140
Views
12
CrossRef citations to date
0
Altmetric
Original

The NK1.1+T cells alive in irradiated mice play an important role in a Th1/Th2 balance

, , PhD &
Pages 161-170 | Received 12 Sep 2005, Accepted 08 Feb 2006, Published online: 26 Aug 2009

References

  • Abbas A K, Murphy K M, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787–793
  • Arase H, Arase N, Ogasawara K, Good R A, Onoe K. An NK1.1+CD4+CD8− single-positive thymocyte subpopulation that expresses a highly skewed T cell antigen receptor family. Proceedings of the National Academy Science USA 1992; 89: 6506–6510
  • Arase H, Arase N, Nakagawa K, Good R A, Onoe K. NK1.1+CD4+CD8− thymocytes with specific lymphokine secretion. European Journal of Immunology 1993; 23: 307–310
  • Arase H, Arase N, Saito T. Interferon-γ production by natural killer (NK) cells and NK1.1 + T cells upon NKR-P1 cross-linking. Journal of Experimental Medicine 1996; 183: 2391–2396
  • Ballas Z K, Rasmussen W. NK1.1 + thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR−Vβ8+ subset. Journal of Immunology 1990; 145: 1039–1045
  • Bass H, Mosmann T, Strober S. Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation. Journal of Experimental Medicine 1989; 170: 1495–1511
  • Bass H, Adkins B, Strober S. Thymic irradiation inhibits the rapid recovery of TH1 but not TH2-like functions of CD4 + T cells after total lymphoid irradiation. Cellular Immunology 1991; 137: 316–328
  • Bendelac A, Killeen N, Littman D R, Schwartz R H. A subset of CD4+ thymocytes selected by MHC class I molecules. Science 1994; 263: 1774–1778
  • Bendelac A, Rivera M N, Park S H, Roark J H. Mouse CD1-specific NK1 T cells: Development, specificity, and function. Annual Review Immunology 1997; 15: 535–562
  • Brown D R, Fowell D J, Corry D B, Wynn T A, Moskowitz N H, Cheever A W, Locksley R M, Reiner S L. β2-microglobulin-dependent NK1.1+T cells are not essential for T helper cell 2 immune responses. Journal of Experimental Medicine 1996; 184: 1295–1304
  • Chen H, Huang H, Paul W E. NK1.1+CD4+T cells lose NK1.1 expression upon in vitro activation. Journal of Immunology 1997a; 158: 5112–5119
  • Chen H, Paul W E. Cultured NK1.1+CD4+T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1. Journal of Immunology 1997; 159: 2240–2249
  • Chen Y H, Chiu N M, Mandal M, Wang N, Wang C R. Impaired NK1 + T cell development and early IL-4 production in CD1-deficient mice. Immunity 1997b; 6: 459–467
  • Chambers K A, Harrington N P, Ross W M, Filion L G. Relative alterations in blood mononuclear cell populations reflect radiation injury in mice. Cytometry 1998; 31: 45–52
  • Chao D T, Linette G P, Boise L H, White L S, Thompson C B, Korsmeyer S J. Bcl-xL and Bcl-2 repress a common pathway of cell death. Journal of Experimental Medicine 1995; 182: 821–828
  • Coffman R L, Catry J. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. Journal of Immunology 1986; 136: 949–954
  • Cory S. Regulation of lymphocyte survival by the Bcl-2 gene family. Annual Review of Immunology 1995; 13: 513–543
  • Gately M K, Carvajal D M, Connaughton S E, Gillessen S, Warrier R R, Kolinsky K D, Wilkinson V L, Dwyer C M, Higgins G F, Jr, Podlaski F J, Faherty D A, Familletti P C, Stern A S, Presky D H. Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Annual New York Academic Science 1996; 795: 1–12
  • Gillessen S, Carvajal D, Ling P, Podlaski F J, Stremlo D L, Familetti P C, Gubler U, Presky D H, Stern A S, Gately M K. Mouse interleukin 12 (IL-12) p40 homodimer: A potent IL-12 antagonist. European Journal of Immunology 1995; 25: 2000–2006
  • Gubler U, Chua A O, Schoenhaut D S, Dwyer C M, McComas W, Motyka R, Nabavi N, Wolitzky A G, Quinn P M, Familletti P C, Gately M K. Co-expression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proceedings of the National Academy Science USA 1991; 88: 4143–4147
  • Hayashi T, Kusunoki Y, Hakoda M, Morishita Y, Kubo Y, Maki M, Kasagi F, Kodama K, Macphee D G, Kyoizumi S. Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. International Journal of Radiation Biology 2003; 79: 129–136
  • Kimura M, Watanabe H, Ohtsuka K, Iiai T, Tsuchida M, Sato S, Abo T. Radioresistance of intermediate TCR cells and their localization in the body of mice revealed by irradiation. Microbiology and Immunology 1993; 37: 641–652
  • Kajioka E H, Andres M L, Li J, Mao X W, Moyers M F, Nelson G A, Slater J M, Gridley D S. Acute effects of whole-body proton irradiation on the immune system of the mouse. Radiation Research 2000; 153: 587–594
  • Lan F, Zeng D, Higuchi M, Huie P M, Higgins J P, Strober S. Predominance of NK1.1+TCRαβ+ or DX5+TCRαβ+T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: “Natural suppressor” cells. Journal of Immunology 2001; 167: 2087–2096
  • Leite-De-Moraes M C, Moreau G, Arnould A, Machavoine F, Garcia C, Papiernik M, Dy M. IL-4-producing NKT cells are biased towards IFN-γ production by IL-12. Influence of the microenvironment on the functional capacities of NKT cells. European Journal of Immunology 1998; 28: 1507–1515
  • Ling P, Gately M K, Gubler U, Stern A S, Lin P, Hollfelder K, Su C, Pan Y C, Hakimi J. Human IL-12p40 homodimer binds to the IL-12 receptor but does not mediated biologic activity. Journal of Immunology 1995; 154: 116–127
  • Lu F G, Wong C S. Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activity. International Journal of Radiation Biology 2004; 80: 39–51
  • MacDonald H R. NK1.1+T cell receptor-αβ+ cells: New clues to their origin, specificity, and function. Journal of Experimental Medicine 1995; 182: 633–638
  • O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998; 8: 275–283
  • Ohteki T, MacDonald H R. Major histocompatibility complex I related molecules control the development of CD4+CD8− and CD4−CD8− subsets of NK1.1+TCR-α/β+ cells in the liver of mice. Journal of Experiment Medicine 1994; 180: 699–704
  • Park H R, Jo S K, Paik S G. Factors affecting the Th2-like immune response after gamma-irradiation: Low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells. International Journal of Radiation Biology 2005; 81: 221–231
  • Romagnani S. The Th1/Th2 paradigm. Immunology Today 1997; 18: 263–266
  • Sempowski G R, Beckmann M P, Derdak S, Phipps R P. Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Journal of Immunology 1994; 152: 3606–3614
  • Sentman C L, Shutter J R, Hockenbery D, Kanagawa O, Korsmeyer S J. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991; 67: 879–888
  • Shadyro O, Yurkova I, Kisel M, Brede O, Arnhold J. Formation of phosphatidic acid, ceramide, and diglyceride on radiolysis of lipids: Identification by MALDI-TOF mass spectrometry. Free Radical Biology 2004; 36: 1612–1624
  • Smiley S T, Kaplan M H, Grusby M J. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 1997; 275: 977–979
  • Snapper C M, Paul W E. Interferon-γ and B cell stimulatory-factor-I reciprocally regulate Ig isotype production. Science 1987; 236: 944–947
  • Sykes M. Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4−CD8− and αβTCR+NK1.1+ cells. Journal of Immunology 1990; 145: 3209–3215
  • Tamada K, Harada M, Abe K, Li T, Nomoto K. IL-4-producing NK1.1+T cells are resistant to glucocorticoid-induced apoptosis: Implications for the Th1/Th2 balance. Journal of Immunology 1998; 161: 1239–1247
  • Tomura M, Yu W G, Ahn H J, Yamashita M, Yang Y F, Ono S, Hamaoka T, Kawano T, Taniguchi M, Koezuka Y, Fujiwara H. A novel function of Vα14 + CD4 + NKT cells: Stimulation of IL-12 production by antigen-presenting cells in the innate immune system. Journal of Immunology 1999; 163: 93–101
  • Yankelevich B, Knobloch C, Nowicki M, Dennert G. A novel cell type responsible for marrow graft rejection in mice. T cells with NK phenotype cause acute rejection of marrow grafts. Journal of Immunology 1989; 142: 3423–3430
  • Yoshimoto T, Paul W E. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. Journal of Experimental Medicine 1994; 179: 1285–1295
  • Yoshimoto T, Bendelac A, Hu-Li J, Paul W E. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+T cells that promptly produce interleukin 4. Proceedings of the National Academy Science USA 1995a; 92: 11931–11934
  • Yoshimoto T, Bendelac A, Watson C, Hu-Li J, Paul W E. Role of NK1.1+T cells in a TH2 response and in immunoglobulin E production. Science 1995b; 270: 1845–1847
  • Yusuf A H, Luberto C. Ceramide in the eukaryotic stress response. Trends in Cell Biology 2000; 10: 73–80
  • Westermann W, Schobi R, Rieber E P, Frank K H. Th2 cells as effectors in post-irradiation pulmonary damage preceding fibrosis in the rat. International Journal of Radiation Biology 1999; 75: 629–638
  • Wolf S F, Temple P A, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick R M, Kelleher K, Herrmann S H, Clark S C, Azzoni L, Chan S H, Trinchieri G, Perussia B. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. Journal of Immunology 1991; 146: 3074–3081

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.