doi:10.1001/archpsyc.65.7.762
  • Birchwood, M., Connor, C., Lester, H., Patterson, P., Freemantle, N., Marshall, M., … Singh, S. P. (2013). Reducing duration of untreated psychosis: Care pathways to early intervention in psychosis services. The British Journal of Psychiatry : The Journal of Mental Science, 203(1), 58–64. doi:10.1192/bjp.bp.112.125500
  • Birchwood, M., & Macmillan, F. (1993). Early intervention in schizophrenia. The British Journal of Psychiatry : The Journal of Mental Science, 27(3), 374–378.
  • Birchwood, M., McGorry, P., & Jackson, H. (1997). Early intervention in schizophrenia. The British Journal of Psychiatry : The Journal of Mental Science, 170(2), 2–5. doi:10.1192/bjp.170.1.2
  • Bleuler, M. (1978). The schizophrenic disorder - long term patient and family studies. Westford, MA: The Murray Printing Co.
  • Carpenter, W. T., & Strauss, J. S. (1991). The prediction of outcome in schizophrenia IV: Eleven-year follow-up of the Washington IPSS cohort. The Journal of Nervous and Mental Disease, 179(9), 517–525. doi:10.1097/00005053-199109000-00001
  • Chan, S. K. W., Chau, E. H. S., Hui, C. L. M., Chang, W. C., Lee, E. H. M., & Chen, E. Y. H. (2018). Long term effect of early intervention service on duration of untreated psychosis in youth and adult population in Hong Kong. Early Intervention in Psychiatry, 12(3), 331–338. doi: 10.1111/eip.12313.
  • Chang, W. C. (2017). Sustainability of treatment effect of a 3-year early intervention programme for first-episode psychosis. British Journal of Psychiatry, 117, 198929. doi:10.1192/bjp.bp.117.198929
  • Chang, W. C., Chan, G. H. K., Jim, O. T. T., Lau, E. S. K., Hui, C. L. M., Chan, S. K. W., … Chen, E. Y. H. (2015). Optimal duration of an early intervention programme for first-episode psychosis: randomised controlled trial. The British Journal of Psychiatry : The Journal of Mental Science, 206(6), 492–500. doi:10.1192/bjp.bp.114.150144
  • Chong, S. A., Mythily, S., & Verma, S. (2005). Reducing the duration of untreated psychosis and changing help-seeking behaviour in Singapore. Social Psychiatry and Psychiatric Epidemiology, 40(8), 619–621. doi:10.1007/s00127-005-0948-4
  • Ciompi, L., & Clemens, S. (1980). Catamnestic long-term study on the course of life and aging of schizophrenics. Schizophrenia Bulletin, 6(4), 606–618. doi:10.1093/schbul/6.4.606
  • Correll, C. U. (2018). Comparison of early intervention services vs treatment as usual for early-phase psychosis. A systematic review, meta-analysis, and meta-regression. JAMA Psychiatry, 75(6), 555–565. doi:10.1001/jamapsychiatry.2018.0623
  • Chan, S. K. W., Chan, H. Y. V., Devlin, J., Bastiampillai, T., Mohan, T., Hui, C. L. M., … Chen, E. Y. H. (2019). A systematic review of long-term outcomes of patients with psychosis who received early intervention services. International Review of Psychiatry, Advance online publication. doi:10.1080/09540261.2019.1643704
  • Crow, T. J., MacMillan, J. F., Johnson, A. L., & Johnstone, E. C. (1986). The Northwick Park Study in first episodes schizophrenia II. A randomised controlled trial of prophylactic neuroleptic treatment. British Journal of Psychiatry, 148(2), 120–127. doi:10.1192/bjp.148.2.120
  • Dama, M. (2019). Short duration of untreated psychosis enhances negative symptom remission in extended early intervention service for psychosis. Acta Psychiatrica Scandinavica, 140(1), 1–87. doi:10.1111/acps.13033
  • Eaton, W. W., Thara, R., Federman, B., Melton, B., & Liang, K-y. (1995). Structure and course of positive and negative symptomes in schizoprenia. Archives of General Psychiatry, 52(2), 127–134. doi:10.1001/archpsyc.1995.03950140045005
  • Fusar-Poli, P., McGorry, P. D., & Kane, J. M. (2017). Improving outcomes of first-episode psychosis: An overview. World Psychiatry, 16(3), 251–265. doi:10.1002/wps.20446
  • Gafoor, R., Nitsch, D., McCrone, P., Craig, T. K. J., Garety, P. A., Power, P., & McGuire, P. (2010). Effect of early intervention on 5-year outcome in non-affective psychosis. British Journal of Psychiatry, 196(5), 372–376. doi:10.1192/bjp.bp.109.066050
  • Guo, X., Zhai, J., Liu, Z., Fang, M., Wang, B., Wang, C., … Zhao, J. (2010). Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: A randomized, 1-year study. Archives of General Psychiatry, 67(9), 895. doi:10.1001/archgenpsychiatry.2010.105
  • Hegarty, J., Baldessarini, R., Tohen, M., Waternaux, C., & Oepen, G. (1994). One-hundred years of schizophrenia: A meta-analysis of the outcome literature. The American Journal of Psychiatry, 151, 1409.
  • Hegelstad, W. T. V., Larsen, T. K., Auestad, B., Evensen, J., Haahr, U., Joa, I., … McGlashan, T. (2012). Long-term follow -up of the TIPS early detection in psychosis study: Effects on 10-year outcome. American Journal of Psychiatry, 169(4), 374–380. doi:10.1176/appi.ajp.2011.11030459
  • Helgason, L. (1990). Twenty years’ follow-up of first psychiatric preseantation for schizophrenia: What could have been prevented? Acta Psychiatrica Scandinavica, 81(3), 231–235. doi:10.1111/j.1600-0447.1990.tb06486.x
  • Huber, G., Gross, G., Schuttler, R., Linz, M., & Clemens, S. (1980). Longitudinal studies of schizophrenic patients. Schizophrenia Bulletin, 6(4), 592–605. doi:10.1093/schbul/6.4.592
  • Hui, C. L. M., Chang, W. C., Chan, S. K. W., Lee, E. H. M., Tam, W. W. Y., Lai, D. C., … Chen, E. Y. H. (2014). Early intervention and evaluation for adult-onset psychosis: The JCEP study rationale and design. Early Intervention in Psychiatry, 8(3), 261–268. doi:10.1111/eip.12034
  • Jablensky, A., Sartorius, N., Ernberg, G., Anker, M., Korten, A., Cooper, J. E., … Bertelsen, A. (1992). Schizophrenia: Manifestations, incidence and course in different cultures a world health organization ten-country study. Psychological Medicine. Monograph Supplement, 20, 1–97.
  • Joa, I., Johannessen, J. O., Auestad, B., Friis, S., McGlashan, T., Melle, I., … Larsen, T. K. (2008). The key to reducing duration of untreated first psychosis: Information campaigns. Schizophrenia Bulletin, 34(3), 466–472. doi:10.1093/schbul/sbm095
  • Johannessen, J. O., McGlashan, T. H., Larsen, T. K., Horneland, M., Joa, I., Mardal, S., … Vaglum, P. (2001). Early detection strategies for untreated first-episode psychosis. Schizophrenia Research, 51(1), 39–46. doi:10.1016/S0920-9964(01)00237-7
  • Jorgensen, P. (2000). Early detection and assertive community treatment of young psychotics: The opus study rationale and design of the trial. Social Psychiatry and Psychiatric Epidemiology, 35(7), 283–287.
  • Kane, J. M., Robinson, D. G., Schooler, N. R., Mueser, K. T., Penn, D. L., Rosenheck, R. A., … Heinssen, R. K. (2016). Comprehensive versus usual community care for first-episode psychosis: 2-Year outcomes from the NIMH RAISE early treatment program. The American Journal of Psychiatry, 173(4), 362–372. doi:10.1176/appi.ajp.2015.15050632
  • Kraeplin, E. (1919). Dementia Praecox and Paraphrenia. Forgotten. edited by G. M. Robertson. London, UK: FB & c Ltd.
  • Krstev, H., Carbone, S., Harrigan, S. M., Curry, C., Elkins, K., & Mcgorry, P. D. (2004). Early intervention in first-episode psychosis–the impact of a community development campaign. Soc Psychiatry Psychiatr Epidemiol., 39, 711–719.
  • Lambert, M. (2017). Early detection and integrated care for adolescents and young adults with severe psychotic disorders: The ACCESS III study. Acta Psychiatrica Scandinavica, 136(2), 188–200. doi:10.1111/acps.12762
  • Larsen, T. K., McGlashan, T. H., Johannessen, J. O., Friis, S., Guldberg, C., Haahr, U., … Vaglum, P. (2001). Shortened duration of untreated first episode of psychosis: Changes in patient characteristics at treatment. American Journal of Psychiatry, 158(11), 1917–1919. doi:10.1176/appi.ajp.158.11.1917
  • Larsen, T. K., & Opjordsmoen, S. (1996). Early identification and treatment of schizophrenia: Conceptual and ethical considerations. Psychiatry, 59(4), 371–380. doi:10.1080/00332747.1996.11024775
  • Larsen, T. K., Johannessen, J. O., & Opjordsmoen, S. (1998). First-episode schizophrenia with long duration of untreated psychosis. Br J Psychiatr, 172(Suppl 33), 45–52.
  • Lester, H., Birchwood, M., Freemantle, N., Michail, M., & Tait, L. (2009). REDIRECT: Cluster randomised controlled trial of GP training in first-episode psychosis. British Journal of General Practice, 59(563), e183–90. doi:10.3399/bjgp09X420851
  • Lloyd-Evans, B., Crosby, M., Stockton, S., Pilling, S., Hobbs, L., Hinton, M., & Johnson, S. (2011). Initiatives to shorten duration of untreated psychosis: Systematic review. The British Journal of Psychiatry : The Journal of Mental Science, 198(4), 256–263. doi:10.1192/bjp.bp.109.075622
  • Lo, W. H., & Lo, T. (1977). A ten-year follow-up study of Chinese schizophrenics in Hong Kong.. The British Journal of Psychiatry : The Journal of Mental Science, 131, 63–66. doi:10.1192/bjp.131.1.63
  • Lutterman, T., Kazandjian, M., & Urff, J. (2018). Snapshot of State Plans: For using the community mental health block grant 10 percent set-aside to address first episode psychosis. Retrieved from https://www.nasmhpd.org/sites/default/files/Snapshot_of_State_Plans.pdf
  • Malla, A., Joober, R., Iyer, S., Norman, R., Schmitz, N., Brown, T., … Abadi, S. (2017). Comparing three-year extension of early intervention service to regular care following two years of early intervention service in first-episode psychosis: A randomized single blind clinical trial. World Psychiatry, 16(3), 278–286. doi:10.1002/wps.20456
  • Malla, A. K., Norman, R. M. G., & Joober, R. (2005). First-episode psychosis, early intervention, and outcome: What have we learned? Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 50(14), 881–891. doi:10.1177/070674370505001402
  • Malla, A., Norman, R., Scholten, D., Manchanda, R., & McLean, T. (2005). A community intervention for early identification of first episode psychosis: Impact on Duration of Untreated Psychosis (DUP) and patient characteristics. Social Psychiatry and Psychiatric Epidemiology, 40(5), 337–344. doi:10.1007/s00127-005-0901-6
  • Marshall, M., Lewis, S., Lockwood, A., Drake, R., Jones, P., & Croudace, T. (2005). Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: A systematic review. Archives of General Psychiatry, 62(9), 975–983. doi:10.1001/archpsyc.62.9.975
  • Marshall, M., & Rathbone, J. (2011). Early intervention for psychosis. The Cochrane Database of Systematic Reviews, (6), CD004718. doi:10.1002/14651858.CD004718.pub3
  • Mcgorry, P. D., Killackey, E., & Yung, A. R. (2007). Early intervention in psychotic disorders: Detection and treatment of the first episode and the critical early stages. The Medical Journal of Australia, 187(November), 8–10.
  • McGorry, P. D., Edwards, J., Mihalopoulos, C., Harrigan, S. M., & Jackson, H. J. (1996). EPPIC: An evolving system of early detection and optimal management. Schizophrenia Bulletin, 22(2), 305. doi:10.1093/schbul/22.2.305
  • Melle, I., Larsen, T. K., Haahr, U., Friis, S., Johannessen, J. O., Opjordsmoen, S., … McGlashan, T. (2004). Reducing the duration of untreated first-episode psychosis: Effects on clinical presentation. Archives of General Psychiatry, 61(2), 143–150. doi:10.1001/archpsyc.61.2.143
  • Nordentoft, M. (2013). From research to practice: How OPUS treatment was accepted and implemented throughout Denmark. Early Intervention in Psychiatry. 9(2), 156–162. doi:10.1111/eip.12108
  • Oliver, D. (2018). Can we reduce the duration of untreated psychosis ? A systematic review and meta-analysis of controlled interventional studies. Schizophrenia Bulletin. 44(6), 1362–1372. doi:10.1093/schbul/sbx166
  • Padilla, E., Molina, J., Kamis, D., Calvo, M., Stratton, L., Strejilevich, S., … de Erausquin, G. A. (2015). The efficacy of targeted health agents education to reduce the duration of untreated psychosis in a rural population. Schizophrenia Research, 161(2–3), 184–187. doi:10.1016/j.schres.2014.10.039
  • Penttilä, M., Jääskeläinen, E., Hirvonen, N., Isohanni, M., & Miettunen, J. (2014). Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: Systematic review and meta-analysis. British Journal of Psychiatry, 205(2), 88–94. doi:10.1192/bjp.bp.113.127753
  • Perkins, D. O., Gu, H., Boteva, K., & Lieberman, J. A. (2005). Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: A critical review and meta-analysis. The American Journal of Psychiatry, 162(10), 1785–1804. doi:10.1176/appi.ajp.162.10.1785
  • Petersen, L., Jeppesen, P., Thorup, A., Abel, M.-B., Øhlenschlaeger, J., Christensen, T. Ø., … Nordentoft, M. (2005). A randomised multicentre trial of integrated versus standard treatment for patient with a first episode of psychotic illness. BMJ, 331(7517), 602. doi:10.1136/bmj.38565.415000.E01
  • Power, P. (2007). The Lambeth early onset crisis assessment team study: General practitioner education and access to an early detection team in first-episode psychosis. British Journal of Psychiatry, 51, S133–S9. doi:10.1192/bjp.191.51.s133
  • Renwick, L., Gavin, B., McGlade, N., Lacey, P., Goggins, R., Jackson, D., … O'Callaghan, E. (2008). Early intervention service for psychosis: Views from primary care. Early Intervention in Psychiatry, 2(4), 285–290. doi:10.1111/j.1751-7893.2008.00090.x
  • Ruggeri, M., Bonetto, C., Lasalvia, A., Fioritti, A., de Girolamo, G., Santonastaso, P., … Meneghelli, A. (2015). Feasibility and effectiveness of a multi-element psychosocial intervention for first-episode psychosis: Results from the cluster-randomized controlled GET UP PIANO trial in a catchment area of 10 million inhabitants. Schizophrenia Bulletin, 41(5), 1192–1203. doi:10.1093/schbul/sbv058
  • Shepherd, M., Watt, D., Falloon, I., & Smeeton, N. (1989). The natural history of schizophrenia: A five-year follow-up study of outcome and prediction in a representative sample of schizophrenics. Psychological Medicine Monograph Supplement, 10, 1–46. doi:10.1017/S026418010000059X
  • Srihari, V., Guloksuz, S., Li, F., Tek, C., Woods, S., Pollard, J., … Seidman, L. J. (2017). 178.3 Mindmap: A population-based approach to early detection of psychosis in the United States. Schizophrenia Bulletin, 43(suppl_1), S95–S95. doi:10.1093/schbul/sbx021.255
  • The Scottish Schizophrenia Research Group. (1992). The Scottish first episode schizophrenia study VIII. Five-year follow-up: Clinical and psychosocial findings. British Journal of Psychiatry, 161, 496–500. doi:10.1192/bjp.161.4.496
  • Verma, S., Poon, L. Y., Lee, H., Rao, S., & Chong, S. A. (2012). Evolution of early psychosis intervention services in Singapore. East Asian Arch Psychiatry, 22(3), 114–117.
  • World Health Organization. (1993). The ICD-10 classification of mental and behavioural disorders (1st. ed.). Geneva, Switzerland: World Health Organization.
  • Wyatt, J. (1991). Neuroleptics and the natural course of schizophrenia. Schizophrenia Bulletin, 17(2), 325–351. doi:10.1093/schbul/17.2.325
  • Yung, A. R., Organ, B. A., & Harris, M. G. (2003). Management of early psychosis in a generic adult mental health service. Australian & New Zealand Journal of Psychiatry, 37(4), 429–436. doi:10.1046/j.1440-1614.2003.01196.x

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