Low-dose methotrexate in dermatology: the utility of serological monitoring in a real-world cohort

References

• Solomon DH, Glynn RJ, Karlson EW, et al. Adverse effects of low-dose methotrexate: a randomized trial. Ann Intern Med. 2020;172(6):369–380.
   PubMed Web of Science ®Google Scholar
• Ridker PM, Everett BM, Pradhan A, CIRT Investigators, et al. Low-dose methotrexate for the prevention of atherosclerotic events. N Engl J Med. 2019;380(8):752–762.
   PubMed Web of Science ®Google Scholar
• Kivity S, Zafrir Y, Loebstein R, et al. Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients. Autoimmun Rev. 2014;13(11):1109–1113.
   PubMed Web of Science ®Google Scholar
• Vanni KMM, Lyu H, Solomon DH. Cytopenias among patients with rheumatic diseases using methotrexate: a meta-analysis of randomized controlled clinical trials. Rheumatology. 2020;59(4):709–717.
   PubMed Web of Science ®Google Scholar
• Gutierrez-Urena S, Molina JF, Garcia CO, et al. Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis. Arthritis Rheum. 1996;39(2):272–276.
   PubMedGoogle Scholar
• Kuitunen T, Malmstrom J, Palva E, et al. Pancytopenia induced by low-dose methotrexate. A study of the cases reported to the Finnish Adverse Drug Reaction Register from 1991 to 1999. Scand J Rheumatol. 2005;34(3):238–241.
   PubMed Web of Science ®Google Scholar
• Roenigk HH, Jr., Auerbach R, Maibach HI, et al. Methotrexate guidelines–revised. J Am Acad Dermatol. 1982;6(2):145–155.
   PubMed Web of Science ®Google Scholar
• Callen JP, Kulp-Shorten CL. Methotrexate. In: Wolverton SE, editor. Comprehensive dermatologic drug therapy. 3rd ed. Edinburgh: Elsevier; 2013. p. 169–181.
   Google Scholar
• Menter A, Cordoro KM, Davis DMR, et al. Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients. J Am Acad Dermatol. 2020;82(1):161–201.
   PubMed Web of Science ®Google Scholar
• Menter A, Gelfand JM, Connor C, et al. Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies. J Am Acad Dermatol. 2020;82(6):1445–1486.
   PubMed Web of Science ®Google Scholar
• Singh JA, Saag KG, Bridges SL, Jr., et al. 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Care Res. 2016;68(1):1–25.
   PubMed Web of Science ®Google Scholar
• Busger Op Vollenbroek FTM, Doggen CJM, Janssens RWA, et al. Dermatological guidelines for monitoring methotrexate treatment reduce drug-survival compared to rheumatological guidelines. PLOS One. 2018;13(3):e0194401.
   PubMed Web of Science ®Google Scholar
• Lopez-Olivo MA, Siddhanamatha HR, Shea B, et al. Methotrexate for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2014;2014(6):Cd000957.
   PubMed Web of Science ®Google Scholar
• Yazici Y, Sokka T, Kautiainen H, et al. Long term safety of methotrexate in routine clinical care: discontinuation is unusual and rarely the result of laboratory abnormalities. Ann Rheumat Dis. 2005;64(2):207–211.
   PubMed Web of Science ®Google Scholar
• Conway R, Low C, Coughlan RJ, et al. Risk of liver injury among methotrexate users: a meta-analysis of randomised controlled trials. Semin Arthritis Rheum. 2015;45(2):156–162.
   PubMed Web of Science ®Google Scholar
• Khabbazi A, Kolahi S, Dastgiri S, et al. Safety of less frequent monitoring of liver transaminases levels in rheumatic patients treated with low-dose methotrexate. Int J Rheum Dis. 2014;17(6):646–652.
   PubMed Web of Science ®Google Scholar
• Karlsson Sundbaum J, Eriksson N, Hallberg P, et al. Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice. Int J Rheum Dis. 2019;22(7):1226–1232.
   PubMed Web of Science ®Google Scholar
• Ng LC, Lee YY, Lee CK, et al. A retrospective review of methotrexate-induced hepatotoxicity among patients with psoriasis in a tertiary dermatology center in Malaysia. Int J Dermatol. 2013;52(1):102–105.
   PubMed Web of Science ®Google Scholar
• Yee J, Orchard D. Monitoring recommendations for oral azathioprine, methotrexate and cyclosporin in a paediatric dermatology clinic and literature review. Australas J Dermatol. 2018;59(1):31–40.
   PubMed Web of Science ®Google Scholar
• Cabello Zurita C, Grau Perez M, Hernandez Fernandez CP, et al. Effectiveness and safety of methotrexate in psoriasis: an eight-year experience with 218 patients. J Dermatolog Treat. 2017;28(5):401–405.
   PubMed Web of Science ®Google Scholar
• Tournier A, Khemis A, Maccari F, et al. Methotrexate efficacy and tolerance in plaque psoriasis. A prospective real-life multicentre study in France. Annales de Dermatologie et de Venereologie. 2019;146(2):106–114.
   PubMed Web of Science ®Google Scholar
• Yan K, Zhang Y, Han L, et al. Safety and efficacy of methotrexate for Chinese adults with psoriasis with and without psoriatic arthritis. JAMA Dermatol. 2019;155(3):327–334.
   PubMed Web of Science ®Google Scholar
• Herrmann T, Buhnerkempe M, Wilson ML. Initiation of methotrexate with or without a test dose: a retrospective toxicity study. J Am Acad Dermatol. 2019;80(4):1160–1162.
   PubMed Web of Science ®Google Scholar
• Zufall AG, Rama B, Ninmer EK, et al. Methotrexate monitoring in dermatology – a retrospective cohort study. J Drugs Dermatol. 2021;20(3):320–325.
   PubMed Web of Science ®Google Scholar
• Levey AS, Stevens LA, Schmid CH, for the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–612.
   PubMed Web of Science ®Google Scholar
• Schwartz GJ, Haycock GB, Edelmann CM, Jr, et al. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58(2):259–263.
   PubMed Web of Science ®Google Scholar
• NIH. Common terminology criteria for adverse events (CTCAE); 2017 [cited 2019]. Available from: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf.
   Google Scholar
• Rheumatoid Arthritis Clinical Trial Archive Group. The effect of age and renal function on the efficacy and toxicity of methotrexate in rheumatoid arthritis. J Rheumatol. 1995;22(2):218–223.
   PubMed Web of Science ®Google Scholar
• Gelfand JM, Wan J, Zhang H, et al. Risk of liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis receiving methotrexate: a population-based study. J Am Acad Dermatol. 2021;84(6):1636–1643.
   Web of Science ®Google Scholar
• Bafna P, Sahoo RR, Hazarika K, et al. Prevalence of liver fibrosis by Fibroscan in patients on long-term methotrexate therapy for rheumatoid arthritis. Clin Rheumatol. 2021. doi: 10.1007/s10067-021-05678-8.
   PubMed Web of Science ®Google Scholar
• Bauer B, Chyou PH, Stratman EJ, et al. Noninvasive testing for nonalcoholic steatohepatitis and hepatic fibrosis in patients with psoriasis receiving long-term methotrexate sodium therapy. JAMA Dermatol. 2017;153(10):977–982.
   PubMed Web of Science ®Google Scholar
• Giannini EH, Brewer EJ, Kuzmina N, et al. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group. N Engl J Med. 1992;326(16):1043–1049.
   PubMed Web of Science ®Google Scholar
• Anderson K, Putterman E, Rogers RS, et al. Treatment of severe pediatric atopic dermatitis with methotrexate: a retrospective review. Pediatr Dermatol. 2019;36(3):298–302.
   PubMed Web of Science ®Google Scholar
• Dvorakova V, O'Regan GM, Irvine AD. Methotrexate for severe childhood atopic dermatitis: clinical experience in a Tertiary Center. Pediatr Dermatol. 2017;34(5):528–534.
   PubMed Web of Science ®Google Scholar
• Purvis D, Lee M, Agnew K, et al. Long-term effect of methotrexate for childhood atopic dermatitis. J Paediatr Child Health. 2019;55(12):1487–1491.
   PubMed Web of Science ®Google Scholar