The effect of ¹¹¹In radionuclide distance and auger electron energy on direct induction of DNA double-strand breaks: a Monte Carlo study using Geant4 toolkit

References

• Agostinelli S, Allison J, Amako K, Apostolakis J, Araujo H, Arce P, Asai M, Axen D, Banerjee S, Barrand G. 2003. GEANT4 – a simulation toolkit. Nucl Instr Meth Phys Res. 506:250–303.
   Web of Science ®Google Scholar
• Alizadeh E, Sanz AG, García G, Sanche L. 2013. Radiation damage to DNA: the indirect effect of low-energy electrons. J Phys Chem Lett. 4:820–825.
   PubMed Web of Science ®Google Scholar
• Alizadeh E, Sanz AG, Madugundu GS, García G, Wagner JR, Sanche L. 2014. Thymidine decomposition induced by low-energy electrons and soft X rays under N2 and O2 atmospheres. Radiat Res. 181:629–640.
   PubMed Web of Science ®Google Scholar
• Alizadeh E, Orlando TM, Sanche L. 2015. Biomolecular damage induced by ionizing radiation: the direct and indirect effects of low-energy electrons on DNA. Annual Rev Phys Chem. 66:379–398.
   PubMed Web of Science ®Google Scholar
• Antonovic L, Brahme A, Furusawa Y, Toma-Dasu I. 2012. Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions. J Radiat Res. 54:18–26.
   PubMed Web of Science ®Google Scholar
• Balagurumoorthy P, Xu X, Wang K, Adelstein SJ, Kassis AI. 2012. Effect of distance between decaying 125I and DNA on Auger-electron induced double-strand break yield. Int J Radiat Biol. 88:998–1008.
   PubMed Web of Science ®Google Scholar
• Bernal MA, Bordage M-C, Brown J, Davídková M, Delage E, El Bitar Z, Enger S, Francis Z, Guatelli S, Ivanchenko V. 2015. Track structure modeling in liquid water: a review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit. Phys Med. 31:861–874.
   PubMed Web of Science ®Google Scholar
• Bernstein FC, Koetzle TF, Williams GJ, Meyer EF, Brice MD, Rodgers JR, Kennard O, Shimanouchi T, Tasumi M. 1978. The Protein Data Bank: a computer-based archival file for macromolecular structures. Arch Biochem Biophys. 185:584–591.
   PubMed Web of Science ®Google Scholar
• Boswell CA, Brechbiel MW. 2005. Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you. J Nucl Med. 46:1946–1947.
   PubMed Web of Science ®Google Scholar
• Bousis C, Emfietzoglou D, Hadjidoukas P, Nikjoo H. 2010. Monte Carlo single-cell dosimetry of Auger-electron emitting radionuclides. Phys Med Biol. 55:2555.
   PubMed Web of Science ®Google Scholar
• Buchegger F, Perillo-Adamer F, Dupertuis YM, Delaloye AB. 2006. Auger radiation targeted into DNA: a therapy perspective. Eur J Nucl Med Mol Imaging. 33:1352–1363.
   PubMed Web of Science ®Google Scholar
• Cai Z, Chen Z, Bailey KE, Scollard DA, Reilly RM, Vallis KA. 2008. Relationship between induction of phosphorylated H2AX and survival in breast cancer cells exposed to 111In-DTPA-hEGF. J Nucl Med. 49:1353–1361.
   PubMed Web of Science ®Google Scholar
• Cai Z, Pignol J-P, Chan C, Reilly RM. 2010. Cellular dosimetry of 111In using Monte Carlo N-particle computer code: comparison with analytic methods and correlation with in vitro cytotoxicity. J Nucl Med. 51:462–470.
   PubMed Web of Science ®Google Scholar
• Chauvie S, Francis Z, Guatelli S, Incerti S, Mascialino B, Montarou G, Moretto P, Nieminen P, Pia M. 2006. Models of biological effects of radiation in the Geant4 Toolkit. In: Phlips B, editor. IEEE Nuclear Science Symposium Conference Record; 2006; New Jersey: IEEE, p. 803–805.
   Google Scholar
• Chauvie S, Francis Z, Guatelli S, Incerti S, Mascialino B, Moretto P, Nieminen P, Pia MG. 2007. Geant4 physics processes for microdosimetry simulation: design foundation and implementation of the first set of models. IEEE Trans Nucl Sci. 54:2619–2628.
   Web of Science ®Google Scholar
• Delage E, Pham Q, Karamitros M, Payno H, Stepan V, Incerti S, Maigne L, Perrot Y. 2015. PDB4DNA: implementation of DNA geometry from the Protein Data Bank (PDB) description for Geant4-DNA Monte-Carlo simulations. Comp Phys Commun. 192:282–288.
   Web of Science ®Google Scholar
• Emfietzoglou D, Kostarelos K, Hadjidoukas P, Bousis C, Fotopoulos A, Pathak A, Nikjoo H. 2008. Subcellular S-factors for low-energy electrons: a comparison of Monte Carlo simulations and continuous-slowing-down calculations. Int J Radiat Biol. 84:1034–1044.
   PubMed Web of Science ®Google Scholar
• Francis Z, Incerti S, Capra R, Mascialino B, Montarou G, Stepan V, Villagrasa C. 2011. Molecular scale track structure simulations in liquid water using the Geant4-DNA Monte-Carlo processes. Appl Radiat Isot. 69:220–226.
   PubMed Web of Science ®Google Scholar
• Freudenberg R, Kotzerke J. 2010. Cellular dosimetry using the Geant4 Monte Carlo toolkit. J Nucl Med. 51:1488–1489.
   PubMed Web of Science ®Google Scholar
• Friedland W, Dingfelder M, Kundrát P, Jacob P. 2011. Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC. Mutat Res. 711:28–40.
   PubMed Web of Science ®Google Scholar
• Hirayama R, Ito A, Tomita M, Tsukada T, Yatagai F, Noguchi M, Matsumoto Y, Kase Y, Ando K, Okayasu R. 2009. Contributions of direct and indirect actions in cell killing by high-LET radiations. Radiat Res. 171:212–218.
   PubMed Web of Science ®Google Scholar
• Howell RW. 1992. Radiation spectra for Auger‐electron emitting radionuclides: report No. 2 of AAPM Nuclear Medicine Task Group No. 6. Med Phys. 19:1371–1383.
   PubMed Web of Science ®Google Scholar
• Incerti S, Baldacchino G, Bernal M, Capra R, Champion C, Francis Z, Guèye P, Mantero A, Mascialino B, Moretto P. 2010a. The Geant4-DNA project. Int J Model Simul Sci Comput. 1:157–178.
   Google Scholar
• Incerti S, Champion C, Tran H, Karamitros M, Bernal M, Francis Z, Ivanchenko V, Mantero A, collaboration G-D. 2013. Energy deposition in small-scale targets of liquid water using the very low energy electromagnetic physics processes of the Geant4 toolkit. Nucl Instr Meth Phys Res. 306:158–164.
   Google Scholar
• Incerti S, Douglass M, Penfold S, Guatelli S, Bezak E. 2016. Review of Geant4-DNA applications for micro and nanoscale simulations. Phys Med. 32:1187–1200.
   PubMed Web of Science ®Google Scholar
• Incerti S, Ivanchenko A, Karamitros M, Mantero A, Moretto P, Tran H, Mascialino B, Champion C, Ivanchenko V, Bernal M. 2010b. Comparison of GEANT4 very low energy cross section models with experimental data in water. Med Phys. 37:4692–4708.
   PubMed Web of Science ®Google Scholar
• Ito A, Nakano H, Kusano Y, Hirayama R, Furusawa Y, Murayama C, Mori T, Katsumura Y, Shinohara K. 2006. Contribution of indirect action to radiation-induced mammalian cell inactivation: dependence on photon energy and heavy-ion LET. Radiat Res. 165:703–712.
   PubMed Web of Science ®Google Scholar
• Kassis AI. 2003. Cancer therapy with Auger electrons: are we almost there? J Nucl Med. 44:1479–1481.
   PubMed Web of Science ®Google Scholar
• Kassis AI. 2004. The amazing world of Auger electrons. Int J Radiat Biol. 80:789–803.
   PubMed Web of Science ®Google Scholar
• Kassis AI, Adelstein SJ. 2005. Radiobiologic principles in radionuclide therapy. J Nucl Med. 46(Suppl. 1):4S–12S.
   PubMed Web of Science ®Google Scholar
• Kassis A, Sahu S, Makrigiorgos G. 1994. The effects of indium-111 decay on pBR322 DNA. J Nucl Med. 35.
   Web of Science ®Google Scholar
• Kyriakou I, Emfietzoglou D, Ivanchenko V, Bordage M, Guatelli S, Lazarakis P, Tran H, Incerti S. 2017. Microdosimetry of electrons in liquid water using the low-energy models of Geant4. J Appl Phys. 122:024303.
   Web of Science ®Google Scholar
• Kyriakou I, Incerti S, Francis Z. 2015. Technical note: improvements in geant4 energy-loss model and the effect on low-energy electron transport in liquid water. Med Phys. 42:3870–3876.
   PubMed Web of Science ®Google Scholar
• Kyriakou I, Šefl M, Nourry V, Incerti S. 2016. The impact of new Geant4-DNA cross section models on electron track structure simulations in liquid water. J Appl Phys. 119:194902.
   Web of Science ®Google Scholar
• Li Z, Cloutier P, Sanche L, Wagner JR. 2010. Low-energy electron-induced DNA damage: effect of base sequence in oligonucleotide trimers. J Am Chem Soc. 132:5422–5427.
   PubMed Web of Science ®Google Scholar
• Liamsuwan T, Emfietzoglou D, Uehara S, Nikjoo H. 2012. Microdosimetry of low-energy electrons. Int J Radiat Biol. 88:899–907.
   PubMed Web of Science ®Google Scholar
• Lobachevsky PN, White J, Leung M, Skene C, White J, Martin RF. 2008. Plasmid breakage by 125I-labelled DNA ligands: effect of DNA-iodine atom distance on breakage efficiency. Int J Radiat Biol. 84:991–1000.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Emfietzoglou D, Charlton D. 2008. The Auger effect in physical and biological research. Int J Radiat Biol. 84:1011–1026.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Emfietzoglou D, Liamsuwan T, Taleei R, Liljequist D, Uehara S. 2016. Radiation track, DNA damage and response-a review. Rep Prog Phys. 79:116601.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Goodhead D, Charlton D, Paretzke H. 1989. Energy deposition in small cylindrical targets by ultrasoft X-rays. Phys Med Biol. 34:691.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Uehara S, Emfietzoglou D, Cucinotta F. 2006. Track-structure codes in radiation research. Radiat Meas. 41:1052–1074.
   Web of Science ®Google Scholar
• Piroozfar B, Alirezapoor B, Motamedi Sedeh F, Jalilian AR, Mirzaei M, Raisali G. 2016. Evaluation of DNA damage in a Her2+ cell line induced by an Auger-emitting immunoconjugate. Iranian J Nucl Med. 24:106–113.
   Web of Science ®Google Scholar
• Pomplun E. 1991. A new DNA target model for track structure calculations and its first application to I-125 Auger electrons. Int J Radiat Biol. 59:625–642.
   PubMed Web of Science ®Google Scholar
• Pszona S, Grosswendt B, Bantsar A, Cieszykowska I, Czarnacki W. 2012. Nanodosimetry of 125I–Auger electrons–Experiment and modeling. Radiat Meas. 47:1092–1096.
   Web of Science ®Google Scholar
• Raisali G, Mirzakhanian L, Masoudi SF, Semsarha F. 2013. Calculation of DNA strand breaks due to direct and indirect effects of Auger electrons from incorporated 123I and 125I radionuclides using the Geant4 computer code. Int J Radiat Biol. 89:57–64.
   PubMed Web of Science ®Google Scholar
• Sanche L. 2002. Nanoscopic aspects of radiobiological damage: Fragmentation induced by secondary low-energy electrons. Mass Spectrom Rev. 21:349–369.
   PubMed Web of Science ®Google Scholar
• Sanche L. 2005. Low energy electron-driven damage in biomolecules. Eur Phys J D. 35:367–390.
   Web of Science ®Google Scholar
• Semsarha F, Goliaei B, Raisali G, Khalafi H, Mirzakhanian L. 2014. An investigation on the radiation sensitivity of DNA conformations to 60 Co gamma rays by using Geant4 toolkit. Nucl Instr Meth Phys Res. 323:75–81.
   Google Scholar
• Tajik M, Rozatian AS, Semsarha F. 2015. Calculation of direct effects of 60Co gamma rays on the different DNA structural levels: a simulation study using the Geant4-DNA toolkit. Nucl Instr Meth Phys Res. 346:53–60.
   Google Scholar
• Tavares AAS, Tavares JMR. 2010. 99mTc Auger electrons for targeted tumour therapy: a review. Int J Radiat Biol. 86:261–270.
   PubMed Web of Science ®Google Scholar
• Watanabe R, Wada S, Funayama T, Kobayashi Y, Saito K, Furusawa Y. 2011. Monte Carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths. Radiat Prot Dosim. 143:186–190.
   PubMed Web of Science ®Google Scholar
• Yakushev E, Kovalík A, Filosofov D, Korolev N, Lebedev N, Lubashevski A, Rösch F, Novgorodov A. 2005. An experimental comparison of the K- and L-Auger electron spectra generated in the decays of 140Nd and 111In. Appl Radiat Isot. 62:451–456.
   PubMed Web of Science ®Google Scholar
• Zhang L, Tan Z. 2010. A new calculation on spectrum of direct DNA damage induced by low-energy electrons. Radiat Environ Biophys. 49:15–26.
   PubMed Web of Science ®Google Scholar