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Pantothenol

Topical use of dexpanthenol: a 70th anniversary article

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Pages 766-773 | Received 07 Apr 2017, Accepted 27 Apr 2017, Published online: 14 May 2017

References

  • Kelly GS. Pantothenic acid. Monograph. Altern Med Rev. 2011;16:263–74.
  • Lanska DJ. The discovery of niacin, biotin, and pantothenic acid. Ann Nutr Metab. 2012;61:246–53.
  • Williams RJ, Saunders DH. The effects of inositol, crystalline vitamin B(1) and ”pantothenic acid”; on the growth of different strains of yeast . Biochem J. 1934;28:1887–93.
  • Stüttgen G, Krause H. Die percutane absorption von Tritium-markiertem panthenol bei mensch und tier. Arch Klin Exp Derm. 1960;209:578–82.
  • Wollina U, Kubicki J. Multiaktive eigenschaften von dexpanthenol-haltigen externa. Kosm Med. 2007;2:14–18.
  • Abiko Y, Tomikawa M, Shimizu M. Enzymatic conversion of pantothenylalcohol to pantothenic acid. J Vitaminol (Kyoto). 1969;15:59–69.
  • Proksch E, Jensen JM, Dexpanthenol. In Barel AO, Paye M, Maibach HI, ed. Handbook of Cosmetic Science and Technology. 2nd ed. New York, London: Taylor & Francis Group; 2006, p. 399–406.
  • Proksch E, Holleran WM, Menon GK, et al. Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol. 1993;128:473–82.
  • Slyshenkov VS, Rakowska M, Moiseenok AG, Wojtczak L. Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation. Free Radic Biol Med. 1995;19:767–72.
  • Proksch E, Nissen HP. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. J Dermatolog Treat. 2002;13:173–8.
  • Wollina U. Zur klinischen wirksamkeit von dexpanthenol. Kosm Med. 2001;4:180–4.
  • Hosemann W, Wigand ME, Göde U, et al. Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol. 1991;248:390–4.
  • Hosemann W, Göde U, Länger F, Wigand ME. Experimentelle untersuchungen zur wunderheilung in den nasennebenhöhlen. HNO. 1991;39:48–54.
  • Weimann BI, Hermann D. Studies on wound healing: effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture. Int J Vitam Nutr Res. 1999;69:113–19.
  • Wollina U, Kubicki J. Dexpanthenol supports healing of superficial wounds and injuries. Kosm Med. 2006;27:240–9.
  • Marquardt Y, Amann PM, Heise R, et al. Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments. Lasers Surg Med. 2015;47:257–65.
  • Oguz A, Uslukaya O, Alabalık U, et al. Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study. Int Surg. 2015;100:656–61.
  • Danby SG. Biological variation in skin barrier function: from A (atopic dermatitis) to X (xerosis). Curr Probl Dermatol. 2016;49:47–60.
  • Giménez-Arnau A. Standards for the protection of skin barrier function. Curr Probl Dermatol. 2016;49:123–34.
  • Lodén M. Treatments improving skin barrier function. Curr Probl Dermatol 2016;49:112–22.
  • Björklund S, Pham QD, Jensen LB, et al. The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. J Colloid Interface Sci. 2016;479:207–20.
  • Proksch E. The role of emollients in the management of diseases with chronic dry skin. Skin Pharmacol Physiol. 2008;21:75–80.
  • Ring J, Alomar A, Bieber T, et al. Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol. 2012;26:1045–60.
  • Simpson EL, Berry TM, Brown PA, Hanifin JM. A pilot study of emollient therapy for the primary prevention of atopic dermatitis. J Am Acad Dermatol. 2010;63:587–93.
  • Simpson EL, Chalmers JR, Hanifin JM, et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol. 2014;134:818–23.
  • Gelmetti C, Metz M, Proksch E. Expert panel on best practices in atopic dermatitis management: outcome and recommendations. KOM Dermatol. 2015;10:1–4.
  • Gehring W, Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000;50:659–63.
  • Gehring W, Gloor M. Der repetitive waschtest als modell zur beurteilung von hautschutzpräparaten am beispiel einer dexpanthenolhaltigen formulierung. Akt Dermatol. 2001;27:279–84.
  • Gehring W, Gloor M. Der effekt von dexpanthenol bei experimentell geschädigter haut. Z Hautkr. 2001;76:212–18.
  • Biro K, Thaçi D, Ochsendorf FR, et al. Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis. 2003;49:80–4.
  • Goujon C, Alleaume B, de Bony R, Girard P. Randomized single-blind pilot comparison study of the efficacy and tolerability of Bepanthen® Ointment in subjects with bilateral dryness of the hands. Réal Thérap Dermatol. 1997;66:47–33.
  • Camargo FB Jr, Gaspar LR, Maia Campos PM. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011;62:361–70.
  • Stettler H, Kurka P, Lunau N, et al. A new topical panthenol-containing emollient: results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora. J Dermatolog Treat. 2017;28:173–80.
  • Stettler H, Kurka P, Wagner C, et al. A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants. J Dermatolog Treat. 2016;22:1–7. [Epub ahead of print]
  • Distelmaier M, Gaffal E, Wenzel J, et al. Anwendungsbeobachtung bepanthol körperlotion plus bei atopischer haut. Kosm Med. 2007;4:182–5.
  • Stettler H, Kurka P, Dominicus R, et al. Improved itch relief with new product formulation for topical treatment in patients with mild-to-moderate atopic dermatitis: results from an exploratory trial. KOM Dermatol. 2016;11:1–10.
  • Klunk C, Domingues E, Wiss K. An update on diaper dermatitis. Clin Dermatol. 2014;32:477–87.
  • Adam R. Skin care of the diaper area. Pediatr Dermatol. 2008;25:427–33.
  • Atherton DJ, Proksch E, Schauber J, Stalder JF. Irritant diaper dermatitis: best practice management. SelfCare. 2015;6(S1):1–11.
  • Atherton DJ. A review of the pathophysiology, prevention and treatment of irritant diaper dermatitis. Curr Med Res Opin. 2004;20:645–9.
  • Stamatas GN, Tierney NK. Diaper dermatitis: etiology, manifestations, prevention, and management. Pediatr Dermatol. 2014;31:1–7.
  • Atherton DJ. Understanding irritant napkin dermatitis. Int J Dermatol. 2016;55:7–9.
  • Atherton DJ, Mills K. What can be done to keep babies' skin healthy? RCM Midwives. 2004;7:288–90.
  • Sznurkowska K, Liberek A, Brzozowska Cieloch K, et al. Evaluation of a new cosmetic topical formulation in the management of irritant diaper dermatitis in infants. SelfCare. 2015;6(S1):12–24.
  • Putet G, Guy B, Pages S, et al. An open pilot study on the effects of Bepanthen® ointment in the prevention of diaper dermatitis in premature and full-term infants. Réal Pédiatr. 2000;52:659–63.
  • Putet G, Guy B, Andres P, et al. Effect of Bepanthen® ointment in the prevention and treatment of diaper rash on premature and full-term babies. Réal Pédiatr. 2001;63:33–8.
  • Wolff HH, Kieser M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur J Pediatr. 2007;166:943–8.
  • Al-Momani T, Tawalbeh A, Shatnawi M, et al. Napkin dermatitis in babies: characteristics and efficacy of panthenol treatment. WJPMR 2016;2:22–4.
  • Proksch E. Dexpanthenol-haltige externa zur pflege trockener haut bei diabetikern. Kosm Med. 2008;6:22–5.
  • Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738–46.
  • Nast A, Carreras M, Thompson AR, et al. Scar management: using silicone-based products in primary health care. Wounds Int. 2016;7:23–7.
  • Lorenz K, Sicker M, Schmelzer E, et al. Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp Dermatol. 2008;17:925–32.
  • Wiederholt T, Heise R, Skazik C, et al. Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009;18:969–78.
  • Lacroix B, Didier E, Grenier JF. Effects of pantothenic acid on fibroblastic cell cultures. Res Exp Med (Berl). 1988;188:391–6.
  • Hauptmann S, Schäfer H, Fritz A, Hauptmann P. Untersuchung der wachstumsbeeinflussenden wirkung von wundsalben an der zellkultur. Hautarzt. 1992;43:432–5.
  • Hoeller Obrigkeit D, Oepen T, Jugert FK, et al. Xenobiotics in vitro: the influence of L-cystine, pantothenate, and miliacin on metabolic and proliferative capacity of keratinocytes. Cutan Ocul Toxicol. 2006;25:13–22.
  • Takamiya M, Fujita S, Saigusa K, Aoki Y. Simultaneous detection of eight cytokines in human dermal wounds with a multiplex bead-based immunoassay for wound age estimation. Int J Legal Med. 2008;122:143–8.
  • Heise R, Skazik C, Marquardt Y, et al. Dexpanthenol modulates gene expression in skin wound healing in vivo. Skin Pharmacol Physiol. 2012;25:241–8.
  • Pugliese PT, Farina JC, Chautems Y. Efficacité du dexpanthénol dans la cicatrisation: etude en double-aveugle sur plaies chirurgicales. Evaluation par ultrasons et examens histologiques. Nouv Dermatol. 1995;14:130–8.
  • Hartel M, Illing P, Mercer JB, et al. Therapy of acute wounds with water-filtered infrared-A (wIRA). GMS Krankenhaushyg Interdiszip. 2007;2:1–15.
  • Morland-Schultz K, Hill PD. Prevention of and therapies for nipple pain: a systematic review. J Obstet Gynecol Neonatal Nurs. 2005;34:428–37.
  • Grünberger V. Behandlung der Brustrhagaden mit Bepanthensalbe. Wien Med Wochenschr. 1948;98:150–1.
  • Hofhansl W, Baumgarten K. Erfahrungen mit panthenol in der gynäkologie und der geburtshilfe. Wien Med Wochenschr. 1959;109:775–6.
  • Dubecq JP, Detchart M. Etude d’un onguent pantothénique dans la prophylaxie et le traitement des crevasses du sein. Méd Prat. 1977;177:1–2.
  • Kuşcu NK, Koyuncu F, Laçin S. Collagenase treatment of sore nipples. Int J Gynaecol Obstet. 2002;76:81–2.
  • Shanazi M, Farshbaf Khalili A, Kamalifard M, et al. Comparison of the effects of lanolin, peppermint, and dexpanthenol creams on treatment of traumatic nipples in breastfeeding mothers. J Caring Sci. 2015;4:297–307.
  • Staubach P, Meinert R, Grabbe S. Mamillenekzem in der Stillzeit: wie wirksam ist die therapie mit einer dexpanthenol-haltigen salbe? Hebamme. 2008;21:166–9.
  • Girard P, Beraud A, Goujou C, et al. Effet de Bépanthène® onguent sur le modèle de cicatrisation du site de prélèvement de greffe: étude biométrologique, clinique et évaluation par le patient, en double aveugle contre véhicule. Nouv Dermatol. 1998;17:559–70.
  • Celebi S, Tepe C, Yelken K, Celik O. Efficacy of dexpanthenol for pediatric post-tonsillectomy pain and wound healing. Ann Otol Rhinol Laryngol. 2013;122:464–7.
  • Büttemeyer R, Vogt PM, Peter FW, Steinau HU. [Treatment of burns]. Med Monatsschr Pharm. 1995; 18:31–9.
  • Grivet-Seyve M, Bellon C, Maares J, et al. Evaluation de l’effet hydratant de Bepanthen® burn relief foam spray contre comparateurs, dans le traitement de la brûlure du premier degré. Réal Thérap Dermatol. 2003;25:38–47.
  • Mustoe TA, Cooter RD, Gold MH, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002;110:560–71.
  • Bloemen MC, van der Veer WM, Ulrich MM, et al. Prevention and curative management of hypertrophic scar formation. Burns. 2009;35:463–75.
  • Stettler H, Kurka P, Kalentyeva J, et al. Clinical innovation: treatment with an anti-scar gel and massage ball improves physical parameters of hypertrophic scars. Wounds Int. 2016;7:18–23.
  • Radtke MA, Lee-Seifert C, Rustenbach SJ, et al. Patientennutzen und anwendungsmerkmale der behandlung irritierter haut mit dexpanthenolhaltiger salbe. Hautarzt. 2009;60:414–19.
  • Augustin M. Hoher patientennutzen mit dexpanthenol-haltiger salbe. DAZ. 2010;150:3031–3.