1-Methylxanthine enhances the radiosensitivity of tumor cells

References

• Asaad N A, Zeng Z C, Guan J, Thacker J, Iliakis G. Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: Reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants. Oncogene 2000; 19: 5788–5800
   PubMed Web of Science ®Google Scholar
• Barratt R A, Kao G, Mckenna W G, Kuang J, Muschel R J. The G2 block induced by DNA damage: A caffeine-resistant component independent of Cdc25C, MPM-2 phosphorylation, and H1 kinase activity. Cancer Research 1998; 58: 2639–2645
   PubMedGoogle Scholar
• Binder A, Bohm L. Influence of irradiation and pentoxifylline on histone H3 phosphorylation in human tumour cell lines. Cell Proliferation 2002; 35: 37–47
   PubMedGoogle Scholar
• Blasina A, Paegle E S, McGowan C H. The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells. Molecular Biology of Cell 1997; 8: 1013–1023
   PubMedGoogle Scholar
• Bohm L. Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation. Radiation Oncology 2006; 1: 12
   PubMed Web of Science ®Google Scholar
• Bohm L, Roos W P, Serafin A M. Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives. Toxicology 2003; 193: 153–160
   PubMed Web of Science ®Google Scholar
• Bohm L, Theron T, Binder A. Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage. Biochimica et Biophysica Acta 2000; 1499: 1–10
   PubMed Web of Science ®Google Scholar
• Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown J P, Sedivy J M, Kinzler K W, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497–1501
   PubMed Web of Science ®Google Scholar
• Choi E K, Ji I M, Lee S R, Kook Y H, Griffin R J, Lim B U, Kim J S, Lee D S, Song C W, Park H J. Radiosensitization of tumor cells by modulation of ATM kinase. International Journal of Radiation Biology 2006; 82: 277–283
   PubMed Web of Science ®Google Scholar
• Choi E K, Roberts K P, Griffin R J, Han T, Park H J, Song C W, Park H J. Effect of pH on radiation-induced p53 expression. International Journal of Radiation Oncology Biology Physics 2004; 60: 1264–1271
   PubMed Web of Science ®Google Scholar
• Choi E K, Terai K, Ji I M, Kook Y H, Park K H, Oh E T, Griffin R J, Lim B U, Kim J S, Lee D S, Boothman D A, Loren M, Song C W, Park H J. Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells. Neoplasia 2007; 9: 634–642
   PubMed Web of Science ®Google Scholar
• Cortez D, Wang Y, Qin J, Elledge S J. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 1999; 286: 1162–1166
   PubMed Web of Science ®Google Scholar
• Dikomey E, Dahm-DJ, Brammer I, Martensen R, Kaina B. Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. International Journal of Radiation Biology 1998; 73: 269–278
   PubMed Web of Science ®Google Scholar
• Fernandez-Capetillo O, Chen H T, Celeste A, Ward I, Romanienko P J, Morales J C, Naka K, Xia Z, Camerini O RD, Motoyama N, Carpenter P B, Bonner W M, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature Cell Biology 2002; 4: 993–997
   PubMed Web of Science ®Google Scholar
• Furnari B, Rhind N, Russell P. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science 1997; 277: 1495–1497
   PubMed Web of Science ®Google Scholar
• Geraets L, Moonen H J, Wouters E F, Bast A, Hageman G J. Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. Biochemical Pharmacology 2006; 72: 902–910
   PubMed Web of Science ®Google Scholar
• Guillouf C, Rosselli F, Krishnaraju K, Moustacchi E, Hoffman B, Liebermann D A. p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis. Oncogene 1995; 10: 2263–2270
   PubMed Web of Science ®Google Scholar
• Hwang A, Muschel R J. Radiation and the G2 phase of the cell cycle. Radiation Research 1998; 150: S52–59
   PubMedGoogle Scholar
• Iliakis G, Wang Y, Guan J, Wang H. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 2003; 22: 5834–5847
   PubMed Web of Science ®Google Scholar
• Innocente S A, Abrahamson J L, Cogswell J P, Lee J M. p53 regulates a G2 checkpoint through cyclin B1. Proceedings of the National Academy of Science of the USA 1999; 96: 2147–2152
   PubMed Web of Science ®Google Scholar
• Ismail I H, Nystrom S, Nygeren J, Hammarsten O. Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks. Journal of Biological Chemistry 2005; 280: 4649–4655
   PubMedGoogle Scholar
• Ito K, Nakazato T, Miyakawa Y, Yamato K, Ikeda Y, Kizaki M. Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells. Journal of Cellular Physiology 2003; 196: 276–283
   PubMedGoogle Scholar
• Jha M N, Bamburg J R, Bernstein B W, Bedford J S. Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells. Radiation Research 2002; 157: 26–31
   PubMed Web of Science ®Google Scholar
• Kastan M B, Lim D S. The many substrates and functions of ATM. Nature Reviews Molecular Cell Biology 2000; 1: 179–186
   PubMed Web of Science ®Google Scholar
• Lavin M F, Birrell G, Chen P, Kozlov S, Scott S, Gueven N. ATM signaling and genomic stability in response to DNA damage. Mutation Research 2005; 569: 123–132
   PubMed Web of Science ®Google Scholar
• Leach S D, Scatena C D, Keefer C J, Goodman H A, Song S Y, Yang L, Pietenpol J A. Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis. Cancer Research 1998; 58: 3231–3236
   PubMed Web of Science ®Google Scholar
• Lopez-Girona A, Furnari B, Mondesrt O, Russell P. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 1999; 397: 172–175
   PubMed Web of Science ®Google Scholar
• Lowndes N F, Toh G W. DNA repair: The importance of phosphorylating histone H2AX. Current Biology 2005; 15: R99–102
   PubMed Web of Science ®Google Scholar
• Maity A, Hwang A, Janss A, Phillips P, Mckenna W G, Muschel R J. Delayed cyclin B1 expression during the G2 arrest following DNA damage. Oncogene 1996; 13: 1647–1657
   PubMedGoogle Scholar
• Matsuoka S, Huang M, Elledge S J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998; 282: 1893–1897
   PubMed Web of Science ®Google Scholar
• Musk S RR, Steel G G. Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity. International Journal of Radiation Biology 1990; 57: 1105–1112
   PubMed Web of Science ®Google Scholar
• Nakamura A, Sedelnikova O A, Redon C, Pilch D R, Sinogeeva N I, Shroff R, Lichten M, Bonner W M. Techniques for gamma-H2AX detection. Methods in Enzymology 2006; 409: 236–250
   PubMed Web of Science ®Google Scholar
• Park H J, Lee S H, Chung H, Rhee Y H, Lim B U, Ha S W, Griffin R J, Lee H S, Song C W, Choi E K. Influence of environmental pH on G2-phase arrest caused by ionizing radiation. Radiation Research 2003; 159: 86–93
   PubMed Web of Science ®Google Scholar
• Park M, Chae H D, Yun J, Jung M, Kim Y S, Kim S H, Han M H, Shin D Y. Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest. Cancer Research 2000; 60: 542–545
   PubMed Web of Science ®Google Scholar
• Peng C Y, Graves P R, Thoma R S, Wu Z, Shaw A S, Piwnica-Worms H. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 1997; 277: 1501–1505
   PubMed Web of Science ®Google Scholar
• Rengelshausen J, Lindenmaier H, Cihlar T, Walter-Sack I, Haefeli W E, Weiss J. Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine. Biochemical Biophysical and Research Communications 2004; 320: 90–94
   PubMedGoogle Scholar
• Rogaku E P, Pilch D R, Orr A H, Ivanova V S, Bonner W M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. Journal of Biological Chemistry 1998; 273: 5858–5868
   PubMedGoogle Scholar
• Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proceedings of the National Academy of Science of the USA 2003; 100: 5057–5062
   PubMed Web of Science ®Google Scholar
• Sancar A, Lindsey-Boltz L A, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annual Review of Biochemistry 2004; 73: 39–85
   PubMed Web of Science ®Google Scholar
• Sanchez Y, Wong C, Thoma R S, Richman R, Wu Z, Piwnica-Worms H, Elledge S J. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25. Science 1997; 277: 1497–1501
   PubMed Web of Science ®Google Scholar
• Sarkaria J N, Busby E C, Tibbetts R S, Roos P, Taya Y, Karnitz L M, Abraham R T. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Research 1999; 59: 4375–4382
   PubMed Web of Science ®Google Scholar
• Shiloh Y. ATM and ATR: networking cellular responses to DNA damage. Current Opinion in Genetics and Development 2001; 11: 71–77
   PubMed Web of Science ®Google Scholar
• Smits V A, Medema R H. Checking out the G(2)/M transition. Biochimica et Biophysica Acta 2001; 1519: 1–12
   PubMed Web of Science ®Google Scholar
• Theron T, Binder A, Verheye-Dua F, Bohm L. The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline. International Journal of Radiation Biology 2000; 76: 1197–1208
   PubMed Web of Science ®Google Scholar
• Theron T, Bohm L. Influence of the G2 cell cycle block abrogator pentoxifylline on the expression and subcellular location of cyclin B1 and p34cdc2 in HeLa cervical carcinoma cells. Cell Proliferation 2000; 33: 39–50
   PubMed Web of Science ®Google Scholar
• Vernimmen F, Verheye-Dua F, Du Toit H, Bohm L. Effect of pentoxifylline on radiation damage and tumor growth. Strahlentherapie und Onkologie 1994; 170: 595–601
   PubMedGoogle Scholar
• Wang H, Boecker W, Wang H, Wang X, Guan J, Thompson L H, Nickoloff J A, Iliakis G. Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks. Oncogene 2004; 23: 824–834
   PubMed Web of Science ®Google Scholar
• Wang X, Wang H, Iliakis G, Wang Y. Caffeine-induced radiosensitization is independent of nonhomologous end joining of DNA double-strand breaks. Radiation Research 2003; 159: 426–432
   PubMed Web of Science ®Google Scholar