Radiation and hypoxia-induced non-targeted effects in normoxic and hypoxic conditions in human lung cancer cells

References

• Baskar R, Balajee AS, Geard CR. 2007. Effects of low and high LET radiations on bystander human lung fibroblast cell survival. Int J Radiat Biol. 83:551–559.
   PubMed Web of Science ®Google Scholar
• Bhatt AN, Chauhan A, Khanna S, Rai Y, Singh S, Soni R, Kalra N, Dwarakanath BS. 2015. Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells. BMC Cancer. 15:335.
   PubMed Web of Science ®Google Scholar
• Boyd M, Ross SC, Dorrens J, Fullerton NE, Tan KW, Zalutsky MR, Mairs RJ. 2006. Radiation-induced biologic bystander effect elicited in vitro by targeted radiopharmaceuticals labeled with alpha-, beta-, and auger electron-emitting radionuclides. J Nucl Med. 47:1007–1015.
   PubMed Web of Science ®Google Scholar
• Chendil D, Oakes R, Alcock RA, Patel N, Mayhew C, Mohiuddin M, Gallicchio VS, Ahmed MM. 2000. Low dose fractionated radiation enhances the radiosensitization effect of paclitaxel in colorectal tumor cells with mutant p53. Cancer. 89:1893–1900.
   PubMed Web of Science ®Google Scholar
• Dey S, Spring PM, Arnold S, Valentino J, Chendil D, Regine WF, Mohiuddin M, Ahmed MM. 2003. Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell lines. Clin Cancer Res. 9:1557–1565.
   PubMed Web of Science ®Google Scholar
• Fu XY, Zhang SW, Ran RQ, Shen ZH, Gu JX, Cao SL. 1998. Restoration of the p16 gene is related to increased radiosensitivity of p16-deficient lung adenocarcinoma cell lines. J Cancer Res Clin Oncol. 124:621–626.
   PubMed Web of Science ®Google Scholar
• Gupta S, Koru-Sengul T, Arnold SM, Devi GR, Mohiuddin M, Ahmed MM. 2011. Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells. Mol Cancer Ther. 10:292–302.
   PubMed Web of Science ®Google Scholar
• Hall EJ, Hei TK. 2003. Genomic instability and bystander effects induced by high-LET radiation. Oncogene. 22:7034–7042.
   PubMed Web of Science ®Google Scholar
• Hedlund EM, Yang X, Zhang Y, Yang Y, Shibuya M, Zhong W, Sun B, Liu Y, Hosaka K, Cao Y. 2013. Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs. Proc Natl Acad Sci USA USA. 110:654–659.
   PubMed Web of Science ®Google Scholar
• Ikeda T, Sun L, Tsuruoka N, Ishigaki Y, Yoshitomi Y, Yoshitake Y, Yonekura H. 2011. Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing. Biochem J. 436:399–407.
   PubMed Web of Science ®Google Scholar
• Joiner MC, Lambin P, Malaise EP, Robson T, Arrand JE, Skov KA, Marples B. 1996. Hypersensitivity to very-low single radiation doses: its relationship to the adaptive response and induced radioresistance. Mutat Res. 358:171–183.
   PubMed Web of Science ®Google Scholar
• Kanagavelu S, Gupta S, Wu X, Philip S, Wattenberg MM, Hodge JW, Couto MD, Chung KD, Ahmed MM. 2014. In vivo effects of lattice radiation therapy on local and distant lung cancer: potential role of immunomodulation. Radiat Res. 182:149–162.
   PubMed Web of Science ®Google Scholar
• Kuwabara K, Ogawa S, Matsumoto M, Koga S, Clauss M, Pinsky DJ, Lyn P, Leavy J, Witte L, Joseph-Silverstein J, et al. 1995. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci USA. 92:4606–4610.
   PubMed Web of Science ®Google Scholar
• Moeller BJ, Cao Y, Li CY, Dewhirst MW. 2004. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell. 5:429–441.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour CB. 2004. Radiation-induced bystander effects-implications for cancer. Nat Rev Cancer. 4:158–164.
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Little JB. 1992. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52:6394–6396.
   PubMed Web of Science ®Google Scholar
• Oquinena S, Inarrairaegui M, Vila JJ, Alegre F, Zozaya JM, Sangro B. 2009. Spontaneous regression of hepatocellular carcinoma: three case reports and a categorized review of the literature. Dig Dis Sci. 54:1147–1153.
   PubMed Web of Science ®Google Scholar
• Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. 2009. Hypoxia and radiation therapy: past history, ongoing research, and future promise. Curr Mol Med. 9:442–458.
   PubMed Web of Science ®Google Scholar
• Sak A, Wurm R, Elo B, Grehl S, Pottgen C, Stuben G, Sinn B, Wolf G, Budach V, Stuschke M. 2003. Increased radiation-induced apoptosis and altered cell cycle progression of human lung cancer cell lines by antisense oligodeoxynucleotides targeting p53 and p21(WAF1/CIP1). Cancer Gene Ther. 10:926–934.
   PubMed Web of Science ®Google Scholar
• Sathishkumar S, Dey S, Meigooni AS, Regine WF, Kudrimoti MS, Ahmed MM, Mohiuddin M. 2002. The impact of TNF-alpha induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiation. Technol Cancer Res Treat. 1:141–147.
   PubMed Web of Science ®Google Scholar
• Shareef MM, Cui N, Burikhanov R, Gupta S, Satishkumar S, Shajahan S, Mohiuddin M, Rangnekar VM, Ahmed MM. 2007. Role of tumor necrosis factor-alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma. Cancer Res. 67:11811–11820.
   PubMed Web of Science ®Google Scholar
• Shi YH, Bingle L, Gong LH, Wang YX, Corke KP, Fang WG. 2007. Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells. Pathology. 39:396–400.
   PubMed Web of Science ®Google Scholar
• Sokolov MV, Smilenov LB, Hall EJ, Panyutin IG, Bonner WM, Sedelnikova OA. 2005. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene. 24:7257–7265.
   PubMed Web of Science ®Google Scholar
• Stamell EF, Wolchok JD, Gnjatic S, Lee NY, Brownell I. 2013. The abscopal effect associated with a systemic anti-melanoma immune response. Int J Radiat Oncol Biol Phys. 85:293–295.
   PubMed Web of Science ®Google Scholar
• Tartier L, Gilchrist S, Burdak-Rothkamm S, Folkard M, Prise KM. 2007. Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells. Cancer Res. 67:5872–5879.
   PubMed Web of Science ®Google Scholar
• Tubin S, Raunik W. 2017. Hunting for abscopal and bystander effects: clinical exploitation of non-targeted effects induced by partial high-single-dose irradiation of the hypoxic tumour segment in oligometastatic patients. Acta Oncol. 56:1333–1339.
   PubMed Web of Science ®Google Scholar
• Tubin S, Valeriani M, Salerno G, Bracci S, Stoppacciaro A, Cardelli P, Osti MF, De Sanctis V, Minniti G, Maurizi Enrici R. 2015. Manipulation of radiation-induced bystander effect in prostate adenocarcinoma by dose and tumor differentiation grade: in vitro study. Int J Radiat Biol. 91:166–171.
   PubMed Web of Science ®Google Scholar
• Vaupel P, Mayer A. 2007. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 26:225–239.
   PubMed Web of Science ®Google Scholar
• Wang R, Coderre JA. 2005. A bystander effect in alpha-particle irradiations of human prostate tumor cells. Radiat Res. 164:711–722.
   PubMed Web of Science ®Google Scholar
• Yang H, Asaad N, Held KD. 2005. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene. 24:2096–2103.
   PubMed Web of Science ®Google Scholar
• Zheng J. 2012. Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). Oncol Lett. 4:1151–1157.
   PubMed Web of Science ®Google Scholar
• Ziello JE, Jovin IS, Huang Y. 2007. Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale J Biol Med. 80:51–60.
   PubMedGoogle Scholar