Sex and tissue-specific differences in low-dose radiation-induced oncogenic signaling

References

• Amundson S, Bittner M, Meltzer P, Trent J, Fornace AJJR 2001. Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress. Compar Biochem Physiol B, Biochem Mol Biol 129:703–710.
   PubMed Web of Science ®Google Scholar
• Amundson SA, Lee RA, Koch-Paiz CA, Bittner ML, Meltzer P, Trent JM et al. 2003, Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res 1:445–452.
   PubMed Web of Science ®Google Scholar
• Bishop JM:. 1991. Molecular themes in oncogenesis. Cell 64:235–248.
   PubMed Web of Science ®Google Scholar
• Bivona TG, Philips MR. 2003. Ras pathway signaling on endomembranes. Curr Opin Cell Biol 15:136–142.
   PubMedGoogle Scholar
• Canadian Council for Animal Care. 1993. Guide to the care and use of experimental animals. Edited by: Ernest D. Olfert, Brenda M. Cross, and A. Ann McWilliam. Canadian Council for Animal Care, Ottawa, ON.
   Google Scholar
• Cantley LC, Auger KR, Carpenter C, Duckworth B, Graniani A, Kepeller R, et al. 1991. Oncogenes and signal transduction. Cell 64:281–302.
   PubMed Web of Science ®Google Scholar
• Cataldi A, Di Pietro R, Centurione L, Rapino M, Santavenere E, Garasi F, et al. 2003. Engagement of PI-3-kinase mediated protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis. Int J Oncol 22:129–135.
   PubMedGoogle Scholar
• Chae HP, Jarvis LJ, Uckun FM. 1993. Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lymphohematopoietic precursor cells. Cancer Res 53:447–451.
   PubMed Web of Science ®Google Scholar
• Contessa JN, Hampton J, Lammering G, Mikkelsen RB, Dent P, Valerie K, et al. 2002. Ionizing radiation activates Erb-B receptor-dependent Akt and p70 S6 kinase signaling in carcinoma cell. Oncogene 21:4032–4041.
   PubMed Web of Science ®Google Scholar
• Gripe TP:. 2001. Rhabromyosarcoma. eMedicine Journal 2(7) (serial online). Available at: http://www.emedicine.com/ped/ topic2005.htm.
   Google Scholar
• Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, et al. 2003. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat Res 159:283–300.
   PubMed Web of Science ®Google Scholar
• Eby MT, Jasmin A, Kumar A, Sharma K, Chaudhary PM. 2000. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death. J Biol Chem 275:15330–15342.
   PubMedGoogle Scholar
• Garcia E, Lacasa D, Giudicelli Y. 2000. Estradiol stimulation of c-fos and c-jun expressions and activator protein-1 deoxyribo-nucleic acid binding activity in rat white adipocyte. Endocrinology 141:2837–2846.
   PubMedGoogle Scholar
• Goodman PA, Niehoff LB, Uckun FM. 1998. Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells. J Biol Chem 273:17742–17748.
   PubMed Web of Science ®Google Scholar
• Gruda MC, Van Amsterdam J, Rizzo CA, Durham SK, Lira S, Bravo R. 1996. Expression of FosB during mouse develop-ment: normal development of FosB knockout mice. Oncogene 12:2177–2185.
   PubMedGoogle Scholar
• Grass HJ, Dower SK. 1995. The TNF ligand superfamily and its relevance for human diseases. Cytokines Cell Mol Ther 1:75–105.
   Google Scholar
• Gupta A, Andrews KL, McDaniel KM, Nagle RB, Bowden GT. 1999. Experimental induction of rhabdomyosarcoma in mice with fractionated doses of 7-irradiation. J Cancer Res Chin Oncol 125:257–267.
   PubMedGoogle Scholar
• Hahn H, Wojnowski L, Zimmer Am, Hall J, Miller G, Zimmer A. 1998. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model with Gorlin syndrome. Nature Med 4:619–622.
   PubMed Web of Science ®Google Scholar
• Haimovitz-Friedman A, Balaban N, McLoughlin M, Ehleiter D, Michaeli J, Vlodavsky I, et al. 1994. Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer Res 54:2591–2597.
   PubMed Web of Science ®Google Scholar
• Hallahan DE, Sukhatme VP, Sherman ML, Virudachalam S, Kufe D, Weichselbaum RR. 1991a. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN. Proc Natl Acad Sci USA 88:2156–2160.
   PubMed Web of Science ®Google Scholar
• Hallahan DE, Virudachalam S, Beckett M, Sherman ML, Kufe D, Weichselbaum RR. 199 lb. Mechanisms of X-ray-mediated protooncogene c-jun expression in radiation-induced human sarcoma cell lines. Int J Radiat Oncol Biol Phys 21:1677-1681.
   Google Scholar
• Hunter T:. 1991. Cooperation between oncogenes. Cell 64:249–270.
   PubMed Web of Science ®Google Scholar
• Kovalchuk 0, Ponton A, Filkowski J, Kovalchuk I. 2004. Dissimilar genome response to acute and chronic low dose radiation in male and female mice. Mutation Res 550:59–72.
   Google Scholar
• Kovary K, Rizzo CA, Ryseck RP, Noguchi T, Raynoschek C, Pelosin JM et al. 1991. Constitutive expression of FosB and its short form, FosB/SF, induces malignant cell transformation in rat-1A cells. New Biol 3:870–879.
   PubMedGoogle Scholar
• Ledgerwood EC, Pober JS, Bradley JR 1999. Recent advances in the molecular basis of TNF signal transduction. Laboratory Investigation 79:1041–1050.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Cho CK, Yoo SY, Kim TH, Lee YS. 1999. Influence of ionizing radiation on induction of apoptotic cell death and cellular redistribution of protein kinase C isozymes in mouse epidermal cells differing in carcinogenesis stages. Mutation Res 3:41–49.
   Google Scholar
• Little JB:. 1999. Induction of genetic instability by ionizing radiation. Compt Rendus l'Acad Sci 322:127–134.
   PubMedGoogle Scholar
• Little JB:. 2000. Radiation carcinogenesis. Carcinogenesis 21:397–404.
   PubMed Web of Science ®Google Scholar
• Nagata S. 1997. Apoptosis by Death Factor. Cell 88:355–365.
   PubMed Web of Science ®Google Scholar
• Niehoff LB, Uckun FM. 2000. Role of PRKCM (PKCmu) in radiation-induced increase of JUN proto-oncogene mRNA levels in B-lineage lymphoid cells. Radiat Res 154:145–150.
   PubMedGoogle Scholar
• Nishizuka Y. 1992. Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C. Science 258:607–614.
   PubMed Web of Science ®Google Scholar
• Oxford G, Theodorescu D. 2003. Ras superfamily monomeric G proteins in carcinoma cell motility. Cancer Lett 189:117–128.
   PubMed Web of Science ®Google Scholar
• Palayoor ST, Macklis RM, Bump EA, Coleman CN. 1995. Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells. Radiation Res 141:235–243.
   PubMed Web of Science ®Google Scholar
• Park WY, Hwang CI, Im CN, Kang MJ, Woo JH, Kim JH, et al. 2002. Identification of radiation-specific responses from gene expression profile. Oncogene 21:8521–8525.
   PubMed Web of Science ®Google Scholar
• Passegue E, Wagner EF. 2000. JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. EMBO J 19:2969–2979.
   PubMed Web of Science ®Google Scholar
• Passegue E, Jochum W, Behrens A, Ricci R, Wagner EF. 2002. JunB can substitute for Jun in mouse development and cell proliferation. Nature Gen 30:158–166.
   PubMedGoogle Scholar
• Pogribny IP, James SJ. 2002. De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats. Cancer Lett 187:69–75.
   PubMed Web of Science ®Google Scholar
• Prestle J, Pfizenmaier K, Brenner J, Johannes FJ. 1996. Protein kinase C mu is located at the Golgi compartment. J Cell Biol 134:1401–1410.
   PubMed Web of Science ®Google Scholar
• Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB, Valerie K. 2000. Signal transduction and cellular radiation responses. Radiat Res 153:245–257.
   PubMed Web of Science ®Google Scholar
• Schuchard M, Landers JP, Sandhu NP, Spelsberg TC. 1993. Steroid hormone regulation of nuclear proto-oncogenes. Endocrine Rev 14:659–669.
   PubMedGoogle Scholar
• Schuermann M, Jooss K, Muller R 1991. FosB is a transforming gene encoding a transcriptional activator. Oncogene 6:567–576.
   PubMedGoogle Scholar
• Serrano M. 2000. The INK4a/ARF locus in murine tumorigen-esis. Carcinogenesis 21:865–869.
   PubMedGoogle Scholar
• Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, et al. 2001. Loss of pl6Ink4a with retention of pl9Arf predisposes mice to tumorigenesis. Nature 413:86–91.
   PubMed Web of Science ®Google Scholar
• Sun P, Yamamoto H, Suetsugu S, Mild H, Takenawa T, Endo T. 2003. Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem 278:4063–4071.
   PubMed Web of Science ®Google Scholar
• Tamas P, Solti Z, Bauer P, files A, Sipeki S, Bauer A, et al. 2003. Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. J Biol Chem 278:5163— 5171.
   Google Scholar
• Uckun FM, Schieven GL, Tuel-Ahlgren LM, Dibirdik I, Myers DE, Ledbetter JA, et al. 1993, Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors. Proc Natl Acad Sci USA 90:252–256.
   PubMed Web of Science ®Google Scholar
• Ullrich RL, Ponnaiya B. 1998. Radiation-induced instability and its relation to radiation carcinogenesis. Int J Radiat Biol 74:747–754.
   PubMed Web of Science ®Google Scholar
• van Kooten C, Banchereau J. 2000. CD4O-CD40 ligand. J Leukocyte Biol 67:2–17.
   PubMed Web of Science ®Google Scholar
• Varadkar PA, Krishna M, Verma NC. 2003. Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and ex vivo. Radiat Res 159:453–457.
   PubMed Web of Science ®Google Scholar
• Wang T, Hong W. 2002. Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein. Mol Biol Cell 13:4317–4332.
   PubMed Web of Science ®Google Scholar
• Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, et al. 1998. Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene 16:1643–1648.
   PubMed Web of Science ®Google Scholar