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Research Article

Anti-inflammatory effect of low-dose X-irradiation and the involvement of a TGF-β 1 -induced down-regulation of leukocyte/endothelial cell adhesion

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Pages 711-719 | Published online: 03 Jul 2009

  • ANTONELLI-ORLIDGE, A., SAUNDERS, K. B., SMITH, S. R. and D'AMDRE, P. A., 1989, An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proceedings of the National Academy of Sciences, USA, 86, 4544-4548.
  • BEETZ, A., PETER, R., OPPEL, T., KAFFENBERGER, W., RUPEC, R. A., MEYER, M., VAN BEUNINGEN, D., KIND, P. and MESSER, G., 2000, NF-kappaB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells. International Journal of Radiation Biology, 72, 33-43.
  • BERETA, J., BERETA, M., COHEN, S. and COHEN, M. C., 1993, Regulation of VCAM-1 expression and involvement in cell adhesion to murine microvascular endothelium. Cellular Immunology, 147, 313-330.
  • BRACH, M. A., HASS, M. L., SHERMAN, R., GUNJI, H., WEICHSELBAUM, R. and KUFE, D., 1991, Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. Journal of Clinical Investigation, 88, 691-695.
  • CHOMCZYNSKI, P. and SACCHI, N., 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Annals of Biochemistry, 162, 156-159.
  • DICHIARA, M. R., KIELY, J. M., GIMBRONE, M. A., JR, LEE, M. E., PERRELLA, M. A. and TOPPER, J. N., 2000, Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals. Journal of Experimental Medicine, 192, 695-704.
  • FISCHER, U., KAMPRAD, F., KOCH, F., LUDEWIG, E., MELZER, R. and HILDEBRANDT, G., 1998, The effects of low-dose Co-60 irradiation on the course of aseptic arthritis in a rabbit knee joint, Strahlentherapie Onkologie, 174, 633-639.
  • GAMBLE, J. R., KHEW-GOODALL, Y., VADAS, M. A. and TI, 1993, Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells. Journal of Immunology, 150, 4494-4503.
  • HALLMANN, R., 1997, Differenzierung und Aktivierung von Endothelzellen am Beispiel der Leukozytenadhäsion, Habilitationsschrift, University Erlangen-Nuremberg, pp. 28-38.
  • HALLMANN, R., JUTILA, M. A., SMITH, C. W., ANDERSON, D. C., KISHIMOTO, T. K. and BUTCHER, E. C., 1991, The peripheral lymph node homing receptor, LECAM-1, is involved in CD18-independent adhesion of human neutrophils to endothelium. Biochemical and Biophysical Research Communications, 174, 236-243.
  • HILDEBRANDT, G., MAGGIORELLA, L., RODEL, F., RODEL, V., WILLIS, D. and TROTT, K. R., 2001, Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cells in-vitro. International Journal of Radiation Biology, 78, 315-325.
  • HILDEBRANDT, G., SEED, M. P., FREEMANTLE, C. N., ALAM, C. A., COLVILLE-NASH, P. R. and TROTT, K. R., 1998a, Effects of low dose ionizing radiation on murine chronic granulomatous tissue. Strahlentherapie Onkologie, 174, 580-588.
  • HILEKBRANDT, G., SEED, M. P., FREEMANTLE, C. N., ALAM, C. A., COLVILLE-NASH, P. R. and TROTT, K. R., 1998b, Mechanisms of the anti-inflammatory activity of low-dose radiation therapy. International Journal of Radiation Biology, 74, 367-378.
  • JORDAN, M., OTTERNESS, I. G., NG, R., GESSNER A., ROLLINGHOFF, M. and BEUSCHER, H. U., 1995, Neutralization of endogenous IL-6 suppresses induction of IL-1 receptor antagonist. Journal of Immunology, 154, 4081-4090.
  • KERN, P. M., KEILHOLZ, L., FORSTER, C., HALLMANN, R., HERRMANN, M. and SEEGENSCHMIEDT, M. H., 2000a, Low-dose radiotherapy selectively reduces adhesion of peripheral blood mononuclear cells to endothelium inutro. Radiotherapy Oncology, 54, 273-282.
  • KERN, P. M., KEILHOLZ, L., FORSTER, C., SEEGENSCHMIEDT M. H., SAUER, R. and HERRMANN, M., 1999, In-vitro apoptosis in peripheral blood mononuclear cells induced by low-dose radiotherapy displays a discontinuous dosedependence International Journal of Radiation Biology, 75, 995-1003.
  • KERN, P. M., KEILHOLZ, L., FORSTER, C., STACH, C., BEYER, T. D., GAIPL, U. S., KALDEN, J. R., HALLMANN, R. and HERRMANN, M., 2000b, UVB-irradiated T-cells under-going apoptosis lose L-selectin by metalloprotesemediated shedding. International Journal of Radiation Biology, 76, 1265-1271.
  • MARTIN, M., VOZENIN, M. C., GAULT, N., CRECHET, F., PFARR, C. M. and LEFAIX, J. L, 1997, Coactivation of AP-1 activity and TGF-betal gene expression in the stress response of normal skin cells to ionizing radiation. Oncogene, 15, 981-989.
  • MULLER, G., BEHRENS, J., NUSSBAUMER, U., BOHLEN, P. and BIRCHMEIER, W., 1987, Inhibitory action of transforming growth factor beta on endothelial cells. Proceedings of the National Academy Sciences, USA, 84, 5600-5604.
  • PARK, S. K., YANG, W. S., LEE, S. K., AHN, H., PARK, J. S., HWANG, O. and LEE, J. D., 2000, TGF-beta(1) down-regulates inflammatory cytokine-induced VCAM-1 expression in cultured human glomerular endothelial cells. Jfephrobgy Dialysis Transplantation, 15, 596-604.
  • PIEK, E., HELDIN, C. H. and TEN DIJKE, P., 1999, Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB Journal, 13, 2105-2124.
  • PODOR, T. J., JIRIK, F. R., LOSKUTOFF, D. J., CARSON, D. A. and LOTZ, M., 1989, Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. Annals of the New York Academy of Sciences, 557, 374-385.
  • PRASAD, A. V., MOHAN, N., CHANDRASEKAR, B. and MELTZ, M. L., 1994, Activation of nuclear factor kappa B in human lymphoblastoid cells by low-dose ionizing radiation. Radiation Research, 138, 367-372.
  • PRASAD, A. V., MOHAN, N., CHANDRASEKAR, B. and MELTZ, M. L., 1995, Induction of transcription of 'immediate early genes' by low-dose ionizing radiation. Radiation Research, 143, 263-272.
  • RHODES, J. M., ENGELMYER, E., TILBERG, A. F. and GIFFORD, R. M., 1995, Transforming growth factor-ß1 serves as an autocrine inhibitor of human endothelial cell/lymphocyte adhesion. Journal Surgical Research, 59, 719-724.
  • RODEL, F., KAMPRAD, F., SAUER, R. and HILDEBRANDT, G., 2002, Low-dose radiotherapy: molecular and functional aspects. Strahlentherapie Onkologie, 178, 1-9.
  • SEEGENSCHMIEDT, M. H., KATALINIC, A., MAKOSKI, H. B., HAASE, W., GADEMANN, G. and HASSENSTEIN, E., 1999, Radiotherapy of benign diseases: a pattern of care study in Germany. Strahlentherapie Onkologie, 175, 541-547.
  • SMITH, W. B., NOACK, L., KHEW-GOODALL, Y., ISENMANN, S., VADAS, M. A. and GAMBLE, J. R., 1996, Transforming growth factor-beta 1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium. Journal of Immunology, 157, 360-368.
  • TROTT, K. R., 1994, Therapeutic effects of low radiation doses. Strahlentherapie Onkologie, 170, 1-12.
  • TROTT, K. R. and KAMPRAD, F., 1999, Radiobiological mechanisms of anti-inflammatory radiotherapy. Radiotherapy and Oncology, 51, 197-203.
  • TROTT, K. R., PARKER, R. and SEED, M. P., 1995, The effect of X-rays on experimental arthritis in the rat. Strahlentherapie Onkologie, 171, 543-588.
  • VAN SNICK, J., 1990, Interleukin-6: an overview. Annual Reviews of Immunology, 8, 253-278.
  • WATSON, C., WHITTAKER, S., SMITH, N., VORA, A. J., DUMONDE, D. C. and BROWN, K. A., 1996, IL-6 acts on endothelial cells to preferentially increase their adherence for lymphocytes. Clinical Experimental Immunology, 105, 112-129.

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