Leptin induction following irradiation is a conserved feature in mammalian epithelial cells and tissues

References

• Amundson SA. 2007. Functional genomics in radiation biology: a gateway to cellular systems-level studies. Radiat Environ Biophys. 47:25–31.
   PubMed Web of Science ®Google Scholar
• Bado A, Levasseur S, Attuoub A, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, et al. 1998. The stomach is a source of leptin. Nature. 394:790–793.
   PubMed Web of Science ®Google Scholar
• Banks AS, Davis SM, Bates SH, Myers MG Jr. 2000. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem. 275:14563–14572.
   PubMed Web of Science ®Google Scholar
• Bouloumié A, Drexler HC, Lafontan M, Busse R. 1998. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res. 83:1059–1066.
   PubMed Web of Science ®Google Scholar
• Bryson JM, Phuyal JL, Swan V, Caterson AD. 1999. Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice. Am J Physiol. 277:E417–E422.
   PubMed Web of Science ®Google Scholar
• Bufalieri F, Licursi V, D’Antonio M, Castrignanò T, Amendola R, Negri R. 2012. The transcriptional response of mammalian cancer cells to irradiation is dominated by a cell cycle signature which is strongly attenuated in non-cancer cells and tissues. Int J Radiat Biol. 88:822–829.
   PubMed Web of Science ®Google Scholar
• Cestelli Guidi M, Mirri C, Fratini E, Licursi V, Negri R, Marcelli A, Amendola R. 2012. In vivo skin leptin modulation after 14 MeV neutron irradiation: a molecular and FT-IR spectroscopic study. Anal Bioanal Chem. 404:1317–1326.
   PubMed Web of Science ®Google Scholar
• Chiani F, Iannone C, Negri R, Paoletti D, D’Antonio M, D’Onorio De Meo P, Castrignanò T. 2009. Radiation genes: a database devoted to microarrays screenings revealing transcriptome alterations induced by ionizing radiation in mammalian cells. Database (Oxford). 2009:bap007.
   PubMed Web of Science ®Google Scholar
• Colaprico A, Silva TC, Olsen C, Garofano L, Cava C, Garolini D, Sabedot TS, Malta TM, Pagnotta SM, Castiglioni I, et al. 2016. TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res. 44:e71.
   PubMed Web of Science ®Google Scholar
• Dam J, Jockers R. 2013. Hunting for the functions of short leptin receptor isoforms. Mol Metab. 2:327–328.
   PubMed Web of Science ®Google Scholar
• Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G. 2000. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 100:197–207.
   PubMed Web of Science ®Google Scholar
• Frank S, Stallmeyer B, Kampfer H, Kolb N, Pfeilscifter J. 2000. Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest. 106:501–509.
   PubMed Web of Science ®Google Scholar
• Fratini E, Licursi V, Artibani M, Kobos K, Colautti P, Negri R, Amendola R. 2011. Dose-dependent onset of regenerative program in neutron irradiated mouse skin. PloS One. 6:e19242.
   PubMed Web of Science ®Google Scholar
• Friedman JM, Halaas JL. 1998. Leptin and the regulation of body weight in mammals. Nature. 395:763–770.
   PubMed Web of Science ®Google Scholar
• Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ. 1996. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA. 93:14564–14568.
   PubMed Web of Science ®Google Scholar
• Guo S, Liu M, Wang G, Torroella-Kouri M, Gonzalez-Perez RR. 2012. Oncogenic role and therapeutic target of leptin signalling in breast cancer and cancer stem cells. Biochim Biophys Acta. 1825:207–222.
   PubMed Web of Science ®Google Scholar
• Hamada N, Bouffler S, Woloschak GE. 2016. Special issue: tissue reactions to ionizing radiation exposure. Mutat Res. 770:217–218.
   PubMed Web of Science ®Google Scholar
• Hoff J. 2000. Methods of blood collection in the mouse. Lab Anim. 29:47–53.
   Web of Science ®Google Scholar
• Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, et al. 2015. Orchestrating high-throughput genomic analysis with bioconductor. Nat Methods. 12:115–121.
   PubMed Web of Science ®Google Scholar
• Hwa JJ, Ghiboudi L, Compton D, Fawzu AB, Strader CD. 1996. Intracerebroventricular injection of leptin increases thermogenesis and mobilizes fat metabolism in ob/ob mice. Horm Metab Res. 8:659–663.
   Web of Science ®Google Scholar
• Jin L, Burguera BG, Couce ME, Scheithauer BW, Lamsan J, Eberhardt NL, Kulig E, Lloyd RV. 1999. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab. 84:2903–2911.
   PubMed Web of Science ®Google Scholar
• Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberg P. 1999. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides. 20:1449–1453.
   PubMed Web of Science ®Google Scholar
• Kume K, Satomura K, Nishisho S, Kitaoka E, Yamanouchi K, Tobiume S, Nagayama M. 2002. Potential role of leptin in endochondral ossification. J Histochem Cytochem. 50:159–169.
   PubMed Web of Science ®Google Scholar
• Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:632–635.
   PubMed Web of Science ®Google Scholar
• Licursi V, Fratini E, Benassi B, Cestelli-Guidi M, Consales C, Marcelli A, Mirri C, Negri R, Amendola R. 2014. A proposed integrated systems approach to the radiation biology of cosmic interest: biophysics and molecular characterization of tissues irradiated with 14 MeV neutrons. Rend Fis Acc Lincei. 25:s23–s27.
   Google Scholar
• Margetic S, Gazzola C, Pegg GG, Hill RA. 2002. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord. 26:1407–1433.
   PubMed Web of Science ®Google Scholar
• Martone M, Angelone M, Pillon M. 1994. The 14 MeV frascati neutron generator. J Nucl Mater. 215:1661–1664.
   Web of Science ®Google Scholar
• Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, et al. 1997. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med. 3:1029–1033.
   PubMed Web of Science ®Google Scholar
• Matsumoto Y, Iwakawa M, Furusawa Y, Ishikawa K, Aoki M, Imadome K, Matsumoto I, Tsujii H, Ando K, Imai T. 2008. Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams. Int J Radiat Biol. 84:299–314.
   PubMed Web of Science ®Google Scholar
• Mezentsev A, Amundson SA. 2011. Global gene expression responses to low- or high-dose radiation in a human three-dimensional tissue model. Radiat Res. 175:677–688.
   PubMed Web of Science ®Google Scholar
• Morash B, Li A, Murphy PR, Wilkinson M, Ur E. 1999. Leptin gene expression in the brain and pituitary gland. Endocrinology. 140:5995–5998.
   PubMed Web of Science ®Google Scholar
• Murad A, Nath AK, Cha ST, Demir E, Flores-Riveros J, Sierra-Honigmann MR. 2003. Leptin is an autocrine/paracrine regulator of wound healing. FASEB J. 17:1895–1897.
   PubMed Web of Science ®Google Scholar
• R Core Team. 2015. R Foundation for Statistical Computing. R: a language and environment for statistical computing. Vienna.
   Google Scholar
• Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. 2015. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e47.
   PubMed Web of Science ®Google Scholar
• Yarandi SS, Hebbar G, Sauer CG, Cole CR, Ziegler TR. 2011. Diverse roles of leptin in the gastrointestinal tract: Modulation of motility, absorption, growth, and inflammation. Nutrition. 27:269–275.
   PubMed Web of Science ®Google Scholar
• Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, et al. 1998. Biological action of leptin as an angiogenic factor. Science. 281:1683–1686.
   PubMed Web of Science ®Google Scholar
• Spicer LJ, Francisco CC. 1997. The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology. 138:3374–3379.
   PubMed Web of Science ®Google Scholar
• Suman S, Kallakury BV, Fornace AJ Jr, Datta K. 2015. Protracted upregulation of leptin and IGF1 is associated with activation of PI3K/Akt and JAK2 pathway in mouse intestine after ionizing radiation exposure. Int J Biol Sci. 11:274–283.
   PubMed Web of Science ®Google Scholar
• Suman S, Kumar S, Fornace AJ, Datta K. 2016. Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine. Sci Rep. 25:31853–31864.
   Web of Science ®Google Scholar
• Trayhurn P, Hoggard N, Mercer JG, Rayner DV. 1999. Leptin: fundamental aspects. Int J Obes Relat Metab Disord. 23:22–28.
   PubMed Web of Science ®Google Scholar
• Uotani S, Bjørbæk C, Tornøe J, Flier JS. 1999. Functional properties of leptin receptor isoforms internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes. 40:279–286.
   Web of Science ®Google Scholar
• Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L. 1998. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 393:684–688.
   PubMed Web of Science ®Google Scholar
• Warters RL, Packard AT, Kramer GF, Gaffney DK, Moos PJ. 2009. Differential gene expression in primary human skin keratinocytes and fibroblasts in response to ionizing radiation. Radiat Res. 172:82–95.
   PubMed Web of Science ®Google Scholar
• Webber J. 1994. Energy balance in obesity. Proc Nutr Soc. 62:539–543.
   Web of Science ®Google Scholar
• Weichselbaum RR, Hallahan DE, Sukhatme V, Dritschilo A, Sherman ML, Kufe DW. 1991. Biological consequences of gene regulation after ionizing radiation exposure. J Natl Cancer Inst. 83:480–484.
   PubMedGoogle Scholar
• Woloschak GE, Chang-Liu CM. 1990. Differential modulation of specific gene expression following high- and low-LET radiations. Radiat Res. 124:183–187.
   PubMed Web of Science ®Google Scholar
• Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong SE, Rosen ED. 2012. FOSL2 promotes leptin gene expression in human and mouse adipocytes. J Clin Invest. 122:1010–1021.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425–432.
   PubMed Web of Science ®Google Scholar