Lymphocyte telomere length correlates with in vitro radiosensitivity in breast cancer cases but is not predictive of acute normal tissue reactions to radiotherapy

References

• Alexander P, Mikulski Z B. Mouse lymphoma cells with different radiosensitivities. Nature 1961; 192: 572–573
   PubMed Web of Science ®Google Scholar
• Andrew T, Aviv A, Faldin F, Sardulescu G L, Gardner J P, Lu X, Kimura M, Kato B S, Valdes A M, Spector T D. Mapping genetic loci that determine leukocyte telomere length in a large sample of unaffected female sibling pairs. American Journal of Human Genetics 2006; 78: 480–486
   PubMed Web of Science ®Google Scholar
• Barber J BP, Burrill W, Spreadborough A R, Levine E, Warren C, Kiltie A E, Roberts S A, Scott D. Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiotherapy and Oncology 2000a; 55: 179–186
   PubMed Web of Science ®Google Scholar
• Barber J BP, West C ML, Kiltie A E, Roberts S A, Scott D. Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygous and heterozygotes and breast cancer patients after radiotherapy. Radiation Research 2000b; 153: 570–578
   PubMed Web of Science ®Google Scholar
• Blasco M A. Telomeres and human disease: Ageing, cancer and beyond. Nature Reviews Genetics 2005; 6: 611–622
   PubMed Web of Science ®Google Scholar
• Broberg K, Bjork J, Paulsson K, Hoglund M, Albin M. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis 2005; 26: 1263–1271
   PubMed Web of Science ®Google Scholar
• Cabuy E, Newton C, Roberts T, Newbold R, Slijepcevic P. Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH. Cytometry 2004; 62: 150–161
   PubMedGoogle Scholar
• Camplejohn R S, Hodgson S, Carter N, Kato B S, Spector T D. Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins. British Journal of Cancer 2006; 95: 520–524
   PubMed Web of Science ®Google Scholar
• Czene K, Lichtenstein P, Hemminki K. Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family Cancer Database. International Journal of Cancer 2002; 99: 260–266
   PubMed Web of Science ®Google Scholar
• Docherty Z, Georgiou A, Langman C, Kesterton I, Rose S, Camplejohn R, Ball J, Barwell J, Gilchrist R, Pangon L, Berg J, Hodgson S. Is chromosome radiosensitivity and apoptotic response to irradiation correlated with cancer susceptibility?. International Journal of Radiation Biology 2007; 83: 1–12
   PubMed Web of Science ®Google Scholar
• Epel E S, Blackburn E H, Lin J, Dhabhar F S, Adler N E, Morrow J D, Cawthon R M. Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences, USA 2004; 101: 17312–17315
   PubMed Web of Science ®Google Scholar
• Finnon P, Wong H-P, Silver A RJ, Slijepcevic P, Bouffler S D. Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line. International Journal of Radiation Biology 2001; 77: 1151–1162
   PubMed Web of Science ®Google Scholar
• Fitzpatrick A L, Kronmal R A, Gardner J P, Psaty B M, Jenny N S, Tracy R P, Waleston J, Kimura M, Aviv A. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. American Journal of Epidemiology 2007; 165: 14–21
   PubMed Web of Science ®Google Scholar
• Fordyce C A, Heaphy C M, Bisoffi M, Wyaco J L, Joste N E, Mangarlik A, Baumgartner K B, Baumgartner R N, Hunt W C, Griffiths J K. Telomere content correlates with stage and prognosis in breast cancer. Breast Cancer Research and Treatment 2006; 99: 193–202
   PubMed Web of Science ®Google Scholar
• Goytisolo F A, Samper E, Martin-Caballero G, Finnon P, Herrera E, Flores J M, Bouffler S D, Blasco M A. Short telomeres result in organismal sensitivity to ionising radiation in mammals. Journal of Experimental Medicine 2000; 155: 345–352
   Google Scholar
• Griffiths J K, Bryant J E, Fordyce C A, Gilliland F D, Joste N E, Moyzis R K. Reduced telomere DNA content is correlated with genomic instability and metastasis in invasive human breast carcinoma. Breast Cancer Research and Treatment 1999; 54: 59–64
   PubMed Web of Science ®Google Scholar
• Harley C B, Futcher A B, Greider C W. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458–460
   PubMed Web of Science ®Google Scholar
• Hu J J, Smith T R, Miller M S, Lohman K, Case D L. Genetic regulation of ionising radiation sensitivity and breast cancer risk. Environmental and Molecular Mutagenesis 2002; 39: 208–215
   PubMed Web of Science ®Google Scholar
• Jeandos E, Schork N J, Kyvik K O, Kimura M, Skurnick J H, Aviv A. Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 2000; 36: 191–200
   Web of Science ®Google Scholar
• Kurz D J, Decory S, Hong Y, Trivier E, Akhmedov A, Erusalimsky J D. Chronic oxidative stress compromises telomere integrity and accelerates onset of senescence in human endothelial cells. Journal of Cell Science 2004; 117: 2417–2426
   PubMed Web of Science ®Google Scholar
• Lavin M F, Bennett I, Ramsay J, Gardiner R A, Seymour G J, Farrell A, Walsh M. Identification of a potentially radiosensitive subgroup among patients with breast cancer. Journal of the National Cancer Institute 1994; 86: 1627–1634
   PubMedGoogle Scholar
• Levine E L. Prediction of normal tissue and tumour response to radiotherapy. University of Cambridge. 2000, MD thesis
   Google Scholar
• Levy T, Agoulnik I, Atkinson E N, Tong X W, Gause H M, Hasenburg A, Runnebaum I B, Stickeler E, Mobus V J, Kaplan A L, Kieback D G. Telomere length in human white blood cells remains constant with age and is shorter in breast cancer patients. Anticancer Research 1998; 18: 1345–1349
   PubMed Web of Science ®Google Scholar
• Lichtenstein P, Holm N V, Verkasalo P K, Iliadou M, Kaprio J, Koskenvo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer. New England Journal of Medicine 2000; 343: 78–85
   PubMed Web of Science ®Google Scholar
• Locatelli I, Lichtenstein P, Yashin A I. The heritability of breast cancer: A Bayesian correlated frailty model applied to Swedish twins data. Twin Research 2004; 7: 182–191
   PubMedGoogle Scholar
• López E, Guerrero R, Núñez M I, del Moral R, Villalobos M, Martinez-Galán J, Valenszuela M T, Muñoz-Gámez J A, Oliver F J, Martín-Oliva D, Ruizdel Almodóvar J M. Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes. Breast Cancer Research 2005; 7: R690–R698
   Web of Science ®Google Scholar
• McIlrath J, Bouffler S D, Samper E, Cuthbert A, Wojcik A, Szumiel I, Bryant P E, Riches A C, Thompson A, Blasco M A, Newbold R F, Slijepcevic P. Telomere length abnormalities in mammalian radiosensitive cells. Cancer Research 2001; 61: 912–915
   PubMed Web of Science ®Google Scholar
• O'Donovan M P, Freemantle M R, Hull G, Bell D A, Arlett C F, Cole J. Extended-term cultures of human T-lymphocytes: A practical alternative to primary human lymphocytes for use in genotoxicity testing. Mutagenesis 1995; 10: 189–201
   PubMed Web of Science ®Google Scholar
• Odagiri E, Kanda N, Jibiki K, Demura R, Aikawa E, Demura H. Reduction of telomere length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma and gynecomastia. Cancer 1993; 73: 2978–2954
   Web of Science ®Google Scholar
• Oldenburg R A, Meijers-Heijboer H, Cornelisse C J, Devilee P. Genetic susceptibility for breast cancer: how many more genes to be found?. Critical Reviews in Oncology and Hematology 2007; 63: 125–149
   PubMed Web of Science ®Google Scholar
• Ozsahin M, Crompton N EA, Gourgou S, Kramar A, Li L, Shi Y Q, Sozzi W J, Zouhair A, Mirimanoff R O, Azna D. CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced later toxicity: A prospective study of 399 patients. Clinical Cancer Research 2005; 11: 7426–7433
   PubMed Web of Science ®Google Scholar
• Perez C, Brady L. Principles and practice of radiation oncology. Lippincott-Raven, Philadelphia 1998
   Google Scholar
• Plumb J A, Milroy R, Kaye S B. Effects of the pH dependence of 3-(4,5-dimethyliazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium based assay. Cancer Research 1989; 49: 4435–4440
   PubMed Web of Science ®Google Scholar
• Plumb J A. Cell sensitivity assays: The MTT assay. Methods in Molecular Medicine 2004; 88: 165–169
   PubMedGoogle Scholar
• Polyak K, Wu T-T, Hamilton S R, Kinzler K W, Vogelstein B. Less death in the dying. Cell Death Differentiation 1997; 4: 242–246
   PubMed Web of Science ®Google Scholar
• Reiger K E, Hong W-J, Gross Tusher V, Tang J, Tibshirani R, Chu G. Toxicity from radiation therapy associated with abnormal transcriptional response to DNA damage. Proceedings of the National Academy of Sciences USA 2004; 101: 6635–6640
   PubMed Web of Science ®Google Scholar
• Roberts S A, Levine E L, Scott D. Influence of intrinsic radiosensitivity on the survival of breast cancer patients. International Journal of Radiation Biology 2003; 79: 311–317
   PubMed Web of Science ®Google Scholar
• Scott D. Chromosomal radiosensitivity and low penetrance predisposition to cancer. Cytogenetics and Genome Research 2004; 104: 365–370
   PubMed Web of Science ®Google Scholar
• Slagboom P E, Droog S, Boomsma D I. Genetic determination of telomere size in humans: A twin study of three age groups. American Journal of Human Genetics 1994; 55: 876–882
   PubMed Web of Science ®Google Scholar
• Slijepcevic P. Is there a link between telomere maintenance and radiosensitivity?. Radiation Research 2004; 161: 82–86
   PubMed Web of Science ®Google Scholar
• Slijepcevic P, Al-Wahiby S. Telomere biology: Integrating chromosomal end protection with DNA damage response. Chromosoma 2005; 114: 275–285
   PubMed Web of Science ®Google Scholar
• Slijepcevic P. The role of DNA damage response proteins at telomeres – an ‘integrative’ model. DNA Repair 2006; 5: 1299–1306
   PubMed Web of Science ®Google Scholar
• Son N H, Murray S, Yanovski J, Hodes R J, Weng N. Lineage specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. Journal of Immunology 2000; 165: 1191–1196
   PubMed Web of Science ®Google Scholar
• Sprung C N, Davey D SP, Goh S K, Radford I R, McKay M J. Uncoupling of telomere length and radiosensitivity in mouse lymphoma cell lines of similar genetic background. International Journal of Radiation Biology 2007; 83: 515–521
   PubMed Web of Science ®Google Scholar
• Suh Y, Lee K-L, Kim W-H, Hun B-G, Vijg J, Park S C. Ageing alters the apoptotic response to genotoxic stress. Nature Medicine 2002; 8: 3–4
   PubMed Web of Science ®Google Scholar
• Svensson J P, Stalpors L JA, Esveldf-von Lange R EE, Franhen N AP, Haveman J, Klein B, Turesson I, Vrielig H, Giphart-Gassler M. Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity. PLoS Medicine 2006; 3: e422
   PubMed Web of Science ®Google Scholar
• Turesson I. Individual variation and dose dependency in the progression rate of skin telangiectasia. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 1569–1574
   PubMed Web of Science ®Google Scholar
• Valdes A M, Andrew T, Gardner J P, Kimura M, Oelsner E, Cherkas L F, Aviv A, Spector T D. Obesity, cigarette smoking and telomere length in women. Lancet 2005; 366: 662–664
   PubMed Web of Science ®Google Scholar
• Von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochemical Sciences 2002; 27: 339–344
   PubMed Web of Science ®Google Scholar
• Wong K-K, Chang S, Weiler S R, Ganesan S, Chaudhuri J, Zhu C, Artandi S E, Rudolph C L, Gottlieb G J, Chin L, Alt F W, DePinho R A. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionising radiation. Nature Genetics 2000; 26: 85–88
   PubMed Web of Science ®Google Scholar
• Wu X, Amos C I, Zhu Y, Zhao H, Grossman B H, Shay J W, Luo S, Hong W K, Spitz M R. Telomere dysfunction: A potential cancer predisposition factor. Journal of the National Cancer Institute 2003; 95: 1211–1218
   PubMed Web of Science ®Google Scholar