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Articles

Real-life experience with chlormethine gel for early-stage mycosis fungoides with emphasis on types and management of cutaneous side-effects#

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Pages 2364-2370 | Received 11 Jul 2021, Accepted 08 Aug 2021, Published online: 24 Aug 2021

References

  • Haserick J, Richardson J, Grant D. Remission of lesions in mycosis fungoides following topical application of nitrogen mustard. Cleve Clin Q. 1959;26(3):144–147.
  • Van Scott EJ. Complete regressions of mycosis fungoides with topical mechlorethamine hydrochloride. JAMA. 1972;222(9):1172.
  • Vonderheid EC, Van Scott EJ, Wallner PE, et al. A 10-year experience with topical mechlorethamine for mycosis fungoides: comparison with patients treated by total-skin electron-beam radiation therapy. Cancer Treat Rep. 1979;63(4):681–689.
  • Price NM, Deneau DG, Hoppe RT. The treatment of mycosis fungoides with ointment-based mechlorethamine. Arch Dermatol. 1982;118(4):234–237.
  • Ramsay DL, Halperin PS, Zeleniuch-Jacquotte A. Topical mechlorethamine therapy for early stage mycosis fungoides. J Am Acad Dermatol. 1988;19(4):684–691.
  • Vonderheid EC, Tan ET, Kantor AF, et al. Long- term efficacy, curative potential, and carcinogenicity of topical mechlorethamine chemotherapy in cutaneous T cell lymphoma. J Am Acad Dermatol. 1989;20(3):416–428.
  • Kim YH, Martinez G, Varghese A, et al. Topical nitrogen mustard in the management of mycosis fungoides: update of the stanford experience. Arch Dermatol. 2003;139(2):165–173.
  • Lindahl LM, Fenger-Gron M, Iversen L. Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis. J Eur Acad Dermatol Venereol. 2013;27(2):163–168.
  • de Quatrebarbes J, Estève E, Bagot M, et al. Treatment of early-stage mycosis fungoides with twice-weekly applications of mechlorethamine and topical corticosteroids: a prospective study. Arch Dermatol. 2005;141(9):1117–1120.
  • National comprehensive cancer network clinical practice guidelines in oncology. Primary cutaneous lymphomas. Version 1.2020. 2020 [cited 2020 Dec 3]. Available from: https://www.nccn.org/professionals/physician_gls/default_nojava.aspx.
  • Willemze R, Hodak E, Zinzani PL, ESMO Guidelines Committee, et al. Primary cutaneous lymphomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29(Suppl 4):iv30–iv40.
  • Trautinger F, Eder J, Assaf C, et al. European organisation for research and treatment of cancer consensus recommendations for the treatment of mycosis fungoides/sézary syndrome – update 2017. Eur J Cancer. 2017;77:57–74.
  • Lessin SR, Duvic M, Guitart J, et al. Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. JAMA Dermatol. 2013;149(1):25–32.
  • Geskin LJ, Bagot M, Hodak E, et al. Chlormethine gel for the treatment of skin lesions in all stages of mycosis fungoides cutaneous t-cell lymphoma: a narrative review and international experience. Dermatol Ther (Heidelb). 2021;11(4):1085–1106.
  • Kim EJ, Guitart J, Querfeld C, et al. The PROVe study: US real-world experience with chlormethine/mechlorethamine gel in combination with other therapies for patients with mycosis fungoides cutaneous T-cell lymphoma . Am J Clin Dermatol. 2021;22(3):407–414.
  • Kim EJ, Geskin L, Guitart J, et al. Real-world experience with mechlorethamine gel in patients with mycosis fungoides-cutaneous lymphoma: preliminary findings from a prospective observational study. J Am Acad Dermatol. 2020;83(3):928–930.
  • Wehkamp U, Jost M, Gosmann J, et al. Management of chlormethine gel treatment in mycosis fungoides patients in two German skin lymphoma centers. JDDG. 2021;19(7):1057–1059.
  • Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105(10):3768–3785.
  • Olsen E, Whittaker S, Kim YH, Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer, et al. Clinical end points and response criteria in mycosis fungoides and Sézary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer. J Clin Oncol. 2011;29(18):2598–2607.
  • Vonderhied EC. Topical mechlorethamine chemotherapy. Considerations on its use in mycosis fungoides. Int J Dermatol. 1984;23:180–186.
  • Vonderheid EC. Treatment planning in cutaneous T-cell lymphoma. Dermatol Ther. 2003;16(4):276–282.
  • Kim YH. Management with topical nitrogen mustard in mycosis fungoides. Dermatol Ther. 2003;16(4):288–298.
  • Querfeld C, Scarisbrick JJ, Assaf C, et al. Post hoc analysis of a randomized, controlled, phase 2 study to assess response rates with chlormethine/mechlorethamine gel in patients with stage IA-IIA mycosis fungoides. Dermatology. 2021; (4):1–11.
  • van Santen S, van Doorn R, Neelis KJ, et al. Recommendations for treatment in folliculotropic mycosis fungoides: report of the Dutch cutaneous lymphoma group. Br J Dermatol. 2017;177(1):223–228.
  • Amitay-Laish I, Prag-Naveh H, Dalal A, et al. Hodak E treatment of early folliculotropic mycosis fungoides with special focus on psoralen plus ultraviolet A. Acta Derm Venereol. 2018;98(10):951–955.
  • Gilmore ES, Alexander-Savio CV, Chung CG, et al. Evaluation and management of patients with early-stage mycosis fungoides who interrupt or discontinue topical mechlorethamine gel because of dermatitis. JAAD Case Rep. 2020;6(9):878–881.
  • Bergman R, Cohen A, Harth Y, et al. Histopathologic findings in the clinically uninvolved skin of patients with mycosis fungoides. Am J Dermatopathol. 1995;17(5):452–456.
  • El-Darouti MA, Marzouk SA, Bosseila M, et al. Microscopic study of normal skin in cases of mycosis fungoides. Int J Dermatol. 2006;45(9):1043–1046.
  • Price NM. Topical mechlorethamine. Cutaneous changes in patients with mycosis fungoides after its administration. Arch Dermatol. 1977;113(10):1387–1389.
  • Flaxman BA, Sosis AC, Van Scott EJ. Changes in melanosome distribution in caucasoid skin following topical application of nitrogen mustard. J Invest Dermatol. 1973;60(5):321–326.
  • Van Scott EJ, Yu RJ. Melanogenesis from topical mechlorethamine and analogues in skin of hairless mice and in vitiligo. J Invest Dermatol. 1975;65(5):476–478.

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