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Cancer

The therapeutic effects of blocking IGF-R1 on mice model of skin cancer

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Pages 803-811 | Received 26 Oct 2019, Accepted 19 Dec 2019, Published online: 03 Jan 2020

References

  • Whiteman DC, Green AC, Olsen CM. The growing burden of invasive melanoma: projections of incidence rates and numbers of new cases in six susceptible populations through 2031. J Invest Dermatol. 2016;136:1161–1171.
  • Apalla Z, Nashan D, Weller RB, et al. Skin cancer: epidemiology, disease burden, pathophysiology, diagnosis, and therapeutic approaches. Dermatol Ther (Heidelb). 2017;7:5–19.
  • Monshi B, Vujic M, Kivaranovic D, et al. The burden of malignant melanoma–lessons to be learned from Austria. Eur J Cancer. 2016;56:45–53.
  • Rudman SM, Philpott MP, Thomas GA, et al. The role of IGF-I in human skin and its appendages: morphogen as well as mitogen? J Invest Dermatol. 1997;109:770–777.
  • Tsitsipatis D, Klotz LO, Steinbrenner H. Multifaceted functions of the forkhead box transcription factors FoxO1 and FoxO3 in skin. Biochim Biophys Acta Gen Subj. 2017;1861:1057–1064.
  • Yu M, King B, Ewert E, et al. Exercise activates p53 and negatively regulates IGF-1 pathway in epidermis within a skin cancer model. PloS One. 2016;11:e0160939.
  • Krbanjevic A, Travers JB, Spandau DF. How wounding via lasers has potential photocarcinogenic preventative effects via dermal remodeling. Curr Derm Rep. 2016;5:222–227.
  • Jung M, Bu SY, Tak KH, et al. Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer. Nutr Res Pract. 2013;7:439–445.
  • Al-Gayyar MMH, Bagalagel A, Noor AO, et al. The therapeutic effects of nicotinamide in hepatocellular carcinoma through blocking IGF-1 and effecting the balance between Nrf2 and PKB. Biomed Pharmacother. 2019;112:108653.
  • Gunschmann C, Stachelscheid H, Akyuz MD, et al. Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev Cell. 2013;26:176–187.
  • DiGiovanni J, Bol DK, Wilker E, et al. Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion. Cancer Res. 2000;60:1561–1570.
  • Alyoussef A. Blocking TGF-beta type 1 receptor partially reversed skin tissue damage in experimentally induced atopic dermatitis in mice. Cytokine. 2018;106:45–53.
  • Alyoussef A, Taha M. Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2. Exp Dermatol. 2019;28:28–34.
  • Alyoussef A, Taha M. Blocking Wnt as a therapeutic target in mice model of skin cancer. Arch Dermatol Res. 2019;311:595–605.
  • Chamcheu JC, Roy T, Uddin MB, et al. Role and therapeutic targeting of the PI3K/Akt/mTOR signaling pathway in skin cancer: a review of current status and future trends on natural and synthetic agents therapy. Cells. 2019;8:803.
  • Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol. 2010;146:283–287.
  • Berrocal A, Cabanas L, Espinosa E, et al. Melanoma: diagnosis, staging, and treatment. Consensus group recommendations. Adv Ther. 2014;31:945–960.
  • Lewis DA, Travers JB, Somani AK, et al. The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. Oncogene. 2010;29:1475–1485.
  • Zaghloul RA, El-Shishtawy MM, El Galil KH, et al. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. Eur J Pharmacol. 2015;746:353–362.
  • Alyoussef A, Al-Gayyar M. Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 in vivo and in vitro. Biomed Pharmacother. 2018;103:362–372.
  • Fei X, Zhang J, Zhao Y, et al. miR-96 promotes invasion and metastasis by targeting GPC3 in non-small cell lung cancer cells. Oncol Lett. 2018;15:9081–9086.
  • Moek KL, Fehrmann RSN, van der Vegt B, et al. Glypican 3 overexpression across a broad spectrum of tumor types discovered with functional genomic mRNA profiling of a large cancer database. Am J Pathol. 2018;188:1973–1981.
  • Xu Y, Mu Y, Wang L, et al. Detailed analysis of molecular mechanisms in primary and metastatic melanoma. J Comput Biol. Forthcoming. 2019.
  • Wang SH, Zhou JD, He QY, et al. MiR-199a inhibits the ability of proliferation and migration by regulating CD44-Ezrin signaling in cutaneous squamous cell carcinoma cells. Int J Clin Exp Pathol. 2014;7:7131–7141.
  • Al-Gayyar MM, Abbas A, Hamdan AM. Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma. Biol Chem. 2016;397:257–267.
  • El Kramani N, Elsherbiny NM, El-Gayar AM, et al. Clinical significance of the TNF-alpha receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia. Cytokine. 2018;111:523–529.
  • Elewa MA, Al-Gayyar MM, Schaalan MF, et al. Hepatoprotective and anti-tumor effects of targeting MMP-9 in hepatocellular carcinoma and its relation to vascular invasion markers. Clin Exp Metastasis. 2015;32:479–493.
  • Goncharuk VN, Ross JS, Carlson JA. Actin-binding protein fascin expression in skin neoplasia. J Cutan Pathol. 2002;29:430–438.

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