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Article

Radiation‐induced apoptosis of oligodendrocytes and its association with increased ceramide and down‐regulated protein kinase B/Akt activity

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Pages 39-51 | Received 26 Jun 2002, Accepted 08 Mar 2003, Published online: 03 Jul 2009

References

  • ALESSI, D. R., ANDJELKOVIC, M., CAUDWRIT, B., CRON, P., MORRICE, N., COHEN, P. and HEMMINGS, B. A., 1996, Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO Journal, 15, 6541–6551.
  • ANDJELKOVIC, M., ALESSI, D. R., MEIER, R., FERNANDEZ, A., LAMB, N. J., FRECH, M., CRON, P., COHEN, P., LUCOCQ, J. M. and HEMMINGS, B. A., 1997, Role of translocation in the activation and function of protein kinase B. Journal of Biological Chemistry, 272, 31 515–31 524.
  • BARRES, B. A., HART, I. K., COLES, H. S., BURNE, J. F., VoYvonic, J. T., RICHARDSON, W. D. and RAFF, M. C., 1992a, Cell death and control of cell survival in the oligodenclrocyte lineage. Cell, 70, 31–46.
  • BARRES, B. A., HART, I. K., COLES, H. S., BURNE, J. F., VoYvonic, J. T., RICHARDSON, W. D. and RAFF, M. C., 1992b, Cell death in the oligodendrocyte lineage. Journal of Neurobiology, 23, 1221–1230.
  • BRUNET, A., BONNI, A., ZIGMOND, M. J., LIN, M. Z., JUO, P., Hu, L. S., ANDERSON, M. J., ARDEN, K. C., BLENIS, J. and GREENBERG, M. E., 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96, 857–868.
  • BURSZTAJN, S., FENG, J. J., BERMAN, S. A. and NAND AA., 2000, Poly (ADP-ribose) polymerase induction is an early signal of apoptosis in human neuroblastoma. Brain Research Molecular Brain Research, 76, 363–376.
  • CASACCIA-BONNEFIL, P., 2000, Cell death in the oligodenclrocyte lineage: a molecular perspective of life/death decisions in development and disease. Glia, 29, 124–135.
  • CASACCIA-BONNEFIL, P., CARTER, B. D., DOBROWSKY, R. T. and CHAO, M. V., 1996, Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature, 383, 716–719.
  • CHALFANT, C. E., KISFILKAWA, K., MUMBY, M. C., KAMIBAYASHI, C., BIELAWSKA, A. and HANNUN, Y. A., 1999, Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. Journal of Biological Chemistry, 274, 20 313–20 317.
  • CHMURA, S. J., NODZENSKI, E., BECKETT, M. A., KUFE, D. W., QUINTANS, J. and WEICHSELBAUM, R. R., 1997, Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Research, 57, 1270–1275.
  • CHOW, B. M., Li, Y. Q and WONG, C. S., 2000, Radiation-induced apoptosis in the adult central nervous system is p53-dependent. Cell Death Differentiation, 7, 712–720.
  • DBAIBO, G. S., PUSHKAREVA, M. Y., RACHED, R. A., ALTER, N., SMYTH, M. J., OBEID, L. M. and HANNUN, Y. A., 1998, p53-dependent ceramide response to genotoxic stress. Journal of Clinical Investigation, 102, 329–339.
  • DOBROWSKY, R. T. and HANNUN, Y. A., 1992, Ceramide stimulates a cytosolic protein phosphatase. Journal of Biological Chemistry, 267, 5048–5051.
  • FRANKE, T. F., YANG, S. I., CHAN, T. 0., DATTA, K, KAZLAUSKAS, A., MORIUSON, D. K., KAPLAN, D. R. and Tsictrus, P. N., 1995, The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phos-phatidylinositol 3-kinase. Cell, 81, 727–736.
  • GARZOTTO, M., HAIMOVITZ-FRIEDMAN, A., LIAO, W. C., WHITE-JONES, M., HURYK, R., HESTON, W. D., CARDON-CARDO, C., KOLESNICK, R. and FuKs, Z., 1999, Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Cancer Research, 59, 5194–5201.
  • GARZOTTO, M., WHITE-JONES, M., JIANG, Y., EFILEITER, D., LIAO, W. C., HAmovrrz-FRIEDmAN, A., Fuxs, Z. and KOLESNICK, R.,1998, 12-0-tetradecanoylphorbol-13-acetate -induce dapoptosis in LNCaP cells is mediated through ceramide synthase. Cancer Research, 58, 2260–2264.
  • GOSWAMI, R., Krtxus, J., DAWSON, S. A. and DAWSON, G., 1999, Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. Journal of Neuroscience Research, 57, 884–893.
  • Gu, C., CASACCIA-BONNEFIL, P., SRINIVASAN, A. and CHAO, M. V., 1999, Oligodendrocyte apoptosis mediated by caspase activation. Journal of Neuroscience Research, 19, 3043–3049.
  • HAIMOVITZ-FRIEDMAN, A., KAN, C. C., EFILEITER, D., PERSAUD, R. S., MCLOUGHLIN, M., Fuxs, Z. and KOLESNICK, R. N., 1994, Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. Journal of Experimental Medicine, 180, 525–535.
  • HERGET, T., ESDAR, C., OEFIRLEIN, S. A., HEINRICH, M., SCHUTZE, S., MAELICKE, A. and VAN ECHTEN-DECKERT, G., 2000, Production of ceramides causes apoptosis during early neural differentiation in vitro. Journal of Biological Chemistry, 275, 30 344–30 354.
  • HERZOG, K. H., CHONG, M. J., KAPSETAKI, M., MORGAN, J. I. and MCKINNON, P. J., 1998, Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science, 280, 1089–1091.
  • HIDA, H., NAGANO, S., TAKEDA, M. and SOLIVEN, B., 1999, Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes. Journal of Neuroscience, 19, 7458–7467.
  • JAFFREZOU, J. P., BRUNO, A. P., MOISAND, A., LEVADE, T. and LAURENT, G., 2001, Activation of a nuclear sphingomyelinase in radiation-induced apoptosis. FASEB Journal, 15, 123–133.
  • KASHII, Y., UCHIDA, M., KIRITO, K., TANAKA, M., NISHIJIMA, K., TOSHEVIA, M., ANDO, T., Kotzumi, K., ENDOH, T., SAWADA, K., Momot, M., MIURA, Y., OZAWA, K. and KOMATSU, N., 2000, A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction. Blood, 96, 941–949.
  • LEE, J. Y., HANNUN, Y. A. and ORED, L. M., 1996, Ceramide inactivates cellular protein kinase Calpha. Journal of Biological Chemistry, 271, 13 169–13 174.
  • Li, Y. Q, JAY, V. and WONG, C. S., 1996, Oligodenclrocytes in the adult rat spinal cord undergo radiation-induced apoptosis. Cancer Research, 56, 5417–5422.
  • LIAO, W. C., HAIMOVITZ-FRIEDMAN, A., PERSAUD, R. S., MCLOUGHLIN, M., EFILEITER, D., ZHANG, N., GATEI, M., LAWN, M., KOLESNICK, R. and Fuxs, Z., 1999, Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. Journal of Biological Chemistry, 274, 17 908–17 917.
  • MATHIAS, S., PA, L. A. and KOLESNICK, R. N., 1998, Signal transduction of stress via ceramide. Biochemical Journal, 335, 465–480.
  • MCCARTHY, K. D. and DE VELLIS, J., 1980, Preparation of separate astroglial and oligodenclroglial cell cultures from rat cerebral tissue. Journal of Cell Biology, 85, 890–902.
  • MERRILL, A. H., JR, VAN EcurEN, G., WANG, E. and SANDHOFF, K., 1993, Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. Journal of Biological Chemistry, 268, 27 299–27 306.
  • O'BRIEN, M. A., MORAVEC, R. A. and Riss, T. L., 2001, Poly (ADP-ribose) polymerase cleavage monitored in situ in apoptotic cells. Biotechniques, 30, 886–891.
  • PRUSCHY, M., RESCH, H., Stu, Y. Q, AALAME, N., GLANZMANN, C. and Borns, S., 1999, Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells. British Journal of Cancer, 80, 693–698.
  • RAF, M. C., MIRSKY, R., FIELDS, K. L., LISAK, R. P., DORFMAN, S. H., SILBERBERG, D. H., GREGSON, N. A., LEIBOWITZ, S. and KENNEDY, M. C., 1978, Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture. Nature, 274, 813–816.
  • SABBATINI, P. and McCoRmicx, F., 1999, Phosphoinositide 3-0H kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis. Journal of Biological Chemistry, 274, 24 263–24 269.
  • SAKURAGAWA, N., Mrro, T. and KAWAD AA., 1994, Niemann—Pick disease: coupling and uncoupling of inhibited sphin-gomyelinase activity and exogenous cholesterol esterifica-tion in fibroblasts by ionophore treatment. Biochimica et Biophysica Acta, 1213, 193–198.
  • SALINAS, M., LOPEZ-VALDALISO, R., MARTIN, D., ALVAREZ, A. and CUADRADO, A., 2000, Inhibition of PKB/Akt 1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Molecular and Cellular Neuroscience, 15, 156–169.
  • SANTANA, P., PENA, L. A., HAIMOVITZ-FRIEDMAN, A., MARTIN, S., GREEN, D., MCLOUGHLIN, M., CORDON-CARDO, C., SCHUCHIVIAN, E. H., Fuxs, Z. and KOLESNICK, R., 1996, Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell, 86, 189–199.
  • SCHUBERT, K. M., SCHEID, M. P. and DURONIO, V., 2000, Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. Journal of Biological Chemistry, 275, 13 330–13 335.
  • SCURLOCK, B. and DAWSON, G., 1999, Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: role of ceramide in apoptosis. Journal of Neuroscience Research, 55, 514–522.
  • SHAW, M., COHEN, P. and ALESSI, D. R., 1998, The activation of protein kinase B by H202 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochemical Journal, 336, 241–246.
  • TONG, X., Liu, B., DONG, Y. and SUN, Z., 2000, Cleavage of ATM during radiation-induced apoptosis: caspase-3-like apoptotic protease as a candidate. International Journal of Radiation Biology, 76, 1387–1395.
  • VE1VIUM, G. S. and McMoRms, F. A., 1996, Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival. Development, 122, 2529–2537.
  • VERHEIJ, M., BOSE, R., UN, X. H., YAO, B., JARvis, W. D., GRANT, S., BIRRER, M. J., SZABO, E., ZON, L. I., KYRIAKIS, J. M., HAIMOVITZ-FRIEDMAN, A., FILK, Z. and KOLESNICK, RN., 1996, Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature, 380, 75–79.
  • VRDOLJAK, E., BILL, C. A., STEPHENS, L. C., VAN DER KOGEL, A. J., ANG, K. K. and ToFrLoN, P. J., 1992, Radiation-induced apoptosis of oligodendrocytes in vitro. International Journal of Radiation Biology, 62, 475–480.
  • WATTERS, D., 1999, Molecular mechanisms of ionizing radiation-induced apoptosis. Immunology and Cell Biology, 77, 263–271.
  • WILLMME, S., VANHOUTTE, P., CABOCHE, J., LEMAIGRE-DUBREULL, Y., MAIUANI, J. and BRUGG, B., 2001, Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. European Journal of Neuroscience, 13, 2037–2046.
  • XTA, Z., DICKENS, M., RAINGEAUD, J., DAVIS, R. J. and GREENBERG, M. E., 1995, Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science, 270, 1326–1331.
  • ZHANG, Y., YAO, B., DELIKAT, S., BAYOUMY, S., LIN, X. H., BASU, S., MCGINLEY, M., CHAN-HUI, P. Y., LICHENSTEIN, H. and KOLESNICK, R., 1997, Kinase suppressor of Ras is ceramide-activated protein kinase. Cell, 89, 63–72.
  • ZHENG, W. H., KAR, S. and QUIRION, R., 2000, Insulin-like growth factor-l-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Mt kinase in PC12 cells. Journal of Biological Chemistry, 275, 39 152–39 158.
  • Zliou, H., SUMMERS, S. A., BIRNBAUM, M. J. and PITTMAN, R. N., 1998, Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. Journal of Biological Chemistry, 273, 16 568–16 575.
  • ZUNDEL, W. and GIACCI AA., 1998, Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes and Development, 12, 1941–1946.

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