Should we instruct patients to rub topical agents into skin? The evidence

References

• Li BS, Ngo MA, Maibach HI. Clinical relevance of complex factors of percutaneous penetration in man. Curr Top Pharmacol. 2017;21:85–107.
   Google Scholar
• Ngo MA, Maibach HI. 15 Factors of percutaneous penetration of pesticides. In: Knaak JB, Timchalk C, Tornero-Velez R, editors. Parameters for pesticide QSAR and PBPK/PD models for human risk assessment. Vol. 1099. Danvers (MA): Oxford University Press; 2012. p. 67–86.
   Google Scholar
• Wester RC, Maibach HI. Cutaneous pharmacokinetics: 10 steps to percutaneous absorption. Drug Metab Rev. 1983;14:169–205.
   PubMed Web of Science ®Google Scholar
• Genina EA, Bashkatov AN, Sinichkin YP, et al. In vitro and in vivo study of dye diffusion into the human skin and hair follicles. J Biomed Opt. 2002;7:471–477.
   PubMed Web of Science ®Google Scholar
• McElnay JC, Benson HA, Harland R, et al. Phonophoresis of methyl nicotinate: a preliminary study to elucidate the mechanism of action. Pharm Res. 1993;10:1726–1731.
   PubMed Web of Science ®Google Scholar
• Lewis DJ, Feldman SR. Practical ways to improve patient adherence. Middletown (DE): CreateSpace Independent Publishing Platform; 2017.
   Google Scholar
• McMaster J, Maibach HI, Wester RC, et al. Does rubbing enhance in vivo dermal absorption? In: Bronaugh R, Maibach HI, editors. Percutaneous absorption. Vol. 1. New York (NY): Marcel Dekker; 1985. p. 359–361.
   Google Scholar
• Draelos ZD. Triamcinolone spray: no-rub application as effective as rub application. J Cosmet Dermatol. 2015;14:286–290.
   PubMed Web of Science ®Google Scholar
• Treffel P, Panisset F, Humbert P, et al. Effect of pressure on in vitro percutaneous absorption of caffeine. Acta Derm Venereol. 1993;73:200–202.
   PubMed Web of Science ®Google Scholar
• Ishii H, Todo H, Sugibayashi K. Effect of sebum and ointment rubbing on the skin permeation of triamcinolone acetonide from white petrolatum ointment. Biol Pharm Bull. 2010;33:876–880.
   PubMed Web of Science ®Google Scholar
• Hasler-Nguyen N, Fotopoulos G. Effect of rubbing on the in vitro skin permeation of diclofenac-diethylamine 1.16% gel. BMC Res Notes. 2012;5:312–316.
   PubMedGoogle Scholar
• Nguyen HX, Puri A, Banga AK. Methods to simulate rubbing of topical formulation for in vitro skin permeation studies. Int J Pharm. 2017;519:22–33.
   PubMedGoogle Scholar
• Vieille-Petit A, Blickenstaff N, Coman G, et al. Metrics and clinical relevance of percutaneous penetration and lateral spreading. Skin Pharmacol Physiol. 2015;28:57–64.
   PubMed Web of Science ®Google Scholar
• Marshall EK, Lynch V, Smith HW. On dichlorethylsulphide (mustard gas) II. Variations in susceptibility of the skin to dichlorethylsulphide. J Pharmacol Exp Ther. 1918;12:291–301.
   Google Scholar
• Trauer S, Richter H, Kuntsche J, et al. Influence of massage and occlusion on the ex vivo skin penetration of rigid liposomes and invasomes. Eur J Pharm Biopharm. 2014;86:301–306.
   PubMed Web of Science ®Google Scholar
• Lademann J, Richter H, Schaefer UF, et al. Hair follicles – a long-term reservoir for drug delivery. Skin Pharmacol Physiol. 2006;19:232–236.
   PubMed Web of Science ®Google Scholar
• Lademann J, Patzelt A, Richter H, et al. Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles. J Biomed Opt. 2009;14:021014.
   PubMed Web of Science ®Google Scholar
• Radtke M, Patzelt A, Knorr F, et al. Ratchet effect for nanoparticle transport in hair follicles. Eur J Pharm Biopharm. 2017;116:125–130.
   PubMed Web of Science ®Google Scholar
• Dubrovsky V. The effect of massage on athletes’ cardiorespiratory systems. Soviet Sports Rev. 1990;25:36–38.
   Google Scholar
• Dubrovsky V. Changes in muscle and venous blood flow after massage. Soviet Sports Rev. 1983;18:134–135.
   Google Scholar
• Hinds T, McEwan I, Perkes J, et al. Effects of massage on limb and skin blood flow after quadriceps exercise. Med Sci Sports Exerc. 2004;36:1308–1313.
   PubMed Web of Science ®Google Scholar
• Shoemaker JK, Tiidus PM, Mader R. Failure of manual massage to alter limb blood flow: measures by Doppler ultrasound. Med Sci Sports Exerc. 1997;29:610–614.
   PubMed Web of Science ®Google Scholar
• Tiidus PM, Shoemaker JK. Effleurage massage, muscle blood flow and long-term post-exercise strength recovery. Int J Sports Med. 1995;16:478–483.
   PubMed Web of Science ®Google Scholar
• Cafarelli E, Flint F. The role of massage in preparation for and recovery from exercise. An overview. Sports Med. 1992;14:1–9.
   PubMed Web of Science ®Google Scholar
• Shin SH, Ghosh P, Newman B, et al. On the road to development of an in vitro permeation test (IVPT) model to compare heat effects on transdermal delivery systems: exploratory studies with nicotine and fentanyl. Pharm Res. 2017;34:1817–1830.
   PubMed Web of Science ®Google Scholar
• Mitragotri S. Sonophoresis: a 50-year journey. Drug Discov Today. 2004;9:735–736.
   PubMed Web of Science ®Google Scholar
• Newman MK, Kill M, Frampton G. Effects of ultrasound alone and combined with hydrocortisone injections by needle or hypo-spray. Am J Phys Med. 1958;37:206–209.
   PubMedGoogle Scholar
• Escobar-Chávez JJ, Díaz-Torres R, Domínguez-Delgado CL, et al. Therapeutic applications of sonophoresis and sonophoretic devices. In: Dragicevic N, Maibach HI, editors. Percutaneous penetration enhancers physical methods in penetration enhancement. Berlin: Springer-Verlag; 2017. p. 31–58.
   Google Scholar
• Chan HP, Zhai H, Hui X, et al. Skin decontamination: principles and perspectives. Toxicol Ind Health. 2013;29:955–968.
   PubMed Web of Science ®Google Scholar
• Hansen S, Naegel A, Heisig M, et al. The role of corneocytes in skin transport revised – a combined computational and experimental approach. Pharm Res. 2009;26:1379–1397.
   PubMed Web of Science ®Google Scholar
• Horita D, Todo H, Sugibayashi K. Analysis of the pretreatment effect of ethanol on the stratum corneum- and hair follicular-penetration of drugs using the hair follicle-plugging method. Chem Pharm Bull. 2014;62:578–585.
   PubMed Web of Science ®Google Scholar
• Nitsche JM, Wang TF, Kasting GB. A two-phase analysis of solute partitioning into the stratum corneum. J Pharm Sci. 2006;95:649–666.
   PubMed Web of Science ®Google Scholar
• Raykar PV, Fung MC, Anderson BD. The role of protein and lipid domains in the uptake of solutes by human stratum corneum. Pharm Res. 1988;5:140–150.
   PubMed Web of Science ®Google Scholar
• Wang L, Chen L, Lian G, et al. Determination of partition and binding properties of solutes to stratum corneum. Int J Pharm. 2010;398:114–122.
   PubMedGoogle Scholar
• Zhu H, Jung EC, Hui X, et al. Proposed human stratum corneum water domain in chemical absorption. J Appl Toxicol. 2016;36:991–996.
   PubMed Web of Science ®Google Scholar
• Lehman PA, Raney SG, Franz TJ. Percutaneous absorption in man: in vitro-in vivo correlation. Skin Pharmacol Physiol. 2011;24:224–230.
   PubMed Web of Science ®Google Scholar
• Hui XH, Maibach HI. Unpublished observations. UCSF; 2018.
   Google Scholar