References
- Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134:1527–1534.
- Olsen JR, Gallacher J, Piguet V, et al. Epidemiology of molluscum contagiosum in children: a systematic review. Fam Pract. 2014;31:130–136.
- Dohil MA, Lin P, Lee J, et al. The epidemiology of molluscum contagiosum in children. J Am Acad Dermatol. 2006;54:47–54.
- McCollum AM, Holman RC, Hughes CM, et al. Molluscum contagiosum in a pediatric American Indian population: incidence and risk factors. Plos One. 2014;9:e103419.
- van der Wouden JC, van der Sande R, Kruithof EJ, et al. Interventions for cutaneous molluscum contagiosum. Cochrane Database Syst Rev. 2017: CD004767.
- Olsen JR, Piguet V, Gallacher J, et al. Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care. Br J Gen Pract. 2016;66:e53–e58.
- Shisler JL. Immune evasion strategies of molluscum contagiosum virus. Adv Virus Res. 2015;92:201–252.
- Forbat E, Al-Niaimi F, Ali FR. Molluscum contagiosum: review and update on management. Pediatr Dermatol. 2017;34:504–515.
- Toutous-Trellu L, Hirschel B, Piguet V, et al. Treatment of cutaneous human papilloma virus, poxvirus and herpes simplex virus infectionswith topical cidofovir in HIV positive patients. Ann Dermatol Venereol. 2004;131:445–449.
- Meadows KP, Tyring SK, Pavia AT, et al. Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiencyvirus-infected patients treated with cidofovir. Arch Dermatol. 1997;133:987–990.
- Suzuki H, Wang B, Shivji GM, et al. Imiquimod, a topical immune response modifier, induces migration of Langerhans cells. J Invest Dermatol. 2000;114:135–141.
- Olsen JR, Gallacher J, Finlay AY, et al. Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study. Lancet Infect Dis. 2015;15:190–195.
- Molluscum contagiosum is best left to clear by itself. NHHR Signal; 2017 Aug 29.
- Smith WA, Siegel D, Lyon VB, et al. Psoriasiform eruption and oral ulcerations as adverse effects of topical 5% imiquimod treatment in children: a report of four cases. Pediatr Dermatol. 2013;30:e157–e160.
- Mashiah J, Brenner S. Possible mechanisms in the induction of vitiligo-like hypopigmentation by topical imiquimod. Clin Exp Dermatol. 2008;33:74–76.
- DiBiagio JR, Pyle T, Green JJ. Reviewing the use of imiquimod for molluscum contagiosum. Dermatol Online J. 2018;24:5.
- Campanelli A, Krischer J, Saurat JH. Topical application of imiquimod and associated fever in children. J Am Acad Dermatol. 2005;52:E1.
- Vermi W, Fisogni S, Salogni L, et al. Spontaneous regression of highly immunogenic Molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J Invest Dermatol. 2011;131:426–434.
- Syed TA, Goswami J, Ahmadpour OA, et al. Treatment of molluscum contagiosum in males with an analog of imiquimod 1% in cream: a placebo-controlled, double-blind study. J Dermatol. 1998;25:309–313.
- Hengge UR, Esser S, Schultewolter T, et al. Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. Br J Dermatol. 2000;143:1026–1031.
- Bayerl C, Feller G, Goerdt S. Experience in treating molluscum contagiosum in children with imiquimod 5% cream. Br J Dermatol. 2003;149:25–29.
- Skinner RB Jr, Ray S, Talanin NY. Treatment of molluscum contagiosum with topical 5% imiquimod cream.2339. J Am Acad Dermatol. 2002;47:S221–S224.
- Skinner RB, Ray S, Talanin NY Jr. Treatment of molluscum contagiosum with imiquimod 5% cream. Pediatr Dermatol. 2000;17:420–420.
- Badavanis G, Pasmatzi E, Monastirli A, et al. Topical imiquimod is an effective and safe drug for molluscum contagiosum in children. Acta Dermatovenerol Croat. 2017;25:164–166.
- Hanna D, Hatami A, Powell J, et al. A prospective randomized trial comparing the efficacy and adverse effects of four recognizedtreatments of molluscum contagiosum in children. Pediatr Dermatol. 2006;23:574–579.
- Saral Y, Kalkan A, Ozdarendeli A, et al. Detection of Molluscum contagiosum virus (MCV) subtype I as a single dominant virus subtype in Molluscum lesions from a Turkish population. Arch Med Res. 2006;37:388–391.
- Raimer SS. New and emerging therapies in pediatric dermatology. Dermatol Clin. 2000;18:73–78.
- Sauder DN. Immunomodulatory and pharmacologic properties of imiquimod. J Am Acad Dermatol. 2000;43:S6–S11.
- Theiler M, Kempf W, Kerl K, et al. Disseminated molluscum contagiosum in a HIV-positive child. Improvement after therapy with 5% imiquimod. J Dermatol Case Rep. 2011;5:19–23.
- Al-Mutairi N, Al-Doukhi A, Al-Farag S, et al. Comparative study on the efficacy, safety, and acceptability of imiquimod 5% cream versus cryotherapy for molluscum contagiosum in children. Pediatr Dermatol. 2010;27:388–394.
- Gamble RG, Echols KF, Dellavalle RP. Imiquimod vs cryotherapy for molluscum contagiosum:a randomized controlled trial. ArchDermatol. 2012;148:109–112.
- Seo SH, Chin HW, Jeong DW, et al. An open, randomized, comparative clinical and histological study of imiquimod 5% cream versus 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Ann Dermatol. 2010;22:156–162.
- Simonart T, De Maertelaer VBr. Curettage treatment for molluscum contagiosum: a follow-up survey study. J Dermatol. 2008;159:1144–1147.
- Harrison CJ1, Miller RL, Bernstein DI. Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs. Antimicrob Agents Chemother. 1994;38:2059–2064.
- Theos AU, Cummins R, Silverberg NB, et al. Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial. Cutis. 2004;74:134–138. 141–2.
- Clinical executive summary [online]. [accessed 2016 Jan 12]. Available from: http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/UCM162961.pdf
- Katz KA. Imiquimod is not an effective drug for molluscum contagiosum. Lancet Infect Dis. 2014;14:372–373.
- Katz KA, Swetman GL. Imiquimod, molluscum, and the need for a better “best pharmaceuticals for children”. Pediatrics. 2013;132:1–3.
- Katz KA, Williams HC, van der Wouden JC. Imiquimod cream for molluscum contagiosum: neither safe nor effective. Pediatr Dermatol. 2018;35:282–283.
- Katz KA. Dermatologists, imiquimod, and treatment of molluscum contagiosum in children: righting wrongs. JAMA Dermatol. 2015;151:125–126.
- Harrison LI, Skinner SL, Marbury TC, et al. Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms. Arch Dermatol Res. 2004;296:6–11.
- Myhre PE, Levy ML, Eichenfield LF, et al. Pharmacokinetics and safety of imiquimod 5% cream in the treatment of molluscum contagiosumin children. Pediatr Dermatol. 2008;25:88–95.
- Farhangian ME, Huang KE, Feldman SR, et al. Treatment of molluscum contagiosum with imiquimod in the United States: a retrospective cross-sectional study. Pediatr Dermatol. 2016;33:227–228.
- Braue A, Ross G, Varigos G, et al. Epidemiology and impact of childhood molluscum contagiosum: a case series and critical review of the literature. Pediatr Dermatol. 2005;22:287–294.