Role of DNA-PKcs in the bystander effect after low- or high-LET irradiation

References

• Akaike T, Yoshida M, Miyamoto Y, Sato K, Kohno M, Sasamoto K, Miyazaki K, Ueda S, Maeda H. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry 1993; 32: 827–832
   PubMed Web of Science ®Google Scholar
• Azzam E I, de Toledo S M, Little J B. Stress signaling from irradiated to non-irradiated cells. Current Cancer Drug Targets 2004; 4: 53–64
   PubMed Web of Science ®Google Scholar
• Azzam E I, de Toledo S M, Little J B. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 2003; 22: 7050–7057
   PubMed Web of Science ®Google Scholar
• Azzam E I, de Toledo S M, Gooding T, Little J B. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiation Research 1998; 150: 497–504
   PubMed Web of Science ®Google Scholar
• Folkard M, Schettino G, Bojnovic B, Gilchrist S, Michette A G, Pfauntsch S J, Prise K M, Micheal B D. A focused ultrasoft X-ray microbeam for targeting cells individually with submicrometer accuracy. Radiation Research 2001; 156: 796–804
   PubMed Web of Science ®Google Scholar
• Goldstein S, Russo A, Samuni A. Reactions of PTIO and carboxy-PTIO with *NO, *NO2 and O2−*. Journal of Biological Chemistry 2003; 278: 50949–50955
   PubMed Web of Science ®Google Scholar
• Gotoh E, Asakawa Y. Detection and evaluation of chromosomal aberrations induced by high doses of gamma-irradiation using immunogold-silver painting of prematurely condensed chromosomes. International Journal of Radiation Biology 1996; 70: 517–520
   PubMed Web of Science ®Google Scholar
• Hamada N, Funayama T, Wada S, Sakashita T, Kakizaki T, Ni M, Kobayashi Y. LET dependent survival of irradiated normal human fibroblasts and their descendents. Radiation Research 2006; 166: 24–30
   PubMed Web of Science ®Google Scholar
• Hu B, Wu L, Han W, Zhang L, Chen S, Xu A, Hei T K, Yu Z. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 2006; 27: 245–251
   PubMed Web of Science ®Google Scholar
• Izzard R A, Jackson S P, Smith G C. Competitive and noncompetitive inhibitor of the DNA-dependent protein kinase. Cancer Research 1999; 59: 2581–2586
   PubMed Web of Science ®Google Scholar
• Kashino G, Prise K M, Schettino G, Folkard M, Vojnovic B, Michael B D, Suzuki K, Kodama S, Watanabe M. Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. Mutation Research 2004; 556: 209–215
   PubMed Web of Science ®Google Scholar
• Little J B. Cellular radiation effects and the bystander response. Mutation Research 2006; 597: 113–118
   PubMed Web of Science ®Google Scholar
• Little J B, Nagasawa H, Li G C, Chen D J. Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiation Research 2003; 159: 262–267
   PubMed Web of Science ®Google Scholar
• Little J B, Azzam E I, de Toledo S M, Nagasawa H. Bystander effects: intercellular transmission of radiation damage signals. Radiation Protection Dosimetry 2002; 99: 159–162
   PubMed Web of Science ®Google Scholar
• Lorimore S A, McIlrath J M, Coates P J, Wright E G. Chromosomal instability in unirradiated hemopoietic cells resulting from a delayed in vivo bystander effect of gamma radiation. Cancer Research 2005; 65: 5668–5673
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Ohtsubo T, Kitai R, Shioura H, Ohnishi T, Kano E. Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma. Cancer Research 1999; 59: 3239–3244
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Kano E. Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiation Research 2001; 155: 387–396
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Takahashi A, Ohnishi T. Radiation-induced adaptive responses and bystander effects. Biological Science in Space 2004; 18: 247–254
   PubMedGoogle Scholar
• Mothersill C, Seymour R J, Seymour C B. Increased radiosensitivity in cells of two human cell lines treated with bystander medium from irradiated repair-deficient cells. Radiation Research 2006; 165: 26–34
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C B. Radiation-induced bystander effects. Implications for cancer. Nature Reviews Cancer 2004; 4: 158–164
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C B. Radiation-induced bystander effects, carcinogenesis and models. Oncogene 2003; 22: 7028–7033
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Peng Y, Wilson P F, Lio Y C, Chen D J, Bedford J S, Little J B. Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiation Research 2005; 164: 141–147
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Huo L, Little J B. Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. International Journal of Radiation Biology 2003; 79: 35–41
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Little J B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Research 1992; 52: 6394–6396
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Little J B. Bystander effect for chromosome aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles. Mutation Research 2002; 508: 121–129
   PubMed Web of Science ®Google Scholar
• Narayanan P K, Goodwin E H, Lehnert B E. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Research 1997; 57: 3963–3971
   PubMed Web of Science ®Google Scholar
• Okayasu R, Takakura K, Poole S, Bedford J S. Radiosensitization of normal human cells by LY294002: cell killing and the rejoining of DNA and interphase chromosome breaks. Journal of Radiation Research 2003; 44: 329–333
   PubMed Web of Science ®Google Scholar
• Shao C, Folkard M, Michael B D, Prise K M. Bystander signaling between glioma cells and fibroblasts targeted with counted particles. International Journal of Cancer 2005; 10: 45–51
   Web of Science ®Google Scholar
• Shao C, Aoki M, Furusawa Y. Bystander effect in lymphoma cells vicinal to irradiated neoplastic epithelial cells: nitric oxide is involved. Journal of Radiation Research 2004; 45: 97–103
   PubMed Web of Science ®Google Scholar
• Shao C, Furusawa Y, Aoki M, Ando K. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiation Research 2003a; 160: 318–323
   PubMed Web of Science ®Google Scholar
• Shao C, Furusawa Y, Aoki M, Matsumoto H, Ando K. Nitric oxide-mediated bystander effect induced by heavy ions in human salivary grand tumor cells. International Journal of Radiation Biology 2002; 78: 837–844
   PubMed Web of Science ®Google Scholar
• Shao C, Furusawa Y, Kobayashi Y, Funayama T, Wada S. Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. FASEB Journal 2003b; 17: 1422–1427
   PubMed Web of Science ®Google Scholar
• Shao C, Stewart V, Folkard M, Micheal B D, Prise K M. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Research 2003c; 63: 8437–8442
   PubMed Web of Science ®Google Scholar
• Schettino G, Folkard M, Michael B D, Prise K M. Low-dose binary behavior of bystander killing after microbeam irradiation of a single cell with focused CK X-rays. Radiation Research 2005; 163: 332–336
   PubMed Web of Science ®Google Scholar
• Schettino G, Folkard M, Prise K M, Vojnovic B, Held D K, Michael B D. Low-dose studies of bystander cell killing with targeted soft X-rays. Radiation Research 2003; 160: 505–511
   PubMed Web of Science ®Google Scholar
• Schettino G, Folkard M, Prise K M, Vojnovic B, Michael B D. Upgrading of the Gray Laboratory soft X-ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X-ray beam of different size. Radiation Protection Dosimetry 2002; 99: 287–288
   PubMed Web of Science ®Google Scholar
• Smith G C, Divecha N, Lakin N D, Jackson S P. DNA-dependent protein kinase and related proteins. Biochemical Society Symposia 1999; 64: 91–104
   PubMedGoogle Scholar
• Sokolov M V, Smilenov L B, Hall E J, Panyutin I G, Bonner W M, Sedelnikova O A. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 2005; 24: 7257–7265
   PubMed Web of Science ®Google Scholar
• Sugimoto T, Dazai K, Sakashita T, Funayama T, Wada S, Hamada N, Kakizaki T, Kobayashi Y, Higashitani A. Cell cycle arrest and apoptosis in Caenorhabditis elegans germline cells following heavy-ion irradiation. International Journal of Radiation Biology 2006; 82: 31–38
   PubMed Web of Science ®Google Scholar
• Suzuki M, Zhou H, Geard C R, Hei T K. Effect of chromatin damage in bystander mammalian cells. Radiation Research 2004; 162: 264–269
   PubMed Web of Science ®Google Scholar
• Yang H, Asaad H, Held D K. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 2005; 24: 2096–2103
   PubMed Web of Science ®Google Scholar
• Yoshioka T, Iwamoto N, Ito K. An application of electron paramagnetic resonance to evaluate nitric oxide and its quenchers. Journal of the American Society of Nephrology 1996; 7: 961–965
   PubMed Web of Science ®Google Scholar
• Zhou H, Suzuki M, Randers-Pehrson G, Vannais D, Chen G, Trosko J E, Waldren C A, Hei T K. Radiation risk to low fluences of alpha particles may be greater than we thought. Proceedings of the National Academy of Science of the USA 2001; 98: 14410–14415
   PubMed Web of Science ®Google Scholar