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Original

Thresholds and transitions for activation of cellular radioprotective mechanisms – correlations between HRS/IRR and the ‘inverse’ dose-rate effect

Pages 479-489 | Received 22 Dec 2006, Accepted 28 Mar 2007, Published online: 03 Jul 2009

References

  • Azzam E I, Detoledo S M, Raaphorst G P, Mitchell R E. Low-dose ionizing radiation decreases the frequency of neoplatic transformation to a low level below the spontaneous rate in C3H 10T1/2 cells. Radiation Research 1996; 146: 369–373
  • Bedford J S, Hall E J. Survival of HELA cells cultured in vitro and exposed to protracted gamma-irradiation. International Journal of Radiation Biology 1963; 7: 377–383
  • Bedford J S, Mitchell J B, Fox M S. Variations in responses of several mammalian cell lines to low dose-rate irradiation. Radiation biology in cancer research, R E Meyn, H R Withers. Raven Press, New York 1980; 251–262
  • Bottino P J, Sparrow A H, Schwemmer S S, Thompson K H. Interrelation of exposure and exposure rate in germinating seeds of barley its concurrence with dose-rate theory. Radiation Research 1975; 15: 17–27
  • Collis S J, Schwaninger J M, Ntambi A J, Keller T W, Nelson W G, Dillehay L E, Deweese T L. Evasion of early response mechanisms following low level radiation-induced DNA damage. Journal of Biological Chemistry 2004; 279: 49624–49632
  • Curtis S B. Lethal and potentially lethal lesions induced by radiation – a unified repair model. Radiation Research 1986; 106: 252–270
  • Dasu A, Denekamp J. Inducible repair and intrinsic radiosensitivity: A complex but predictable relationship?. Radiation Research 2000; 153: 279–288
  • Elmore E, Lao X Y, Kapadia R, Redpath J L. The effect of dose rate on radiation-induced neoplastic transformations in vitro by low doses of low-LET radiation. Radiation Research 2006; 166: 832–838
  • Feinendegen L E. Relative implications of protective responses versus damage deduction at low dose and low-dose-rate exposure using microdose approach. Radiation Protection Dosimetry 2003; 104: 337–346
  • Hall E J, Bedford J S. A comparison of the effects of acute and protracted gamma-radiation on the growth of seedlings of vicia faba, part I. Experimental observations. International Journal of Radiation Biology 1964a; 8: 467–474
  • Hall E J, Bedford J S. Dose rate: Its effect on the survival of hela cells irradiated with gamma rays. Radiation Research 1964b; 22: 305–315
  • Joiner M C, Johns H. Renal damage in the mouse: The response to very small doses per fraction. Radiation Research 1988; 114: 385–398
  • Lambin P, Malaise E P, Loiner M C. The effect of very low radiation on the human bladder carcinoma cell line RT 112. Radiotherapy and Oncology 1994; 32: 63–72
  • Leonard B E. Repair of multiple break chromosomal damage – its impact on the use of the linear-quadratic model for low dose and dose rates, ver. 99.074. The effects of low and very low doses of ionizing radiation on human health, University of Versailles. Elsevier Science B.V., Amsterdam 2000; 449–462
  • Leonard B E. Adaptive response by single cell radiation hits – implications for nuclear workers. Radiation Protection Dosimetry 2005; 116: 387–391
  • Leonard B E. Adaptive response and human risks: Part I. A microdosimetry dose dependent model. International Journal of Radiation Biolology 2007a; 83: 115–131
  • Leonard B E. Adaptive response: Part II. Further modeling for dose rate and time influences. International Journal of Radiation Biolology 2007b; 83: 395–408
  • Ling C, Spiro L, Mitchell J, Stickler R. The variation of OER with dose-rate. Journal of Radiation Oncology Biology and Physics 1985; 11: 1367–1373
  • Marples B, Wouters B G, Collis S J, Chalmers A J, Joiner M C. Review – Low-dose hyper-radiosensitivity: A consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells. Radiation Research 2004; 161: 247–255
  • Mitchell J B, Bedford J S, Bailey S M. Dose-rate effects on the cell cycle and survival of S3 HeLa and V79 cells. Radiation Research 1979a; 79: 520–536
  • Mitchell J B, Bedford J S, Bailey S M. Dose-rate effects in mammalian cells in culture III, comparison of cell killing and cell proliferation during continuous irradiation for six different cell lines. Radiation Research 1979b; 79: 537–551
  • Mitchell J B, Bedford J S, Bailey S M. Dose rate effects in plateau-phase cultures of S3 hela and V79 cells. Radiation Research 1979c; 79: 552–567
  • Morgan W F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiation Research 2003a; 159: 567–580
  • Morgan W F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vivo. Radiation Research 2003b; 159: 581–596
  • Redpath J L, Liang D, Taylor T H, Christie C, Elmore B. The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro. Evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation. Radiation Research 2001; 156: 700–707
  • Redpath J L, Short S C, Woodcock M, Johnson P J. Low-dose reduction in transformation frequency compared to unirradiated controls: The role of hyper-radiosensitivity to cell death. Radiation Research 2003; 159: 433–436
  • Ruiz De Almodovar J M, Bush C, Peacock J H, Steel G G, Whitaker S J, McMillan T J. Dose-rate effect for DNA damage by ionizing radiation in human tumor cells. Radiation Research 1994; 138: S93–S96
  • Shadley J D, Wolff J K. Very low doses of X-rays can cause human lymphocytes to become less susceptible to ionizing radiation. Mutagenesis 1987; 2: 95–96
  • Shadley J D, Wiencke J K. Induction of the adaptive response by x-rays is dependent on radiation intensity. International Journal of Radiation Biology 1989; 56(1)107–118
  • Short S C, Woodcock M, Marples B, Joiner M C. Effects of cell cycle phase on low-dose hyper-radiosensitivity. International Journal of Radiation Biology 2003; 79: 99–105
  • Schultz C J, Geard C R. Radioresponse of human astrocytic tumors across grade as a function of acute and chronic dose rate irradiation. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 1397–1403
  • Thames H D. An ‘incomplete-repair’ model for survival after fractionated and continuous irradiations. International Journal of Radiation Biology 1985; 47: 319–339
  • Ulsh B A, Whicker F W, Hinton T G, Congdon J D, Bedford J S. The dose-rate effect and in vivo lymphocyte response. Radiation Research 2001; 155: 63–73
  • Wells R L, Bedford J S. Dose-rate effects in mammalian cells. IV. Repairable and nonrepairable damage in noncycling C3H 10T1/2 cells. Radiation Research 1983; 94: 105–134
  • Wouters B G, Skarsgard L D. The response of a human tumor cell line to low radiation doses: Evidence of enhanced sensitivity. Radiation Research 1994; 138: S76–S80
  • Wouters B G, Skarsgard L D. Low-dose radiation sensitivity and induced radioresistance to cell killing in HT-29 cells is distinct from the ‘adaptive response’ and cannot be explained by a subpopulation of sensitive cells. Radiation Research 1997; 148: 435–442
  • Wykes S M, Piasentin E, Joiner M C, Wilson G D, Marples B. Low-dose hyper-radiosensitivity is not caused by a failure to recognize DNA double-strand breaks. Radiation Research 2006; 165: 516–524
  • Zhou H, Suzuki M, Randers-Pehrson G, Vannals D, Chen G, Trosko J E, Waldren C A, Hei T K. Radiation risk to low fluences of α particles may be greater than we thought. Proceedings of the National Academy of Science USA 2001; 98: 14410–14415

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