Human fibroblast growth factor 20 (FGF-20; CG53135-05): A novel cytoprotectant with radioprotective potential

References

• Alvarez E, Gerlach V, Gerwien R, Fey E G, Watkins B A, Hahne W F, Sonis S T. Single-dose prevention or short-term treatment with Fibroblast Growth Factor-20 (CG53135-05) reduces the severity and duration of oral mucositis. Supportive Cancer Therapy, 122-127/2005/vol2
   Google Scholar
• Alvarez E, Fey E G, Valax P, Yim Z, Peterson J D, Mesri M, Jeffers M, Dindinger M, Twomlow N, Ghatpande A, LaRochelle W J, Sonis S T, Lichenstein H S. Preclinical characterization of CG53135(FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis. Clinical Cancer Research 2003; 9: 3454–3461
   PubMed Web of Science ®Google Scholar
• Coleman C N, Blakely W F, Fike J R, MacVittie T J, Metting N F, Mitchell J B, Moulder J E, Preston R J, Seed T M, Stone H B, Tofilon P J, Wong R S. Molecular and cellular biology of moderate-dose (1 – 10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17 – 18, 2001. Radiation Research 2003; 159: 812–834
   PubMedGoogle Scholar
• Ding I, Huang K, Wang X, Greig J R, Miller R W, Okunieff P. Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments. Acta Oncologica 1997; 36: 337–340
   PubMed Web of Science ®Google Scholar
• Egan L J, Eckmann L, Greten F R, Chae S, Li Z W, Myhre G M, Robine S, Karin M, Kagnoff M F. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proceedings of the National Academy of Sciences, USA 2004; 101: 2452–2457
   PubMed Web of Science ®Google Scholar
• Gutteridge J M, Halliwell B. Free radicals and antioxidants in the year 2000. A historical look to the future. Annals of the New York Academy of Sciences 2000; 899: 136–147
   PubMed Web of Science ®Google Scholar
• Hall E J. Radiobiology for the radiologist, 5th Edn. Lippincott Williams & Wilkins, Philadelphia, PA 2000; 32–50
   Google Scholar
• Huang T T, Yasunami M, Carlson E J, Gillespie A M, Reaume A G, Hoffman E K, Chan P H, Scott R W, Epstein C J. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Archives of Biochemistry and Biophysics 1997; 344: 424–432
   PubMed Web of Science ®Google Scholar
• Itoh N, Ornitz D M. Evolution of the Fgf and Fgfr gene families. Trends in Genetics 2004; 20: 563–569
   PubMed Web of Science ®Google Scholar
• Jeffers M, McDonald W F, Chillakuru R A, Yang M, Nakase H, Deegler L L, Sylander E D, Rittman B, Bendele A, Sartor R B, Lichenstein H S. A novel human fibroblast growth factor treats experimental intestinal inflammation. Gastroenterology 2002; 123: 1151–1162
   PubMed Web of Science ®Google Scholar
• Jeffers M, Shimkets R, Prayaga S, Boldog F, Yang M, Burgess C, Fernandes E, Rittman B, Shimkets J, LaRochelle W J, Lichenstein H S. Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis. Cancer Research 2001; 61: 3131–3138
   PubMed Web of Science ®Google Scholar
• Kang S K, Rabbani Z N, Folz R J, Golson M L, Huang H, Yu D, Samulski T S, Dewhirst M W, Anscher M S, Vujaskovic Z. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. International Journal Radiation Oncology, Biology, Physics 2003; 57: 1056–1066
   PubMed Web of Science ®Google Scholar
• Lee J M, Johnson J A. An important role of Nrf2-ARE pathway in the cellular defense mechanism. Journal Biochemistry Molecular Biology 2004; 37: 139–143
   PubMedGoogle Scholar
• Li Q, Sanlioglu S, Li S, Ritchie T, Oberley L, Engelhardt J F. GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex. Antioxidants and Redox Signaling 2001; 3: 415–432
   PubMed Web of Science ®Google Scholar
• Maddens S, Charruyer A, Plo I, Dubreuil P, Berger S, Salles B, Laurent G, Jaffrezou J P. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect. Blood 2002; 100: 1294–1301
   PubMed Web of Science ®Google Scholar
• Mashimo H, Wu D C, Podolsky D K, Fishman M C. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996; 274: 262–265
   PubMed Web of Science ®Google Scholar
• Mikkelsen R B, Wardman P. Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 2003; 22: 5734–5754
   PubMed Web of Science ®Google Scholar
• Moulder J E. Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review. International Journal Radiation Biology 2004; 80: 3–10
   PubMed Web of Science ®Google Scholar
• Okunieff P, Li M, Liu W, Sun J, Fenton B, Zhang L, Ding I. Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma. American Journal of Clinical Oncology 2001; 24: 491–495
   PubMed Web of Science ®Google Scholar
• Powers C J, McLeskey S W, Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocrine-Related Cancer 2000; 7: 165–197
   PubMed Web of Science ®Google Scholar
• Riley P A. Free radicals in biology: oxidative stress and the effects of ionizing radiation. International Journal of Radiation Biology 1994; 65: 27–33
   PubMed Web of Science ®Google Scholar
• Shonai T, Adachi M, Sakata K, Takekawa M, Endo T, Imai K, Hareyama M. MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells. Cell Death and Differentiation 2002; 9: 963–971
   PubMed Web of Science ®Google Scholar
• Slupphaug G, Kavli B, Krokan H E. The interacting pathways for prevention and repair of oxidative DNA damage. Mutation Research 2003; 531: 231–251
   PubMed Web of Science ®Google Scholar
• Sun J, Chen Y, Li Y, Ge Z. Role of antioxidant enzymes on ionizing radiation resistance. Free Radical Biology and Medicine 1998; 24: 586–593
   PubMed Web of Science ®Google Scholar
• Suresh A, Tung F, Moreb J, Zucali J R. Role of manganese superoxide dismutase in radioprotection using gene transfer studies. Cancer Gene Therapy 1994; 1: 85–90
   PubMed Web of Science ®Google Scholar
• Szebenyi G, Fallon J F. Fibroblast growth factors as multifunctional signaling factors. International Review of Cytology 1999; 185: 45–106
   PubMedGoogle Scholar
• Tanaka H, Matsumura I, Ezoe S, Satoh Y, Sakamaki T, Albanese C, Machii T, Pestell R G, Kanakura Y. E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. Molecular Cell 2002; 9: 1017–1029
   PubMed Web of Science ®Google Scholar
• Terry N H, Brinkley J, Doig A J, Ma J, Patel N, White R A, Mahajan N, Kang Y. Cellular kinetics of murine lung: model system to determine basis for radioprotection with keratinocyte growth factor. International Journal Radiation Oncology Biology, Physics 2004; 58: 435–444
   PubMed Web of Science ®Google Scholar
• Waselenko J K, MacVittie T J, Blakely W F, Pesik N, Wiley A L, Dickerson W E, Tsu H, Confer D L, Coleman C N, Seed T, Lowry P, Armitage J O, Dainiak N. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Annals of Internal Medicine 2004; 140: 1037–1051
   PubMed Web of Science ®Google Scholar