697
Views
0
CrossRef citations to date
0
Altmetric
Review Article

Tranexamic acid as a therapeutic option for melasma management: meta-analysis and systematic review of randomized controlled trials

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Article: 2361106 | Received 01 Apr 2024, Accepted 13 May 2024, Published online: 06 Jun 2024

References

  • González-Molina V, Martí-Pineda A, González N. Topical treatments for melasma and their mechanism of action. J Clin Aesthet Dermatol. 2022; May15(5):1–13.
  • Kim HJ, Moon SH, Cho SH, et al. Efficacy and safety of tranexamic acid in melasma: a meta-analysis and systematic review. Acta Derm Venereol. 2017;97(7):776–781. doi:10.2340/00015555-2668.
  • Kwon SH, Hwang YJ, Lee SK, et al. Heterogeneous pathology of melasma and its clinical implications. Int J Mol Sci. 2016;17(6):17. doi:10.3390/ijms17060824.
  • Austin E, Nguyen JK, Jagdeo J. Topical treatments for melasma: a systematic review of randomized controlled trials. J Drugs Dermatol. 2019;18(11):S1545961619P1156X. http://europepmc.org/abstract/MED/31741361
  • Wang JV, Jhawar N, Saedi N. Tranexamic acid for melasma: evaluating the various formulations. J Clin Aesthet Dermatol. 2019;12(8):E73–E74.
  • Fatima S, Braunberger T, Mohammad TF, et al. The role of sunscreen in melasma and postinflammatory hyperpigmentation. Indian J Dermatol. 2020;65(1):5–10. doi:10.4103/ijd.IJD_295_18.
  • Zhang L, Tan W-Q, Fang Q-Q, et al. Tranexamic acid for adults with melasma: a systematic review and meta-analysis. Biomed Res Int. 2018;2018:1683414. doi:10.1155/2018/1683414.
  • Kaur A, Bhalla M, Pal Thami G, et al. Clinical efficacy of topical tranexamic acid with microneedling in melasma. Dermatologic Surg. 2020;46(11):e96–e101. https://journals.lww.com/dermatologicsurgery/fulltext/2020/11000/clinical_efficacy_of_topical_tranexamic_acid_with.11.aspx
  • Khurana VK, Misri RR, Agarwal S, et al. A randomized, open-label, comparative study of oral tranexamic acid and tranexamic acid microinjections in patients with melasma. Indian J Dermatol Venereol Leprol. 2019;85(1):39–43. doi:10.4103/ijdvl.IJDVL_801_16.
  • Minni K, Poojary S. Efficacy and safety of oral tranexamic acid as an adjuvant in indian patients with melasma: a prospective, interventional, single-Centre, triple-blind, randomized, placebo-control, parallel group study. J Eur Acad Dermatol Venereol. 2020;34(11):2636–2644. doi:10.1111/jdv.16598.
  • Padhi T, Pradhan S. Oral tranexamic acid with fluocinolone-Based triple combination cream versus fluocinolone-Based triple combination cream alone in melasma: an open labeled randomized comparative trial. Indian J Dermatol. 2015;60(5):520. doi:10.4103/0019-5154.164416.
  • Jia Z, Tian K, Zhong Y, et al. Effectiveness of combination therapy of broadband light and intradermal injection of tranexamic acid in the treatment of chloasma. J Cosmet Dermatol. 2023;22(5):1536–1544. doi:10.1111/jocd.15632.
  • Li Y, Yao C, Zhang H, et al. Efficacy and safety of 755-nm picosecond alexandrite laser with topical tranexamic acid versus laser monotherapy for melasma and facial rejuvenation: a multicenter, randomized, double-blinded, split-face study in chinese patients. Lasers Med Sci. 2022;37(7):2879–2887. doi:10.1007/s10103-022-03566-4.
  • Qu Y, Wang F, Liu J, et al. Clinical observation and dermoscopy evaluation of fractional CO2 laser combined with topical tranexamic acid in melasma treatments. J Cosmet Dermatol. 2021;20(4):1110–1116. doi:10.1111/jocd.13992.
  • Zhao H, Li M, Zhang X, et al. Comparing the efficacy of myjet-assisted tranexamic acid and vitamin C in treating melasma: a split-face controlled trial. J Cosmet Dermatol. 2020;19(1):47–54. doi:10.1111/jocd.13112.
  • Li T, Yan X, Ting L, et al. Observation on the effect of Nd: YAG 1064nm laser combined with topical tranexamic acid on chloasma. In 2020 International Conference on Public Health and Data Science (ICPHDS); 2020 Nov 20; Guangzhou, China. IEEE; 2020. p. 302–306. https://ieeexplore.ieee.org/abstract/document/9361947
  • Xu Y, Ma R, Juliandri J, et al. Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma: a randomized, self-controlled, split-face study. Medicine (Baltimore). 2017;96(19):e6897. May doi:10.1097/MD.0000000000006897.
  • Gamea MM, Kamal DA, Donia AA, et al. Comparative study between topical tranexamic acid alone versus its combination with autologous platelet rich plasma for treatment of melasma. J Dermatolog Treat. 2022;33(2):798–804. doi:10.1080/09546634.2020.1781755.
  • Elkamshoushi AM, Romisy D, Omar SS. Oral tranexamic acid, hydroquinone 4% and low-fluence 1064 nm Q-switched Nd: YAG laser for mixed melasma: clinical and dermoscopic evaluation. J Cosmet Dermatol. 2022;21(2):657–668. doi:10.1111/jocd.14140.
  • Badran AY, Ali AU, Gomaa AS. Efficacy of topical versus intradermal injection of tranexamic acid in egyptian melasma patients: a randomised clinical trial. Australas J Dermatol. 2021;62(3):e373–9–e379. doi:10.1111/ajd.13575.
  • Zaky MS, Obaid ZM, Khalil EA, et al. Microneedling-assisted topical tranexamic acid solution versus 4% hydroquinone for treating melasma: a split-face randomized study. J Cosmet Dermatol. 2021;20(12):4011–4016. doi:10.1111/jocd.14440.
  • Tawfic SO, Abdel Halim DM, Albarbary A, et al. Assessment of combined fractional CO2 and tranexamic acid in melasma treatment. Lasers Surg Med. 2019;51(1):27–33. doi:10.1002/lsm.23032.
  • Behrangi E, Shemshadi M, Ghassemi M, et al. Comparison of efficacy and safety of tranexamic acid mesotherapy versus oral tranexamic acid in patients with melasma undergoing Q-switched fractional 1064-nm Nd: YAG laser: a blinded RCT and follow-up. J Cosmet Dermatol. 2022;21(1):279–289. doi:10.1111/jocd.14496.
  • Karrabi M, Mansournia MA, Sharestanaki E, et al. Clinical evaluation of efficacy and tolerability of cysteamine 5% cream in comparison with tranexamic acid mesotherapy in subjects with melasma: a single-blind, randomized clinical trial study. Arch Dermatol Res. 2021;313(7):539–547. doi:10.1007/s00403-020-02133-7.
  • Shamsi Meymandi S, Mozayyeni A, Shamsi Meymandi M, et al. Efficacy of microneedling plus topical 4% tranexamic acid solution vs 4% hydroquinone in the treatment of melasma: a single-blind randomized clinical trial. J Cosmet Dermatol. 2020;19(11):2906–2911. doi:10.1111/jocd.13392.
  • Basit A, Rahman A, Uddin R. Oral tranexemic acid with triple combination cream (flucinolone + hydroquinone + tretinoin) versus triple combination cream alone in treatment of melasma. J Ayub Med Coll Abbottabad-Pakistan. 2021 Apr 1;33(2):293–298.
  • Shihab N, Prihartono J, Tovar-Garza A, et al. Randomised, controlled, double-blind study of combination therapy of oral tranexamic acid and topical hydroquinone in the treatment of melasma. Australas J Dermatol. 2020;61(3):237–242. doi:10.1111/ajd.13267.
  • Shin JU, Park J, Oh SH, et al. Oral tranexamic acid enhances the efficacy of low-fluence 1064-Nm quality-switched Neodymium-Doped yttrium aluminum garnet laser treatment for melasma in koreans: a randomized, prospective trial. Dermatol Surg. 2013;39(3 Pt 1):435–442. doi:10.1111/dsu.12060.
  • Rao SK, Rajashekar TS, Ashraf A. Efficacy of intralesional tranexamic acid in melasma: assessment with melasma area severity index and dermatology quality of life index. Turkderm Turkish Arch Dermatology Venereol. 2022;56(2):58–63. doi:10.4274/turkderm.galenos.2022.42709.
  • Shin JU, Park J, Oh SH, et al. Oral tranexamic acid enhances the efficacy of low-fluence 1064-Nm quality-switched neodymium-doped yttrium aluminum garnet laser treatment for melasma in koreans: a randomized, prospective trial. Dermatologic Surg. 2013;39(3):435–442. doi:10.1111/dsu.12060.
  • Feng X, Su H, Xie J. Efficacy and safety of tranexamic acid in the treatment of adult melasma: an updated meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2021;46(5):1263–1273. doi:10.1111/jcpt.13430.