2,241
Views
8
CrossRef citations to date
0
Altmetric
Review Articles

Off-label dermatologic uses of IL-17 inhibitors

&
Pages 41-47 | Received 03 Feb 2020, Accepted 24 Feb 2020, Published online: 09 Mar 2020

References

  • Blauvelt A, Chiricozzi A. The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis. Clinic Rev Allerg Immunol. 2018;55(3):379–390.
  • Malakouti M, Brown GE, Wang E, et al. The role of IL-17 in psoriasis. J Dermatolog Treat. 2015;26(1):41–44.
  • Bissonnette R, Luger T, Thaci D, et al. Secukinumab demonstrates high sustained efficacy and a favourable safety profile in patients with moderate-to-severe psoriasis through 5 years of treatment (SCULPTURE Extension Study). J Eur Acad Dermatol Venereol. 2018;32(9):1507–1514.
  • Gordon KB, Colombel JF, Hardin DS. Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis. N Engl J Med. 2016;375(21):2102.
  • Puig L, Lebwohl M, Bachelez H, et al. Long-term efficacy and safety of brodalumab in the treatment of psoriasis: 120-week results from the randomized, double-blind, placebo- and active comparator-controlled phase 3 AMAGINE-2 trial. J Am Acad Dermatol. 2019;82(2):352–359.
  • Cosentyx® (secukinumab) [package insert]. Food and drug administration. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2015.
  • Taltz® (ixekizumab) [package insert]. Food and drug administration. Indianapolis, IN: Eli Lilly and Company; 2016.
  • Siliq® (brodalumab) [package insert]. Food and Drug Administration. Bridgewater, NJ: Valeant Pharmaceuticals North America; 2017.
  • Matusiak Ł, Szczęch J, Bieniek A, et al. Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents. J Am Acad Dermatol. 2017;76(4):670–675.
  • Feldmeyer L, Mylonas A, Demaria O, et al. Interleukin 23-Helper T cell 17 axis as a treatment target for pityriasis rubra pilaris. JAMA Dermatol. 2017;153(4):304–308.
  • Prussick L, Rothstein B, Joshipura D, et al. Open-label, investigator-initiated, single-site exploratory trial evaluating secukinumab, an anti-interleukin-17A monoclonal antibody, for patients with moderate-to-severe hidradenitis suppurativa. Br J Dermatol. 2019;181(3):609–611.
  • Marasca C, Megna M, Balato A, et al. Secukinumab and hidradenitis suppurativa: Friends or foes?. JAAD Case Rep. 2019;5(2):184–187.
  • Thorlacius L, Theut Riis P, Jemec G. Severe hidradenitis suppurativa responding to treatment with secukinumab: a case report. Br J Dermatol. 2018;179(1):182–185.
  • Schuch A, Fischer T, Boehner A, et al. Successful treatment of severe recalcitrant hidradenitis suppurativa with the interleukin-17A antibody secukinumab. Acta Derm Venerol. 2018;98(1):151–152.
  • Jorgensen AR, Yao Y, Thomsen SF. Therapeutic response to secukinumab in a 36-year-old woman with hidradenitis suppurativa. Case Rep Dermatol Med. 2018;2018:8685136.
  • Wain T, Choy B, Satchell AC, et al. Secukinumab in pityriasis rubra pilaris: a case series demonstrating variable response and the need for minimal clinical datasets. JAAD Case Rep. 2018;4(5):500–505.
  • Bonomo L, Levitt JO. Secukinumab emerges as a rapidly effective therapy for pityriasis rubra pilaris. Cutis. 2018;101(5):367–369.
  • Schuster D, Pfister-Wartha A, Bruckner-Tuderman L, et al. Successful treatment of refractory pityriasis rubra pilaris with secukinumab. JAMA Dermatol. 2016;152(11):1278–1280.
  • Gauci ML, Jachiet M, Gottlieb J, et al. Successful treatment of type II pityriasis rubra pilaris with secukinumab. JAAD Case Rep. 2016;2(6):462–464.
  • Di Scala G, Bettiol A, Cojan RD, et al. Efficacy of the anti-IL 17 secukinumab in refractory Behcet’s syndrome: a preliminary study. J Autoimmun. 2019;97:108–113.
  • Guttman-Yassky E, Nia JK, Hashim PW, et al. Efficacy and safety of secukinumab treatment in adults with extensive alopecia areata. Arch Dermatol Res. 2018;310(8):607–614.
  • Todberg T, Zachariae C, Krustrup D, et al. The effect of treatment with anti-interleukin-17 in patients with allergic contact dermatitis. Contact Dermatitis. 2018;78(6):431–432.
  • Cotter C, Tobin AM, O’Connor R, et al. Severe refractory hidradenitis suppurativa: treatment with ixekizumab, two case reports. Br J Dermatol. 2018;179:24–73.
  • Heibel MD, Heibel HD. Successful treatment of type I pityriasis rubra pilaris with ixekizumab. JAAD Case Rep. 2018;4(8):774–776.
  • Chastagner M, Hoelt P, Kanitakis J, et al. Successful treatment of TNFα inhibitor-resistant pityriasis rubra pilaris with ixekizumab and acitretin. Eur J Dermatol. 2019;29(2):218–220.
  • Hanfstingl K, Pekar-Lukacs A, Motz R, et al. Successful treatment of pityriasis rubra pilaris with ixekizumab. Case Rep Dermatol. 2018;10(2):97–100.
  • ClinicalTrials.gov. Bethesda (MD): National Library of Medicine. [cited 2019 Dec 11]. Available form: https://clinicaltrials.gov/
  • Danesh MJ, Kimball AB. Brodalumab and suicidal ideation in the context of a recent economic crisis in the United States. J Am Acad Dermatol. 2016;74(1):190–192.
  • Na SY, Park MJ, Park S, et al. Up-regulation of Th17 and related cytokines in Behcet’s disease corresponding to disease activity. Clin Exp Rheumatol. 2013;31(3 Suppl 77):32–40.
  • Cavani A. Immune regulatory mechanisms in allergic contact dermatitis and contact sensitization. Chem Immunol Allergy. 2008;94:93–100.
  • Ito T, Hashizume H, Shimauchi T, et al. CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase. J Dermatol Sci. 2013;69(2):140–147.
  • van de Kerkhof PC, Griffiths CE, Reich K, et al. Secukinumab long-term safety experience: A pooled analysis of 10 phase II and III clinical studies in patients with moderate to severe plaque psoriasis. J Am Acad Dermatol. 2016;75(1):83–98 e4.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.