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Article

Cell cycle arrest and aberration yield in normal human fibroblasts. I. Effects of X‐rays and 195 MeV u−1 C ions

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Pages 621-634 | Received 11 May 2004, Published online: 03 Jul 2009

References

  • ANDERSON, R. M., MARDSEN, S. J., WRIGHT, E. G., KADITIM, M. A., GOODHEAD, D. T. and GRIFFIN, C. S., 2000, Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET cz-particles. International Journal of Radiation Biology, 76, 31–42.
  • AZZAM, E. I., DE TOLEDO, S. M., GOODING, T. and LITTLE, J. B., 1998, Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiation Research, 150, 497–504.
  • AZZAM, E. I., DE TOLEDO, S. M., WAKER, A. J. and LITTLE, J. B., 2000, High and low fluences of cz-particles induce a GI checkpoint in human diploid fibroblasts. Cancer Research, 60, 2623–2631.
  • BAYREUTHER, K., RODEMANN, H. P., FRANCZ, P. I. and MAIER, K., 1988, Differentiation of fibroblast stem cells. Journal of Cell Science, 10 (suppl.), 115–130.
  • BOEI, J. J. W. A., VERMEULEN, S. and NATARAJAN, A. T., 1996, Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three post-irradiation divisions of human lymphocytes. Mutation Research, 349, 127–135.
  • BORGMANN, K., ROPER, B., EL-AWADY, R. A., BRACKROCK, S., BIGALKE, M., DORK, T., ALBERTI, W., DIKOMEY, E. and DAB:NA-DANE, J., 2002, Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiotherapy and Oncology, 64, 141–152.
  • BURNET, N. G., NYMAN, J., TURESSON, I., WURM, R., YARNOLD, J. R. and PEACOCK, J. H., 1992, Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity. Lancet, 339, 1570–1571.
  • CHAUNG, W., Mr, L.-J. and BOORSTEIN, R. J., 1997, The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair. Nucleic Acid Research, 25, 992–994.
  • CoLLYN-D'Hoomm, M., HEMON, D., GILET, R., CURTIS, S. B., VALLERON, A. J. and MALAISE, E. P., 1981, Comparative effects of 60Co y-rays and neon and helium ions on cell cycle duration and division probability of EMT 6 cells. A time-lapse cinematography study. International Journal of Radiation Biology, 39, 297–306.
  • CORNFORTH, M. and BEDFORD, J., 1987, A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Radiation Research, 111, 385–405.
  • DESIIVIONE, J. N., DOLEZALOVA, H., REDPATH, J. L. and STANBRIDGE, E. J., 2000, Prolonged cell cycle arrest in irradiated human diploid skin fibroblasts: the role of nutrient deprivation. Radiation Research, 153, 131–143.
  • DILEONARDO, A., LINK, S. P., CLARKIN, K. and WAHL, G. M., 1994, DNA damage triggers a prolonged p53-dependent G1-arrest and long-term induction of Cip 1 in normal human fibroblasts. Genes and Development, 5, 2540–2551.
  • FOURNIER, C., 1999, Zellulare und molekularbiologische Grundlagen der Fibrose nach lonenbestrahlung. PhD thesis, University of Darmstadt.
  • FOURNIER, C., SCHOLZ, M., WEYRATHER, W. K., RODEMANN, H. P. and KRAFr, G., 2001, Changes in fibrosis-related parameters after high- and low-LET irradiation of fibroblasts. International Journal of Radiation Biology, 77, 713–722.
  • GADBOIS, D. M., CRISSMAN, H. A., NASTASI, A., HABBERSETT, R., WANG, S. K., CHEN, D. and LEHNERT, B. E., 1996, Alterations in the progression of cells through the cell cycle after exposure to cz-particles or y-rays. Radiation Research, 146, 414–424.
  • GEORGE, K., WU, H., WILLINGHAM, V., FURUSAWA, Y., KAWATA, T. and CUCINOTIA, F. A., 2001, High- and low LET induced chromosome damage in human lumphocytes: a time-course of aberrations in metaphase and interphase. International Journal of Radiation Biology, 77, 175–183.
  • HABERER, T., BECHER, W., SCHARDT, D. and KRAFT, G., 1993, Magnetic scanning system for heavy ion therapy. Nuclear Instruments and Methods in Physics Research, A330, 296–305.
  • HEINIUCH, W., WIEGEL, B. and KRAFr, G., 1991,;ffi dEhlx, range and restricted energy loss of heavy ions in the region 1 -.,E,„1000 MeV u-1. GSI Preprint, 91–30.
  • HERSKIND, C. and RODEMANN, H. P., 2000, Spontaneous and radiation-induceddifferentiationoffibroblasts.Experimental Gerontology, 35, 745–755.
  • HOFFMANN, G. R., SAYER, M. A. and LITTLEFIELD, L. G., 2002, Higher frequency of chromosome aberrations in late-arising first-division metaphases than in early-arising metaphases after exposure of human lymphocytes to X-rays in Go. International Journal of Radiation Biology, 78, 765–772.
  • ISCN 1978, An international system for human cytogenetic nomenclature. Cytogenetics and Cell Genetics, 21, 309–404.
  • JOHANSEN, J., BENTZEN, S. M., OVERGAARD, J. and OVERGAARD, M., 1996, Relationship between the in vitro racliosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiotherapy and Oncology, 40, 101–109.
  • JOHANSEN, J., STREFFER, C., FUHRMANN, C., BENTZEN, S. M., STAUSBOL-GRON, B., OVERGAARD, M. and OVERGAARD, J., 1998, Racliosensitivity of normal fibroblasts from breast cancer patients assessed by the micronucleus and colony assays. International Journal of Radiation Biology, 73, 671–678.
  • KAUFMAN, G. E., MILLER, M. W., SAVAGE, J. R. and PAPWORTH, D. G., 1974, Chromosome aberration yields from multiple fixation regimes. Journal of Theoretical Biology, 44, 91–103.
  • KOLIN-GERRESHEIM, J. and BAUCHINGER, M., 1981, Dependence of the frequency of harlequin-stained cells on BrdU concentration in human lymphocyte cultures. Mutation Research, 91, 251–254.
  • LINK, S. P., CLARKIN, K. C. and WAHL, G. M., 1997, P53 mediated permanent arrest over multiple cell cycles in response to y-irradiation. Cancer Research, 57, 1171–1179.
  • LITTLE, J. and NAGASAWA, H., 1985, Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts. Radiation Research, 101, 81–93.
  • MOEM SS., 1991, The genetic toxicology of 5-bromodeoxyuridine in mammalian cells. Mutation Research, 258, 161–188.
  • MURRAY, J. D., 1993, Mathematical Biology (Berlin: Springer).
  • NACHIRAB, U., OPPrrz, U., FLENTJE, M. and STOPPER, H., 1998, Radiation-induced micronucleus formation in human skin fibroblasts of patients showing severe and normal tissue damage. International Journal of Radiation Biology, 73, 279–287.
  • NASONOVA, E., RriTEE, S., FOMENKOVA, T. and KRAFT, G., 1998, Induction of chromosomal damage in CHO-Kl and their repair-deficient mutant xrs5 by X-ray and particle irradiation. Advances in Space Research, 22, 569–578.
  • NASONOVA, E., RrrrEE, S., GunowsEA-Now, E. and KEAY'', G., 2001, High LET induced chromosomal damage: time-dependent expression. Physica Medica, 17, (Suppl. 1), 198–201.
  • PERRY, P. and WOLFF, S., 1974, New Giemsa method for differential staining of sister chromatids. Nature, 251, 156–158.
  • PINCU, M., KnEvIE-Smirrx, K. and NORMAN, A., 1986, A modified harlequin staining for cell kinetics. Cell and Tissue Kinetics, 19, 275–287.
  • PURROTT, R. J., VuLPis, N. and LLOYD, D. C., 1980, The use of harlequin staining to measure delay in the human lymphocyte cell cycle induced by in vitro X-irradiation. Mutation Research, 69, 275–282.
  • RAVE-FRANK, M., VIRSIK-KOP PP., PRADIER, 0., NITSCHE, M., GRUNEFELD, S. and SCHMIDBERGER, H., 2001, In vitro response of human dermal fibroblasts to X-irradiation: relationship between radiation-induced clonogenic cell death, chromosome aberrations and markers of proliferative senescence or differentiation. International Journal of Radiation Biology, 77, 1163–1174.
  • RITTER, S., NASONOVA, E., SCHOLZ, M., KRAIT-WEYRATHER, W. and KRAFT, G., 1996, Comparison of chromosomal damage induced by X-rays and Ar-ions with an LET of 1840 keV/pm in G1 V79 cells. International Journal of Radiation Biology, 69, 155–166.
  • RITTER, S., NASONOVA, E., GunowsEA-Now, E., SCHOLZ, M. and KRAFT, G., 2000, High LET induced chromosome aberrations in V79 cells analysed in first and second post-irradiation metaphases. International Journal of Radiation Biology, 76, 149–161.
  • RITTER, S., NASONOVA, E., FURUSAWA, Y. and ANDo, K., 2002a, Relationship between aberration yield and mitotic delay in human lymphocytes exposed to 200 MeV u-1 Fe ions or X-rays. Journal of Radiation Research, 43 (suppl.), S175—S179.
  • RITTER, S., NASONOVA, E. and GunowsEA-NowAx, 2002b, Effect of LET on the yield and quality of chromosomal damage in metaphase cells: a time-course study. International Journal of Radiation Biology, 78, 191–202.
  • RITTER, S., NASONOVA, E., GUDOWSKA-NOWAK, E., SCHOLZ, M. and KEAY'', G., 2002c, Integrated chromosome aberration yields determined for V79 cells after high LET exposure [Erratum]. International Journal of Radiation Biology, 78, 1063–1064.
  • RODEMANN, H. P., 1993, Differential gene expression, protein synthesis, and degradation in againg fibroblasts. In A. Bernd, J. Bereiter-Hahn, F. Hevert and H. Holzmann (eds), Cell and Tissue Culture Models in Dermatological Research (Heidelberg: Springer), pp. 272–277.
  • RODEMANN, H. P., PETERSON, H. P., SCHWENKE, K. and VON WANGENHEIM, K. H., 1991, Terminal differentiation of human fibroblasts is induced by radiation. Scanning Microscopy, 5, 1135–1143.
  • RUSSELL, N. S., ARLETT, C. F., BARTELINK, H. and BEGG, A. C., 1995, Use of fluorescence in situ hybridization to determine the relationship between chromosome aberrations and cell survival in eight human fibroblast strains. International Journal of Radiation Biology, 68, 185–196.
  • RUSSELL, N. S., LARA, P. C., GRUMIVIELS, A., HART, A. A. M., COCO-MARTIN, J. M., BARTELINK, H. and BEGG, A. C., 2000, In vitro differentiation characteristics of human skin fibroblasts: correlations with radiotherapy-induced breast fibrosis in patients. International Journal of Radiation Biology, 76, 231–240.
  • SAVAGE, J. R. K., 1975, Classification and relationships of induced chromosomal structural changes. Journal of Medical Genetics, 12, 103–122.
  • SCHOLZ, M., KRAIT-WEYRATHER, W., RITTER, S. and KRAFT, G., 1994, Cell cycle delays induced by heavy ion irradiation of synchronous mammalian cells. International Journal of Radiation Biology, 66, 59–75.
  • SCHOLZ, M., RITTER, S. and KRAFT, G., 1998, Analysis of chromosome damage based on the time course of aberrations. International Journal of Radiation Biology, 74, 325–331.
  • SCHWARTZ, D. and ROTTER, V., 1998, p53-dependent cell cycle control: response to genotoxic stress. Cancer Biology, 8, 325–336.
  • SCOIT, D. and LYONS, C. Y., 1979, Homogeneous sensitivity of human peripheral blood lymphocytes to radiation-induced chromosome damage. Nature, 278, 756–758.
  • VIRSIK-PEUCKERT, P., RAVE-FRANK, M., LANGEBRAKE, U. and SCHMTDBERGER, H., 1997, Differences in the yield of dicentrics and reciprocal translocations observed in the chromosomes of irradiated human fibroblasts and blood lymphocytes from the same healthy individuals. Radiation Research, 148, 209–215.
  • WEYRATHER, W. K., RITTER, S., SCHOLZ, M. and KRAFT, G., 1999,
  • RBE for carbon track-segment irradiation in cell lines of differing repair capacity. International Journal of Radiation Biology, 75, 1357-1364.
  • WILLIAMS, K. J., BoyLE, J. M., BIRCH, J. M., NORTON, J. D. and ScoTr, D., 1997, Cell cycle arrest defect in Li-Fraumeni syndrome: a mechanism of cancer predisposition?. Oncogene, 14, 277–282.
  • WU, H., DURANTE, M., GEORGE, K. and YANG, C., 1997, Induction of chromosome aberrations in human cells by charged particles. Radiation Research, 148, S 102—S 107.

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