Hypothermia modulates the DNA damage response to ionizing radiation in human peripheral blood lymphocytes

References

• Ainsbury EA, Bakhanova E, Barquinero JF, Brai M, Chumak V, Correcher V, Darroudi F, Fattibene P, Gruel G, Guclu I, et al. 2011. Review of retrospective dosimetry techniques for external ionising radiation exposures. Radiat Prot Dosimetry. 147:573–592.
   PubMed Web of Science ®Google Scholar
• Bajerska A, Liniecki J. 1969. The influence of temperature at irradiation in vitro on the yield of chromosomal aberrations in peripheral blood lymphocytes. Int J Radiat Biol Relat Stud Phys Chem Med. 16:483–493.
   PubMed Web of Science ®Google Scholar
• Batchelor E, Loewer A, Lahav G. 2009. The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer. 9:371–377.
   PubMed Web of Science ®Google Scholar
• Beckerman R, Prives C. 2010. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2:a000935.
   PubMed Web of Science ®Google Scholar
• Blackford AN, Jackson SP. 2017. ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response. Mol Cell. 66:801–817.
   PubMed Web of Science ®Google Scholar
• Brehwens K, Staaf E, Haghdoost S, Gonzalez AJ, Wojcik A. 2010. Cytogenetic damage in cells exposed to ionizing radiation under conditions of a changing dose rate. Radiat Res. 173:283–289.
   PubMed Web of Science ®Google Scholar
• Brzoska K, Kruszewski M. 2015. Toward the development of transcriptional biodosimetry for the identification of irradiated individuals and assessment of absorbed radiation dose. Radiat Environ Biophys. 54:353–363.
   PubMed Web of Science ®Google Scholar
• Brzozowska K, Johannes C, Obe G, Hentschel R, Morand J, Moss R, Wittig A, Sauerwein W, Liniecki J, Szumiel I, et al. 2009. Effect of temperature during irradiation on the level of micronuclei in human peripheral blood lymphocytes exposed to X-rays and neutrons. Int J Radiat Biol. 85:891–899.
   PubMed Web of Science ®Google Scholar
• Budworth H, Snijders AM, Marchetti F, Mannion B, Bhatnagar S, Kwoh E, Tan Y, Wang SX, Blakely WF, Coleman M, et al. 2012. DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. PLoS One. 7:e48619.
   PubMed Web of Science ®Google Scholar
• Cheng L, Lisowska H, Sollazzo A, Wegierek-Ciuk A, Stepien K, Kuszewski T, Lankoff A, Haghdoost S, Wojcik A. 2015. Modulation of radiation-induced cytogenetic damage in human peripheral blood lymphocytes by hypothermia. Mutat Res Genet Toxicol Environ Mutagen. 793:96–100.
   PubMed Web of Science ®Google Scholar
• Claesson AK, Stenerlow B, Jacobsson L, Elmroth K. 2007. Relative biological effectiveness of the alpha-particle emitter (211)At for double-strand break induction in human fibroblasts. Radiat Res. 167:312–318.
   PubMed Web of Science ®Google Scholar
• Dang L, Lisowska H, Manesh SS, Sollazzo A, Deperas-Kaminska M, Staaf E, Haghdoost S, Brehwens K, Wojcik A. 2012. Radioprotective effect of hypothermia on cells - a multiparametric approach to delineate the mechanisms. Int J Radiat Biol. 88:507–514.
   PubMed Web of Science ®Google Scholar
• Edwards AA, Virsik-Peuckert P, Bryant P. 1996. Mechanisms of radiation-induced chromosome aberrations. Mutat Res. 366:117–128.
   PubMed Web of Science ®Google Scholar
• Geiger C, Weber KJ, Wenz F. 1999. Radiation induced chromosome aberrations and clonogenic survival in human lymphoblastoid cell lines with different p53 status. Strahlenther Onkol. 175:289–292.
   PubMed Web of Science ®Google Scholar
• Ghandhi SA, Smilenov LB, Elliston CD, Chowdhury M, Amundson SA. 2015. Radiation dose-rate effects on gene expression for human biodosimetry. BMC Med Genomics. 8:22–30.
   PubMed Web of Science ®Google Scholar
• Gumrich K, Virsik-Peuckert RP, Harder D. 1986. Temperature and the formation of radiation-induced chromosome aberrations. I. The effect of irradiation temperature. Int J Radiat Biol Relat Stud Phys Chem Med. 49:665–672.
   PubMedGoogle Scholar
• IAEA. 2011. Cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies.
   Google Scholar
• Jeggo PA. 1997. DNA-PK: at the cross-roads of biochemistry and genetics. Mutat Res. 384:1–14.
   PubMed Web of Science ®Google Scholar
• Kabacik S, Mackay A, Tamber N, Manning G, Finnon P, Paillier F, Ashworth A, Bouffler S, Badie C. 2011. Gene expression following ionising radiation: identification of biomarkers for dose estimation and prediction of individual response. Int J Radiat Biol. 87:115–129.
   PubMed Web of Science ®Google Scholar
• Lane D. 1998. Awakening angels. Nature. 394:616–617.
   PubMed Web of Science ®Google Scholar
• Lisowska H, Brehwens K, Zolzer F, Wegierek-Ciuk A, Czub J, Lankoff A, Haghdoost S, Wojcik A. 2014. Effect of hypothermia on radiation-induced micronuclei and delay of cell cycle progression in TK6 cells. Int J Radiat Biol. 90:318–324.
   PubMed Web of Science ®Google Scholar
• Lisowska H, Wegierek-Ciuk A, Banasik-Nowak A, Braziewicz J, Wojewodzka M, Wojcik A, Lankoff A. 2013. The dose-response relationship for dicentric chromosomes and gamma-H2AX foci in human peripheral blood lymphocytes: influence of temperature during exposure and intra- and inter-individual variability of donors. International Journal of Radiation Biology. 89:191–199.
   PubMed Web of Science ®Google Scholar
• Lucas JN, Deng W, Hsieh WA, Galvan N, Gale KL, Morrison DP. 1999. Exposure temperature, but not donor age, is a confounding factor for in vitro translocation production by chronic irradiation. Int J Radiat Biol. 75:673–680.
   PubMed Web of Science ®Google Scholar
• Lundholm L, Haag P, Juntti T, Lewensohn R, Viktorsson K. 2014. Phosphoprotein analysis reveals MEK inhibition as a way to target non-small cell lung cancer tumor initiating cells. Int J Radiat Biol. 90:718–726.
   PubMed Web of Science ®Google Scholar
• Lundholm L, Haag P, Zong D, Juntti T, Mork B, Lewensohn R, Viktorsson K. 2013. Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest. Cell Death Dis. 4:e478.
   PubMed Web of Science ®Google Scholar
• Pantelias GE, Maillie HD. 1985. Direct analysis of radiation-induced chromosome fragments and rings in unstimulated human peripheral blood lymphocytes by means of the premature chromosome condensation technique. Mutat Res. 149:67–72.
   PubMed Web of Science ®Google Scholar
• Perry P, Wolff S. 1974. New Giemsa method for the differential staining of sister chromatids. Nature. 251:156–157.
   PubMed Web of Science ®Google Scholar
• Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E, Anderson CW. 2002. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem. 277:12491–12494.
   PubMed Web of Science ®Google Scholar
• Savage JRK. 1975. Classification and relationship of induced chromosomal structural changes. J Med Genet. 12:103–122.
   Google Scholar
• Szumiel I. 2008. Intrinsic radiation sensitivity: cellular signaling is the key. Radiat Res. 169:241–258.
   Web of Science ®Google Scholar
• Virsik-Peuckert RP, Harder D. 1986. Temperature and the formation of radiation-induced chromosome aberrations. II. The temperature dependence of lesion repair and lesion interaction. Int J Radiat Biol Relat Stud Phys Chem Med. 49:673–681.
   PubMedGoogle Scholar
• Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B. 1999. Identification and classification of p53-regulated genes. Proc Natl Acad Sci USA. 96:14517–14522.
   PubMed Web of Science ®Google Scholar