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Original Articles

Radiation protection and mitigation potential of phenylbutyrate: delivered via oral administration

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Pages 907-919 | Received 12 Jan 2017, Accepted 23 Jun 2017, Published online: 27 Jul 2017

References

  • Benzie IF, Strain JJ. 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 239:70–76.
  • Brown SL, Kolozsvary A, Liu J, Ryu S, Kim JH. 2008. Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. Radiat Res. 169:474–478.
  • Carducci MA, Gore S. 1997. Phenylbutyrate (PB) for refractory solid tumors: Phase I clinical and pharmacological evaluation of intravenous and oral PB. Anticancer Res. 17:3972–3973.
  • Chung YL, Wang AJ, Yao LF. 2004. Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy. Mol Cancer Ther. 3:317–325.
  • Chung YL, Lee MY, Pui NN. 2009. Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis. Carcinogenesis. 30:1387–1397.
  • Davis T, Kennedy C, Chiew YE, Clarke CL, deFazio A. 2000. Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clin Cancer Res. 6:4334–4342.
  • DiGiuseppe JA, Weng LJ, Yu KH, Fu S, Kastan MB, Samid D, Gore SD. 1999. Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis. Leukemia. 8:1243–1253.
  • Dover GJ, Brusilow S, Charache S. 1994. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate. Blood. 84:339–343.
  • Epperly M, Jin SQ, Nie S, Cao S, Zhang X, Franciola D, Wang H, Fink M, Greenberger JS. 2007. Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation. Radiat Res. 168:552–559.
  • Ferrandina G, Filippini P, Ferlini C, Maggiano N, Stoler AB, Fruscella E, Mozzetti S, Mancuso S, Freedman RS, Scambia G, et al. 2000. Growth inhibitory effects and radiosensitization induced by fatty aromatic acids on human cervical cancer cells. Oncol Res. 12:429–440.
  • Fibach E, Prasanna P, Rodgers GP, Samid D. 1993. Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia. Blood. 82:2203–2209.
  • Gore SD, Samid D, Weng LJ. 1997. Clinical development of sodium phenylbutyrate (SPB) as a putative differentiating agent in myeloid malignancies. Anticancer Res. 17:3981–3982.
  • Gore SD, Weng LJ, Figg WD, Zhai S, Donehower RC, Dover G, Grever MR, Griffin C, Grochow LB, Hawkins A, et al. 2002. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Clin Cancer Res. 8:963–970.
  • Hafer N, Maidment BW, Hatchett RJ. 2010. The NIAID Radiation Countermeasures Program business model. Biosecur Bioterror. 8:357–363.
  • Haydont V, Bourgier C, Pocard M, Lusinchi A, Aigueperse J, Mathé D, Bourhis J, Vozenin-Brotons MC. 2007. Pravastatin Inhibits the Rho/CCN2/extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats. Clin Cancer Res. 13:5331–5334.
  • Hudgins WR, Fibach E, Safaya S, Rieder RF, Miller AC, Samid D. 1996. Transcriptional upregulation of gamma-globin by phenylbutyrate and analogous aromatic fatty acids. Biochem Pharmacol. 52:1227–1233.
  • Jung M. 2001. Inhibitors of histone deacetylase as new anticancer agents. Curr Med Chem. 8:1505–1511.
  • Katzung BG. 2009. Basic and clinical pharmacology, 11th ed. New York, NY: McGraw-Hill.
  • Końca K, Lankoff A, Banasik A, Lisowska H, Kuszewski T, Góźdź S, Koza Z, Wojcik A. 2003. A cross platform public domain PC-image analysis program for the comet assay. Mutat Res. 10:15–20.
  • Kulp SK, Chen CS, Wang DS, Chen CY, Chen CS. 2006. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Clin Cancer Res. 12:5199–5206.
  • Massague J, Blain SW, Lo RS. 2001. TGFh signaling in growth control, cancer, and heritable disorders. Cell. 103:295–309.
  • Miller AC, Cohen S, Stewart M, Rivas R, Lison P. 2011. Radioprotection by the histone deacetylase inhibitor phenylbutyrate. Radiat Environ Biophys. 50:585–596.
  • Miller AC, Whittaker T, Thibault A, Samid D. 1997. Modulation of radiation response of human tumor cells by the differentiation inducers, phenylacetate and phenylbutyrate. Int J Radiat Biol. 72:211–218.
  • Miller AC, Samid D. 1997. Modification of radiation response based on the use of inhibitors of the mevalonate pathway of cholesterol synthesis. Adv Exp Med Biol. 400B:825–830.
  • Miller AC, Whittaker T, Page N. 2001. Suppression of depleted uranium-induced neoplastic transformation of human cells by the phenyl fatty acid, phenyl acetate: chemoprevention by targeting the p21RAS protein pathway. Radiat Res. 155:163–170.
  • Nübel T, Damrot J, Roos W, Kaina B, Fritz G. 2006. Lovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaks. Clin Cancer Res. 2:933–939.
  • Pace BS, White GL, Dover GJ, Boosalis MS, Faller DV, Perrine SP. 2002. Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. Blood. 100:4640–4648.
  • Paoluzzi L, Figg WD. 2004. Histone deacetylase inhibitors are potent radiation protectants. Cancer Biol Ther. 3:612–613.
  • Phuphanich S, Baker SD, Grossman SA, Carson KA, Gilbert MR, Fisher JD, Carducci MA. 2005. Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic study. Neuro Oncol. 7:177–182.
  • Prasanna P, Thibault A, Liu L, Samid D. 1996. Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells. J Neurochem. 66:710–716.
  • Rael LT, Thomas GW, Craun ML, Curtis CG, Bar-Or R, Bar-Or D. 2007. Lipid peroxidation and the thiobarbituric acid assay: standardization of the assay when using saturated and unsaturated fatty acids. J Biochem Mol Biol. 37:749–752.
  • Resar LM, Segal JB, Fitzpatrick LK, Friedmann A, Brusilow SW, Dover GJ. 2002. Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy. J Pediatr Hematol Oncol. 9:737–741.
  • Samid D, Shack S, Sherman LT. 1992. Phenylacetate: a novel nontoxic inducer of tumor cell differentiation. Cancer Res. 52:1988–1992.
  • Samid D, Shack S, Myers CE. 1993. Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate. J Clin Invest. 91:2288–2295.
  • Samid D, Hudgins WR, Shack S, Liu L, Prasanna P, Myers CE. 1997. Phenylacetate and phenylbutyrate as novel, nontoxic differentiation inducers. Advances. Experimental. Med Biol. 400A:501–505.
  • Samid D, Wells M, Greene ME, Shen W, Palmer CN, Thibault A. 2000. Peroxisome proliferator-activated receptor gamma as a novel target in cancer therapy: binding and activation by an aromatic fatty acid with clinical antitumor activity. Clin Cancer Res. 6:933–941.
  • Seed TM. 2002. New strategies for the prevention of radiation injury. JRR. 43:S239–S244.
  • Seed TM. 2005. Radiation protectants: current status and future prospects. Health Phys. 89:531–545.
  • Singh VK, Brown DS, Kao TC. 2010. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor. Int J Radiat Oncol Biol. 86:12–21.
  • Rahman L, Kode A, Biswas SK. 2007. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc. 1:3159–3165.
  • Thibault A, Figg WD, Samid D. 1996. A Phase I study of the differentiating agent phenylbutyrate in patients with cancer. Proceedings Annual Meeting American Society Clinical Oncology 15:A1539.
  • Wang J, Boerma M, Fu Q, Kulkarni A, Fink LM, Hauer-Jensen M. 2007. Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism. Int J Radiat Oncol Biol Phys. 68:1483–1490.
  • Weiss JF, Landauer MR, Hogan JB, Gunter-Smith PJ, Benson KA, Neta R, Hanson WR. 1997. Modification of radiation-induced gastrointestinal and hematopoietic injury in mice by combinations of agents: effects of indomethacin and caffeine. Adv Exp Med Biol. 400B:865–872.
  • Whitnall MH, Inal CE, Jackson WE, Miner VL, Villmar V, Seed TM. 2001. In vivo radioprotection against gamma-irradiation with 5-androstendiol: stimulation of the innate immune system. Radiat Res. 156:283–293.
  • Wieser R. 2002. The transforming growth factor signaling pathway in tumorigenesis. Curr Opin Oncol. 13:70–77.
  • Wojewódzka M, Kruszewski M, Buraczewska I, Xu W, Massuda E, Zhang J, Szumiel I. 2007. Sirtuin inhibition increases the rate of non-homologous end-joining of DNA double strand breaks. Acta Biochim Polish 54:63–69.

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